Details of the Target

General Information of Target

Target ID LDTP15705
Target Name BTB/POZ domain-containing protein KCTD12 (KCTD12)
Gene Name KCTD12
Gene ID 115207
Synonyms
C13orf2; KIAA1778; PFET1; BTB/POZ domain-containing protein KCTD12; Pfetin; Predominantly fetal expressed T1 domain
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEAARTAVLRVKRKRSAEPAEALVLACKRLRSDAVESAAQKTSEGLERAAENNVFHLVAT
VCSQEEPVQPLLREVLRPSRDSQQRVRRNLRASAREVRQEGRYRVLSSRRSLGTTSSGQE
SEYTPGNPEAAGNSGFQLLDLVHEEGEPEAASAGSCKTSDPDVILCNSVELIRERLTVSE
DGPGVRRQEEQKHDDYVYDIYYLETATPGWIENILSVQPYSQEWELVNDDQEPEDIYDDE
DDENSENNWRNEYPEEESSDGDEDSRGSADYNSLSEEERGSSRQRMWSKYPLDVQKEFGY
DSPHDLDSD
Target Bioclass
Other
Subcellular location
Presynaptic cell membrane
Function
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.
Uniprot ID
Q96CX2
Ensemble ID
ENST00000377474.4
HGNC ID
HGNC:14678
ChEMBL ID
CHEMBL4523424

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.88  LDD0402  [1]
AZ-9
 Probe Info  		5.63  LDD0393  [2]
TH211
 Probe Info  		Y214(7.67)  LDD0257  [3]
STPyne
 Probe Info  		K229(9.09)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
BTD
 Probe Info  		C50(0.92)  LDD2092  [5]
DA-P3
 Probe Info  		35.28  LDD0183  [6]
AHL-Pu-1
 Probe Info  		C50(2.09)  LDD0168  [7]
HHS-465
 Probe Info  		Y106(1.54); Y119(4.40); Y161(8.17)  LDD2237  [8]
DBIA
 Probe Info  		C50(1.27)  LDD0080  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
IPM
 Probe Info  		N.A.  LDD0005  [13]
SF
 Probe Info  		Y218(0.00); Y119(0.00); Y106(0.00); Y91(0.00)  LDD0028  [14]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
1c-yne
 Probe Info  		N.A.  LDD0228  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
AOyne
 Probe Info  		5.60  LDD0443  [18]
MPP-AC
 Probe Info  		N.A.  LDD0428  [19]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		7.84  LDD1779  [20]
C165
 Probe Info  		15.03  LDD1845  [20]
C232
 Probe Info  		33.13  LDD1905  [20]
FFF probe11
 Probe Info  		14.44  LDD0471  [21]
FFF probe12
 Probe Info  		8.27  LDD0473  [21]
FFF probe13
 Probe Info  		17.04  LDD0475  [21]
FFF probe2
 Probe Info  		20.00  LDD0463  [21]
FFF probe3
 Probe Info  		20.00  LDD0464  [21]
FFF probe6
 Probe Info  		7.92  LDD0467  [21]
JN0003
 Probe Info  		15.50  LDD0469  [21]
VE-P
