Details of the Target

General Information of Target

Target ID LDTP11336
Target Name Chitinase domain-containing protein 1 (CHID1)
Gene Name CHID1
Gene ID 66005
Synonyms
Chitinase domain-containing protein 1; Stabilin-1-interacting chitinase-like protein; SI-CLP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTQGKLSVANKAPGTEGQQQVHGEKKEAPAVPSAPPSYEEATSGEGMKAGAFPPAPTAVP
LHPSWAYVDPSSSSSYDNGFPTGDHELFTTFSWDDQKVRRVFVRKVYTILLIQLLVTLAV
VALFTFCDPVKDYVQANPGWYWASYAVFFATYLTLACCSGPRRHFPWNLILLTVFTLSMA
YLTGMLSSYYNTTSVLLCLGITALVCLSVTVFSFQTKFDFTSCQGVLFVLLMTLFFSGLI
LAILLPFQYVPWLHAVYAALGAGVFTLFLALDTQLLMGNRRHSLSPEEYIFGALNIYLDI
IYIFTFFLQLFGTNRE
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 18 family
Subcellular location
Secreted
Function
Saccharide- and LPS-binding protein with possible roles in pathogen sensing and endotoxin neutralization. Ligand-binding specificity relates to the length of the oligosaccharides, with preference for chitotetraose (in vitro).
Uniprot ID
Q9BWS9
Ensemble ID
ENST00000323578.13
HGNC ID
HGNC:28474

