Details of the Target

General Information of Target

Target ID LDTP05922
Target Name Dynactin subunit 2 (DCTN2)
Gene Name DCTN2
Gene ID 10540
Synonyms
DCTN50; Dynactin subunit 2; 50 kDa dynein-associated polypeptide; Dynactin complex 50 kDa subunit; DCTN-50; p50 dynamitin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADPKYADLPGIARNEPDVYETSDLPEDDQAEFDAEELTSTSVEHIIVNPNAAYDKFKDK
RVGTKGLDFSDRIGKTKRTGYESGEYEMLGEGLGVKETPQQKYQRLLHEVQELTTEVEKI
KTTVKESATEEKLTPVLLAKQLAALKQQLVASHLEKLLGPDAAINLTDPDGALAKRLLLQ
LEATKNSKGGSGGKTTGTPPDSSLVTYELHSRPEQDKFSQAAKVAELEKRLTELETAVRC
DQDAQNPLSAGLQGACLMETVELLQAKVSALDLAVLDQVEARLQSVLGKVNEIAKHKASV
EDADTQSKVHQLYETIQRWSPIASTLPELVQRLVTIKQLHEQAMQFGQLLTHLDTTQQMI
ANSLKDNTTLLTQVQTTMRENLATVEGNFASIDERMKKLGK
Target Bioclass
Other
Family
Dynactin subunit 2 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length. Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development.
Uniprot ID
Q13561
Ensemble ID
ENST00000434715.7
HGNC ID
HGNC:2712

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
KMS12BM SNV: p.S40I .
SHP77 SNV: p.M88L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
TH211
 Probe Info  		Y313(20.00)  LDD0260  [3]
FBP2
 Probe Info  		4.79  LDD0323  [4]
TH216
 Probe Info  		Y313(20.00)  LDD0259  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [5]
OPA-S-S-alkyne
 Probe Info  		K65(1.14); K175(2.59)  LDD3494  [6]
Probe 1
 Probe Info  		Y6(24.91); Y86(14.54); Y207(14.23)  LDD3495  [7]
THZ1-DTB
 Probe Info  		C240(1.08)  LDD0460  [8]
AHL-Pu-1
 Probe Info  		C256(2.53); C240(3.20)  LDD0168  [9]
Alkyne-RA190
 Probe Info  		3.19  LDD0299  [10]
HHS-482
 Probe Info  		Y313(1.06)  LDD0285  [11]
HHS-475
 Probe Info  		Y6(0.08); Y313(0.76); Y86(1.85); Y81(3.48)  LDD0264  [12]
HHS-465
 Probe Info  		Y313(7.59); Y6(2.14); Y81(7.25); Y86(4.31)  LDD2237  [13]
DBIA
 Probe Info  		C240(0.95); C256(1.04); C240(0.97); C256(0.97)  LDD1492  [14]
5E-2FA
 Probe Info  		H210(0.00); H310(0.00)  LDD2235  [15]
ATP probe
 Probe Info  		K175(0.00); K289(0.00)  LDD0199  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [17]
ATP probe
 Probe Info  		N.A.  LDD0035  [18]
IPM
 Probe Info  		C256(0.00); C240(0.00)  LDD2156  [19]
NHS
 Probe Info  		K132(0.00); K65(0.00); K175(0.00)  LDD0010  [20]
SF
 Probe Info  		N.A.  LDD0028  [21]
STPyne
 Probe Info  		K289(0.00); K140(0.00); K308(0.00); K175(0.00)  LDD0009  [20]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [22]
1c-yne
 Probe Info  		K96(0.00); K156(0.00)  LDD0228  [23]
Acrolein
 Probe Info  		N.A.  LDD0217  [24]
AOyne
 Probe Info  		15.00  LDD0443  [25]
NAIA_5
 Probe Info  		C256(0.00); C240(0.00)  LDD2223  [26]
PAL-AfBPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C071
 Probe Info  		10.13  LDD1767  [27]
C107
 Probe Info  		6.36  LDD1794  [27]
C153
 Probe Info  		18.77  LDD1834  [27]
C161
 Probe Info  		10.41  LDD1841  [27]
C201
 Probe Info  		36.76  LDD1877  [27]
C226
 Probe Info  		5.50  LDD1899  [27]
C231
 Probe Info  		11.47  LDD1904  [27]
C243
 Probe Info  		15.03  LDD1916  [27]
C282
 Probe Info  		15.56  LDD1952  [27]
C305
 Probe Info  		13.27  LDD1974  [27]
C339
 Probe Info  		8.46  LDD2002  [27]
C390
 Probe Info  		21.26  LDD2049  [27]
C407
 Probe Info  		18.25  LDD2064  [27]
FFF probe11
 Probe Info  		13.75  LDD0471  [28]
FFF probe12
 Probe Info  		12.06  LDD0473  [28]
FFF probe13
 Probe Info  		20.00  LDD0475  [28]
FFF probe14
 Probe Info  		20.00  LDD0477  [28]