 Probe Info  		N.A.  LDD0396  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C50(2.09)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C50(2.73)  LDD0169  [7]
 LDCM0214  AC1 PaTu 8988t C50(0.33)  LDD1093  [9]
 LDCM0215  AC10 HEK-293T C323(0.96); C50(0.99)  LDD0813  [9]
 LDCM0216  AC100 HEK-293T C50(1.09)  LDD0814  [9]
 LDCM0217  AC101 HEK-293T C50(0.94)  LDD0815  [9]
 LDCM0218  AC102 HEK-293T C50(1.14)  LDD0816  [9]
 LDCM0219  AC103 HEK-293T C50(0.78)  LDD0817  [9]
 LDCM0220  AC104 HEK-293T C50(1.16)  LDD0818  [9]
 LDCM0221  AC105 HEK-293T C50(1.35)  LDD0819  [9]
 LDCM0222  AC106 HEK-293T C50(1.10)  LDD0820  [9]
 LDCM0223  AC107 HEK-293T C50(1.07)  LDD0821  [9]
 LDCM0224  AC108 HEK-293T C50(1.26)  LDD0822  [9]
 LDCM0225  AC109 HEK-293T C50(1.07)  LDD0823  [9]
 LDCM0226  AC11 HEK-293T C323(0.85); C50(0.99)  LDD0824  [9]
 LDCM0227  AC110 HEK-293T C50(1.08)  LDD0825  [9]
 LDCM0228  AC111 HEK-293T C50(1.18)  LDD0826  [9]
 LDCM0229  AC112 HEK-293T C50(0.98)  LDD0827  [9]
 LDCM0230  AC113 HEK-293T C50(1.14)  LDD0828  [9]
 LDCM0231  AC114 HEK-293T C50(0.96)  LDD0829  [9]
 LDCM0232  AC115 HEK-293T C50(1.19)  LDD0830  [9]
 LDCM0233  AC116 HEK-293T C50(0.85)  LDD0831  [9]
 LDCM0234  AC117 HEK-293T C50(1.01)  LDD0832  [9]
 LDCM0235  AC118 HEK-293T C50(0.68)  LDD0833  [9]
 LDCM0236  AC119 HEK-293T C50(0.98)  LDD0834  [9]
 LDCM0237  AC12 HEK-293T C323(1.23); C50(0.94)  LDD0835  [9]
 LDCM0238  AC120 HEK-293T C50(0.80)  LDD0836  [9]
 LDCM0239  AC121 HEK-293T C50(1.19)  LDD0837  [9]
 LDCM0240  AC122 HEK-293T C50(1.22)  LDD0838  [9]
 LDCM0241  AC123 HEK-293T C50(1.03)  LDD0839  [9]
 LDCM0242  AC124 HEK-293T C50(1.17)  LDD0840  [9]
 LDCM0243  AC125 HEK-293T C50(1.11)  LDD0841  [9]
 LDCM0244  AC126 HEK-293T C50(1.15)  LDD0842  [9]
 LDCM0245  AC127 HEK-293T C50(0.89)  LDD0843  [9]
 LDCM0246  AC128 HEK-293T C50(1.32)  LDD0844  [9]
 LDCM0247  AC129 HEK-293T C50(1.31)  LDD0845  [9]
 LDCM0249  AC130 HEK-293T C50(0.91)  LDD0847  [9]
 LDCM0250  AC131 HEK-293T C50(0.87)  LDD0848  [9]
 LDCM0251  AC132 HEK-293T C50(1.86)  LDD0849  [9]
 LDCM0252  AC133 HEK-293T C50(0.86)  LDD0850  [9]
 LDCM0253  AC134 HEK-293T C50(1.25)  LDD0851  [9]
 LDCM0254  AC135 HEK-293T C50(0.97)  LDD0852  [9]
 LDCM0255  AC136 HEK-293T C50(1.34)  LDD0853  [9]
 LDCM0256  AC137 HEK-293T C50(1.72)  LDD0854  [9]
 LDCM0257  AC138 HEK-293T C50(1.68)  LDD0855  [9]
 LDCM0258  AC139 HEK-293T C50(1.29)  LDD0856  [9]
