Details of the Target

General Information of Target

Target ID LDTP09110
Target Name NAD(P)H-hydrate epimerase (NAXE)
Gene Name NAXE
Gene ID 128240
Synonyms
AIBP; APOA1BP; YJEFN1; NAD(P)H-hydrate epimerase; EC 5.1.99.6; Apolipoprotein A-I-binding protein; AI-BP; NAD(P)HX epimerase; NAXE; YjeF N-terminal domain-containing protein 1; YjeF_N1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSRLRALLGLGLLVAGSRVPRIKSQTIACRSGPTWWGPQRLNSGGRWDSEVMASTVVKYL
SQEEAQAVDQELFNEYQFSVDQLMELAGLSCATAIAKAYPPTSMSRSPPTVLVICGPGNN
GGDGLVCARHLKLFGYEPTIYYPKRPNKPLFTALVTQCQKMDIPFLGEMPAEPMTIDELY
ELVVDAIFGFSFKGDVREPFHSILSVLKGLTVPIASIDIPSGWDVEKGNAGGIQPDLLIS
LTAPKKSATQFTGRYHYLGGRFVPPALEKKYQLNLPPYPDTECVYRLQ
Target Bioclass
Enzyme
Family
NnrE/AIBP family
Subcellular location
Mitochondrion
Function
Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. {|HAMAP-Rule:MF_03159}.
Uniprot ID
Q8NCW5
Ensemble ID
ENST00000368235.8
HGNC ID
HGNC:18453

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
FADU SNV: p.S107I DBIA    Probe Info 
HT1197 SNV: p.K58M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.66  LDD0318  [1]
TH216
 Probe Info  		Y255(12.21)  LDD0259  [2]
JZ128-DTB
 Probe Info  		C115(0.00); C127(0.00)  LDD0462  [3]
THZ1-DTB
 Probe Info  		C127(1.06); C115(1.05); C91(1.03)  LDD0460  [3]
BTD
 Probe Info  		C115(1.05)  LDD2108  [4]
HHS-475
 Probe Info  		Y142(1.00); Y141(1.08)  LDD0264  [5]
HHS-465
 Probe Info  		Y255(10.00)  LDD2237  [6]
Acrolein
 Probe Info  		C283(0.00); C158(0.00)  LDD0222  [7]
DBIA
 Probe Info  		C283(2.54)  LDD0080  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		K148(0.00); K269(0.00); K270(0.00); K246(0.00)  LDD0199  [10]
m-APA
 Probe Info  		N.A.  LDD2231  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C283(0.00); C158(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C283(0.00); C158(0.00)  LDD0037  [11]
ATP probe
 Probe Info  		N.A.  LDD0035  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
IPM
 Probe Info  		N.A.  LDD2156  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
AOyne
 Probe Info  		5.10  LDD0443  [17]
NAIA_5
 Probe Info  		C158(0.00); C91(0.00); C283(0.00); C127(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C145
 Probe Info  		11.08  LDD1827  [18]
C165
 Probe Info  		13.45  LDD1845  [18]
C174
 Probe Info  		11.47  LDD1854  [18]
C218
 Probe Info  		12.13  LDD1892  [18]
C258
 Probe Info  		6.19  LDD1931  [18]
FFF probe12
 Probe Info  		12.25  LDD0473  [19]
FFF probe13
 Probe Info  		8.47  LDD0475  [19]
FFF probe3
 Probe Info  		20.00  LDD0464  [19]
FFF probe6
 Probe Info  		6.12  LDD0467  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C115(1.06); C127(1.06)  LDD0531  [8]
 LDCM0215  AC10 HEK-293T C115(1.08); C127(1.08)  LDD0813  [8]
 LDCM0216  AC100 HEK-293T C115(0.99); C127(1.01); C283(1.54)  LDD0814  [8]
 LDCM0217  AC101 HEK-293T C115(0.84); C127(0.79); C283(1.37)  LDD0815  [8]
 LDCM0218  AC102 HEK-293T C115(0.99); C127(0.97); C283(1.26)  LDD0816  [8]
 LDCM0219  AC103 HEK-293T C115(0.88); C127(0.79); C283(1.47)  LDD0817  [8]
 LDCM0220  AC104 HEK-293T C115(1.05); C127(1.09); C283(1.68)  LDD0818  [8]
 LDCM0221  AC105 HEK-293T C115(0.91); C127(0.88); C283(0.99)  LDD0819  [8]
 LDCM0222  AC106 HEK-293T C115(0.89); C127(0.94); C283(1.10)  LDD0820  [8]