FFF probe15
 Probe Info  		5.70  LDD0478  [28]
FFF probe2
 Probe Info  		20.00  LDD0463  [28]
FFF probe3
 Probe Info  		20.00  LDD0464  [28]
FFF probe4
 Probe Info  		10.84  LDD0466  [28]
FFF probe6
 Probe Info  		6.10  LDD0467  [28]
FFF probe9
 Probe Info  		5.53  LDD0470  [28]
JN0003
 Probe Info  		20.00  LDD0469  [28]
VE-P
 Probe Info  		N.A.  LDD0396  [29]
Alk-rapa
 Probe Info  		4.47  LDD0213  [30]
OEA-DA
 Probe Info  		6.22  LDD0046  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C256(2.53); C240(3.20)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C256(5.51); C240(4.19)  LDD0169  [9]
 LDCM0214  AC1 HEK-293T C240(1.18); C256(1.04)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C240(0.99); C256(1.08)  LDD1508  [14]
 LDCM0226  AC11 HEK-293T C240(1.17); C256(1.06); C240(1.05); C256(1.05)  LDD1509  [14]
 LDCM0237  AC12 HEK-293T C240(1.04); C256(1.17); C240(1.31); C256(1.31)  LDD1510  [14]
 LDCM0259  AC14 HEK-293T C240(1.02); C256(1.16); C240(1.04); C256(1.04)  LDD1512  [14]
 LDCM0270  AC15 HEK-293T C240(1.06); C256(1.06); C240(1.09); C256(1.09)  LDD1513  [14]
 LDCM0276  AC17 HEK-293T C240(1.19); C256(1.17)  LDD1515  [14]
 LDCM0277  AC18 HEK-293T C240(0.93); C256(0.97)  LDD1516  [14]
 LDCM0278  AC19 HEK-293T C240(0.77); C256(0.88); C240(1.37); C256(1.37)  LDD1517  [14]
 LDCM0279  AC2 HEK-293T C240(0.91); C256(0.99)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C240(1.10); C256(1.19); C240(1.15); C256(1.15)  LDD1519  [14]
 LDCM0281  AC21 HEK-293T C240(1.04); C256(1.08)  LDD1520  [14]
 LDCM0282  AC22 HEK-293T C240(1.08); C256(1.15); C240(1.10); C256(1.10)  LDD1521  [14]
 LDCM0283  AC23 HEK-293T C240(1.00); C256(1.19); C240(1.14); C256(1.14)  LDD1522  [14]
 LDCM0284  AC24 HEK-293T C240(1.11); C256(1.15); C240(1.14); C256(1.14)  LDD1523  [14]
 LDCM0285  AC25 HEK-293T C240(1.18); C256(1.17)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C240(0.99); C256(1.00)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C240(1.00); C256(0.92); C240(1.00); C256(1.00)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C240(0.99); C256(1.11); C240(1.07); C256(1.07)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C240(1.09); C256(1.01)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C240(1.08); C256(0.96); C240(0.96); C256(0.96)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C240(0.99); C256(1.02); C240(0.95); C256(0.95)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C240(0.99); C256(1.03); C240(1.06); C256(1.06)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C240(1.09); C256(1.04); C240(1.25); C256(1.25)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C240(1.36); C256(1.30)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C240(1.10); C256(1.20)  LDD1534  [14]
 LDCM0296  AC35 HEK-293T C240(1.25); C256(1.19); C240(1.23); C256(1.23)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C240(1.15); C256(1.39); C240(1.18); C256(1.18)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C240(1.09); C256(1.06)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C240(1.02); C256(1.02); C240(1.12); C256(1.12)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C240(1.08); C256(1.15); C240(1.06); C256(1.06)  LDD1539  [14]
 LDCM0301  AC4 HEK-293T C240(1.04); C256(1.04); C240(0.97); C256(0.97)  LDD1540  [14]