 LDCM0259  AC14 HEK-293T C323(1.07); C50(0.93)  LDD0857  [9]
 LDCM0260  AC140 HEK-293T C50(1.32)  LDD0858  [9]
 LDCM0261  AC141 HEK-293T C50(1.41)  LDD0859  [9]
 LDCM0262  AC142 HEK-293T C50(1.45)  LDD0860  [9]
 LDCM0263  AC143 HEK-293T C50(0.84)  LDD0861  [9]
 LDCM0264  AC144 HEK-293T C50(1.04)  LDD0862  [9]
 LDCM0265  AC145 HEK-293T C50(0.98)  LDD0863  [9]
 LDCM0266  AC146 HEK-293T C50(0.93)  LDD0864  [9]
 LDCM0267  AC147 HEK-293T C50(0.74)  LDD0865  [9]
 LDCM0268  AC148 HEK-293T C50(0.69)  LDD0866  [9]
 LDCM0269  AC149 HEK-293T C50(1.00)  LDD0867  [9]
 LDCM0270  AC15 HEK-293T C323(1.29); C50(0.99)  LDD0868  [9]
 LDCM0271  AC150 HEK-293T C50(0.71)  LDD0869  [9]
 LDCM0272  AC151 HEK-293T C50(0.97)  LDD0870  [9]
 LDCM0273  AC152 HEK-293T C50(1.00)  LDD0871  [9]
 LDCM0274  AC153 HEK-293T C50(0.88)  LDD0872  [9]
 LDCM0621  AC154 HEK-293T C50(0.80)  LDD2162  [9]
 LDCM0622  AC155 HEK-293T C50(0.96)  LDD2163  [9]
 LDCM0623  AC156 HEK-293T C50(0.94)  LDD2164  [9]
 LDCM0624  AC157 HEK-293T C50(0.81)  LDD2165  [9]
 LDCM0276  AC17 HEK-293T C50(1.32)  LDD0874  [9]
 LDCM0277  AC18 HEK-293T C50(1.09)  LDD0875  [9]
 LDCM0278  AC19 HEK-293T C50(1.08)  LDD0876  [9]
 LDCM0279  AC2 PaTu 8988t C50(0.34)  LDD1158  [9]
 LDCM0280  AC20 HEK-293T C50(1.15)  LDD0878  [9]
 LDCM0281  AC21 HEK-293T C50(1.22)  LDD0879  [9]
 LDCM0282  AC22 HEK-293T C50(1.21)  LDD0880  [9]
 LDCM0283  AC23 HEK-293T C50(1.33)  LDD0881  [9]
 LDCM0284  AC24 HEK-293T C50(1.19)  LDD0882  [9]
 LDCM0285  AC25 PaTu 8988t C50(0.98)  LDD1164  [9]
 LDCM0286  AC26 PaTu 8988t C50(1.28)  LDD1165  [9]
 LDCM0287  AC27 PaTu 8988t C50(1.09)  LDD1166  [9]
 LDCM0288  AC28 PaTu 8988t C50(1.14)  LDD1167  [9]
 LDCM0289  AC29 PaTu 8988t C50(1.03)  LDD1168  [9]
 LDCM0290  AC3 PaTu 8988t C50(0.41)  LDD1169  [9]
 LDCM0291  AC30 PaTu 8988t C50(0.88)  LDD1170  [9]
 LDCM0292  AC31 PaTu 8988t C50(0.98)  LDD1171  [9]
 LDCM0293  AC32 PaTu 8988t C50(0.88)  LDD1172  [9]
 LDCM0294  AC33 PaTu 8988t C50(1.18)  LDD1173  [9]
 LDCM0295  AC34 PaTu 8988t C50(1.11)  LDD1174  [9]
 LDCM0296  AC35 HEK-293T C50(1.04)  LDD0894  [9]
 LDCM0297  AC36 HEK-293T C50(0.95)  LDD0895  [9]
 LDCM0298  AC37 HEK-293T C50(0.93)  LDD0896  [9]
 LDCM0299  AC38 HEK-293T C50(1.02)  LDD0897  [9]
 LDCM0300  AC39 HEK-293T C50(1.31)  LDD0898  [9]
 LDCM0301  AC4 PaTu 8988t C50(0.29)  LDD1180  [9]
 LDCM0302  AC40 HEK-293T C50(0.78)  LDD0900  [9]
