Details of the Target

General Information of Target

Target ID LDTP03061
Target Name Cation-dependent mannose-6-phosphate receptor (M6PR)
Gene Name M6PR
Gene ID 4074
Synonyms
MPR46; MPRD; Cation-dependent mannose-6-phosphate receptor; CD Man-6-P receptor; CD-MPR; 46 kDa mannose 6-phosphate receptor; MPR 46
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFPFYSCWRTGLLLLLLAVAVRESWQTEEKTCDLVGEKGKESEKELALVKRLKPLFNKSF
ESTVGQGSDTYIYIFRVCREAGNHTSGAGLVQINKSNGKETVVGRLNETHIFNGSNWIML
IYKGGDEYDNHCGKEQRRAVVMISCNRHTLADNFNPVSEERGKVQDCFYLFEMDSSLACS
PEISHLSVGSILLVTFASLVAVYVVGGFLYQRLVVGAKGMEQFPHLAFWQDLGNLVADGC
DFVCRSKPRNVPAAYRGVGDDQLGEESEERDDHLLPM
Target Type
Successful
Target Bioclass
Transporter and channel
Subcellular location
Lysosome membrane
Function
Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
TTD ID
T97174
Uniprot ID
P20645
DrugMap ID
TT95ICL
Ensemble ID
ENST00000000412.8
HGNC ID
HGNC:6752
ChEMBL ID
CHEMBL5788

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 23 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBP2
 Probe Info  		2.37  LDD0323  [1]
ONAyne
 Probe Info  		K50(9.09)  LDD0274  [2]
STPyne
 Probe Info  		K50(7.32); K53(6.92)  LDD0277  [2]
BTD
 Probe Info  		C32(8.72)  LDD1699  [3]
OPA-S-S-alkyne
 Probe Info  		K99(1.86); K50(2.84); K44(2.90)  LDD3494  [4]
Probe 1
 Probe Info  		Y255(18.08)  LDD3495  [5]
JZ128-DTB
 Probe Info  		C244(0.00); C240(0.00)  LDD0462  [6]
THZ1-DTB
 Probe Info  		C244(1.07)  LDD0460  [6]
FBPP2
 Probe Info  		2.69  LDD0054  [1]
HPAP
 Probe Info  		3.83  LDD0064  [7]
Alkyne-RA190
 Probe Info  		2.44  LDD0299  [8]
DBIA
 Probe Info  		C132(1.73)  LDD0080  [9]
m-APA
 Probe Info  		H148(0.00); H131(0.00)  LDD2231  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C145(0.00); C132(0.00); C32(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C145(0.00); C32(0.00)  LDD0037  [11]
IPM
 Probe Info  		N.A.  LDD2156  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [14]
Acrolein
 Probe Info  		H148(0.00); C32(0.00); C132(0.00)  LDD0217  [15]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [15]
Methacrolein
 Probe Info  		C132(0.00); C32(0.00)  LDD0218  [15]
AOyne
 Probe Info  		12.60  LDD0443  [16]
NAIA_5
 Probe Info  		C145(0.00); C132(0.00); C32(0.00)  LDD2223  [17]
PAL-AfBPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C064
 Probe Info  		6.06  LDD1761  [18]
C170
 Probe Info  		8.11  LDD1850  [18]
C208
 Probe Info  		7.73  LDD1883  [18]
C212
 Probe Info  		15.14  LDD1886  [18]
C215
 Probe Info  		5.06  LDD1889  [18]
C216
 Probe Info  		5.03  LDD1890  [18]
C256
 Probe Info  		5.24  LDD1929  [18]
C299
 Probe Info  		6.02  LDD1968  [18]
C310
 Probe Info  		9.13  LDD1977  [18]
C363
 Probe Info  		18.38  LDD2024  [18]
C364
 Probe Info  		15.89  LDD2025  [18]
C390
 Probe Info  		22.78  LDD2049  [18]
C393
 Probe Info  		5.24  LDD2052  [18]
C433
 Probe Info  		7.16  LDD2088  [18]
STS-1
 Probe Info  		N.A.  LDD0137  [19]
STS-2
 Probe Info  		N.A.  LDD0138  [19]
VE-P
 Probe Info  		N.A.  LDD0396  [20]
Alk-rapa
 Probe Info  		2.22  LDD0213  [21]
OEA-DA
 Probe Info  		3.97  LDD0046  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C32(1.06)  LDD2142  [3]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C32(0.81)  LDD2095  [3]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C32(0.59)  LDD2130  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C145(0.63)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C145(1.09)  LDD2152  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C32(0.86)  LDD2103  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C32(0.61)  LDD2132  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C32(0.63)  LDD2131  [3]
 LDCM0214  AC1 HEK-293T C32(1.17); C132(1.17); C244(0.92); C240(1.10)  LDD1507  [23]
