Details of the Target

General Information of Target

Target ID LDTP02565
Target Name Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM)
Gene Name ACADM
Gene ID 34
Synonyms
Medium-chain specific acyl-CoA dehydrogenase, mitochondrial; MCAD; EC 1.3.8.7; Medium chain acyl-CoA dehydrogenase; MCADH
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEI
IPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQ
TAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKG
DEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNM
GQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEAT
KYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAF
AGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYK
N
Target Bioclass
Enzyme
Family
Acyl-CoA dehydrogenase family
Subcellular location
Mitochondrion matrix
Function
Medium-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Electron transfer flavoprotein (ETF) is the electron acceptor that transfers electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Among the different mitochondrial acyl-CoA dehydrogenases, medium-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 6 to 12 carbons long primary chains.
Uniprot ID
P11310
Ensemble ID
ENST00000370841.9
HGNC ID
HGNC:89
ChEMBL ID
CHEMBL4295713

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.R281K .
HT SNV: p.K217E .
KYSE30 SNV: p.E237D .
MIAPACA2 SNV: p.A205V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		4.53  LDD0215  [2]
TH211
 Probe Info  		Y183(20.00); Y419(20.00); Y158(11.08); Y73(9.62)  LDD0257  [3]
TH214
 Probe Info  		Y73(14.24)  LDD0258  [3]
TH216
 Probe Info  		Y183(14.56); Y419(12.18); Y353(8.34); Y400(7.69)  LDD0259  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K279(1.67); K420(10.00)  LDD0277  [5]
Probe 1
 Probe Info  		Y67(11.12); Y183(43.72)  LDD3495  [6]
NAIA_5
 Probe Info  		C8(20.00)  LDD2227  [7]
HPAP
 Probe Info  		3.03  LDD0062  [8]
HHS-482
 Probe Info  		Y183(0.77); Y353(1.02); Y397(0.28); Y400(0.49)  LDD0285  [9]
Acrolein
 Probe Info  		N.A.  LDD0227  [10]
DBIA
 Probe Info  		C156(0.99); C156(1.23); C159(1.23)  LDD1492  [11]
ATP probe
 Probe Info  		K271(0.00); K279(0.00)  LDD0199  [12]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [13]
ATP probe
 Probe Info  		N.A.  LDD0035  [14]
IPM
 Probe Info  		C159(0.00); C156(0.00)  LDD2156  [15]
NHS
 Probe Info  		K217(0.00); K259(0.00); K271(0.00); K279(0.00)  LDD0010  [16]
SF
 Probe Info  		N.A.  LDD0028  [17]
Phosphinate-6
 Probe Info  		C156(0.00); C244(0.00)  LDD0018  [18]
1c-yne
 Probe Info  		K279(0.00); K217(0.00); K259(0.00); K69(0.00)  LDD0228  [19]