 LDCM0303  AC41 HEK-293T C50(1.08)  LDD0901  [9]
 LDCM0304  AC42 HEK-293T C50(1.20)  LDD0902  [9]
 LDCM0305  AC43 HEK-293T C50(0.95)  LDD0903  [9]
 LDCM0306  AC44 HEK-293T C50(0.96)  LDD0904  [9]
 LDCM0307  AC45 HEK-293T C50(1.23)  LDD0905  [9]
 LDCM0308  AC46 HEK-293T C50(1.15)  LDD0906  [9]
 LDCM0309  AC47 HEK-293T C50(1.53)  LDD0907  [9]
 LDCM0310  AC48 HEK-293T C50(1.06)  LDD0908  [9]
 LDCM0311  AC49 HEK-293T C50(1.23)  LDD0909  [9]
 LDCM0312  AC5 PaTu 8988t C50(0.30)  LDD1191  [9]
 LDCM0313  AC50 HEK-293T C50(1.34)  LDD0911  [9]
 LDCM0314  AC51 HEK-293T C50(1.40)  LDD0912  [9]
 LDCM0315  AC52 HEK-293T C50(1.20)  LDD0913  [9]
 LDCM0316  AC53 HEK-293T C50(1.15)  LDD0914  [9]
 LDCM0317  AC54 HEK-293T C50(1.28)  LDD0915  [9]
 LDCM0318  AC55 HEK-293T C50(1.39)  LDD0916  [9]
 LDCM0319  AC56 HEK-293T C50(1.26)  LDD0917  [9]
 LDCM0320  AC57 HEK-293T C323(1.32); C50(0.86)  LDD0918  [9]
 LDCM0321  AC58 HEK-293T C323(1.07); C50(1.07)  LDD0919  [9]
 LDCM0322  AC59 HEK-293T C323(0.88); C50(0.95)  LDD0920  [9]
 LDCM0323  AC6 HEK-293T C323(0.81); C50(0.82)  LDD0921  [9]
 LDCM0324  AC60 HEK-293T C323(1.51); C50(0.87)  LDD0922  [9]
 LDCM0325  AC61 HEK-293T C323(1.00); C50(1.26)  LDD0923  [9]
 LDCM0326  AC62 HEK-293T C323(0.99); C50(1.27)  LDD0924  [9]
 LDCM0327  AC63 HEK-293T C323(1.08); C50(1.55)  LDD0925  [9]
 LDCM0328  AC64 HEK-293T C323(1.22); C50(1.25)  LDD0926  [9]
 LDCM0329  AC65 HEK-293T C323(1.07); C50(1.19)  LDD0927  [9]
 LDCM0330  AC66 HEK-293T C323(0.93); C50(1.34)  LDD0928  [9]
 LDCM0331  AC67 HEK-293T C323(1.00); C50(1.19)  LDD0929  [9]
 LDCM0332  AC68 HEK-293T C50(0.84)  LDD0930  [9]
 LDCM0333  AC69 HEK-293T C50(0.99)  LDD0931  [9]
 LDCM0334  AC7 HEK-293T C323(0.88); C50(0.85)  LDD0932  [9]
 LDCM0335  AC70 HEK-293T C50(0.82)  LDD0933  [9]
 LDCM0336  AC71 HEK-293T C50(0.81)  LDD0934  [9]
 LDCM0337  AC72 HEK-293T C50(0.87)  LDD0935  [9]
 LDCM0338  AC73 HEK-293T C50(0.77)  LDD0936  [9]
 LDCM0339  AC74 HEK-293T C50(0.77)  LDD0937  [9]
 LDCM0340  AC75 HEK-293T C50(0.62)  LDD0938  [9]
 LDCM0341  AC76 HEK-293T C50(0.76)  LDD0939  [9]
 LDCM0342  AC77 HEK-293T C50(0.77)  LDD0940  [9]
 LDCM0343  AC78 HEK-293T C50(0.90)  LDD0941  [9]
 LDCM0344  AC79 HEK-293T C50(0.88)  LDD0942  [9]
 LDCM0345  AC8 HEK-293T C323(0.99); C50(0.92)  LDD0943  [9]
 LDCM0346  AC80 HEK-293T C50(0.71)  LDD0944  [9]
