Details of the Target

General Information of Target

Target ID LDTP12966
Target Name Vesicle-associated membrane protein-associated protein A (VAPA)
Gene Name VAPA
Gene ID 9218
Synonyms
VAP33; Vesicle-associated membrane protein-associated protein A; VAMP-A; VAMP-associated protein A; VAP-A; 33 kDa VAMP-associated protein; VAP-33
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MARPPRQHPGVWASLLLLLLTGPAACAASPADDGAGPGGRGPRGRARGDTGADEAVPRHD
SSYGTFAGEFYDLRYLSEEGYPFPTAPPVDPFAKIKVDDCGKTKGCFRYGKPGCNAETCD
YFLSYRMIGADVEFELSADTDGWVAVGFSSDKKMGGDDVMACVHDDNGRVRIQHFYNVGQ
WAKEIQRNPARDEEGVFENNRVTCRFKRPVNVPRDETIVDLHLSWYYLFAWGPAIQGSIT
RHDIDSPPASERVVSIYKYEDIFMPSAAYQTFSSPFCLLLIVALTFYLLMGTP
Target Bioclass
Transporter and channel
Family
VAMP-associated protein (VAP) (TC 9.B.17) family
Subcellular location
Endoplasmic reticulum membrane
Function
Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking.
Uniprot ID
Q9P0L0
Ensemble ID
ENST00000340541.4
HGNC ID
HGNC:12648

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IGR1 SNV: p.I67T DBIA    Probe Info 
PF382 SNV: p.M96V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 37 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Alkylaryl probe 1
 Probe Info  		20.00  LDD0387  [2]
A-EBA
 Probe Info  		4.95  LDD0215  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
W1
 Probe Info  		14.36  LDD0235  [5]
YN-1
 Probe Info  		100.00  LDD0444  [6]
YN-4
 Probe Info  		100.00  LDD0445  [6]
ONAyne
 Probe Info  		N.A.  LDD0273  [7]
OPA-S-S-alkyne
 Probe Info  		K174(1.89); K180(1.96); K188(1.99); K211(4.31)  LDD3494  [8]
DBIA
 Probe Info  		C128(1.50)  LDD3311  [9]
DA-P3
 Probe Info  		5.28  LDD0180  [10]
5E-2FA
 Probe Info  		H11(0.00); H208(0.00); H163(0.00)  LDD2235  [11]
ATP probe
 Probe Info  		K125(0.00); K211(0.00); K26(0.00); K24(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C128(0.00); C179(0.00); C60(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [14]
Lodoacetamide azide
 Probe Info  		C128(0.00); C60(0.00); C179(0.00)  LDD0037  [13]
ATP probe
 Probe Info  		K180(0.00); K52(0.00)  LDD0035  [15]
BTD
 Probe Info  		N.A.  LDD0004  [16]
NAIA_4
 Probe Info  		C60(0.00); C179(0.00)  LDD2226  [17]
TFBX
 Probe Info  		N.A.  LDD0027  [18]
WYneO
 Probe Info  		N.A.  LDD0022  [16]
IPM
 Probe Info  		N.A.  LDD0005  [16]
NHS
 Probe Info  		K205(0.00); K38(0.00); K10(0.00); K125(0.00)  LDD0010  [16]
SF
 Probe Info  		N.A.  LDD0028  [19]
STPyne
 Probe Info  		K125(0.00); K211(0.00)  LDD0009  [16]
VSF
 Probe Info  		N.A.  LDD0007  [16]
Phosphinate-6
 Probe Info  		C60(0.00); C179(0.00)  LDD0018  [20]
1d-yne
 Probe Info  		N.A.  LDD0357  [21]
Acrolein
