Details of the Target

General Information of Target

Target ID LDTP09328
Target Name Adenosine 3'-phospho 5'-phosphosulfate transporter 1 (SLC35B2)
Gene Name SLC35B2
Gene ID 347734
Synonyms
PAPST1; Adenosine 3'-phospho 5'-phosphosulfate transporter 1; PAPS transporter 1; Putative MAPK-activating protein PM15; Putative NF-kappa-B-activating protein 48; Solute carrier family 35 member B2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDARWWAVVVLAAFPSLGAGGETPEAPPESWTQLWFFRFVVNAAGYASFMVPGYLLVQYF
RRKNYLETGRGLCFPLVKACVFGNEPKASDEVPLAPRTEAAETTPMWQALKLLFCATGLQ
VSYLTWGVLQERVMTRSYGATATSPGERFTDSQFLVLMNRVLALIVAGLSCVLCKQPRHG
APMYRYSFASLSNVLSSWCQYEALKFVSFPTQVLAKASKVIPVMLMGKLVSRRSYEHWEY
LTATLISIGVSMFLLSSGPEPRSSPATTLSGLILLAGYIAFDSFTSNWQDALFAYKMSSV
QMMFGVNFFSCLFTVGSLLEQGALLEGTRFMGRHSEFAAHALLLSICSACGQLFIFYTIG
QFGAAVFTIIMTLRQAFAILLSCLLYGHTVTVVGGLGVAVVFAALLLRVYARGRLKQRGK
KAVPVESPVQKV
Target Bioclass
Transporter and channel
Family
Nucleotide-sugar transporter family, SLC35B subfamily
Subcellular location
Golgi apparatus membrane
Function
Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes. Mediates the transport from the cytosol into the lumen of the Golgi of 3'-phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment.
Uniprot ID
Q8TB61
Ensemble ID
ENST00000393812.4
HGNC ID
HGNC:16872

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.S137T .
CORL23 SNV: p.L241R .
HCT15 SNV: p.L380F DBIA    Probe Info 
HT SNV: p.L17P .
MOLT4 SNV: p.A47V IA-alkyne    Probe Info 
PFSK1 Deletion: p.F354del .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
HDSF-alk
 Probe Info  		2.48  LDD0197  [1]
FBPP2
 Probe Info  		2.35  LDD0318  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
YN-4
 Probe Info  		100.00  LDD0445  [4]
AHL-Pu-1
 Probe Info  		C199(2.23)  LDD0170  [5]
EA-probe
 Probe Info  		C199(0.84)  LDD2210  [6]
DBIA
 Probe Info  		C199(0.78)  LDD0531  [7]
ATP probe
 Probe Info  		K216(0.00); K219(0.00)  LDD0199  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
IPM
 Probe Info  		C73(0.00); C80(0.00)  LDD0005  [11]
NHS
 Probe Info  		N.A.  LDD0010  [11]
STPyne
 Probe Info  		N.A.  LDD0009  [11]
Acrolein
 Probe Info  		C73(0.00); C80(0.00)  LDD0217  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
AOyne
 Probe Info  		12.90  LDD0443  [13]
PAL-AfBPP Probe
Click To Hide/Show 123 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		11.39  LDD1714  [14]
C007
 Probe Info  		8.06  LDD1716  [14]
C022
 Probe Info  		16.56  LDD1728  [14]
C026
 Probe Info  		5.98  LDD1732  [14]
C040
 Probe Info  		17.27  LDD1740  [14]
C041
 Probe Info  		8.34  LDD1741  [14]
C049
 Probe Info  		7.06  LDD1747  [14]
C055
 Probe Info  		19.97  LDD1752  [14]
C056
 Probe Info  		34.78  LDD1753  [14]
C063
 Probe Info  		20.82  LDD1760  [14]
C067
 Probe Info  		6.36  LDD1763  [14]
C070
 Probe Info  		21.11  LDD1766  [14]
C072
 Probe Info  		10.63  LDD1768  [14]
C082
 Probe Info  		7.62  LDD1774  [14]
C087
 Probe Info  		9.65  LDD1779  [14]
C091
 Probe Info  		18.13  LDD1782  [14]
C092
 Probe Info  		23.43  LDD1783  [14]
C094
 Probe Info  		25.81  LDD1785  [14]
C106
 Probe Info  		28.25  LDD1793  [14]
C107
 Probe Info  		11.39  LDD1794  [14]
C108
 Probe Info  		16.45  LDD1795  [14]
C112
 Probe Info  		33.36  LDD1799  [14]
C129
 Probe Info  		6.32  LDD1811  [14]
C130
 Probe Info  		9.78  LDD1812  [14]
C134
 Probe Info  		33.59  LDD1816  [14]
C135
 Probe Info  		18.90  LDD1817  [14]
C139
 Probe Info  		12.91  LDD1821  [14]
C141
 Probe Info  		19.56  LDD1823  [14]
C143
 Probe Info  		33.36  LDD1825  [14]