 LDCM0347  AC81 HEK-293T C50(0.77)  LDD0945  [9]
 LDCM0348  AC82 HEK-293T C50(0.96)  LDD0946  [9]
 LDCM0349  AC83 HEK-293T C323(1.10); C50(1.32)  LDD0947  [9]
 LDCM0350  AC84 HEK-293T C323(1.19); C50(1.56)  LDD0948  [9]
 LDCM0351  AC85 HEK-293T C323(1.25); C50(1.16)  LDD0949  [9]
 LDCM0352  AC86 HEK-293T C323(1.34); C50(1.11)  LDD0950  [9]
 LDCM0353  AC87 HEK-293T C323(1.29); C50(1.39)  LDD0951  [9]
 LDCM0354  AC88 HEK-293T C323(1.40); C50(0.89)  LDD0952  [9]
 LDCM0355  AC89 HEK-293T C323(1.27); C50(1.38)  LDD0953  [9]
 LDCM0357  AC90 HEK-293T C323(1.22); C50(1.10)  LDD0955  [9]
 LDCM0358  AC91 HEK-293T C323(1.01); C50(1.17)  LDD0956  [9]
 LDCM0359  AC92 HEK-293T C323(1.26); C50(1.19)  LDD0957  [9]
 LDCM0360  AC93 HEK-293T C323(1.62); C50(1.33)  LDD0958  [9]
 LDCM0361  AC94 HEK-293T C323(1.38); C50(1.34)  LDD0959  [9]
 LDCM0362  AC95 HEK-293T C323(1.12); C50(1.23)  LDD0960  [9]
 LDCM0363  AC96 HEK-293T C323(1.43); C50(1.09)  LDD0961  [9]
 LDCM0364  AC97 HEK-293T C323(1.68); C50(1.08)  LDD0962  [9]
 LDCM0365  AC98 HEK-293T C50(1.05)  LDD0963  [9]
 LDCM0366  AC99 HEK-293T C50(1.12)  LDD0964  [9]
 LDCM0248  AKOS034007472 HEK-293T C323(1.21); C50(0.86)  LDD0846  [9]
 LDCM0356  AKOS034007680 HEK-293T C323(1.33); C50(1.01)  LDD0954  [9]
 LDCM0275  AKOS034007705 HEK-293T C323(1.05); C50(0.99)  LDD0873  [9]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0087  Capsaicin HEK-293T 4.46  LDD0185  [6]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [17]
 LDCM0367  CL1 HEK-293T C50(1.00)  LDD0965  [9]
 LDCM0368  CL10 HEK-293T C50(1.02)  LDD0966  [9]
 LDCM0369  CL100 PaTu 8988t C50(0.28)  LDD1248  [9]
 LDCM0370  CL101 HEK-293T C323(0.96); C50(0.88)  LDD0968  [9]
 LDCM0371  CL102 HEK-293T C323(1.07); C50(0.90)  LDD0969  [9]
 LDCM0372  CL103 HEK-293T C323(1.10); C50(0.93)  LDD0970  [9]
 LDCM0373  CL104 HEK-293T C323(1.13); C50(0.85)  LDD0971  [9]
 LDCM0374  CL105 HEK-293T C50(1.22)  LDD0972  [9]
 LDCM0375  CL106 HEK-293T C50(1.13)  LDD0973  [9]
 LDCM0376  CL107 HEK-293T C50(1.07)  LDD0974  [9]
 LDCM0377  CL108 HEK-293T C50(0.96)  LDD0975  [9]
 LDCM0378  CL109 HEK-293T C50(1.02)  LDD0976  [9]
 LDCM0379  CL11 HEK-293T C50(0.97)  LDD0977  [9]
 LDCM0380  CL110 HEK-293T C50(1.15)  LDD0978  [9]
 LDCM0381  CL111 HEK-293T C50(1.20)  LDD0979  [9]
 LDCM0382  CL112 PaTu 8988t C50(1.15)  LDD1261  [9]