 LDCM0302  AC40 HEK-293T C240(1.12); C256(1.17); C240(1.08); C256(1.08)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C240(1.26); C256(1.30)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C240(1.01); C256(1.08)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C240(1.10); C256(1.08); C240(1.32); C256(1.32)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C240(1.12); C256(1.29); C240(1.12); C256(1.12)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C240(1.07); C256(1.19)  LDD1546  [14]
 LDCM0308  AC46 HEK-293T C240(1.06); C256(1.06); C240(1.18); C256(1.18)  LDD1547  [14]
 LDCM0309  AC47 HEK-293T C240(1.00); C256(1.10); C240(1.23); C256(1.23)  LDD1548  [14]
 LDCM0310  AC48 HEK-293T C240(1.15); C256(1.30); C240(1.38); C256(1.38)  LDD1549  [14]
 LDCM0311  AC49 HEK-293T C240(1.35); C256(1.27)  LDD1550  [14]
 LDCM0312  AC5 HEK-293T C240(1.02); C256(0.99)  LDD1551  [14]
 LDCM0313  AC50 HEK-293T C240(0.91); C256(1.02)  LDD1552  [14]
 LDCM0314  AC51 HEK-293T C240(1.05); C256(1.05); C240(1.24); C256(1.24)  LDD1553  [14]
 LDCM0315  AC52 HEK-293T C240(1.04); C256(1.26); C240(1.18); C256(1.18)  LDD1554  [14]
 LDCM0316  AC53 HEK-293T C240(1.19); C256(1.23)  LDD1555  [14]
 LDCM0317  AC54 HEK-293T C240(1.03); C256(1.22); C240(1.20); C256(1.20)  LDD1556  [14]
 LDCM0318  AC55 HEK-293T C240(1.15); C256(1.13); C240(1.33); C256(1.33)  LDD1557  [14]
 LDCM0319  AC56 HEK-293T C240(1.06); C256(1.18); C240(1.19); C256(1.19)  LDD1558  [14]
 LDCM0320  AC57 HEK-293T C240(1.11); C256(1.24)  LDD1559  [14]
 LDCM0321  AC58 HEK-293T C240(1.04); C256(1.04)  LDD1560  [14]
 LDCM0322  AC59 HEK-293T C240(1.03); C256(1.08); C240(1.10); C256(1.10)  LDD1561  [14]
 LDCM0323  AC6 HEK-293T C240(0.96); C256(0.97); C240(0.98); C256(0.98)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C240(1.08); C256(1.17); C240(1.20); C256(1.20)  LDD1563  [14]
 LDCM0325  AC61 HEK-293T C240(1.10); C256(1.10)  LDD1564  [14]
 LDCM0326  AC62 HEK-293T C240(1.12); C256(1.12); C240(1.15); C256(1.15)  LDD1565  [14]
 LDCM0327  AC63 HEK-293T C240(0.98); C256(1.04); C240(1.04); C256(1.04)  LDD1566  [14]
 LDCM0328  AC64 HEK-293T C240(1.09); C256(1.11); C240(1.32); C256(1.32)  LDD1567  [14]
 LDCM0334  AC7 HEK-293T C240(0.95); C256(1.01); C240(0.90); C256(0.90)  LDD1568  [14]
 LDCM0345  AC8 HEK-293T C240(1.05); C256(0.95); C240(0.92); C256(0.92)  LDD1569  [14]
 LDCM0248  AKOS034007472 HEK-293T C240(1.07); C256(1.21)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C240(1.25); C256(1.16)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C240(1.09); C256(1.11); C240(1.23); C256(1.23)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 11.37  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa H310(0.00); H108(0.00)  LDD0222  [24]
 LDCM0367  CL1 HEK-293T C240(0.91); C256(0.95); C240(1.01); C256(1.01)  LDD1571  [14]
 LDCM0368  CL10 HEK-293T C240(0.95); C256(1.11); C240(1.29); C256(1.29)  LDD1572  [14]
 LDCM0369  CL100 HEK-293T C240(0.95); C256(0.99); C240(1.18); C256(1.18)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C240(1.10); C256(1.09); C240(1.03); C256(1.03)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C240(0.84); C256(1.00)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C240(1.18); C256(1.22); C240(1.41); C256(1.41)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C240(1.03); C256(0.98); C240(1.19); C256(1.19)  LDD1577  [14]
 LDCM0374  CL105 HEK-293T C240(1.08); C256(1.10); C240(1.20); C256(1.20)  LDD1578  [14]
 LDCM0375  CL106 HEK-293T C240(1.03); C256(1.11)  LDD1579  [14]