 LDCM0223  AC107 HEK-293T C115(0.90); C127(0.87); C283(1.49)  LDD0821  [8]
 LDCM0224  AC108 HEK-293T C115(0.94); C127(0.99); C283(1.12)  LDD0822  [8]
 LDCM0225  AC109 HEK-293T C115(0.92); C127(0.91); C283(1.41)  LDD0823  [8]
 LDCM0226  AC11 HEK-293T C115(1.51); C127(1.51)  LDD0824  [8]
 LDCM0227  AC110 HEK-293T C115(0.99); C127(0.83); C283(1.91)  LDD0825  [8]
 LDCM0228  AC111 HEK-293T C115(1.17); C127(0.82); C283(2.42)  LDD0826  [8]
 LDCM0229  AC112 HEK-293T C115(1.14); C127(0.91); C283(2.24)  LDD0827  [8]
 LDCM0230  AC113 HCT 116 C115(1.29); C127(1.29)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C115(0.78); C127(0.83)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C115(0.71); C127(0.98)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C115(1.01); C127(0.86)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C115(0.98); C127(0.77)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C115(1.04); C127(0.81)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C115(0.97); C127(0.99)  LDD0553  [8]
 LDCM0237  AC12 HEK-293T C115(0.89); C127(0.89)  LDD0835  [8]
 LDCM0238  AC120 HCT 116 C115(1.17); C127(0.81)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C115(0.84); C127(0.81)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C115(0.97); C127(0.66)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C115(0.81); C127(0.87)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C115(0.75); C127(0.86)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C115(0.87); C127(0.93)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C115(1.19); C127(0.93)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C115(0.83); C127(0.83)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C115(1.07); C127(1.07)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C115(1.28); C127(1.28)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C115(1.39); C127(1.39)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C115(1.01); C127(1.01)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C115(1.31); C127(1.31)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C115(1.52); C127(1.52)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C115(0.92); C127(0.92)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C115(1.07); C127(1.07)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C115(1.15); C127(1.15)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C115(1.07); C127(1.07)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C115(0.99); C127(0.99)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C115(1.27); C127(1.27)  LDD0575  [8]
 LDCM0259  AC14 HEK-293T C115(1.07); C127(1.07)  LDD0857  [8]
 LDCM0260  AC140 HCT 116 C115(1.24); C127(1.24)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C115(1.22); C127(1.22)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C115(1.02); C127(1.02)  LDD0579  [8]
 LDCM0263  AC143 HEK-293T C115(0.74); C127(0.75)  LDD0861  [8]
 LDCM0264  AC144 HEK-293T C115(1.13); C127(0.85)  LDD0862  [8]
 LDCM0265  AC145 HEK-293T C115(0.97); C127(1.04)  LDD0863  [8]
 LDCM0266  AC146 HEK-293T C115(1.06); C127(0.93)  LDD0864  [8]
 LDCM0267  AC147 HEK-293T C115(0.90); C127(0.93)  LDD0865  [8]
 LDCM0268  AC148 HEK-293T C115(0.95); C127(0.77)  LDD0866  [8]
 LDCM0269  AC149 HEK-293T C115(0.68); C127(0.83)  LDD0867  [8]