 LDCM0383  CL113 PaTu 8988t C50(0.82)  LDD1262  [9]
 LDCM0384  CL114 PaTu 8988t C50(1.00)  LDD1263  [9]
 LDCM0385  CL115 PaTu 8988t C50(0.97)  LDD1264  [9]
 LDCM0386  CL116 PaTu 8988t C50(1.01)  LDD1265  [9]
 LDCM0387  CL117 HEK-293T C50(1.20)  LDD0985  [9]
 LDCM0388  CL118 HEK-293T C50(0.90)  LDD0986  [9]
 LDCM0389  CL119 HEK-293T C50(0.96)  LDD0987  [9]
 LDCM0390  CL12 HEK-293T C50(1.31)  LDD0988  [9]
 LDCM0391  CL120 HEK-293T C50(1.34)  LDD0989  [9]
 LDCM0392  CL121 HEK-293T C50(1.26)  LDD0990  [9]
 LDCM0393  CL122 HEK-293T C50(1.35)  LDD0991  [9]
 LDCM0394  CL123 HEK-293T C50(0.87)  LDD0992  [9]
 LDCM0395  CL124 HEK-293T C50(1.13)  LDD0993  [9]
 LDCM0396  CL125 HEK-293T C323(0.96); C50(1.14)  LDD0994  [9]
 LDCM0397  CL126 HEK-293T C323(1.34); C50(0.77)  LDD0995  [9]
 LDCM0398  CL127 HEK-293T C323(1.09); C50(1.02)  LDD0996  [9]
 LDCM0399  CL128 HEK-293T C323(1.05); C50(1.08)  LDD0997  [9]
 LDCM0400  CL13 HEK-293T C50(1.11)  LDD0998  [9]
 LDCM0401  CL14 HEK-293T C50(0.98)  LDD0999  [9]
 LDCM0402  CL15 HEK-293T C50(1.12)  LDD1000  [9]
 LDCM0403  CL16 HEK-293T C323(0.68); C50(1.10)  LDD1001  [9]
 LDCM0404  CL17 HEK-293T C323(0.70); C50(1.25)  LDD1002  [9]
 LDCM0405  CL18 HEK-293T C323(0.79); C50(1.03)  LDD1003  [9]
 LDCM0406  CL19 HEK-293T C323(0.95); C50(1.26)  LDD1004  [9]
 LDCM0407  CL2 HEK-293T C50(1.17)  LDD1005  [9]
 LDCM0408  CL20 HEK-293T C323(1.15); C50(1.35)  LDD1006  [9]
 LDCM0409  CL21 HEK-293T C323(1.07); C50(1.21)  LDD1007  [9]
 LDCM0410  CL22 HEK-293T C323(1.00); C50(1.46)  LDD1008  [9]
 LDCM0411  CL23 HEK-293T C323(0.88); C50(1.06)  LDD1009  [9]
 LDCM0412  CL24 HEK-293T C323(0.84); C50(1.10)  LDD1010  [9]
 LDCM0413  CL25 HEK-293T C323(0.94); C50(1.00)  LDD1011  [9]
 LDCM0414  CL26 HEK-293T C323(1.02); C50(1.27)  LDD1012  [9]
 LDCM0415  CL27 HEK-293T C323(1.11); C50(1.06)  LDD1013  [9]
 LDCM0416  CL28 HEK-293T C323(0.98); C50(0.93)  LDD1014  [9]
 LDCM0417  CL29 HEK-293T C323(0.98); C50(1.51)  LDD1015  [9]
 LDCM0418  CL3 HEK-293T C50(1.07)  LDD1016  [9]
 LDCM0419  CL30 HEK-293T C323(1.13); C50(1.30)  LDD1017  [9]
 LDCM0420  CL31 HEK-293T C50(0.95)  LDD1018  [9]
 LDCM0421  CL32 HEK-293T C50(1.06)  LDD1019  [9]
 LDCM0422  CL33 HEK-293T C50(1.01)  LDD1020  [9]
 LDCM0423  CL34 HEK-293T C50(0.99)  LDD1021  [9]
 LDCM0424  CL35 HEK-293T C50(1.01)  LDD1022  [9]
 LDCM0425  CL36 HEK-293T C50(1.03)  LDD1023  [9]