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A375 SNV: p.P269S DBIA    Probe Info 
HCC1143 SNV: p.V180L DBIA    Probe Info 
IGROV1 Deletion: p.V375_G383del DBIA    Probe Info 
KASUMI2 SNV: p.S257G .
MOLT4 SNV: p.R116C; p.R292Ter .
RL952 SNV: p.D262N DBIA    Probe Info 
TOV21G SNV: p.L224I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.00  LDD0403  [1]
DBIA
 Probe Info  		C306(3.62)  LDD3314  [2]
BTD
 Probe Info  		C68(0.51)  LDD2109  [3]
Acrolein
 Probe Info  		N.A.  LDD0224  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [5]
NAIA_5
 Probe Info  		N.A.  LDD2223  [6]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		11.63  LDD1725  [7]
C102
 Probe Info  		6.15  LDD1790  [7]
C116
 Probe Info  		5.43  LDD1803  [7]
C338
 Probe Info  		29.24  LDD2001  [7]
C355
 Probe Info  		39.95  LDD2016  [7]
VE-P
 Probe Info  		N.A.  LDD0396  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0270  AC15 HEK-293T C281(1.06)  LDD1513  [9]
 LDCM0281  AC21 HEK-293T C281(0.98)  LDD1520  [9]
 LDCM0283  AC23 HEK-293T C281(1.18)  LDD1522  [9]
 LDCM0289  AC29 HEK-293T C281(1.05)  LDD1528  [9]
 LDCM0292  AC31 HEK-293T C281(1.03)  LDD1531  [9]
 LDCM0298  AC37 HEK-293T C281(1.21)  LDD1537  [9]
 LDCM0300  AC39 HEK-293T C281(1.18)  LDD1539  [9]
 LDCM0307  AC45 HEK-293T C281(1.10)  LDD1546  [9]
 LDCM0309  AC47 HEK-293T C281(1.09)  LDD1548  [9]
 LDCM0312  AC5 HEK-293T C281(1.09)  LDD1551  [9]
 LDCM0316  AC53 HEK-293T C281(1.13)  LDD1555  [9]
 LDCM0318  AC55 HEK-293T C281(1.08)  LDD1557  [9]
 LDCM0325  AC61 HEK-293T C281(1.10)  LDD1564  [9]
 LDCM0327  AC63 HEK-293T C281(1.10)  LDD1566  [9]
 LDCM0334  AC7 HEK-293T C281(1.23)  LDD1568  [9]
 LDCM0248  AKOS034007472 HEK-293T C281(1.04)  LDD1511  [9]
 LDCM0156  Aniline NCI-H1299 12.00  LDD0403  [1]
 LDCM0369  CL100 HEK-293T C281(0.90)  LDD1573  [9]
 LDCM0372  CL103 HEK-293T C281(0.98)  LDD1576  [9]
 LDCM0373  CL104 HEK-293T C281(0.97)  LDD1577  [9]
 LDCM0376  CL107 HEK-293T C281(0.97)  LDD1580  [9]
 LDCM0377  CL108 HEK-293T C281(0.99)  LDD1581  [9]
 LDCM0379  CL11 HEK-293T C281(1.19)  LDD1583  [9]
 LDCM0381  CL111 HEK-293T C281(0.90)  LDD1585  [9]
 LDCM0382  CL112 HEK-293T C281(0.94)  LDD1586  [9]
 LDCM0385  CL115 HEK-293T C281(1.09)  LDD1589  [9]
 LDCM0386  CL116 HEK-293T C281(1.00)  LDD1590  [9]
 LDCM0389  CL119 HEK-293T C281(1.08)  LDD1593  [9]
 LDCM0391  CL120 HEK-293T C281(1.01)  LDD1595  [9]
 LDCM0394  CL123 HEK-293T C281(0.85)  LDD1598  [9]
 LDCM0395  CL124 HEK-293T C281(0.96)  LDD1599  [9]
 LDCM0398  CL127 HEK-293T C281(1.02)  LDD1602  [9]
 LDCM0399  CL128 HEK-293T C281(1.00)  LDD1603  [9]
 LDCM0402  CL15 HEK-293T C281(0.97)  LDD1606  [9]
 LDCM0403  CL16 HEK-293T C281(0.98)  LDD1607  [9]
 LDCM0409  CL21 HEK-293T C281(1.05)  LDD1613  [9]
 LDCM0411  CL23 HEK-293T C281(1.19)  LDD1615  [9]
 LDCM0415  CL27 HEK-293T C281(1.00)  LDD1619  [9]
 LDCM0416  CL28 HEK-293T C281(0.87)  LDD1620  [9]
 LDCM0418  CL3 HEK-293T C281(1.09)  LDD1622  [9]
 LDCM0422  CL33 HEK-293T C281(0.99)  LDD1626  [9]
 LDCM0424  CL35 HEK-293T C281(1.15)  LDD1628  [9]
 LDCM0428  CL39 HEK-293T C281(1.01)  LDD1632  [9]
 LDCM0429  CL4 HEK-293T C281(0.97)  LDD1633  [9]
 LDCM0430  CL40 HEK-293T C281(0.94)  LDD1634  [9]
 LDCM0435  CL45 HEK-293T C281(1.00)  LDD1639  [9]
 LDCM0437  CL47 HEK-293T C281(1.26)  LDD1641  [9]
 LDCM0443  CL52 HEK-293T C281(1.03)  LDD1646  [9]
 LDCM0448  CL57 HEK-293T C281(1.09)  LDD1651  [9]
 LDCM0450  CL59 HEK-293T C281(1.01)  LDD1653  [9]
 LDCM0455  CL63 HEK-293T C281(0.99)  LDD1658  [9]
 LDCM0456  CL64 HEK-293T C281(0.97)  LDD1659  [9]
 LDCM0461  CL69 HEK-293T C281(1.02)  LDD1664  [9]
 LDCM0464  CL71 HEK-293T C281(1.03)  LDD1667  [9]
 LDCM0469  CL76 HEK-293T C281(0.99)  LDD1672  [9]
 LDCM0475  CL81 HEK-293T C281(1.21)  LDD1678  [9]
 LDCM0477  CL83 HEK-293T C281(1.08)  LDD1680  [9]
 LDCM0481  CL87 HEK-293T C281(1.03)  LDD1684  [9]
 LDCM0482  CL88 HEK-293T C281(0.99)  LDD1685  [9]
 LDCM0484  CL9 HEK-293T C281(1.21)  LDD1687  [9]
 LDCM0488  CL93 HEK-293T C281(1.26)  LDD1691  [9]
 LDCM0490  CL95 HEK-293T C281(0.96)  LDD1693  [9]
 LDCM0494  CL99 HEK-293T C281(0.99)  LDD1697  [9]
 LDCM0495  E2913 HEK-293T C281(0.95)  LDD1698  [9]
 LDCM0468  Fragment33 HEK-293T C281(1.00)  LDD1671  [9]
 LDCM0022  KB02 786-O C306(2.19)  LDD2247  [2]
 LDCM0023  KB03 786-O C306(2.73)  LDD2664  [2]
 LDCM0024  KB05 IGR37 C306(3.62)  LDD3314  [2]
 LDCM0109  NEM HeLa N.A.  LDD0224  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C68(0.51)  LDD2109  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C68(0.93)  LDD2127  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C68(1.14)  LDD2136  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C68(0.99)  LDD2143  [3]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402