 Probe Info  		H208(0.00); H11(0.00); C179(0.00); H195(0.00)  LDD0217  [22]
Crotonaldehyde
 Probe Info  		H208(0.00); C179(0.00); H195(0.00)  LDD0219  [22]
Methacrolein
 Probe Info  		H208(0.00); C179(0.00)  LDD0218  [22]
AOyne
 Probe Info  		14.50  LDD0443  [23]
MPP-AC
 Probe Info  		N.A.  LDD0428  [24]
NAIA_5
 Probe Info  		C128(0.00); C179(0.00); C60(0.00)  LDD2223  [17]
TER-AC
 Probe Info  		N.A.  LDD0426  [24]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C191
 Probe Info  		9.92  LDD1868  [25]
C193
 Probe Info  		5.03  LDD1869  [25]
FFF probe13
 Probe Info  		20.00  LDD0475  [26]
FFF probe2
 Probe Info  		6.26  LDD0463  [26]
FFF probe3
 Probe Info  		8.30  LDD0464  [26]
DA-2
 Probe Info  		N.A.  LDD0072  [27]
OEA-DA
 Probe Info  		3.76  LDD0046  [28]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C179(0.53); C128(0.33)  LDD2142  [29]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C128(0.75)  LDD2112  [29]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C179(0.60)  LDD2095  [29]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C179(1.00)  LDD2130  [29]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C179(1.27); C128(1.24)  LDD2117  [29]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C179(1.12); C128(1.33)  LDD2152  [29]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C179(0.95); C128(0.97)  LDD2103  [29]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C179(0.52)  LDD2132  [29]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C179(0.72)  LDD2131  [29]
 LDCM0214  AC1 HEK-293T C179(1.28); C128(0.93); C60(1.33)  LDD1507  [30]
 LDCM0215  AC10 HEK-293T C128(1.00); C60(1.18)  LDD1508  [30]
 LDCM0226  AC11 HEK-293T C179(1.13); C128(1.06); C60(1.04)  LDD1509  [30]
 LDCM0237  AC12 HEK-293T C179(1.39); C128(0.99); C60(1.05)  LDD1510  [30]
 LDCM0259  AC14 HEK-293T C179(1.07); C128(1.10); C60(0.96)  LDD1512  [30]
 LDCM0270  AC15 HEK-293T C179(1.07); C128(1.02); C60(0.93)  LDD1513  [30]
 LDCM0276  AC17 HEK-293T C179(1.06); C128(0.93); C60(1.07)  LDD1515  [30]
 LDCM0277  AC18 HEK-293T C128(0.97); C60(1.13)  LDD1516  [30]
 LDCM0278  AC19 HEK-293T C179(0.92); C128(0.95); C60(1.11)  LDD1517  [30]
 LDCM0279  AC2 HEK-293T C128(1.00); C60(1.24)  LDD1518  [30]
 LDCM0280  AC20 HEK-293T C179(1.24); C128(1.06); C60(1.11)  LDD1519  [30]
 LDCM0281  AC21 HEK-293T C179(1.06); C128(1.07); C60(1.12)  LDD1520  [30]
 LDCM0282  AC22 HEK-293T C179(1.00); C128(1.10); C60(1.17)  LDD1521  [30]
 LDCM0283  AC23 HEK-293T C179(1.10); C128(1.06); C60(1.08)  LDD1522  [30]
 LDCM0284  AC24 HEK-293T C179(1.04); C128(1.19); C60(0.96)  LDD1523  [30]
 LDCM0285  AC25 HEK-293T C179(1.13); C128(0.99); C60(1.10)  LDD1524  [30]