 LDCM0426  CL37 HEK-293T C50(1.03)  LDD1024  [9]
 LDCM0428  CL39 HEK-293T C50(1.05)  LDD1026  [9]
 LDCM0429  CL4 HEK-293T C50(1.10)  LDD1027  [9]
 LDCM0430  CL40 HEK-293T C50(0.90)  LDD1028  [9]
 LDCM0431  CL41 HEK-293T C50(0.98)  LDD1029  [9]
 LDCM0432  CL42 HEK-293T C50(0.97)  LDD1030  [9]
 LDCM0433  CL43 HEK-293T C50(1.11)  LDD1031  [9]
 LDCM0434  CL44 HEK-293T C50(1.00)  LDD1032  [9]
 LDCM0435  CL45 HEK-293T C50(1.00)  LDD1033  [9]
 LDCM0436  CL46 HEK-293T C50(1.20)  LDD1034  [9]
 LDCM0437  CL47 HEK-293T C50(1.15)  LDD1035  [9]
 LDCM0438  CL48 HEK-293T C50(1.09)  LDD1036  [9]
 LDCM0439  CL49 HEK-293T C50(1.09)  LDD1037  [9]
 LDCM0440  CL5 HEK-293T C50(1.08)  LDD1038  [9]
 LDCM0441  CL50 HEK-293T C50(1.04)  LDD1039  [9]
 LDCM0442  CL51 HEK-293T C50(1.30)  LDD1040  [9]
 LDCM0443  CL52 HEK-293T C50(1.07)  LDD1041  [9]
 LDCM0444  CL53 HEK-293T C50(0.98)  LDD1042  [9]
 LDCM0445  CL54 HEK-293T C50(1.10)  LDD1043  [9]
 LDCM0446  CL55 HEK-293T C50(1.09)  LDD1044  [9]
 LDCM0447  CL56 HEK-293T C50(1.12)  LDD1045  [9]
 LDCM0448  CL57 HEK-293T C50(1.16)  LDD1046  [9]
 LDCM0449  CL58 HEK-293T C50(1.41)  LDD1047  [9]
 LDCM0450  CL59 HEK-293T C50(1.39)  LDD1048  [9]
 LDCM0451  CL6 HEK-293T C50(1.14)  LDD1049  [9]
 LDCM0452  CL60 HEK-293T C50(1.31)  LDD1050  [9]
 LDCM0453  CL61 HEK-293T C50(1.03)  LDD1051  [9]
 LDCM0454  CL62 HEK-293T C50(0.97)  LDD1052  [9]
 LDCM0455  CL63 HEK-293T C50(0.96)  LDD1053  [9]
 LDCM0456  CL64 HEK-293T C50(0.91)  LDD1054  [9]
 LDCM0457  CL65 HEK-293T C50(1.10)  LDD1055  [9]
 LDCM0458  CL66 HEK-293T C50(0.95)  LDD1056  [9]
 LDCM0459  CL67 HEK-293T C50(1.10)  LDD1057  [9]
 LDCM0460  CL68 HEK-293T C50(1.10)  LDD1058  [9]
 LDCM0461  CL69 HEK-293T C50(0.98)  LDD1059  [9]
 LDCM0462  CL7 HEK-293T C50(0.98)  LDD1060  [9]
 LDCM0463  CL70 HEK-293T C50(0.98)  LDD1061  [9]
 LDCM0464  CL71 HEK-293T C50(0.97)  LDD1062  [9]
 LDCM0465  CL72 HEK-293T C50(0.96)  LDD1063  [9]
 LDCM0466  CL73 HEK-293T C50(1.08)  LDD1064  [9]
 LDCM0467  CL74 HEK-293T C50(0.91)  LDD1065  [9]
 LDCM0469  CL76 HEK-293T C50(1.02)  LDD1067  [9]
 LDCM0470  CL77 HEK-293T C50(0.97)  LDD1068  [9]
 LDCM0471  CL78 HEK-293T C50(0.99)  LDD1069  [9]
 LDCM0472  CL79 HEK-293T C50(1.10)  LDD1070  [9]
 LDCM0473  CL8 HEK-293T C50(0.77)  LDD1071  [9]
 LDCM0474  CL80 HEK-293T C50(1.09)  LDD1072  [9]