C153
 Probe Info  		22.16  LDD1834  [14]
C159
 Probe Info  		16.68  LDD1839  [14]
C160
 Probe Info  		14.52  LDD1840  [14]
C161
 Probe Info  		20.97  LDD1841  [14]
C163
 Probe Info  		12.91  LDD1843  [14]
C165
 Probe Info  		16.34  LDD1845  [14]
C166
 Probe Info  		9.19  LDD1846  [14]
C169
 Probe Info  		31.56  LDD1849  [14]
C170
 Probe Info  		7.52  LDD1850  [14]
C178
 Probe Info  		19.56  LDD1857  [14]
C186
 Probe Info  		13.09  LDD1864  [14]
C187
 Probe Info  		16.80  LDD1865  [14]
C194
 Probe Info  		12.55  LDD1870  [14]
C196
 Probe Info  		13.00  LDD1872  [14]
C197
 Probe Info  		6.23  LDD1873  [14]
C198
 Probe Info  		18.90  LDD1874  [14]
C201
 Probe Info  		37.79  LDD1877  [14]
C206
 Probe Info  		25.46  LDD1881  [14]
C210
 Probe Info  		41.93  LDD1884  [14]
C218
 Probe Info  		14.22  LDD1892  [14]
C219
 Probe Info  		5.46  LDD1893  [14]
C220
 Probe Info  		18.13  LDD1894  [14]
C225
 Probe Info  		7.26  LDD1898  [14]
C226
 Probe Info  		6.73  LDD1899  [14]
C228
 Probe Info  		23.26  LDD1901  [14]
C229
 Probe Info  		13.64  LDD1902  [14]
C231
 Probe Info  		38.85  LDD1904  [14]
C232
 Probe Info  		47.50  LDD1905  [14]
C233
 Probe Info  		19.03  LDD1906  [14]
C234
 Probe Info  		7.46  LDD1907  [14]
C235
 Probe Info  		50.21  LDD1908  [14]
C238
 Probe Info  		23.92  LDD1911  [14]
C240
 Probe Info  		12.38  LDD1913  [14]
C252
 Probe Info  		16.68  LDD1925  [14]
C258
 Probe Info  		5.43  LDD1931  [14]
C264
 Probe Info  		17.39  LDD1935  [14]
C270
 Probe Info  		7.62  LDD1940  [14]
C273
 Probe Info  		17.39  LDD1943  [14]
C277
 Probe Info  		16.11  LDD1947  [14]
C280
 Probe Info  		9.58  LDD1950  [14]
C282
 Probe Info  		19.43  LDD1952  [14]
C285
 Probe Info  		29.04  LDD1955  [14]
C287
 Probe Info  		25.46  LDD1957  [14]
C288
 Probe Info  		10.34  LDD1958  [14]
C289
 Probe Info  		41.36  LDD1959  [14]
C290
 Probe Info  		5.90  LDD1960  [14]
C293
 Probe Info  		20.53  LDD1963  [14]
C296
 Probe Info  		18.13  LDD1966  [14]
C299
 Probe Info  		8.75  LDD1968  [14]
C305
 Probe Info  		12.73  LDD1974  [14]
C307
 Probe Info  		8.63  LDD1975  [14]
C310
 Probe Info  		23.26  LDD1977  [14]
C314
 Probe Info  		16.91  LDD1981  [14]
C322
 Probe Info  		6.32  LDD1988  [14]
C326
 Probe Info  		11.63  LDD1990  [14]
C338
 Probe Info  		10.27  LDD2001  [14]
C339
 Probe Info  		11.79  LDD2002  [14]
C348
 Probe Info  		24.42  LDD2009  [14]
C349
 Probe Info  		28.25  LDD2010  [14]
C350
 Probe Info  		55.72  LDD2011  [14]
C355
 Probe Info  		34.30  LDD2016  [14]
C356
 Probe Info  		11.47  LDD2017  [14]
C357
 Probe Info  		7.31  LDD2018  [14]
C362
 Probe Info  		62.25  LDD2023  [14]
C363
 Probe Info  		28.05  LDD2024  [14]
C364
 Probe Info  		30.48  LDD2025  [14]
C366
 Probe Info  		18.13  LDD2027  [14]
C367
 Probe Info  		7.89  LDD2028  [14]
C373
 Probe Info  		6.23  LDD2033  [14]
C376
 Probe Info  		18.38  LDD2036  [14]
C378
 Probe Info  		8.34  LDD2037  [14]
C380
 Probe Info  		6.06  LDD2039  [14]
C382
 Probe Info  		16.91  LDD2041  [14]
C383
 Probe Info  		14.52  LDD2042  [14]
C386
 Probe Info  		8.94  LDD2045  [14]
C388
 Probe Info  		59.30  LDD2047  [14]
C390
 Probe Info  		32.45  LDD2049  [14]
C399
 Probe Info  		10.70  LDD2058  [14]
C403
 Probe Info  		25.46  LDD2061  [14]
C407
 Probe Info  		20.97  LDD2064  [14]
C413
 Probe Info  		19.84  LDD2069  [14]
C419
 Probe Info  		10.63  LDD2074  [14]
C424
 Probe Info  		9.85  LDD2079  [14]
C426
 Probe Info  		20.11  LDD2081  [14]
C429
 Probe Info  		24.25  LDD2084  [14]
C431
 Probe Info  		23.92  LDD2086  [14]