 LDCM0270  AC15 HEK-293T C115(1.04); C127(1.04)  LDD0868  [8]
 LDCM0271  AC150 HEK-293T C115(0.85); C127(0.78)  LDD0869  [8]
 LDCM0272  AC151 HEK-293T C115(1.19); C127(0.98)  LDD0870  [8]
 LDCM0273  AC152 HEK-293T C115(1.09); C127(0.84)  LDD0871  [8]
 LDCM0274  AC153 HEK-293T C115(1.10); C127(0.84)  LDD0872  [8]
 LDCM0621  AC154 HEK-293T C115(1.19); C127(0.83)  LDD2162  [8]
 LDCM0622  AC155 HEK-293T C115(1.04); C127(0.92)  LDD2163  [8]
 LDCM0623  AC156 HEK-293T C115(1.33); C127(0.92)  LDD2164  [8]
 LDCM0624  AC157 HEK-293T C115(1.58); C127(1.20)  LDD2165  [8]
 LDCM0276  AC17 HCT 116 C115(0.86); C127(0.86)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C115(0.74); C127(0.74)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C115(1.13); C127(1.13)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C115(1.11); C127(1.11)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C115(0.99); C127(0.99)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C115(0.75); C127(0.75)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C115(0.79); C127(0.79)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C115(0.99); C127(0.99)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C115(1.01); C127(1.01)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C115(0.60); C127(0.60)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C115(0.85); C127(0.85)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C115(0.69); C127(0.69)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C115(0.84); C127(0.84)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C115(0.71); C127(0.71)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C115(2.28); C127(2.28)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C115(1.11); C127(1.11)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C115(0.94); C127(0.94)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C115(0.68); C127(0.68)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C115(0.93); C127(0.93)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C115(0.69); C127(0.69)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C115(0.93); C127(0.93)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C115(0.99); C127(0.99)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C115(0.97); C127(0.97)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C115(1.13); C127(1.13)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C115(0.94); C127(0.94)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C115(1.65); C127(1.65)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C115(0.88); C127(0.88)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C115(1.05); C127(1.05)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C115(0.88); C127(0.88)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C115(1.08); C127(1.08)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C115(0.72); C127(0.72)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C115(1.26); C127(1.26)  LDD0624  [8]
 LDCM0308  AC46 HEK-293T C115(0.63)  LDD0906  [8]
 LDCM0309  AC47 HEK-293T C115(1.27)  LDD0907  [8]
 LDCM0310  AC48 HEK-293T C115(1.19)  LDD0908  [8]
 LDCM0311  AC49 HEK-293T C115(1.01)  LDD0909  [8]
 LDCM0312  AC5 HCT 116 C115(0.75); C127(0.75)  LDD0629  [8]
 LDCM0313  AC50 HEK-293T C115(0.97)  LDD0911  [8]
 LDCM0314  AC51 HEK-293T C115(0.83)  LDD0912  [8]