1d-yne
 Probe Info  		N.A.  LDD0357  [19]
PAL-AfBPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C109
 Probe Info  		17.27  LDD1796  [20]
C116
 Probe Info  		14.42  LDD1803  [20]
C153
 Probe Info  		23.75  LDD1834  [20]
C157
 Probe Info  		27.86  LDD1837  [20]
C162
 Probe Info  		15.78  LDD1842  [20]
C180
 Probe Info  		10.93  LDD1859  [20]
C203
 Probe Info  		16.68  LDD1878  [20]
C204
 Probe Info  		9.85  LDD1879  [20]
C219
 Probe Info  		15.89  LDD1893  [20]
C230
 Probe Info  		24.25  LDD1903  [20]
C233
 Probe Info  		14.93  LDD1906  [20]
C283
 Probe Info  		37.79  LDD1953  [20]
C323
 Probe Info  		6.32  LDD1989  [20]
C351
 Probe Info  		9.51  LDD2012  [20]
C398
 Probe Info  		10.93  LDD2057  [20]
C404
 Probe Info  		5.06  LDD2062  [20]
FFF probe13
 Probe Info  		12.21  LDD0475  [21]
FFF probe15
 Probe Info  		12.44  LDD0478  [21]
FFF probe3
 Probe Info  		5.13  LDD0464  [21]
FFF probe4
 Probe Info  		20.00  LDD0466  [21]
FFF probe6
 Probe Info  		12.91  LDD0482  [21]
FFF probe7
 Probe Info  		17.93  LDD0483  [21]
STS-2
 Probe Info  		N.A.  LDD0138  [22]
DA-2
 Probe Info  		N.A.  LDD0070  [23]
STS-1
 Probe Info  		N.A.  LDD0068  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C156(1.13)  LDD1507  [11]
 LDCM0215  AC10 HEK-293T C156(1.06)  LDD1508  [11]
 LDCM0226  AC11 HEK-293T C156(1.08)  LDD1509  [11]
 LDCM0237  AC12 HEK-293T C156(1.00); C159(1.01)  LDD1510  [11]
 LDCM0259  AC14 HEK-293T C156(1.05); C159(0.88)  LDD1512  [11]
 LDCM0270  AC15 HEK-293T C156(0.95); C159(1.01)  LDD1513  [11]
 LDCM0276  AC17 HEK-293T C156(1.14)  LDD1515  [11]
 LDCM0277  AC18 HEK-293T C156(1.21)  LDD1516  [11]
 LDCM0278  AC19 HEK-293T C156(0.96)  LDD1517  [11]
 LDCM0279  AC2 HEK-293T C156(0.91)  LDD1518  [11]
 LDCM0280  AC20 HEK-293T C156(1.00); C159(1.05)  LDD1519  [11]
 LDCM0281  AC21 HEK-293T C156(1.05); C159(1.18)  LDD1520  [11]
 LDCM0282  AC22 HEK-293T C156(1.14); C159(1.22)  LDD1521  [11]
 LDCM0283  AC23 HEK-293T C156(0.84); C159(0.86)  LDD1522  [11]
 LDCM0284  AC24 HEK-293T C156(0.88); C159(0.82)  LDD1523  [11]
 LDCM0285  AC25 HEK-293T C156(1.12)  LDD1524  [11]
 LDCM0286  AC26 HEK-293T C156(1.16)  LDD1525  [11]
 LDCM0287  AC27 HEK-293T C156(1.10)  LDD1526  [11]
 LDCM0288  AC28 HEK-293T C156(1.17); C159(1.01)  LDD1527  [11]
 LDCM0289  AC29 HEK-293T C156(1.10); C159(1.32)  LDD1528  [11]
 LDCM0290  AC3 HEK-293T C156(1.22)  LDD1529  [11]
 LDCM0291  AC30 HEK-293T C156(1.08); C159(1.19)  LDD1530  [11]
 LDCM0292  AC31 HEK-293T C156(1.05); C159(0.95)  LDD1531  [11]
 LDCM0293  AC32 HEK-293T C156(0.99); C159(1.19)  LDD1532  [11]