FFF probe11
 Probe Info  		20.00  LDD0471  [15]
FFF probe13
 Probe Info  		20.00  LDD0475  [15]
FFF probe2
 Probe Info  		20.00  LDD0463  [15]
FFF probe3
 Probe Info  		20.00  LDD0464  [15]
JN0003
 Probe Info  		20.00  LDD0469  [15]
STS-1
 Probe Info  		N.A.  LDD0136  [16]
VE-P
 Probe Info  		N.A.  LDD0396  [17]
OEA-DA
 Probe Info  		20.00  LDD0046  [18]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C199(2.23)  LDD0170  [5]
 LDCM0214  AC1 HCT 116 C199(0.78)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C199(0.67)  LDD0532  [7]
 LDCM0216  AC100 PaTu 8988t C199(0.86)  LDD1095  [7]
 LDCM0217  AC101 PaTu 8988t C199(1.02)  LDD1096  [7]
 LDCM0218  AC102 PaTu 8988t C199(1.13)  LDD1097  [7]
 LDCM0219  AC103 PaTu 8988t C199(0.84)  LDD1098  [7]
 LDCM0220  AC104 PaTu 8988t C199(0.95)  LDD1099  [7]
 LDCM0221  AC105 PaTu 8988t C199(1.03)  LDD1100  [7]
 LDCM0222  AC106 PaTu 8988t C199(0.76)  LDD1101  [7]
 LDCM0223  AC107 PaTu 8988t C199(1.05)  LDD1102  [7]
 LDCM0224  AC108 PaTu 8988t C199(0.88)  LDD1103  [7]
 LDCM0225  AC109 PaTu 8988t C199(0.85)  LDD1104  [7]
 LDCM0226  AC11 HCT 116 C199(0.63)  LDD0543  [7]
 LDCM0227  AC110 PaTu 8988t C199(0.92)  LDD1106  [7]
 LDCM0228  AC111 PaTu 8988t C199(0.76)  LDD1107  [7]
 LDCM0229  AC112 PaTu 8988t C199(0.83)  LDD1108  [7]
 LDCM0230  AC113 HCT 116 C199(1.19)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C199(0.86)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C199(0.76)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C199(0.78)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C199(0.80)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C199(0.84)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C199(0.85)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C199(0.81)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C199(0.85)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C199(0.74)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C199(0.83)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C199(0.88)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C199(1.06)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C199(0.81)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C199(0.70)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C199(0.67)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C199(1.47)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C199(1.27)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C199(0.83)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C199(1.75)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C199(1.10)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C199(1.20)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C199(1.21)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C199(1.11)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C199(1.45)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C199(1.37)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C199(1.49)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C199(1.09)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C199(0.72)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C199(0.93)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C199(1.02)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C199(1.95)  LDD0579  [7]
 LDCM0270  AC15 HCT 116 C199(0.66)  LDD0587  [7]
 LDCM0276  AC17 HEK-293T C199(0.52)  LDD0874  [7]
 LDCM0277  AC18 HEK-293T C199(0.72)  LDD0875  [7]
 LDCM0278  AC19 HEK-293T C199(0.57)  LDD0876  [7]
 LDCM0279  AC2 HCT 116 C199(0.87)  LDD0596  [7]