 LDCM0315  AC52 HEK-293T C115(1.37)  LDD0913  [8]
 LDCM0316  AC53 HEK-293T C115(0.85)  LDD0914  [8]
 LDCM0317  AC54 HEK-293T C115(1.26)  LDD0915  [8]
 LDCM0318  AC55 HEK-293T C115(0.88)  LDD0916  [8]
 LDCM0319  AC56 HEK-293T C115(0.88)  LDD0917  [8]
 LDCM0320  AC57 HEK-293T C115(1.06)  LDD0918  [8]
 LDCM0321  AC58 HEK-293T C115(0.85)  LDD0919  [8]
 LDCM0322  AC59 HEK-293T C115(1.09)  LDD0920  [8]
 LDCM0323  AC6 HEK-293T C115(1.05); C127(1.05)  LDD0921  [8]
 LDCM0324  AC60 HEK-293T C115(1.07)  LDD0922  [8]
 LDCM0325  AC61 HEK-293T C115(1.16)  LDD0923  [8]
 LDCM0326  AC62 HEK-293T C115(0.90)  LDD0924  [8]
 LDCM0327  AC63 HEK-293T C115(1.00)  LDD0925  [8]
 LDCM0328  AC64 HEK-293T C115(0.90)  LDD0926  [8]
 LDCM0329  AC65 HEK-293T C115(0.97)  LDD0927  [8]
 LDCM0330  AC66 HEK-293T C115(1.21)  LDD0928  [8]
 LDCM0331  AC67 HEK-293T C115(1.25)  LDD0929  [8]
 LDCM0332  AC68 HCT 116 C115(1.23); C127(1.23)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C115(0.99); C127(0.99)  LDD0650  [8]
 LDCM0334  AC7 HEK-293T C115(1.22); C127(1.22)  LDD0932  [8]
 LDCM0335  AC70 HCT 116 C115(0.72); C127(0.72)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C115(1.17); C127(1.17)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C115(1.23); C127(1.23)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C115(1.12); C127(1.12)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C115(1.19); C127(1.19)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C115(0.81); C127(0.81)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C115(1.07); C127(1.07)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C115(0.84); C127(0.84)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C115(0.91); C127(0.91)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C115(1.08); C127(1.08)  LDD0661  [8]
 LDCM0345  AC8 HEK-293T C115(1.10); C127(1.10)  LDD0943  [8]
 LDCM0346  AC80 HCT 116 C115(1.02); C127(1.02)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C115(0.83); C127(0.83)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C115(0.23); C127(0.23)  LDD0665  [8]
 LDCM0349  AC83 HEK-293T C115(1.02); C283(0.97)  LDD0947  [8]
 LDCM0350  AC84 HEK-293T C115(1.02); C283(1.00)  LDD0948  [8]
 LDCM0351  AC85 HEK-293T C115(1.05); C283(0.99)  LDD0949  [8]
 LDCM0352  AC86 HEK-293T C115(1.00); C283(0.98)  LDD0950  [8]
 LDCM0353  AC87 HEK-293T C115(1.08); C283(1.03)  LDD0951  [8]
 LDCM0354  AC88 HEK-293T C115(0.98); C283(1.14)  LDD0952  [8]
 LDCM0355  AC89 HEK-293T C115(1.07); C283(1.25)  LDD0953  [8]
 LDCM0357  AC90 HEK-293T C115(0.99); C283(1.12)  LDD0955  [8]
 LDCM0358  AC91 HEK-293T C115(1.05); C283(1.04)  LDD0956  [8]
 LDCM0359  AC92 HEK-293T C115(1.01); C283(1.06)  LDD0957  [8]
 LDCM0360  AC93 HEK-293T C115(1.02); C283(1.34)  LDD0958  [8]
 LDCM0361  AC94 HEK-293T C115(1.13); C283(1.27)  LDD0959  [8]
 LDCM0362  AC95 HEK-293T C115(1.17); C283(1.06)  LDD0960  [8]
 LDCM0363  AC96 HEK-293T C115(1.02); C283(1.02)  LDD0961  [8]
 LDCM0364  AC97 HEK-293T C115(1.42); C283(1.17)  LDD0962  [8]
 LDCM0365  AC98 HEK-293T C115(0.84); C127(0.82); C283(1.03)  LDD0963  [8]
 LDCM0366  AC99 HEK-293T C115(0.83); C127(0.88); C283(1.14)  LDD0964  [8]
 LDCM0248  AKOS034007472 HEK-293T C115(1.03); C127(1.03)  LDD0846  [8]
 LDCM0356  AKOS034007680 HEK-293T C115(0.73); C127(0.73)  LDD0954  [8]