 LDCM0215  AC10 HCT 116 C145(1.00)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C145(1.17)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C145(1.01)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C145(1.03)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C145(0.59)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C145(1.23)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C145(0.82)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C145(0.72)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C145(0.42)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C145(1.68)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C145(1.14)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C145(0.73)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C145(1.34)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C145(0.88)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C145(0.53)  LDD0546  [9]
 LDCM0237  AC12 HCT 116 C145(0.68)  LDD0554  [9]
 LDCM0259  AC14 HCT 116 C145(0.93)  LDD0576  [9]
 LDCM0270  AC15 HCT 116 C145(1.17)  LDD0587  [9]
 LDCM0276  AC17 HCT 116 C145(0.93)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C145(0.90)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C145(0.96)  LDD0595  [9]
 LDCM0279  AC2 HEK-293T C32(0.98); C240(1.00)  LDD1518  [23]
 LDCM0280  AC20 HCT 116 C145(1.02)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C145(0.84)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C145(0.84)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C145(0.84)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C145(1.10)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C145(1.21)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C145(1.36)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C145(1.21)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C145(1.17)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C145(1.36)  LDD0606  [9]
 LDCM0290  AC3 HEK-293T C32(1.06); C240(1.04)  LDD1529  [23]
 LDCM0291  AC30 HCT 116 C145(1.33)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C145(1.36)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C145(1.17)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C145(1.32)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C145(1.07)  LDD0612  [9]
 LDCM0296  AC35 HEK-293T C32(1.09); C240(1.27)  LDD1535  [23]
 LDCM0297  AC36 HEK-293T C32(1.04); C244(1.00); C240(1.05)  LDD1536  [23]
 LDCM0298  AC37 HEK-293T C32(1.07); C132(0.98); C244(1.26); C240(1.31)  LDD1537  [23]
 LDCM0299  AC38 HEK-293T C32(1.09); C132(1.07); C244(1.05); C240(1.05)  LDD1538  [23]
 LDCM0300  AC39 HEK-293T C32(1.10); C244(0.94); C240(0.89)  LDD1539  [23]
 LDCM0301  AC4 HEK-293T C32(1.04); C244(0.91); C240(0.97)  LDD1540  [23]
 LDCM0302  AC40 HEK-293T C32(1.02); C132(1.21); C244(0.94); C240(1.23)  LDD1541  [23]
 LDCM0303  AC41 HEK-293T C32(1.09); C132(1.09); C244(0.92); C240(0.90)  LDD1542  [23]
 LDCM0304  AC42 HEK-293T C32(1.14); C240(1.21)  LDD1543  [23]
 LDCM0305  AC43 HEK-293T C32(1.09); C240(1.06)  LDD1544  [23]
 LDCM0306  AC44 HEK-293T C32(1.02); C244(1.31); C240(0.86)  LDD1545  [23]
 LDCM0307  AC45 HEK-293T C32(1.12); C132(1.01); C244(1.39); C240(1.17)  LDD1546  [23]
 LDCM0308  AC46 HCT 116 C145(1.09)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C145(1.05)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C145(1.20)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C145(0.55)  LDD0628  [9]
 LDCM0312  AC5 HEK-293T C32(1.08); C132(1.03); C244(0.98); C240(1.04)  LDD1551  [23]
 LDCM0313  AC50 HCT 116 C145(0.61)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C145(1.32)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C145(1.03)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C145(0.93)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C145(0.82)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C145(0.57)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C145(0.35)  LDD0636  [9]
 LDCM0320  AC57 HEK-293T C32(1.12); C132(1.11); C244(0.83); C240(0.91)  LDD1559  [23]
 LDCM0321  AC58 HEK-293T C32(0.99); C240(1.19)  LDD1560  [23]
 LDCM0322  AC59 HEK-293T C32(1.02); C240(1.02)  LDD1561  [23]
 LDCM0323  AC6 HCT 116 C145(0.86)  LDD0640  [9]
 LDCM0324  AC60 HEK-293T C32(1.01); C244(1.14); C240(1.02)  LDD1563  [23]
 LDCM0325  AC61 HEK-293T C32(1.27); C132(1.03); C244(1.00); C240(1.16)  LDD1564  [23]
 LDCM0326  AC62 HEK-293T C32(1.11); C132(1.04); C244(1.14); C240(0.97)  LDD1565  [23]
