Details of the Target

General Information of Target

Target ID LDTP10965
Target Name Nucleosome assembly protein 1-like 4 (NAP1L4)
Gene Name NAP1L4
Gene ID 4676
Synonyms
NAP2; Nucleosome assembly protein 1-like 4; Nucleosome assembly protein 2; NAP-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVPGPYQAATGPSSAPSAPPSYEETVAVNSYYPTPPAPMPGPTTGLVTGPDGKGMNPPS
YYTQPAPIPNNNPITVQTVYVQHPITFLDRPIQMCCPSCNKMIVSQLSYNAGALTWLSCG
SLCLLGCIAGCCFIPFCVDALQDVDHYCPNCRALLGTYKRL
Target Bioclass
Other
Family
Nucleosome assembly protein (NAP) family
Subcellular location
Nucleus
Function Acts as a histone chaperone in nucleosome assembly.
Uniprot ID
Q99733
Ensemble ID
ENST00000380542.9
HGNC ID
HGNC:7640
ChEMBL ID
CHEMBL3886061

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.P11S .
CASKI SNV: p.M137I .
KMCH1 SNV: p.S229Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P8
 Probe Info  		10.00  LDD0451  [1]
FBPP2
 Probe Info  		3.18  LDD0318  [2]
TH211
 Probe Info  		Y85(5.03); Y180(7.37)  LDD0260  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K105(9.53); K140(10.00); K26(1.39); K263(10.00)  LDD0277  [5]
AZ-9
 Probe Info  		E43(10.00)  LDD2209  [6]
Probe 1
 Probe Info  		Y180(11.39)  LDD3495  [7]
m-APA
 Probe Info  		12.05  LDD0403  [8]
DBIA
 Probe Info  		C77(1.68)  LDD3311  [9]
BTD
 Probe Info  		C77(1.28)  LDD2089  [10]
HHS-482
 Probe Info  		Y55(0.87); Y85(1.03); Y95(0.87)  LDD0285  [11]
HHS-475
 Probe Info  		Y55(0.70); Y85(1.82)  LDD0264  [12]
HHS-465
 Probe Info  		Y85(6.81)  LDD2237  [13]
5E-2FA
 Probe Info  		N.A.  LDD2235  [14]
ATP probe
 Probe Info  		K61(0.00); K64(0.00); K83(0.00); K263(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [17]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [16]
NAIA_4
 Probe Info  		N.A.  LDD2226  [19]
1d-yne
 Probe Info  		N.A.  LDD0356  [20]
Compound 10
 Probe Info  		N.A.  LDD2216  [21]
IPM
 Probe Info  		N.A.  LDD0147  [22]
NHS
 Probe Info  		N.A.  LDD0010  [23]
SF
 Probe Info  		Y55(0.00); Y85(0.00)  LDD0028  [24]
TFBX
 Probe Info  		N.A.  LDD0148  [22]
Ox-W18
 Probe Info  		W163(0.00); W254(0.00)  LDD2175  [25]
1c-yne
 Probe Info  		K19(0.00); K282(0.00)  LDD0228  [20]
Acrolein
 Probe Info  		H89(0.00); H50(0.00)  LDD0217  [26]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [26]
Methacrolein
 Probe Info  		N.A.  LDD0218  [26]
AOyne
 Probe Info  		5.20  LDD0443  [27]
NAIA_5
 Probe Info  		N.A.  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 78 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.68  LDD1714  [28]
C053
 Probe Info  		8.69  LDD1751  [28]
C055
 Probe Info  		11.79  LDD1752  [28]
C082
 Probe Info  		5.70  LDD1774  [28]
C087
 Probe Info  		9.51  LDD1779  [28]
C106
 Probe Info  		24.76  LDD1793  [28]
C107
 Probe Info  		6.54  LDD1794  [28]
C108
 Probe Info  		9.06  LDD1795  [28]
C112
 Probe Info  		20.82  LDD1799  [28]
C134
 Probe Info  		22.94  LDD1816  [28]
C141
 Probe Info  		9.58  LDD1823  [28]
C143
 Probe Info  		14.22  LDD1825  [28]
C145
 Probe Info  		8.57  LDD1827  [28]
C147
 Probe Info  		14.72  LDD1829  [28]
C159
 Probe Info  		8.06  LDD1839  [28]
C160
 Probe Info  		8.06  LDD1840  [28]
C161
 Probe Info  		12.21  LDD1841  [28]
C170
 Probe Info  		7.31  LDD1850  [28]
C173
 Probe Info  		7.46  LDD1853  [28]
C178
 Probe Info  		16.45  LDD1857  [28]
C187
 Probe Info  		18.25  LDD1865  [28]
C194
 Probe Info  		8.46  LDD1870  [28]
C201
 Probe Info  		27.28  LDD1877  [28]
C206
 Probe Info  		17.27  LDD1881  [28]
C213
 Probe Info  		15.35  LDD1887  [28]
C218
 Probe Info  		15.03  LDD1892  [28]
C219
 Probe Info  		5.70  LDD1893  [28]
C220
 Probe Info  		13.09  LDD1894  [28]
C228
 Probe Info  		19.43  LDD1901  [28]
C231
 Probe Info  		13.55  LDD1904  [28]
C233
 Probe Info  		17.03  LDD1906  [28]
C234
 Probe Info  		5.98  LDD1907  [28]
C246
 Probe Info  		13.27  LDD1919  [28]
C265
 Probe Info  		15.67  LDD1936  [28]
C269
 Probe Info  		7.36  LDD1939  [28]
C277
 Probe Info  		8.94  LDD1947  [28]
C284
 Probe Info  		42.81  LDD1954  [28]
C287
 Probe Info  		11.08  LDD1957  [28]
C288
 Probe Info  		8.22  LDD1958  [28]
C296
 Probe Info  		13.00  LDD1966  [28]
C310
 Probe Info  		16.68  LDD1977  [28]