 LDCM0475  CL81 HEK-293T C50(1.02)  LDD1073  [9]
 LDCM0476  CL82 HEK-293T C50(1.02)  LDD1074  [9]
 LDCM0477  CL83 HEK-293T C50(0.92)  LDD1075  [9]
 LDCM0478  CL84 HEK-293T C50(1.05)  LDD1076  [9]
 LDCM0479  CL85 HEK-293T C50(1.13)  LDD1077  [9]
 LDCM0480  CL86 HEK-293T C50(1.20)  LDD1078  [9]
 LDCM0481  CL87 HEK-293T C50(1.29)  LDD1079  [9]
 LDCM0482  CL88 HEK-293T C50(1.26)  LDD1080  [9]
 LDCM0483  CL89 HEK-293T C50(1.13)  LDD1081  [9]
 LDCM0484  CL9 HEK-293T C50(0.79)  LDD1082  [9]
 LDCM0485  CL90 HEK-293T C50(1.17)  LDD1083  [9]
 LDCM0486  CL91 PaTu 8988t C50(0.30)  LDD1365  [9]
 LDCM0487  CL92 PaTu 8988t C50(0.22)  LDD1366  [9]
 LDCM0488  CL93 PaTu 8988t C50(0.24)  LDD1367  [9]
 LDCM0489  CL94 PaTu 8988t C50(0.26)  LDD1368  [9]
 LDCM0490  CL95 PaTu 8988t C50(0.27)  LDD1369  [9]
 LDCM0491  CL96 PaTu 8988t C50(0.35)  LDD1370  [9]
 LDCM0492  CL97 PaTu 8988t C50(0.26)  LDD1371  [9]
 LDCM0493  CL98 PaTu 8988t C50(0.30)  LDD1372  [9]
 LDCM0494  CL99 PaTu 8988t C50(0.28)  LDD1373  [9]
 LDCM0189  Compound 16 HEK-293T 11.41  LDD0492  [21]
 LDCM0191  Compound 21 HEK-293T 5.46  LDD0493  [21]
 LDCM0190  Compound 34 HEK-293T 6.91  LDD0497  [21]
 LDCM0192  Compound 35 HEK-293T 5.39  LDD0491  [21]
 LDCM0193  Compound 36 HEK-293T 3.74  LDD0494  [21]
 LDCM0195  Compound 38 HEK-293T 4.77  LDD0499  [21]
 LDCM0196  Compound 39 HEK-293T 7.06  LDD0496  [21]
 LDCM0197  Compound 40 HEK-293T 3.83  LDD0495  [21]
 LDCM0181  Compound 41 HEK-293T 6.22  LDD0502  [21]
 LDCM0495  E2913 HEK-293T C50(1.02); C300(0.95)  LDD1698  [23]
 LDCM0031  Epigallocatechin gallate HEK-293T 35.28  LDD0183  [6]
 LDCM0468  Fragment33 HEK-293T C50(0.94)  LDD1066  [9]
 LDCM0427  Fragment51 HEK-293T C50(1.08)  LDD1025  [9]
 LDCM0022  KB02 HCT 116 C50(1.27)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C50(0.98)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C50(1.23)  LDD0082  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C50(0.92)  LDD2092  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C50(1.63)  LDD2105  [5]
 LDCM0032  Oleacein HEK-293T 6.98  LDD0184  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 792 (ZNF792) Krueppel C2H2-type zinc-finger protein family Q3KQV3
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BTB/POZ domain-containing protein KCTD12 (KCTD12) . Q96CX2

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402