 LDCM0280  AC20 HEK-293T C199(0.63)  LDD0878  [7]
 LDCM0281  AC21 HEK-293T C199(0.47)  LDD0879  [7]
 LDCM0282  AC22 HEK-293T C199(0.64)  LDD0880  [7]
 LDCM0283  AC23 HEK-293T C199(0.51)  LDD0881  [7]
 LDCM0284  AC24 HEK-293T C199(0.65)  LDD0882  [7]
 LDCM0285  AC25 HCT 116 C199(0.96)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C199(0.63)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C199(0.63)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C199(0.73)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C199(0.63)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C199(0.84)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C199(0.78)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C199(0.56)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C199(0.62)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C199(0.72)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C199(0.72)  LDD0612  [7]
 LDCM0296  AC35 HEK-293T C80(1.06); C199(1.05)  LDD1535  [19]
 LDCM0297  AC36 HEK-293T C80(1.06); C199(1.07)  LDD1536  [19]
 LDCM0298  AC37 HEK-293T C80(1.02); C199(0.92)  LDD1537  [19]
 LDCM0299  AC38 HEK-293T C80(1.02)  LDD1538  [19]
 LDCM0300  AC39 HEK-293T C80(1.03); C199(1.08)  LDD1539  [19]
 LDCM0301  AC4 HCT 116 C199(0.77)  LDD0618  [7]
 LDCM0302  AC40 HEK-293T C80(0.85); C199(0.98)  LDD1541  [19]
 LDCM0303  AC41 HEK-293T C80(0.99); C199(1.01)  LDD1542  [19]
 LDCM0304  AC42 HEK-293T C80(1.03); C199(0.87)  LDD1543  [19]
 LDCM0305  AC43 HEK-293T C80(1.04); C199(1.01)  LDD1544  [19]
 LDCM0306  AC44 HEK-293T C80(1.03); C199(0.92)  LDD1545  [19]
 LDCM0307  AC45 HEK-293T C80(0.97); C199(0.92)  LDD1546  [19]
 LDCM0308  AC46 HEK-293T C80(0.98)  LDD1547  [19]
 LDCM0309  AC47 HEK-293T C80(1.03); C199(1.04)  LDD1548  [19]
 LDCM0310  AC48 HEK-293T C80(0.98); C199(1.51)  LDD1549  [19]
 LDCM0311  AC49 HEK-293T C80(0.87); C199(0.94)  LDD1550  [19]
 LDCM0312  AC5 HCT 116 C199(0.79)  LDD0629  [7]
 LDCM0313  AC50 HEK-293T C80(1.04); C199(0.82)  LDD1552  [19]
 LDCM0314  AC51 HEK-293T C80(1.02); C199(1.09)  LDD1553  [19]
 LDCM0315  AC52 HEK-293T C80(0.98); C199(1.07)  LDD1554  [19]
 LDCM0316  AC53 HEK-293T C80(0.97); C199(0.90)  LDD1555  [19]
 LDCM0317  AC54 HEK-293T C80(1.00)  LDD1556  [19]
 LDCM0318  AC55 HEK-293T C80(0.99); C199(1.04)  LDD1557  [19]
 LDCM0319  AC56 HEK-293T C80(0.92); C199(1.09)  LDD1558  [19]
 LDCM0320  AC57 HCT 116 C199(1.19)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C199(1.19)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C199(1.25)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C199(0.69)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C199(1.11)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C199(0.97)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C199(1.18)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C199(1.19)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C199(1.18)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C199(0.88)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C199(1.23)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C199(0.75)  LDD0648  [7]
 LDCM0332  AC68 HEK-293T C199(0.90)  LDD0930  [7]
 LDCM0333  AC69 HEK-293T C199(1.02)  LDD0931  [7]
 LDCM0334  AC7 HCT 116 C199(0.81)  LDD0651  [7]
 LDCM0335  AC70 HEK-293T C199(0.80)  LDD0933  [7]
 LDCM0336  AC71 HEK-293T C199(0.96)  LDD0934  [7]
 LDCM0337  AC72 HEK-293T C199(0.88)  LDD0935  [7]
 LDCM0338  AC73 HEK-293T C199(0.89)  LDD0936  [7]
 LDCM0339  AC74 HEK-293T C199(0.87)  LDD0937  [7]
