Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C116  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 7 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01687  Apoptosis-inducing factor 1, mitochondrial (AIFM1) 17.5
 LDTP02565  Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM) 14.4
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) 14.2
 LDTP13751  Exonuclease 1 (EXO1) 8.7
 LDTP12013  dCTP pyrophosphatase 1 (DCTPP1) 8.4
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) 7.8
 LDTP11336  Chitinase domain-containing protein 1 (CHID1) 5.4
Transporter and channel
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 6.4
Other
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01075  Protein CutA (CUTA) 9.5

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587