 LDCM0275  AKOS034007705 HEK-293T C115(0.68); C127(0.68)  LDD0873  [8]
 LDCM0020  ARS-1620 HCC44 C283(0.93); C115(0.76); C127(0.76)  LDD2171  [8]
 LDCM0108  Chloroacetamide HeLa C283(0.00); C158(0.00)  LDD0222  [7]
 LDCM0367  CL1 HEK-293T C158(1.12); C283(0.87); C127(1.17); C115(1.17)  LDD1571  [20]
 LDCM0368  CL10 HEK-293T C158(1.18); C283(1.00); C127(1.00); C115(1.72)  LDD1572  [20]
 LDCM0369  CL100 HCT 116 C115(1.73); C127(1.73)  LDD0686  [8]
 LDCM0370  CL101 HEK-293T C115(0.77); C127(0.77)  LDD0968  [8]
 LDCM0371  CL102 HEK-293T C115(1.01); C127(1.01)  LDD0969  [8]
 LDCM0372  CL103 HEK-293T C115(0.93); C127(0.93)  LDD0970  [8]
 LDCM0373  CL104 HEK-293T C115(1.18); C127(1.18)  LDD0971  [8]
 LDCM0374  CL105 HCT 116 C115(0.74); C127(0.74)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C115(0.61); C127(0.61)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C115(0.69); C127(0.69)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C115(0.63); C127(0.63)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C115(0.90); C127(0.90)  LDD0695  [8]
 LDCM0379  CL11 HEK-293T C158(1.70); C283(1.22); C127(0.88); C115(1.22)  LDD1583  [20]
 LDCM0380  CL110 HCT 116 C115(0.75); C127(0.75)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C115(0.84); C127(0.84)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C115(0.58); C127(0.58)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C115(0.79); C127(0.79)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C115(1.24); C127(1.24)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C115(0.62); C127(0.62)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C115(0.87); C127(0.87)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C115(1.19); C127(1.19)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C115(0.83); C127(0.83)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C115(0.92); C127(0.92)  LDD0706  [8]
 LDCM0390  CL12 HEK-293T C158(1.30); C283(1.12); C127(1.06); C115(1.57)  LDD1594  [20]
 LDCM0391  CL120 HCT 116 C115(1.46); C127(1.46)  LDD0708  [8]
 LDCM0392  CL121 HEK-293T C115(1.20)  LDD0990  [8]
 LDCM0393  CL122 HEK-293T C115(1.10)  LDD0991  [8]
 LDCM0394  CL123 HEK-293T C115(1.04)  LDD0992  [8]
 LDCM0395  CL124 HEK-293T C115(0.84)  LDD0993  [8]
 LDCM0396  CL125 HEK-293T C115(1.28)  LDD0994  [8]
 LDCM0397  CL126 HEK-293T C115(1.01)  LDD0995  [8]
 LDCM0398  CL127 HEK-293T C115(0.90)  LDD0996  [8]
 LDCM0399  CL128 HEK-293T C115(1.26)  LDD0997  [8]
 LDCM0400  CL13 HEK-293T C158(1.06); C283(0.93); C127(1.13); C115(1.10)  LDD1604  [20]
 LDCM0401  CL14 HEK-293T C158(1.00); C283(1.01); C127(1.03)  LDD1605  [20]
 LDCM0402  CL15 HEK-293T C158(0.81); C283(0.93); C127(0.79); C115(0.96)  LDD1606  [20]
 LDCM0403  CL16 HEK-293T C115(0.96); C127(1.32)  LDD1001  [8]
 LDCM0404  CL17 HEK-293T C115(0.92); C127(1.10)  LDD1002  [8]
 LDCM0405  CL18 HEK-293T C115(1.05); C127(1.04)  LDD1003  [8]
 LDCM0406  CL19 HEK-293T C115(1.25); C127(1.28)  LDD1004  [8]
 LDCM0407  CL2 HEK-293T C158(0.99); C283(1.02); C127(1.00)  LDD1611  [20]
 LDCM0408  CL20 HEK-293T C115(1.09); C127(1.07)  LDD1006  [8]
 LDCM0409  CL21 HEK-293T C115(1.01); C127(0.95)  LDD1007  [8]
 LDCM0410  CL22 HEK-293T C115(0.99); C127(1.05)  LDD1008  [8]
 LDCM0411  CL23 HEK-293T C115(0.98); C127(1.12)  LDD1009  [8]