 LDCM0294  AC33 HEK-293T C156(1.11)  LDD1533  [11]
 LDCM0295  AC34 HEK-293T C156(1.06)  LDD1534  [11]
 LDCM0296  AC35 HEK-293T C156(1.16)  LDD1535  [11]
 LDCM0297  AC36 HEK-293T C156(1.09); C159(1.15)  LDD1536  [11]
 LDCM0298  AC37 HEK-293T C156(0.88); C159(1.17)  LDD1537  [11]
 LDCM0299  AC38 HEK-293T C156(0.99); C159(1.24)  LDD1538  [11]
 LDCM0300  AC39 HEK-293T C156(0.95); C159(0.81)  LDD1539  [11]
 LDCM0301  AC4 HEK-293T C156(1.09); C159(1.23)  LDD1540  [11]
 LDCM0302  AC40 HEK-293T C156(1.03); C159(1.17)  LDD1541  [11]
 LDCM0303  AC41 HEK-293T C156(1.09)  LDD1542  [11]
 LDCM0304  AC42 HEK-293T C156(1.08)  LDD1543  [11]
 LDCM0305  AC43 HEK-293T C156(1.07)  LDD1544  [11]
 LDCM0306  AC44 HEK-293T C156(1.09); C159(1.23)  LDD1545  [11]
 LDCM0307  AC45 HEK-293T C156(1.09); C159(1.32)  LDD1546  [11]
 LDCM0308  AC46 HEK-293T C156(1.03); C159(0.91)  LDD1547  [11]
 LDCM0309  AC47 HEK-293T C156(1.01); C159(0.82)  LDD1548  [11]
 LDCM0310  AC48 HEK-293T C156(0.89); C159(1.27)  LDD1549  [11]
 LDCM0311  AC49 HEK-293T C156(0.97)  LDD1550  [11]
 LDCM0312  AC5 HEK-293T C156(1.04); C159(1.38)  LDD1551  [11]
 LDCM0313  AC50 HEK-293T C156(0.99)  LDD1552  [11]
 LDCM0314  AC51 HEK-293T C156(0.97)  LDD1553  [11]
 LDCM0315  AC52 HEK-293T C156(0.99); C159(1.08)  LDD1554  [11]
 LDCM0316  AC53 HEK-293T C156(0.95); C159(1.21)  LDD1555  [11]
 LDCM0317  AC54 HEK-293T C156(0.94); C159(1.25)  LDD1556  [11]
 LDCM0318  AC55 HEK-293T C156(0.97); C159(0.98)  LDD1557  [11]
 LDCM0319  AC56 HEK-293T C156(0.97); C159(1.23)  LDD1558  [11]
 LDCM0320  AC57 HEK-293T C156(1.13)  LDD1559  [11]
 LDCM0321  AC58 HEK-293T C156(1.14)  LDD1560  [11]
 LDCM0322  AC59 HEK-293T C156(1.14)  LDD1561  [11]
 LDCM0323  AC6 HEK-293T C156(1.16); C159(1.26)  LDD1562  [11]
 LDCM0324  AC60 HEK-293T C156(1.11); C159(1.08)  LDD1563  [11]
 LDCM0325  AC61 HEK-293T C156(1.15); C159(1.22)  LDD1564  [11]
 LDCM0326  AC62 HEK-293T C156(1.09); C159(1.48)  LDD1565  [11]
 LDCM0327  AC63 HEK-293T C156(1.03); C159(0.97)  LDD1566  [11]
 LDCM0328  AC64 HEK-293T C156(1.01); C159(0.99)  LDD1567  [11]
 LDCM0334  AC7 HEK-293T C156(0.89); C159(0.87)  LDD1568  [11]
 LDCM0345  AC8 HEK-293T C156(1.12); C159(1.22)  LDD1569  [11]
 LDCM0248  AKOS034007472 HEK-293T C156(1.00); C159(1.13)  LDD1511  [11]
 LDCM0356  AKOS034007680 HEK-293T C156(1.09)  LDD1570  [11]
 LDCM0275  AKOS034007705 HEK-293T C156(0.96); C159(1.03)  LDD1514  [11]
 LDCM0632  CL-Sc Hep-G2 C8(20.00)  LDD2227  [7]
 LDCM0367  CL1 HEK-293T C156(1.06)  LDD1571  [11]
 LDCM0368  CL10 HEK-293T C156(0.66); C159(0.97)  LDD1572  [11]
