Details of the Target

General Information of Target

Target ID LDTP03175
Target Name Galanin peptides (GAL)
Gene Name GAL
Gene ID 51083
Synonyms
GAL1; GALN; GLNN; Galanin peptides [Cleaved into: Galanin; Galanin message-associated peptide; GMAP)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARGSALLLASLLLAAALSASAGLWSPAKEKRGWTLNSAGYLLGPHAVGNHRSFSDKNGL
TSKRELRPEDDMKPGSFDRSIPENNIMRTIIEFLSFLHLKEAGALDRLLDLPAAASSEDI
ERS
Target Type
Literature-reported
Target Bioclass
Other
Family
Galanin family
Subcellular location
Secreted
Function
Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion.
TTD ID
T67877
Uniprot ID
P22466
DrugMap ID
TTXZAJ5
Ensemble ID
ENST00000265643.4
HGNC ID
HGNC:4114

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.76  LDD0054  [1]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		32.67  LDD1752  [2]
C056
 Probe Info  		56.49  LDD1753  [2]
C067
 Probe Info  		5.86  LDD1763  [2]
C070
 Probe Info  		19.70  LDD1766  [2]
C071
 Probe Info  		8.94  LDD1767  [2]
C072
 Probe Info  		17.15  LDD1768  [2]
C141
 Probe Info  		11.63  LDD1823  [2]
C143
 Probe Info  		16.45  LDD1825  [2]
C149
 Probe Info  		8.34  LDD1830  [2]
C153
 Probe Info  		26.35  LDD1834  [2]
STS-2
 Probe Info  		N.A.  LDD0139  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0008  Tranylcypromine SH-SY5Y 2.76  LDD0054  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cystathionine beta-synthase (CBS) Cysteine synthase/cystathionine beta-synthase family P35520
RAC-alpha serine/threonine-protein kinase (AKT1) AGC Ser/Thr protein kinase family P31749
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Galanin receptor type 1 (GALR1) G-protein coupled receptor 1 family P47211
Galanin receptor type 2 (GALR2) G-protein coupled receptor 1 family O43603
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA) SGT family O43765
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
3 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.