 LDCM0412  CL24 HEK-293T C115(0.88); C127(1.09)  LDD1010  [8]
 LDCM0413  CL25 HEK-293T C115(1.06); C127(1.06)  LDD1011  [8]
 LDCM0414  CL26 HEK-293T C115(0.98); C127(1.00)  LDD1012  [8]
 LDCM0415  CL27 HEK-293T C115(1.10); C127(1.08)  LDD1013  [8]
 LDCM0416  CL28 HEK-293T C115(0.92); C127(1.01)  LDD1014  [8]
 LDCM0417  CL29 HEK-293T C115(1.08); C127(1.08)  LDD1015  [8]
 LDCM0418  CL3 HEK-293T C158(0.81); C283(1.23); C127(0.90); C115(1.13)  LDD1622  [20]
 LDCM0419  CL30 HEK-293T C115(1.17); C127(1.02)  LDD1017  [8]
 LDCM0420  CL31 HEK-293T C127(1.26)  LDD1018  [8]
 LDCM0421  CL32 HEK-293T C127(1.03)  LDD1019  [8]
 LDCM0422  CL33 HEK-293T C127(1.13)  LDD1020  [8]
 LDCM0423  CL34 HEK-293T C127(0.81)  LDD1021  [8]
 LDCM0424  CL35 HEK-293T C127(1.05)  LDD1022  [8]
 LDCM0425  CL36 HEK-293T C127(0.88)  LDD1023  [8]
 LDCM0426  CL37 HEK-293T C127(0.97)  LDD1024  [8]
 LDCM0428  CL39 HEK-293T C127(1.00)  LDD1026  [8]
 LDCM0429  CL4 HEK-293T C158(0.84); C283(1.00); C127(0.95)  LDD1633  [20]
 LDCM0430  CL40 HEK-293T C127(0.89)  LDD1028  [8]
 LDCM0431  CL41 HEK-293T C127(0.89)  LDD1029  [8]
 LDCM0432  CL42 HEK-293T C127(0.87)  LDD1030  [8]
 LDCM0433  CL43 HEK-293T C127(0.97)  LDD1031  [8]
 LDCM0434  CL44 HEK-293T C127(1.00)  LDD1032  [8]
 LDCM0435  CL45 HEK-293T C127(0.93)  LDD1033  [8]
 LDCM0436  CL46 HEK-293T C115(1.10); C127(1.04)  LDD1034  [8]
 LDCM0437  CL47 HEK-293T C115(1.02); C127(1.00)  LDD1035  [8]
 LDCM0438  CL48 HEK-293T C115(1.18); C127(1.01)  LDD1036  [8]
 LDCM0439  CL49 HEK-293T C115(1.03); C127(0.97)  LDD1037  [8]
 LDCM0440  CL5 HEK-293T C158(0.88); C283(0.98); C127(1.10)  LDD1644  [20]
 LDCM0441  CL50 HEK-293T C115(1.07); C127(1.03)  LDD1039  [8]
 LDCM0442  CL51 HEK-293T C115(1.03); C127(0.71)  LDD1040  [8]
 LDCM0443  CL52 HEK-293T C115(0.78); C127(0.75)  LDD1041  [8]
 LDCM0444  CL53 HEK-293T C115(0.98); C127(0.94)  LDD1042  [8]
 LDCM0445  CL54 HEK-293T C115(0.98); C127(0.87)  LDD1043  [8]
 LDCM0446  CL55 HEK-293T C115(1.28); C127(1.27)  LDD1044  [8]
 LDCM0447  CL56 HEK-293T C115(1.12); C127(1.13)  LDD1045  [8]
 LDCM0448  CL57 HEK-293T C115(0.88); C127(0.76)  LDD1046  [8]
 LDCM0449  CL58 HEK-293T C115(0.84); C127(0.80)  LDD1047  [8]
 LDCM0450  CL59 HEK-293T C115(0.87); C127(0.81)  LDD1048  [8]
 LDCM0451  CL6 HEK-293T C158(0.88); C283(1.06); C127(0.82)  LDD1654  [20]
 LDCM0452  CL60 HEK-293T C115(1.08); C127(0.92)  LDD1050  [8]
 LDCM0453  CL61 HEK-293T C115(0.81); C127(0.75)  LDD1051  [8]
 LDCM0454  CL62 HEK-293T C115(0.95); C127(0.85)  LDD1052  [8]
 LDCM0455  CL63 HEK-293T C115(0.85); C127(0.68)  LDD1053  [8]
 LDCM0456  CL64 HEK-293T C115(1.11); C127(1.21)  LDD1054  [8]
 LDCM0457  CL65 HEK-293T C115(1.13); C127(1.15)  LDD1055  [8]
 LDCM0458  CL66 HEK-293T C115(0.75); C127(0.39)  LDD1056  [8]
 LDCM0459  CL67 HEK-293T C115(0.89); C127(0.75)  LDD1057  [8]
 LDCM0460  CL68 HEK-293T C115(0.89); C127(0.75)  LDD1058  [8]
 LDCM0461  CL69 HEK-293T C115(1.10); C127(1.29)  LDD1059  [8]
 LDCM0462  CL7 HEK-293T C158(0.95); C283(1.08); C127(1.01); C115(1.36)  LDD1665  [20]
 LDCM0463  CL70 HEK-293T C115(0.93); C127(0.80)  LDD1061  [8]
 LDCM0464  CL71 HEK-293T C115(0.79); C127(0.63)  LDD1062  [8]
 LDCM0465  CL72 HEK-293T C115(0.86); C127(0.79)  LDD1063  [8]
 LDCM0466  CL73 HEK-293T C115(0.90); C127(0.74)  LDD1064  [8]