 LDCM0369  CL100 HEK-293T C156(1.08)  LDD1573  [11]
 LDCM0370  CL101 HEK-293T C156(1.11)  LDD1574  [11]
 LDCM0371  CL102 HEK-293T C156(1.06); C159(1.11)  LDD1575  [11]
 LDCM0372  CL103 HEK-293T C156(0.95); C159(1.06)  LDD1576  [11]
 LDCM0373  CL104 HEK-293T C156(1.07)  LDD1577  [11]
 LDCM0374  CL105 HEK-293T C156(1.07)  LDD1578  [11]
 LDCM0375  CL106 HEK-293T C156(1.06); C159(1.13)  LDD1579  [11]
 LDCM0376  CL107 HEK-293T C156(1.10); C159(0.86)  LDD1580  [11]
 LDCM0377  CL108 HEK-293T C156(1.08)  LDD1581  [11]
 LDCM0378  CL109 HEK-293T C156(1.12)  LDD1582  [11]
 LDCM0379  CL11 HEK-293T C156(0.75); C159(0.70)  LDD1583  [11]
 LDCM0380  CL110 HEK-293T C156(1.02); C159(1.10)  LDD1584  [11]
 LDCM0381  CL111 HEK-293T C156(1.04); C159(0.93)  LDD1585  [11]
 LDCM0382  CL112 HEK-293T C156(1.16)  LDD1586  [11]
 LDCM0383  CL113 HEK-293T C156(1.11)  LDD1587  [11]
 LDCM0384  CL114 HEK-293T C156(1.08); C159(1.16)  LDD1588  [11]
 LDCM0385  CL115 HEK-293T C156(1.14); C159(1.14)  LDD1589  [11]
 LDCM0386  CL116 HEK-293T C156(1.05)  LDD1590  [11]
 LDCM0387  CL117 HEK-293T C156(1.09)  LDD1591  [11]
 LDCM0388  CL118 HEK-293T C156(1.01); C159(1.14)  LDD1592  [11]
 LDCM0389  CL119 HEK-293T C156(1.01); C159(1.00)  LDD1593  [11]
 LDCM0390  CL12 HEK-293T C156(0.76); C159(0.70)  LDD1594  [11]
 LDCM0391  CL120 HEK-293T C156(1.05)  LDD1595  [11]
 LDCM0392  CL121 HEK-293T C156(1.06)  LDD1596  [11]
 LDCM0393  CL122 HEK-293T C156(1.08); C159(1.05)  LDD1597  [11]
 LDCM0394  CL123 HEK-293T C156(1.04); C159(0.93)  LDD1598  [11]
 LDCM0395  CL124 HEK-293T C156(0.98)  LDD1599  [11]
 LDCM0396  CL125 HEK-293T C156(1.10)  LDD1600  [11]
 LDCM0397  CL126 HEK-293T C156(1.17); C159(1.28)  LDD1601  [11]
 LDCM0398  CL127 HEK-293T C156(1.13); C159(1.14)  LDD1602  [11]
 LDCM0399  CL128 HEK-293T C156(1.20)  LDD1603  [11]
 LDCM0400  CL13 HEK-293T C156(0.94)  LDD1604  [11]
 LDCM0401  CL14 HEK-293T C156(1.01); C159(1.06)  LDD1605  [11]
 LDCM0402  CL15 HEK-293T C156(0.92); C159(0.86)  LDD1606  [11]
 LDCM0403  CL16 HEK-293T C156(1.10)  LDD1607  [11]
 LDCM0404  CL17 HEK-293T C156(0.89)  LDD1608  [11]
 LDCM0405  CL18 HEK-293T C156(0.95)  LDD1609  [11]
 LDCM0406  CL19 HEK-293T C156(0.93)  LDD1610  [11]
 LDCM0407  CL2 HEK-293T C156(0.98); C159(1.21)  LDD1611  [11]
 LDCM0408  CL20 HEK-293T C156(0.82); C159(0.97)  LDD1612  [11]
 LDCM0409  CL21 HEK-293T C156(0.80); C159(0.98)  LDD1613  [11]
 LDCM0410  CL22 HEK-293T C156(0.72); C159(0.81)  LDD1614  [11]
 LDCM0411  CL23 HEK-293T C156(0.71); C159(0.66)  LDD1615  [11]
 LDCM0412  CL24 HEK-293T C156(0.78); C159(0.82)  LDD1616  [11]