 LDCM0376  CL107 HEK-293T C240(1.13); C256(1.10); C240(1.30); C256(1.30)  LDD1580  [14]
 LDCM0377  CL108 HEK-293T C240(1.06); C256(1.13); C240(1.22); C256(1.22)  LDD1581  [14]
 LDCM0378  CL109 HEK-293T C240(0.92); C256(0.98); C240(1.30); C256(1.30)  LDD1582  [14]
 LDCM0379  CL11 HEK-293T C240(0.98); C256(1.04); C240(1.03); C256(1.03)  LDD1583  [14]
 LDCM0380  CL110 HEK-293T C240(0.83); C256(0.91)  LDD1584  [14]
 LDCM0381  CL111 HEK-293T C240(0.93); C256(0.98); C240(1.69); C256(1.69)  LDD1585  [14]
 LDCM0382  CL112 HEK-293T C240(1.17); C256(1.08); C240(1.21); C256(1.21)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C240(1.08); C256(1.20); C240(1.23); C256(1.23)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C240(1.13); C256(1.03)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C240(1.01); C256(1.09); C240(1.15); C256(1.15)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C240(1.03); C256(1.18); C240(1.21); C256(1.21)  LDD1590  [14]
 LDCM0387  CL117 HEK-293T C240(1.18); C256(1.27); C240(1.13); C256(1.13)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C240(0.97); C256(1.04)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C240(1.06); C256(1.14); C240(1.27); C256(1.27)  LDD1593  [14]
 LDCM0390  CL12 HEK-293T C240(1.01); C256(1.16); C240(1.62); C256(1.62)  LDD1594  [14]
 LDCM0391  CL120 HEK-293T C240(0.96); C256(1.05); C240(1.21); C256(1.21)  LDD1595  [14]
 LDCM0392  CL121 HEK-293T C240(1.04); C256(1.25); C240(1.17); C256(1.17)  LDD1596  [14]
 LDCM0393  CL122 HEK-293T C240(1.06); C256(1.16)  LDD1597  [14]
 LDCM0394  CL123 HEK-293T C240(1.10); C256(1.05); C240(1.56); C256(1.56)  LDD1598  [14]
 LDCM0395  CL124 HEK-293T C240(1.02); C256(1.15); C240(1.39); C256(1.39)  LDD1599  [14]
 LDCM0396  CL125 HEK-293T C240(1.11); C256(1.16); C240(1.06); C256(1.06)  LDD1600  [14]
 LDCM0397  CL126 HEK-293T C240(1.08); C256(1.13)  LDD1601  [14]
 LDCM0398  CL127 HEK-293T C240(1.01); C256(1.13); C240(1.15); C256(1.15)  LDD1602  [14]
 LDCM0399  CL128 HEK-293T C240(1.10); C256(1.22); C240(1.13); C256(1.13)  LDD1603  [14]
 LDCM0400  CL13 HEK-293T C240(0.86); C256(1.03); C240(1.17); C256(1.17)  LDD1604  [14]
 LDCM0401  CL14 HEK-293T C240(1.10); C256(1.18)  LDD1605  [14]
 LDCM0402  CL15 HEK-293T C240(0.96); C256(1.08); C240(1.42); C256(1.42)  LDD1606  [14]
 LDCM0403  CL16 HEK-293T C240(1.09); C256(1.08); C240(1.16); C256(1.16)  LDD1607  [14]
 LDCM0404  CL17 HEK-293T C240(1.32); C256(1.08)  LDD1608  [14]
 LDCM0405  CL18 HEK-293T C240(1.10); C256(1.04)  LDD1609  [14]
 LDCM0406  CL19 HEK-293T C240(1.45); C256(1.24); C240(1.25); C256(1.25)  LDD1610  [14]
 LDCM0407  CL2 HEK-293T C240(0.95); C256(0.96)  LDD1611  [14]
 LDCM0408  CL20 HEK-293T C240(1.11); C256(1.24); C240(1.25); C256(1.25)  LDD1612  [14]
 LDCM0409  CL21 HEK-293T C240(1.13); C256(1.24)  LDD1613  [14]
 LDCM0410  CL22 HEK-293T C240(1.11); C256(1.16); C240(0.92); C256(0.92)  LDD1614  [14]
 LDCM0411  CL23 HEK-293T C240(1.08); C256(1.08); C240(1.18); C256(1.18)  LDD1615  [14]
 LDCM0412  CL24 HEK-293T C240(1.05); C256(1.20); C240(1.44); C256(1.44)  LDD1616  [14]
 LDCM0413  CL25 HEK-293T C240(0.92); C256(1.10); C240(1.17); C256(1.17)  LDD1617  [14]
 LDCM0414  CL26 HEK-293T C240(0.96); C256(1.35)  LDD1618  [14]
 LDCM0415  CL27 HEK-293T C240(1.05); C256(1.14); C240(1.29); C256(1.29)  LDD1619  [14]
 LDCM0416  CL28 HEK-293T C240(1.20); C256(1.01); C240(1.27); C256(1.27)  LDD1620  [14]