 LDCM0327  AC63 HEK-293T C32(1.08); C244(1.16); C240(1.00)  LDD1566  [23]
 LDCM0328  AC64 HEK-293T C32(0.99); C132(1.10); C244(0.98); C240(0.95)  LDD1567  [23]
 LDCM0334  AC7 HCT 116 C145(0.77)  LDD0651  [9]
 LDCM0345  AC8 HCT 116 C145(1.97)  LDD0662  [9]
 LDCM0365  AC98 HCT 116 C145(0.21)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C145(0.99)  LDD0683  [9]
 LDCM0545  Acetamide MDA-MB-231 C132(0.43)  LDD2138  [3]
 LDCM0248  AKOS034007472 HCT 116 C145(0.97)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C145(0.99)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C145(0.56)  LDD0592  [9]
 LDCM0020  ARS-1620 HCC44 C132(1.42); C145(1.01)  LDD2171  [9]
 LDCM0498  BS-3668 MDA-MB-231 C32(0.75); C145(0.69)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa H148(0.00); C132(0.00); C32(0.00); H131(0.00)  LDD0222  [15]
 LDCM0367  CL1 PaTu 8988t C145(1.17)  LDD1246  [9]
 LDCM0368  CL10 PaTu 8988t C145(1.04)  LDD1247  [9]
 LDCM0369  CL100 HEK-293T C32(1.04); C132(0.95); C244(0.91); C240(0.88)  LDD1573  [23]
 LDCM0370  CL101 HCT 116 C145(0.77)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C145(0.73)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C145(0.77)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C145(0.75)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C145(1.11)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C145(0.74)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C145(0.74)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C145(0.73)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C145(0.94)  LDD0695  [9]
 LDCM0379  CL11 PaTu 8988t C145(1.23)  LDD1258  [9]
 LDCM0380  CL110 HCT 116 C145(0.78)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C145(0.85)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C145(0.87)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C145(1.14)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C145(1.20)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C145(1.74)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C145(1.43)  LDD0703  [9]
 LDCM0387  CL117 HEK-293T C32(1.16); C240(1.06)  LDD1591  [23]
 LDCM0388  CL118 HEK-293T C32(1.17); C132(1.21); C240(1.07)  LDD1592  [23]
 LDCM0389  CL119 HEK-293T C32(1.15); C240(1.23)  LDD1593  [23]
 LDCM0390  CL12 PaTu 8988t C145(1.36)  LDD1269  [9]
 LDCM0391  CL120 HEK-293T C32(1.10); C132(0.94); C244(1.01); C240(0.94)  LDD1595  [23]
 LDCM0392  CL121 HCT 116 C145(0.97)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C145(0.88)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C145(0.91)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C145(0.71)  LDD0712  [9]
 LDCM0396  CL125 HEK-293T C32(1.15); C240(1.02)  LDD1600  [23]
 LDCM0397  CL126 HEK-293T C32(1.12); C132(1.11); C240(0.98)  LDD1601  [23]
 LDCM0398  CL127 HEK-293T C32(1.09); C240(1.29)  LDD1602  [23]
 LDCM0399  CL128 HEK-293T C32(1.04); C132(0.96); C244(1.15); C240(1.08)  LDD1603  [23]
 LDCM0400  CL13 PaTu 8988t C145(1.16)  LDD1279  [9]
 LDCM0401  CL14 PaTu 8988t C145(1.36)  LDD1280  [9]
 LDCM0402  CL15 PaTu 8988t C145(1.30)  LDD1281  [9]
 LDCM0403  CL16 HEK-293T C32(1.07); C132(0.95); C244(1.09); C240(0.81)  LDD1607  [23]
 LDCM0404  CL17 HEK-293T C32(1.04); C132(1.13); C244(0.92); C240(1.07)  LDD1608  [23]
 LDCM0405  CL18 HEK-293T C32(1.07); C240(1.15)  LDD1609  [23]
 LDCM0406  CL19 HEK-293T C32(1.12); C240(1.09)  LDD1610  [23]
 LDCM0407  CL2 PaTu 8988t C145(1.35)  LDD1286  [9]
 LDCM0408  CL20 HEK-293T C32(1.04); C244(0.95); C240(0.93)  LDD1612  [23]
 LDCM0409  CL21 HEK-293T C32(1.20); C132(1.24); C244(1.24); C240(0.66)  LDD1613  [23]
 LDCM0410  CL22 HEK-293T C32(1.03); C132(1.33); C244(1.03); C240(0.95)  LDD1614  [23]
 LDCM0411  CL23 HEK-293T C32(1.06); C244(0.78); C240(0.94)  LDD1615  [23]
 LDCM0412  CL24 HEK-293T C32(1.05); C132(1.24); C244(1.01); C240(1.08)  LDD1616  [23]
 LDCM0413  CL25 HEK-293T C32(1.04); C240(1.04)  LDD1617  [23]
 LDCM0414  CL26 HEK-293T C32(0.98); C132(1.05); C240(0.83)  LDD1618  [23]
 LDCM0415  CL27 HEK-293T C32(1.12); C240(0.94)  LDD1619  [23]
 LDCM0416  CL28 HEK-293T C32(1.05); C132(0.96); C244(0.94); C240(0.77)  LDD1620  [23]