 LDCM0340  AC75 HEK-293T C199(0.87)  LDD0938  [7]
 LDCM0341  AC76 HEK-293T C199(0.95)  LDD0939  [7]
 LDCM0342  AC77 HEK-293T C199(0.91)  LDD0940  [7]
 LDCM0343  AC78 HEK-293T C199(0.87)  LDD0941  [7]
 LDCM0344  AC79 HEK-293T C199(0.92)  LDD0942  [7]
 LDCM0345  AC8 HCT 116 C199(0.89)  LDD0662  [7]
 LDCM0346  AC80 HEK-293T C199(0.87)  LDD0944  [7]
 LDCM0347  AC81 HEK-293T C199(0.86)  LDD0945  [7]
 LDCM0348  AC82 HEK-293T C199(0.84)  LDD0946  [7]
 LDCM0365  AC98 PaTu 8988t C199(0.85)  LDD1244  [7]
 LDCM0366  AC99 PaTu 8988t C199(1.00)  LDD1245  [7]
 LDCM0248  AKOS034007472 HCT 116 C199(0.74)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C199(0.63)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C199(0.58)  LDD0592  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0367  CL1 HCT 116 C199(1.39)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C199(0.78)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C199(0.87)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C199(0.58)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C199(0.77)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C199(0.69)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C199(0.72)  LDD0690  [7]
 LDCM0374  CL105 HEK-293T C199(0.76)  LDD0972  [7]
 LDCM0375  CL106 HEK-293T C199(0.60)  LDD0973  [7]
 LDCM0376  CL107 HEK-293T C199(0.66)  LDD0974  [7]
 LDCM0377  CL108 HEK-293T C199(0.60)  LDD0975  [7]
 LDCM0378  CL109 HEK-293T C199(0.65)  LDD0976  [7]
 LDCM0379  CL11 HCT 116 C199(0.98)  LDD0696  [7]
 LDCM0380  CL110 HEK-293T C199(0.67)  LDD0978  [7]
 LDCM0381  CL111 HEK-293T C199(0.62)  LDD0979  [7]
 LDCM0382  CL112 HCT 116 C199(1.07)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C199(0.77)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C199(0.68)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C199(0.70)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C199(0.82)  LDD0703  [7]
 LDCM0387  CL117 HEK-293T C80(0.96); C199(1.10)  LDD1591  [19]
 LDCM0388  CL118 HEK-293T C80(0.83); C199(0.89)  LDD1592  [19]
 LDCM0389  CL119 HEK-293T C80(1.01); C199(1.05)  LDD1593  [19]
 LDCM0390  CL12 HCT 116 C199(1.07)  LDD0707  [7]
 LDCM0391  CL120 HEK-293T C80(0.88); C199(1.02)  LDD1595  [19]
 LDCM0392  CL121 HEK-293T C80(1.06); C199(1.08)  LDD1596  [19]
 LDCM0393  CL122 HEK-293T C80(1.04); C199(0.94)  LDD1597  [19]
 LDCM0394  CL123 HEK-293T C80(1.34); C199(0.97)  LDD1598  [19]
 LDCM0395  CL124 HEK-293T C80(0.96); C199(0.96)  LDD1599  [19]
 LDCM0396  CL125 HCT 116 C199(1.88)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C199(1.09)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C199(1.36)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C199(1.11)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C199(1.01)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C199(1.08)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C199(0.80)  LDD0719  [7]
 LDCM0403  CL16 HEK-293T C199(0.99)  LDD1001  [7]
 LDCM0404  CL17 HEK-293T C199(0.72)  LDD1002  [7]
 LDCM0405  CL18 HEK-293T C199(0.85)  LDD1003  [7]
 LDCM0406  CL19 HEK-293T C199(0.87)  LDD1004  [7]
 LDCM0407  CL2 HCT 116 C199(0.98)  LDD0724  [7]
 LDCM0408  CL20 HEK-293T C199(0.70)  LDD1006  [7]
 LDCM0409  CL21 HEK-293T C199(0.73)  LDD1007  [7]
 LDCM0410  CL22 HEK-293T C199(0.71)  LDD1008  [7]
 LDCM0411  CL23 HEK-293T C199(0.77)  LDD1009  [7]
 LDCM0412  CL24 HEK-293T C199(0.73)  LDD1010  [7]
 LDCM0413  CL25 HEK-293T C199(0.77)  LDD1011  [7]
 LDCM0414  CL26 HEK-293T C199(0.77)  LDD1012  [7]
 LDCM0415  CL27 HEK-293T C199(0.80)  LDD1013  [7]