 LDCM0417  CL29 HEK-293T C240(1.06); C256(1.08)  LDD1621  [14]
 LDCM0418  CL3 HEK-293T C240(0.94); C256(1.02); C240(1.18); C256(1.18)  LDD1622  [14]
 LDCM0419  CL30 HEK-293T C240(1.11); C256(0.97)  LDD1623  [14]
 LDCM0420  CL31 HEK-293T C240(1.23); C256(1.01); C240(1.17); C256(1.17)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C240(1.09); C256(1.32); C240(1.15); C256(1.15)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C240(1.04); C256(1.20)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C240(1.01); C256(1.03); C240(1.27); C256(1.27)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C240(1.12); C256(1.07); C240(0.99); C256(0.99)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C240(0.98); C256(1.15); C240(1.20); C256(1.20)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C240(1.02); C256(1.26); C240(1.21); C256(1.21)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C240(1.15); C256(1.23); C240(1.13); C256(1.13)  LDD1632  [14]
 LDCM0429  CL4 HEK-293T C240(0.86); C256(0.59); C240(1.07); C256(1.07)  LDD1633  [14]
 LDCM0430  CL40 HEK-293T C240(1.05); C256(1.16); C240(1.48); C256(1.48)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C240(1.26); C256(1.18)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C240(1.01); C256(0.96)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C240(0.95); C256(1.00); C240(1.16); C256(1.16)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C240(1.04); C256(1.14); C240(1.13); C256(1.13)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C240(1.13); C256(1.22)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C240(1.17); C256(1.09); C240(1.08); C256(1.08)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C240(1.06); C256(0.93); C240(0.94); C256(0.94)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C240(1.18); C256(1.36); C240(1.58); C256(1.58)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C240(0.94); C256(1.00); C240(1.07); C256(1.07)  LDD1643  [14]
 LDCM0440  CL5 HEK-293T C240(1.23); C256(1.04)  LDD1644  [14]
 LDCM0441  CL50 HEK-293T C240(1.10); C256(1.15)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C240(0.99); C256(1.04); C240(1.35); C256(1.35)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C240(1.28); C256(1.16)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C240(1.12); C256(1.13)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C240(1.17); C256(1.10); C240(1.13); C256(1.13)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C240(1.10); C256(1.23); C240(1.13); C256(1.13)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C240(1.06); C256(1.16)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C240(1.15); C256(1.17); C240(1.16); C256(1.16)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C240(1.09); C256(1.11); C240(1.14); C256(1.14)  LDD1653  [14]
 LDCM0451  CL6 HEK-293T C240(0.95); C256(0.89)  LDD1654  [14]
 LDCM0452  CL60 HEK-293T C240(1.18); C256(1.35); C240(1.50); C256(1.50)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C240(1.03); C256(1.12); C240(1.11); C256(1.11)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C240(0.84); C256(1.07)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C240(1.11); C256(1.18); C240(1.41); C256(1.41)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C240(0.96); C256(1.01); C240(1.27); C256(1.27)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C240(1.24); C256(1.23)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C240(1.16); C256(1.19)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C240(1.17); C256(1.00); C240(1.03); C256(1.03)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C240(1.04); C256(1.24); C240(1.27); C256(1.27)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C240(1.31); C256(1.29)  LDD1664  [14]