C313
 Probe Info  		13.36  LDD1980  [28]
C317
 Probe Info  		6.50  LDD1983  [28]
C338
 Probe Info  		11.79  LDD2001  [28]
C343
 Probe Info  		15.35  LDD2005  [28]
C347
 Probe Info  		5.94  LDD2008  [28]
C348
 Probe Info  		13.45  LDD2009  [28]
C349
 Probe Info  		8.82  LDD2010  [28]
C350
 Probe Info  		26.17  LDD2011  [28]
C354
 Probe Info  		9.32  LDD2015  [28]
C356
 Probe Info  		8.17  LDD2017  [28]
C363
 Probe Info  		17.88  LDD2024  [28]
C366
 Probe Info  		6.28  LDD2027  [28]
C376
 Probe Info  		7.16  LDD2036  [28]
C380
 Probe Info  		5.17  LDD2039  [28]
C382
 Probe Info  		21.86  LDD2041  [28]
C383
 Probe Info  		12.64  LDD2042  [28]
C386
 Probe Info  		15.56  LDD2045  [28]
C388
 Probe Info  		41.36  LDD2047  [28]
C390
 Probe Info  		37.01  LDD2049  [28]
C391
 Probe Info  		22.94  LDD2050  [28]
C403
 Probe Info  		17.88  LDD2061  [28]
C407
 Probe Info  		11.79  LDD2064  [28]
C413
 Probe Info  		16.34  LDD2069  [28]
C420
 Probe Info  		14.93  LDD2075  [28]
FFF probe11
 Probe Info  		10.48  LDD0471  [29]
FFF probe12
 Probe Info  		20.00  LDD0473  [29]
FFF probe13
 Probe Info  		20.00  LDD0475  [29]
FFF probe14
 Probe Info  		20.00  LDD0477  [29]
FFF probe15
 Probe Info  		7.59  LDD0478  [29]
FFF probe2
 Probe Info  		17.67  LDD0463  [29]
FFF probe3
 Probe Info  		18.32  LDD0464  [29]
FFF probe4
 Probe Info  		17.58  LDD0466  [29]
FFF probe6
 Probe Info  		5.27  LDD0468  [29]
FFF probe7
 Probe Info  		13.13  LDD0483  [29]
FFF probe9
 Probe Info  		20.00  LDD0470  [29]
JN0003
 Probe Info  		15.96  LDD0469  [29]
OEA-DA
 Probe Info  		8.02  LDD0046  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C77(0.86)  LDD2142  [10]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C77(0.60)  LDD2095  [10]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C77(1.44)  LDD2117  [10]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C77(0.53)  LDD2132  [10]
 LDCM0545  Acetamide MDA-MB-231 C77(0.91)  LDD2138  [10]
 LDCM0520  AKOS000195272 MDA-MB-231 C77(1.05)  LDD2113  [10]
 LDCM0156  Aniline NCI-H1299 12.05  LDD0403  [8]
 LDCM0108  Chloroacetamide HeLa H89(0.00); H50(0.00)  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C77(1.37)  LDD2227  [19]
 LDCM0191  Compound 21 HEK-293T 8.77  LDD0508  [29]
 LDCM0190  Compound 34 HEK-293T 7.83  LDD0510  [29]
 LDCM0192  Compound 35 HEK-293T 6.17  LDD0509  [29]
 LDCM0193  Compound 36 HEK-293T 7.90  LDD0511  [29]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C77(1.25)  LDD1702  [10]
 LDCM0625  F8 Ramos C77(0.64)  LDD2187  [31]
 LDCM0572  Fragment10 Ramos C77(0.63)  LDD2189  [31]
 LDCM0573  Fragment11 Ramos C77(0.08)  LDD2190  [31]
 LDCM0574  Fragment12 Ramos C77(0.74)  LDD2191  [31]
 LDCM0575  Fragment13 Ramos C77(1.37)  LDD2192  [31]
 LDCM0576  Fragment14 Ramos C77(1.07)  LDD2193  [31]
 LDCM0579  Fragment20 Ramos C77(0.77)  LDD2194  [31]
 LDCM0580  Fragment21 Ramos C77(1.27)  LDD2195  [31]
 LDCM0582  Fragment23 Ramos C77(1.65)  LDD2196  [31]
 LDCM0578  Fragment27 Ramos C77(1.07)  LDD2197  [31]
 LDCM0586  Fragment28 Ramos C77(0.38)  LDD2198  [31]
 LDCM0588  Fragment30 Ramos C77(1.63)  LDD2199  [31]
 LDCM0589  Fragment31 Ramos C77(0.99)  LDD2200  [31]
 LDCM0590  Fragment32 Ramos C77(0.78)  LDD2201  [31]
 LDCM0468  Fragment33 Ramos C77(1.74)  LDD2202  [31]
 LDCM0596  Fragment38 Ramos C77(1.55)  LDD2203  [31]
 LDCM0566  Fragment4 Ramos C77(0.71)  LDD2184  [31]
 LDCM0610  Fragment52 Ramos C77(1.74)  LDD2204  [31]
 LDCM0614  Fragment56 Ramos C77(1.48)  LDD2205  [31]
 LDCM0569  Fragment7 Ramos C77(0.40)  LDD2186  [31]
 LDCM0571  Fragment9 Ramos C77(0.59)  LDD2188  [31]
 LDCM0116  HHS-0101 DM93 Y55(0.70); Y85(1.82)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y55(0.77); Y85(2.62)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y55(0.65); Y85(2.40)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y55(0.71); Y85(1.75)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y55(0.92); Y85(2.02)  LDD0268  [12]
 LDCM0107  IAA HeLa H89(0.00); H50(0.00)  LDD0221  [26]