 LDCM0416  CL28 HEK-293T C199(0.81)  LDD1014  [7]
 LDCM0417  CL29 HEK-293T C199(0.86)  LDD1015  [7]
 LDCM0418  CL3 HCT 116 C199(1.00)  LDD0735  [7]
 LDCM0419  CL30 HEK-293T C199(0.69)  LDD1017  [7]
 LDCM0420  CL31 HCT 116 C199(0.87)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C199(0.76)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C199(0.77)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C199(0.76)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C199(0.86)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C199(0.87)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C199(0.98)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C199(0.86)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C199(0.91)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C199(0.84)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C199(0.98)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C199(0.81)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C199(0.93)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C199(0.76)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C199(0.72)  LDD0752  [7]
 LDCM0436  CL46 PaTu 8988t C199(1.08)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C199(0.93)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C199(0.87)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C199(0.99)  LDD1318  [7]
 LDCM0440  CL5 HCT 116 C199(1.11)  LDD0757  [7]
 LDCM0441  CL50 PaTu 8988t C199(0.90)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C199(0.82)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C199(1.04)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C199(1.01)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C199(0.83)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C199(0.84)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C199(0.21)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C199(1.03)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C199(1.07)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C199(1.00)  LDD1329  [7]
 LDCM0451  CL6 HCT 116 C199(0.90)  LDD0768  [7]
 LDCM0452  CL60 PaTu 8988t C199(0.89)  LDD1331  [7]
 LDCM0453  CL61 HCT 116 C199(0.84)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C199(0.83)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C199(0.71)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C199(0.71)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C199(0.89)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C199(0.72)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C199(0.84)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C199(0.67)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C199(0.83)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C199(1.01)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C199(0.71)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C199(0.65)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C199(0.90)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C199(0.91)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C199(0.78)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C199(0.71)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C199(1.15)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C199(0.82)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C199(0.75)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C199(1.16)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C199(0.91)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C199(0.84)