 LDCM0467  CL74 HEK-293T C115(1.03); C127(0.86)  LDD1065  [8]
 LDCM0469  CL76 HEK-293T C115(0.99); C127(0.66)  LDD1067  [8]
 LDCM0470  CL77 HEK-293T C115(0.94); C127(0.78)  LDD1068  [8]
 LDCM0471  CL78 HEK-293T C115(0.78); C127(0.65)  LDD1069  [8]
 LDCM0472  CL79 HEK-293T C115(0.92); C127(0.73)  LDD1070  [8]
 LDCM0473  CL8 HEK-293T C158(0.93); C127(0.75)  LDD1676  [20]
 LDCM0474  CL80 HEK-293T C115(0.83); C127(0.59)  LDD1072  [8]
 LDCM0475  CL81 HEK-293T C115(0.87); C127(0.67)  LDD1073  [8]
 LDCM0476  CL82 HEK-293T C115(1.25); C127(0.85)  LDD1074  [8]
 LDCM0477  CL83 HEK-293T C115(1.02); C127(0.83)  LDD1075  [8]
 LDCM0478  CL84 HEK-293T C115(0.83); C127(0.61)  LDD1076  [8]
 LDCM0479  CL85 HEK-293T C115(0.82); C127(0.62)  LDD1077  [8]
 LDCM0480  CL86 HEK-293T C115(0.77); C127(0.44)  LDD1078  [8]
 LDCM0481  CL87 HEK-293T C115(0.96); C127(0.77)  LDD1079  [8]
 LDCM0482  CL88 HEK-293T C115(0.91); C127(0.72)  LDD1080  [8]
 LDCM0483  CL89 HEK-293T C115(0.95); C127(0.72)  LDD1081  [8]
 LDCM0484  CL9 HEK-293T C158(0.80); C283(0.98); C127(1.18); C115(0.90)  LDD1687  [20]
 LDCM0485  CL90 HEK-293T C115(0.97); C127(0.85)  LDD1083  [8]
 LDCM0486  CL91 HCT 116 C115(0.85); C127(0.85)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C115(1.08); C127(1.08)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C115(1.20); C127(1.20)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C115(0.70); C127(0.70)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C115(1.41); C127(1.41)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C115(0.94); C127(0.94)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C115(1.19); C127(1.19)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C115(1.02); C127(1.02)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C115(1.43); C127(1.43)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C158(0.77); C283(1.16); C127(0.86); C115(0.83)  LDD1698  [20]
 LDCM0468  Fragment33 HEK-293T C115(1.05); C127(0.91)  LDD1066  [8]
 LDCM0427  Fragment51 HEK-293T C127(0.91)  LDD1025  [8]
 LDCM0116  HHS-0101 DM93 Y142(1.00); Y141(1.08)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y141(0.96); Y142(1.54)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y142(0.84); Y141(0.85)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y141(1.18); Y142(2.36)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y141(0.89); Y142(2.27)  LDD0268  [5]
 LDCM0179  JZ128 PC-3 C115(0.00); C127(0.00)  LDD0462  [3]
 LDCM0022  KB02 HCT 116 C283(2.54)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C283(2.30)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C283(2.06)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0224  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C115(1.05)  LDD2108  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C115(0.61)  LDD2134  [4]
 LDCM0131  RA190 MM1.R C115(1.42); C127(1.42)  LDD0304  [21]
 LDCM0021  THZ1 HeLa S3 C127(1.06); C115(1.05); C91(1.03)  LDD0460  [3]

References

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Mass spectrometry data entry: PXD018580
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
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9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD044402
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.