 LDCM0413  CL25 HEK-293T C156(1.03)  LDD1617  [11]
 LDCM0414  CL26 HEK-293T C156(1.00); C159(1.05)  LDD1618  [11]
 LDCM0415  CL27 HEK-293T C156(1.01); C159(1.02)  LDD1619  [11]
 LDCM0416  CL28 HEK-293T C156(1.02)  LDD1620  [11]
 LDCM0417  CL29 HEK-293T C156(0.93)  LDD1621  [11]
 LDCM0418  CL3 HEK-293T C156(1.03); C159(1.02)  LDD1622  [11]
 LDCM0419  CL30 HEK-293T C156(0.87)  LDD1623  [11]
 LDCM0420  CL31 HEK-293T C156(0.88)  LDD1624  [11]
 LDCM0421  CL32 HEK-293T C156(0.82); C159(1.04)  LDD1625  [11]
 LDCM0422  CL33 HEK-293T C156(0.77); C159(0.84)  LDD1626  [11]
 LDCM0423  CL34 HEK-293T C156(0.75); C159(0.76)  LDD1627  [11]
 LDCM0424  CL35 HEK-293T C156(0.72); C159(0.66)  LDD1628  [11]
 LDCM0425  CL36 HEK-293T C156(0.75); C159(0.68)  LDD1629  [11]
 LDCM0426  CL37 HEK-293T C156(1.04)  LDD1630  [11]
 LDCM0428  CL39 HEK-293T C156(0.98); C159(0.82)  LDD1632  [11]
 LDCM0429  CL4 HEK-293T C156(1.01)  LDD1633  [11]
 LDCM0430  CL40 HEK-293T C156(0.94)  LDD1634  [11]
 LDCM0431  CL41 HEK-293T C156(0.97)  LDD1635  [11]
 LDCM0432  CL42 HEK-293T C156(0.94)  LDD1636  [11]
 LDCM0433  CL43 HEK-293T C156(0.94)  LDD1637  [11]
 LDCM0434  CL44 HEK-293T C156(0.87); C159(0.92)  LDD1638  [11]
 LDCM0435  CL45 HEK-293T C156(0.77); C159(0.77)  LDD1639  [11]
 LDCM0436  CL46 HEK-293T C156(0.81); C159(0.63)  LDD1640  [11]
 LDCM0437  CL47 HEK-293T C156(0.72); C159(0.68)  LDD1641  [11]
 LDCM0438  CL48 HEK-293T C156(0.71); C159(0.74)  LDD1642  [11]
 LDCM0439  CL49 HEK-293T C156(1.10)  LDD1643  [11]
 LDCM0440  CL5 HEK-293T C156(1.02)  LDD1644  [11]
 LDCM0441  CL50 HEK-293T C156(1.01); C159(1.07)  LDD1645  [11]
 LDCM0443  CL52 HEK-293T C156(1.00)  LDD1646  [11]
 LDCM0444  CL53 HEK-293T C156(0.94)  LDD1647  [11]
 LDCM0445  CL54 HEK-293T C156(0.91)  LDD1648  [11]
 LDCM0446  CL55 HEK-293T C156(1.07)  LDD1649  [11]
 LDCM0447  CL56 HEK-293T C156(0.89); C159(1.10)  LDD1650  [11]
 LDCM0448  CL57 HEK-293T C156(0.86); C159(0.86)  LDD1651  [11]
 LDCM0449  CL58 HEK-293T C156(0.86); C159(0.87)  LDD1652  [11]
 LDCM0450  CL59 HEK-293T C156(0.79); C159(0.69)  LDD1653  [11]
 LDCM0451  CL6 HEK-293T C156(0.90)  LDD1654  [11]
 LDCM0452  CL60 HEK-293T C156(0.79); C159(0.83)  LDD1655  [11]
 LDCM0453  CL61 HEK-293T C156(1.10)  LDD1656  [11]
 LDCM0454  CL62 HEK-293T C156(1.02); C159(1.15)  LDD1657  [11]
 LDCM0455  CL63 HEK-293T C156(0.98); C159(1.18)  LDD1658  [11]
 LDCM0456  CL64 HEK-293T C156(1.01)  LDD1659  [11]
 LDCM0457  CL65 HEK-293T C156(0.97)  LDD1660  [11]
 LDCM0458  CL66 HEK-293T C156(0.95)  LDD1661  [11]
 LDCM0459  CL67 HEK-293T C156(0.93)  LDD1662  [11]