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C199(0.79)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C199(0.71)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C199(0.77)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C199(0.75)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C199(1.02)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C199(0.71)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C199(0.78)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C199(0.81)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C199(1.20)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C199(1.16)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C199(0.80)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C199(0.96)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C199(0.89)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C199(0.82)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C199(0.75)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C199(0.77)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C199(0.92)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C199(0.75)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C199(0.82)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C80(1.09); C199(1.08)  LDD1698  [19]
 LDCM0175  Ethacrynic acid HeLa C199(0.84)  LDD2210  [6]
 LDCM0625  F8 Ramos C73(1.32); C80(0.97)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C73(3.88); C80(2.58)  LDD2189  [20]
 LDCM0573  Fragment11 Ramos C73(0.36)  LDD2190  [20]
 LDCM0574  Fragment12 Ramos C80(1.63)  LDD2191  [20]
 LDCM0575  Fragment13 Ramos C73(1.06); C80(0.96)  LDD2192  [20]
 LDCM0576  Fragment14 Ramos C80(1.04)  LDD2193  [20]
 LDCM0579  Fragment20 Ramos C80(2.39)  LDD2194  [20]
 LDCM0580  Fragment21 Ramos C73(1.31); C80(1.03)  LDD2195  [20]
 LDCM0582  Fragment23 Ramos C73(3.21); C80(1.17)  LDD2196  [20]
 LDCM0578  Fragment27 Ramos C73(0.74); C80(0.76)  LDD2197  [20]
 LDCM0586  Fragment28 Ramos C73(0.99); C80(1.16)  LDD2198  [20]
 LDCM0588  Fragment30 Ramos C73(1.06); C80(1.15)  LDD2199  [20]
 LDCM0589  Fragment31 Ramos C73(1.77); C80(1.03)  LDD2200  [20]
 LDCM0590  Fragment32 Ramos C73(2.64); C80(1.93)  LDD2201  [20]
 LDCM0468  Fragment33 HCT 116 C199(0.83)  LDD0785  [7]
 LDCM0596  Fragment38 Ramos C73(1.66); C80(1.68)  LDD2203  [20]
 LDCM0566  Fragment4 Ramos C80(2.07)  LDD2184  [20]
 LDCM0427  Fragment51 HCT 116 C199(0.93)  LDD0744  [7]
 LDCM0610  Fragment52 Ramos C73(1.43); C80(1.47)  LDD2204  [20]
 LDCM0614  Fragment56 Ramos C73(0.97); C80(0.98)  LDD2205  [20]
 LDCM0569  Fragment7 Ramos C73(3.73); C80(3.97)  LDD2186  [20]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HEK-293T C80(0.79); C199(0.94)  LDD1492  [19]
 LDCM0023  KB03 HEK-293T C80(0.95); C199(0.95)  LDD1497  [19]
 LDCM0024  KB05 G361 C80(4.29); C66(3.05)  LDD3311  [21]
 LDCM0628  OTUB2-COV-1 HEK-293T C73(0.96)  LDD2207  [22]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NADH-cytochrome b5 reductase 3 (CYB5R3) Flavoprotein pyridine nucleotide cytochrome reductase family P00387
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Early activation antigen CD69 (CD69) . Q07108
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4
Protein shisa-like-1 (SHISAL1) Shisa family Q3SXP7
Transmembrane protein 248 (TMEM248) TMEM248 family Q9NWD8
Testis-expressed protein 29 (TEX29) . Q8N6K0

References

1 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
18 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
22 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.