Details of the Target

General Information of Target

Target ID LDTP13172
Target Name Cathepsin F (CTSF)
Gene Name CTSF
Gene ID 8722
Synonyms
Cathepsin F; CATSF; EC 3.4.22.41
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPSLQEGAQLGENKPSTCSFSIERILGLDQKKDCVPLMKPHRPWADTCSSSGKDGNLCL
HVPNPPSGISFPSVVDHPMPEERASKYENYFSASERLSLKRELSWYRGRRPRTAFTQNQI
EVLENVFRVNCYPGIDIREDLAQKLNLEEDRIQIWFQNRRAKLKRSHRESQFLMAKKNFN
TNLLE
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Peptidase C1 family
Subcellular location
Lysosome
Function Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
TTD ID
T77236
Uniprot ID
Q9UBX1
DrugMap ID
TTJOKD1
Ensemble ID
ENST00000310325.10
HGNC ID
HGNC:2531
ChEMBL ID
CHEMBL2517

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C333(2.13)  LDD3383  [1]
FBPP2
 Probe Info  		3.86  LDD0054  [2]
YN-1
 Probe Info  		E242(0.00); E243(0.00)  LDD0447  [3]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		11.96  LDD1850  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C124(1.16)  LDD1508  [5]
 LDCM0237  AC12 HEK-293T C124(1.03)  LDD1510  [5]
 LDCM0277  AC18 HEK-293T C124(1.04)  LDD1516  [5]
 LDCM0279  AC2 HEK-293T C124(1.24)  LDD1518  [5]
 LDCM0280  AC20 HEK-293T C124(1.13)  LDD1519  [5]
 LDCM0286  AC26 HEK-293T C124(1.21)  LDD1525  [5]
 LDCM0288  AC28 HEK-293T C124(1.05)  LDD1527  [5]
 LDCM0295  AC34 HEK-293T C124(1.32)  LDD1534  [5]
 LDCM0297  AC36 HEK-293T C124(1.06)  LDD1536  [5]
 LDCM0301  AC4 HEK-293T C124(0.96)  LDD1540  [5]
 LDCM0304  AC42 HEK-293T C124(1.25)  LDD1543  [5]
 LDCM0306  AC44 HEK-293T C124(0.86)  LDD1545  [5]
 LDCM0313  AC50 HEK-293T C124(1.00)  LDD1552  [5]
 LDCM0315  AC52 HEK-293T C124(1.00)  LDD1554  [5]
 LDCM0321  AC58 HEK-293T C124(1.02)  LDD1560  [5]
 LDCM0324  AC60 HEK-293T C124(1.00)  LDD1563  [5]
 LDCM0405  CL18 HEK-293T C124(1.09)  LDD1609  [5]
 LDCM0408  CL20 HEK-293T C124(0.98)  LDD1612  [5]
 LDCM0419  CL30 HEK-293T C124(1.23)  LDD1623  [5]
 LDCM0421  CL32 HEK-293T C124(1.41)  LDD1625  [5]
 LDCM0432  CL42 HEK-293T C124(1.37)  LDD1636  [5]
 LDCM0434  CL44 HEK-293T C124(1.01)  LDD1638  [5]
 LDCM0445  CL54 HEK-293T C124(0.93)  LDD1648  [5]
 LDCM0447  CL56 HEK-293T C124(0.92)  LDD1650  [5]
 LDCM0451  CL6 HEK-293T C124(1.29)  LDD1654  [5]
 LDCM0458  CL66 HEK-293T C124(0.92)  LDD1661  [5]
 LDCM0460  CL68 HEK-293T C124(1.13)  LDD1663  [5]
 LDCM0471  CL78 HEK-293T C124(1.32)  LDD1674  [5]
 LDCM0473  CL8 HEK-293T C124(1.50)  LDD1676  [5]
 LDCM0474  CL80 HEK-293T C124(1.31)  LDD1677  [5]
 LDCM0485  CL90 HEK-293T C124(1.73)  LDD1688  [5]
 LDCM0487  CL92 HEK-293T C124(1.04)  LDD1690  [5]
 LDCM0022  KB02 A2058 C333(2.25)  LDD2253  [1]
 LDCM0023  KB03 A2058 C333(3.27)  LDD2670  [1]
 LDCM0024  KB05 OVCAR-5 C333(2.13)  LDD3383  [1]
 LDCM0008  Tranylcypromine SH-SY5Y 3.86  LDD0054  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 11 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Benzoyl-arginine-alanine-methyl Ketone Small molecular drug D0L5WS
Benzoyl-tyrosine-alanine-methyl Ketone Small molecular drug D0X6WQ
Pmid22686657c(R)-26 Small molecular drug D06WQP
Wrr-112 Small molecular drug D0T0IX
Wrr-99 Small molecular drug D0B5IL
4-morpholin-4-yl-piperidine-1-carboxylic Acid [1-(3-benzenesulfonyl-1-propyl-allylcarbamoyl)-2-phenylethyl]-amide . DB02243
Benzoyl-tyrosine-alanine-fluoro-methyl Ketone . DB08775
Benzyl N-[(2s)-5-(Diaminomethylamino)-1-[[(2s)-4-fluoro-3-oxobutan-2-yl]Amino]-1-oxopentan-2-yl]Carbamate . DB03536
Homophenylalaninylmethane . D0L4OT
[1-(1-benzyl-3-hydroxy-2-oxo-propylcarbamoyl)-2-phenyl-ethyl]-carbamic Acid Benzyl Ester . DB01871
[1-(1-methyl-45-dioxo-pent-2-enylcarbamoyl)-2-phenyl-ethyl]-carbamic Acid Benzyl Ester . DB01810
Patented
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid27998201-compound-12 Small molecular drug D06XCD
Pmid27998201-compound-5 Small molecular drug D05OIU

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402