 LDCM0460  CL68 HEK-293T C156(0.84); C159(1.11)  LDD1663  [11]
 LDCM0461  CL69 HEK-293T C156(0.83); C159(0.80)  LDD1664  [11]
 LDCM0462  CL7 HEK-293T C156(0.99)  LDD1665  [11]
 LDCM0463  CL70 HEK-293T C156(0.78); C159(0.67)  LDD1666  [11]
 LDCM0464  CL71 HEK-293T C156(0.73); C159(0.47)  LDD1667  [11]
 LDCM0465  CL72 HEK-293T C156(0.75); C159(0.70)  LDD1668  [11]
 LDCM0466  CL73 HEK-293T C156(1.07)  LDD1669  [11]
 LDCM0467  CL74 HEK-293T C156(1.10); C159(1.10)  LDD1670  [11]
 LDCM0469  CL76 HEK-293T C156(1.05)  LDD1672  [11]
 LDCM0470  CL77 HEK-293T C156(0.89)  LDD1673  [11]
 LDCM0471  CL78 HEK-293T C156(0.96)  LDD1674  [11]
 LDCM0472  CL79 HEK-293T C156(0.96)  LDD1675  [11]
 LDCM0473  CL8 HEK-293T C156(0.82); C159(1.22)  LDD1676  [11]
 LDCM0474  CL80 HEK-293T C156(0.89); C159(0.95)  LDD1677  [11]
 LDCM0475  CL81 HEK-293T C156(0.88); C159(1.28)  LDD1678  [11]
 LDCM0476  CL82 HEK-293T C156(0.77); C159(1.06)  LDD1679  [11]
 LDCM0477  CL83 HEK-293T C156(0.78); C159(0.74)  LDD1680  [11]
 LDCM0478  CL84 HEK-293T C156(0.72); C159(0.78)  LDD1681  [11]
 LDCM0479  CL85 HEK-293T C156(1.13)  LDD1682  [11]
 LDCM0480  CL86 HEK-293T C156(1.17); C159(1.38)  LDD1683  [11]
 LDCM0481  CL87 HEK-293T C156(1.09); C159(0.92)  LDD1684  [11]
 LDCM0482  CL88 HEK-293T C156(1.07)  LDD1685  [11]
 LDCM0483  CL89 HEK-293T C156(0.99)  LDD1686  [11]
 LDCM0484  CL9 HEK-293T C156(0.89); C159(0.89)  LDD1687  [11]
 LDCM0485  CL90 HEK-293T C156(0.86)  LDD1688  [11]
 LDCM0486  CL91 HEK-293T C156(1.03)  LDD1689  [11]
 LDCM0487  CL92 HEK-293T C156(0.89); C159(1.11)  LDD1690  [11]
 LDCM0488  CL93 HEK-293T C156(0.93); C159(0.92)  LDD1691  [11]
 LDCM0489  CL94 HEK-293T C156(0.87); C159(1.16)  LDD1692  [11]
 LDCM0490  CL95 HEK-293T C156(0.73); C159(0.80)  LDD1693  [11]
 LDCM0491  CL96 HEK-293T C156(0.85); C159(0.72)  LDD1694  [11]
 LDCM0492  CL97 HEK-293T C156(1.05)  LDD1695  [11]
 LDCM0493  CL98 HEK-293T C156(1.02); C159(1.17)  LDD1696  [11]
 LDCM0494  CL99 HEK-293T C156(1.11); C159(1.57)  LDD1697  [11]
 LDCM0495  E2913 HEK-293T C156(1.05); C159(1.25)  LDD1698  [11]
 LDCM0625  F8 Ramos 0.78  LDD2187  [25]
 LDCM0572  Fragment10 Ramos 1.20  LDD2189  [25]
 LDCM0573  Fragment11 Ramos 0.05  LDD2190  [25]
 LDCM0574  Fragment12 Ramos 1.51  LDD2191  [25]
 LDCM0575  Fragment13 Ramos 1.22  LDD2192  [25]
 LDCM0576  Fragment14 Ramos 1.01  LDD2193  [25]
 LDCM0579  Fragment20 Ramos 1.29  LDD2194  [25]
 LDCM0580  Fragment21 Ramos 0.96  LDD2195  [25]
 LDCM0582  Fragment23 Ramos 1.23  LDD2196  [25]
 LDCM0578  Fragment27 Ramos 1.22  LDD2197  [25]
 LDCM0586  Fragment28 Ramos 1.01  LDD2198  [25]