 LDCM0462  CL7 HEK-293T C240(1.11); C256(0.91); C240(0.96); C256(0.96)  LDD1665  [14]
 LDCM0463  CL70 HEK-293T C240(1.28); C256(1.21); C240(1.27); C256(1.27)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C240(1.09); C256(1.14); C240(1.16); C256(1.16)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C240(1.13); C256(1.51); C240(1.18); C256(1.18)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C240(0.88); C256(0.98); C240(1.29); C256(1.29)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C240(1.02); C256(0.97)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C240(0.92); C256(1.01); C240(1.00); C256(1.00)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C240(1.23); C256(0.98)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C240(1.03); C256(0.98)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C240(1.13); C256(0.91); C240(1.18); C256(1.18)  LDD1675  [14]
 LDCM0473  CL8 HEK-293T C240(0.78); C256(1.04); C240(1.27); C256(1.27)  LDD1676  [14]
 LDCM0474  CL80 HEK-293T C240(0.95); C256(1.15); C240(1.04); C256(1.04)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C240(1.09); C256(1.22)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C240(0.99); C256(0.99); C240(1.16); C256(1.16)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C240(1.07); C256(1.02); C240(1.37); C256(1.37)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C240(1.02); C256(1.05); C240(1.21); C256(1.21)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C240(1.08); C256(1.25); C240(1.39); C256(1.39)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C240(1.14); C256(1.14)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C240(1.05); C256(1.18); C240(1.17); C256(1.17)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C240(0.92); C256(1.08); C240(1.26); C256(1.26)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C240(1.17); C256(1.17)  LDD1686  [14]
 LDCM0484  CL9 HEK-293T C240(1.05); C256(1.08)  LDD1687  [14]
 LDCM0485  CL90 HEK-293T C240(1.07); C256(1.00)  LDD1688  [14]
 LDCM0486  CL91 HEK-293T C240(1.01); C256(1.08); C240(1.18); C256(1.18)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C240(1.06); C256(1.30); C240(1.50); C256(1.50)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C240(0.60); C256(1.17)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C240(1.08); C256(1.26); C240(1.02); C256(1.02)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C240(1.22); C256(1.05); C240(1.53); C256(1.53)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C240(1.09); C256(1.11); C240(1.21); C256(1.21)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C240(0.97); C256(1.07); C240(1.05); C256(1.05)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C240(0.94); C256(1.11)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C240(1.00); C256(1.03); C240(1.07); C256(1.07)  LDD1697  [14]
 LDCM0185  Compound 17 HEK-293T 5.28  LDD0512  [28]
 LDCM0182  Compound 18 HEK-293T 5.99  LDD0501  [28]
 LDCM0191  Compound 21 HEK-293T 10.00  LDD0493  [28]
 LDCM0190  Compound 34 HEK-293T 19.61  LDD0497  [28]
