Details of the Target

General Information of Target

Target ID LDTP08327
Target Name Osteopetrosis-associated transmembrane protein 1 (OSTM1)
Gene Name OSTM1
Gene ID 28962
Synonyms
GL; Osteopetrosis-associated transmembrane protein 1; Chloride channel 7 beta subunit
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPGPTAAQRRCSLPPWLPLGLLLWSGLALGALPFGSSPHRVFHDLLSEQQLLEVEDLSL
SLLQGGGLGPLSLPPDLPDLDPECRELLLDFANSSAELTGCLVRSARPVRLCQTCYPLFQ
QVVSKMDNISRAAGNTSESQSCARSLLMADRMQIVVILSEFFNTTWQEANCANCLTNNSE
ELSNSTVYFLNLFNHTLTCFEHNLQGNAHSLLQTKNYSEVCKNCREAYKTLSSLYSEMQK
MNELENKAEPGTHLCIDVEDAMNITRKLWSRTFNCSVPCSDTVPVIAVSVFILFLPVVFY
LSSFLHSEQKKRKLILPKRLKSSTSFANIQENSN
Target Bioclass
Transporter and channel
Family
OSTM1 family
Subcellular location
Lysosome membrane
Function Required for osteoclast and melanocyte maturation and function.
Uniprot ID
Q86WC4
Ensemble ID
ENST00000193322.8
HGNC ID
HGNC:21652

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.50  LDD0054  [1]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		21.41  LDD1793  [2]
C107
 Probe Info  		6.82  LDD1794  [2]
C108
 Probe Info  		8.40  LDD1795  [2]
C170
 Probe Info  		26.91  LDD1850  [2]
C171
 Probe Info  		7.26  LDD1851  [2]
C293
 Probe Info  		37.01  LDD1963  [2]
C296
 Probe Info  		23.92  LDD1966  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0008  Tranylcypromine SH-SY5Y 3.50  LDD0054  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
H(+)/Cl(-) exchange transporter 7 (CLCN7) Chloride channel (TC 2.A.49) family P51798

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587