 LDCM0588  Fragment30 Ramos 1.11  LDD2199  [25]
 LDCM0589  Fragment31 Ramos 1.43  LDD2200  [25]
 LDCM0590  Fragment32 Ramos 1.03  LDD2201  [25]
 LDCM0468  Fragment33 HEK-293T C156(1.03); C159(0.96)  LDD1671  [11]
 LDCM0596  Fragment38 Ramos 1.19  LDD2203  [25]
 LDCM0566  Fragment4 Ramos 1.05  LDD2184  [25]
 LDCM0427  Fragment51 HEK-293T C156(1.00); C159(1.08)  LDD1631  [11]
 LDCM0610  Fragment52 Ramos 1.17  LDD2204  [25]
 LDCM0614  Fragment56 Ramos 1.26  LDD2205  [25]
 LDCM0569  Fragment7 Ramos 0.88  LDD2186  [25]
 LDCM0571  Fragment9 Ramos 1.83  LDD2188  [25]
 LDCM0123  JWB131 DM93 Y183(0.77); Y353(1.02); Y397(0.28); Y400(0.49)  LDD0285  [9]
 LDCM0124  JWB142 DM93 Y183(1.16); Y353(1.76); Y397(0.45); Y400(0.63)  LDD0286  [9]
 LDCM0125  JWB146 DM93 Y183(0.73); Y353(1.15); Y400(0.52)  LDD0287  [9]
 LDCM0126  JWB150 DM93 Y183(1.85); Y353(2.70); Y397(0.13); Y400(1.06)  LDD0288  [9]
 LDCM0127  JWB152 DM93 Y183(1.06); Y353(1.86); Y397(0.32); Y400(1.48)  LDD0289  [9]
 LDCM0128  JWB198 DM93 Y183(0.39); Y397(0.27); Y400(0.18)  LDD0290  [9]
 LDCM0129  JWB202 DM93 Y183(0.65); Y353(1.08); Y397(0.17); Y400(0.55)  LDD0291  [9]
 LDCM0130  JWB211 DM93 Y183(0.64); Y353(0.89); Y397(0.18); Y400(0.61)  LDD0292  [9]
 LDCM0022  KB02 HEK-293T C156(0.99); C156(1.23); C159(1.23)  LDD1492  [11]
 LDCM0023  KB03 HEK-293T C156(0.98); C156(0.95); C159(0.95)  LDD1497  [11]
 LDCM0024  KB05 HEK-293T C156(1.05); C156(1.13); C159(1.13)  LDD1502  [11]
 LDCM0109  NEM HeLa N.A.  LDD0227  [10]
 LDCM0014  Panhematin HEK-293T 3.03  LDD0062  [8]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Flavin Adenine Dinucleotide Small molecular drug DB03147
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
3-thiaoctanoyl-coa . DB03415
Octanoyl-coenzyme A . DB02910

References

1 Labeling Preferences of Diazirines with Protein Biomolecules. J Am Chem Soc. 2021 May 5;143(17):6691-6700. doi: 10.1021/jacs.1c02509. Epub 2021 Apr 20.
Mass spectrometry data entry: PXD025140
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
9 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
14 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
15 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
16 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
17 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
18 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
19 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
23 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
24 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
25 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578