 LDCM0123  JWB131 DM93 Y55(0.87); Y85(1.03); Y95(0.87)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y55(0.58); Y85(0.47)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y55(0.98); Y85(1.26)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y55(6.69); Y85(2.76)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y55(2.11); Y85(1.86)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y55(1.12); Y85(0.97)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y55(0.50); Y85(0.47)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y55(0.68); Y85(0.83); Y95(0.18)  LDD0292  [11]
 LDCM0022  KB02 HEK-293T C77(0.89); C247(1.00)  LDD1492  [32]
 LDCM0023  KB03 HEK-293T C77(1.08); C247(0.99)  LDD1497  [32]
 LDCM0024  KB05 G361 C77(1.68)  LDD3311  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C77(1.75)  LDD2121  [10]
 LDCM0109  NEM HeLa H89(0.00); H50(0.00); H79(0.00)  LDD0223  [26]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C77(1.28)  LDD2089  [10]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C77(0.36)  LDD2096  [10]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C77(1.12)  LDD2098  [10]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C77(1.69)  LDD2099  [10]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C77(0.79)  LDD2100  [10]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C77(1.12)  LDD2101  [10]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C77(0.52)  LDD2104  [10]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C77(0.99)  LDD2107  [10]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C77(0.60)  LDD2108  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C77(0.75)  LDD2109  [10]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C77(0.49)  LDD2110  [10]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C77(1.25)  LDD2111  [10]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C77(0.71)  LDD2114  [10]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C77(0.54)  LDD2115  [10]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C77(0.87)  LDD2116  [10]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C77(0.70)  LDD2118  [10]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C77(0.88)  LDD2120  [10]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C77(0.54)  LDD2122  [10]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C77(0.84)  LDD2123  [10]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C77(0.68)  LDD2124  [10]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C77(1.50)  LDD2125  [10]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C77(0.62)  LDD2126  [10]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C77(1.22)  LDD2127  [10]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C77(1.79)  LDD2129  [10]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C77(0.67)  LDD2133  [10]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C77(1.60)  LDD2136  [10]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C77(0.93)  LDD2137  [10]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C77(1.12)  LDD2140  [10]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C77(0.66)  LDD2141  [10]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C77(0.71)  LDD2143  [10]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C77(0.59)  LDD2145  [10]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C77(0.90)  LDD2146  [10]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C77(0.56)  LDD2148  [10]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C77(0.59)  LDD2151  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Nucleosome assembly protein 1-like 1 (NAP1L1) Nucleosome assembly protein (NAP) family P55209

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
10 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
22 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
23 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
24 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
25 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
26 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
27 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
28 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
29 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
30 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402