 LDCM0192  Compound 35 HEK-293T 8.97  LDD0491  [28]
 LDCM0193  Compound 36 HEK-293T 6.13  LDD0494  [28]
 LDCM0195  Compound 38 HEK-293T 10.93  LDD0499  [28]
 LDCM0196  Compound 39 HEK-293T 9.22  LDD0496  [28]
 LDCM0197  Compound 40 HEK-293T 13.70  LDD0495  [28]
 LDCM0495  E2913 HEK-293T C240(1.05); C256(1.25); C240(1.19); C256(1.19)  LDD1698  [14]
 LDCM0468  Fragment33 HEK-293T C240(0.93); C256(1.02); C240(1.48); C256(1.48)  LDD1671  [14]
 LDCM0427  Fragment51 HEK-293T C240(0.96); C256(1.12)  LDD1631  [14]
 LDCM0116  HHS-0101 DM93 Y6(0.08); Y313(0.76); Y86(1.85); Y81(3.48)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y313(0.55); Y6(0.75); Y86(3.94); Y81(4.43)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y313(0.73); Y81(3.26); Y86(3.62)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y6(0.35); Y313(0.53); Y86(2.64); Y81(3.65)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y313(0.86); Y81(3.03); Y86(3.39)  LDD0268  [12]
 LDCM0107  IAA HeLa N.A.  LDD0221  [24]
 LDCM0123  JWB131 DM93 Y313(1.06)  LDD0285  [11]
 LDCM0124  JWB142 DM93 Y313(1.26)  LDD0286  [11]
 LDCM0125  JWB146 DM93 Y313(1.16)  LDD0287  [11]
 LDCM0126  JWB150 DM93 Y313(2.97)  LDD0288  [11]
 LDCM0127  JWB152 DM93 Y313(1.36)  LDD0289  [11]
 LDCM0128  JWB198 DM93 Y313(1.37)  LDD0290  [11]
 LDCM0129  JWB202 DM93 Y313(0.73)  LDD0291  [11]
 LDCM0130  JWB211 DM93 Y313(1.04)  LDD0292  [11]
 LDCM0022  KB02 HEK-293T C240(0.95); C256(1.04); C240(0.97); C256(0.97)  LDD1492  [14]
 LDCM0023  KB03 HEK-293T C240(1.04); C256(1.01); C240(1.04); C256(1.04)  LDD1497  [14]
 LDCM0024  KB05 HEK-293T C240(1.07); C256(0.95); C240(0.85); C256(0.85)  LDD1502  [14]
 LDCM0109  NEM HeLa H108(0.00); H310(0.00)  LDD0223  [24]
 LDCM0131  RA190 MM1.R 3.19  LDD0299  [10]
 LDCM0090  Rapamycin JHH-7 4.47  LDD0213  [30]
 LDCM0021  THZ1 HeLa S3 C240(1.08)  LDD0460  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Huntingtin (HTT) Huntingtin family P42858
Programmed cell death protein 6 (PDCD6) . O75340
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC1S1) BLOC1S1 family P78537
Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC1S2) BLOC1S2 family Q6QNY1
Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC1S6) BLOC1S6 family Q9UL45
BLOC-1-related complex subunit 6 (BORCS6) BORCS6 family Q96GS4
Coiled-coil domain-containing protein 172 (CCDC172) CCDC172 family P0C7W6
Centromere protein H (CENPH) CENP-H/MCM16 family Q9H3R5
Dynactin subunit 2 (DCTN2) Dynactin subunit 2 family Q13561
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) GADD45 family P24522
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) GADD45 family O95257
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
RAD50-interacting protein 1 (RINT1) RINT1 family Q6NUQ1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Vacuolar protein sorting-associated protein 33A (VPS33A) STXBP/unc-18/SEC1 family Q96AX1
Beta-taxilin (TXLNB) Taxilin family Q8N3L3
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
11 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
19 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
22 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
23 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
24 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
30 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
31 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570