 LDCM0417  CL29 HEK-293T C32(1.04); C132(1.16); C244(0.86); C240(1.10)  LDD1621  [23]
 LDCM0418  CL3 PaTu 8988t C145(1.84)  LDD1297  [9]
 LDCM0419  CL30 HEK-293T C32(1.08); C240(1.01)  LDD1623  [23]
 LDCM0420  CL31 HCT 116 C145(1.05)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C145(0.95)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C145(0.81)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C145(0.49)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C145(0.51)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C145(0.87)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C145(0.59)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C145(0.70)  LDD0745  [9]
 LDCM0429  CL4 PaTu 8988t C145(1.41)  LDD1308  [9]
 LDCM0430  CL40 HCT 116 C145(0.71)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C145(0.73)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C145(0.37)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C145(0.59)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C145(0.77)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C145(0.50)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C145(1.36)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C145(1.05)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C145(0.93)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C145(1.27)  LDD0756  [9]
 LDCM0440  CL5 PaTu 8988t C145(1.33)  LDD1319  [9]
 LDCM0441  CL50 HCT 116 C145(0.98)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C145(1.13)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C145(1.13)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C145(0.82)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C145(0.83)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C145(1.56)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C145(1.12)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C145(1.51)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C145(1.16)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C145(1.33)  LDD0767  [9]
 LDCM0451  CL6 PaTu 8988t C145(1.30)  LDD1330  [9]
 LDCM0452  CL60 HCT 116 C145(1.48)  LDD0769  [9]
 LDCM0453  CL61 PaTu 8988t C145(0.99)  LDD1332  [9]
 LDCM0454  CL62 PaTu 8988t C145(1.96)  LDD1333  [9]
 LDCM0455  CL63 PaTu 8988t C145(1.34)  LDD1334  [9]
 LDCM0456  CL64 PaTu 8988t C145(0.91)  LDD1335  [9]
 LDCM0457  CL65 PaTu 8988t C145(1.23)  LDD1336  [9]
 LDCM0458  CL66 PaTu 8988t C145(0.77)  LDD1337  [9]
 LDCM0459  CL67 PaTu 8988t C145(0.65)  LDD1338  [9]
 LDCM0460  CL68 PaTu 8988t C145(0.57)  LDD1339  [9]
 LDCM0461  CL69 PaTu 8988t C145(0.48)  LDD1340  [9]
 LDCM0462  CL7 PaTu 8988t C145(1.24)  LDD1341  [9]
 LDCM0463  CL70 PaTu 8988t C145(0.62)  LDD1342  [9]
 LDCM0464  CL71 PaTu 8988t C145(1.12)  LDD1343  [9]
 LDCM0465  CL72 PaTu 8988t C145(0.99)  LDD1344  [9]
 LDCM0466  CL73 PaTu 8988t C145(0.63)  LDD1345  [9]
 LDCM0467  CL74 PaTu 8988t C145(1.20)  LDD1346  [9]
 LDCM0469  CL76 HCT 116 C145(1.03)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C145(0.86)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C145(1.17)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C145(0.98)  LDD0789  [9]
 LDCM0473  CL8 PaTu 8988t C145(1.15)  LDD1352  [9]
 LDCM0474  CL80 HCT 116 C145(1.15)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C145(1.04)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C145(0.69)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C145(0.85)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C145(0.57)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C145(1.01)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C145(0.84)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C145(1.04)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C145(0.77)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C145(0.43)  LDD0800  [9]
 LDCM0484  CL9 PaTu 8988t C145(1.22)  LDD1363  [9]
 LDCM0485  CL90 HCT 116 C145(0.79)  LDD0802  [9]
 LDCM0486  CL91 HEK-293T C32(1.16); C240(1.06)  LDD1689  [23]
 LDCM0487  CL92 HEK-293T C32(1.00); C244(1.34); C240(0.87)  LDD1690  [23]
 LDCM0488  CL93 HEK-293T C32(1.34); C132(1.09); C244(1.07); C240(1.22)  LDD1691  [23]
 LDCM0489  CL94 HEK-293T C32(1.15); C132(1.12); C244(1.16); C240(1.16)  LDD1692  [23]
 LDCM0490  CL95 HEK-293T C32(1.17); C244(0.89); C240(1.00)  LDD1693  [23]
 LDCM0491  CL96 HEK-293T C32(1.09); C132(1.21); C244(1.03); C240(1.20)  LDD1694  [23]
 LDCM0492  CL97 HEK-293T C32(1.10); C240(1.09)  LDD1695  [23]
 LDCM0493  CL98 HEK-293T C32(1.08); C132(1.07); C240(1.12)  LDD1696  [23]
 LDCM0494  CL99 HEK-293T C32(1.12); C240(1.04)  LDD1697  [23]
 LDCM0495  E2913 HEK-293T C32(1.11); C240(1.09)  LDD1698  [23]
 LDCM0468  Fragment33 PaTu 8988t C145(0.78)  LDD1347  [9]
 LDCM0427  Fragment51 HCT 116 C145(0.40)  LDD0744  [9]
 LDCM0107  IAA HeLa N.A.  LDD0221  [15]
 LDCM0179  JZ128 PC-3 C244(0.00); C240(0.00)  LDD0462  [6]
 LDCM0022  KB02 HCT 116 C132(1.73)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C132(2.15)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C132(2.40)  LDD0082  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C32(0.35)  LDD2121  [3]
 LDCM0109  NEM HeLa N.A.  LDD0223  [15]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C32(0.98)  LDD2089  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C145(0.69)  LDD2093  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C32(1.10)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C32(1.15)  LDD2099  [3]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C32(0.78)  LDD2100  [3]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C32(0.47)  LDD2104  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C32(0.32)  LDD2106  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C32(0.91); C145(0.88)  LDD2107  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C32(1.32)  LDD2111  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C32(1.44)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C32(0.86)  LDD2120  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C145(0.74)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C32(0.88)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C32(1.29)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C32(0.59)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C32(1.09); C145(0.73)  LDD2129  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C32(1.07)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C32(0.91)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C32(1.07); C145(0.99)  LDD2137  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C32(0.80)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C32(0.97)  LDD2141  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C32(0.69)  LDD2143  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C145(0.84)  LDD2146  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C32(1.34)  LDD2147  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C32(0.56)  LDD2150  [3]
 LDCM0014  Panhematin hPBMC 3.83  LDD0064  [7]
 LDCM0131  RA190 MM1.R 2.44  LDD0299  [8]
 LDCM0090  Rapamycin JHH-7 2.22  LDD0213  [21]
 LDCM0021  THZ1 HeLa S3 C244(1.07)  LDD0460  [6]
 LDCM0008  Tranylcypromine SH-SY5Y 2.69  LDD0054  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dual specificity protein phosphatase 12 (DUSP12) Protein-tyrosine phosphatase family Q9UNI6
GTPase IMAP family member 5 (GIMAP5) AIG1/Toc34/Toc159-like paraseptin GTPase family Q96F15
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ninjurin-2 (NINJ2) Ninjurin family Q9NZG7
Single-pass membrane and coiled-coil domain-containing protein 4 (SMCO4) SMCO4 family Q9NRQ5

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alglucosidase Alfa . D07DUU
Investigative
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
1-3 Sugar Ring Of Pentamannosyl 6-phosphate Small molecular drug D06WSW
Alpha-d-mannose 6-phosphate Small molecular drug DB02900
Alpha-d-mannose-6-phosphate Small molecular drug D0Q0OH

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
7 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
8 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
14 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
21 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
22 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402