 LDCM0286  AC26 HEK-293T C128(1.03); C60(1.13)  LDD1525  [30]
 LDCM0287  AC27 HEK-293T C179(1.08); C128(1.11); C60(1.01)  LDD1526  [30]
 LDCM0288  AC28 HEK-293T C179(1.31); C128(1.10); C60(1.13)  LDD1527  [30]
 LDCM0289  AC29 HEK-293T C179(1.19); C128(1.09); C60(1.12)  LDD1528  [30]
 LDCM0290  AC3 HEK-293T C179(1.14); C128(1.04); C60(1.15)  LDD1529  [30]
 LDCM0291  AC30 HEK-293T C179(1.06); C128(1.12); C60(1.17)  LDD1530  [30]
 LDCM0292  AC31 HEK-293T C179(1.01); C128(1.02); C60(1.10)  LDD1531  [30]
 LDCM0293  AC32 HEK-293T C179(1.05); C128(1.03); C60(0.99)  LDD1532  [30]
 LDCM0294  AC33 HEK-293T C179(1.14); C128(0.95); C60(1.14)  LDD1533  [30]
 LDCM0295  AC34 HEK-293T C128(0.98); C60(1.04)  LDD1534  [30]
 LDCM0296  AC35 HEK-293T C179(1.29); C128(1.06); C60(1.08)  LDD1535  [30]
 LDCM0297  AC36 HEK-293T C179(1.50); C128(1.08); C60(1.12)  LDD1536  [30]
 LDCM0298  AC37 HEK-293T C179(1.33); C128(1.17); C60(1.01)  LDD1537  [30]
 LDCM0299  AC38 HEK-293T C179(1.08); C128(1.15); C60(1.00)  LDD1538  [30]
 LDCM0300  AC39 HEK-293T C179(1.09); C128(1.00); C60(1.00)  LDD1539  [30]
 LDCM0301  AC4 HEK-293T C179(1.26); C128(1.05); C60(1.19)  LDD1540  [30]
 LDCM0302  AC40 HEK-293T C179(1.06); C128(1.11); C60(0.98)  LDD1541  [30]
 LDCM0303  AC41 HEK-293T C179(1.10); C128(0.89); C60(1.10)  LDD1542  [30]
 LDCM0304  AC42 HEK-293T C128(0.92); C60(1.34)  LDD1543  [30]
 LDCM0305  AC43 HEK-293T C179(1.15); C128(1.04); C60(1.08)  LDD1544  [30]
 LDCM0306  AC44 HEK-293T C179(1.33); C128(1.00); C60(1.15)  LDD1545  [30]
 LDCM0307  AC45 HEK-293T C179(1.16); C128(1.10); C60(1.01)  LDD1546  [30]
 LDCM0308  AC46 HEK-293T C179(1.04); C128(1.10); C60(1.02)  LDD1547  [30]
 LDCM0309  AC47 HEK-293T C179(1.03); C128(1.01); C60(1.12)  LDD1548  [30]
 LDCM0310  AC48 HEK-293T C179(1.09); C128(1.10); C60(1.03)  LDD1549  [30]
 LDCM0311  AC49 HEK-293T C179(1.12); C128(0.94); C60(1.07)  LDD1550  [30]
 LDCM0312  AC5 HEK-293T C179(1.30); C128(1.11); C60(1.09)  LDD1551  [30]
 LDCM0313  AC50 HEK-293T C128(1.05); C60(1.16)  LDD1552  [30]
 LDCM0314  AC51 HEK-293T C179(1.27); C128(1.10); C60(1.09)  LDD1553  [30]
 LDCM0315  AC52 HEK-293T C179(1.16); C128(0.99); C60(1.06)  LDD1554  [30]
 LDCM0316  AC53 HEK-293T C179(1.22); C128(1.06); C60(1.06)  LDD1555  [30]
 LDCM0317  AC54 HEK-293T C179(1.08); C128(1.14); C60(1.13)  LDD1556  [30]
 LDCM0318  AC55 HEK-293T C179(1.03); C128(1.00); C60(1.00)  LDD1557  [30]
 LDCM0319  AC56 HEK-293T C179(1.00); C128(1.11); C60(1.00)  LDD1558  [30]
 LDCM0320  AC57 HEK-293T C179(1.19); C128(0.93); C60(1.19)  LDD1559  [30]
 LDCM0321  AC58 HEK-293T C128(1.10); C60(1.06)  LDD1560  [30]
 LDCM0322  AC59 HEK-293T C179(1.16); C128(1.14); C60(1.12)  LDD1561  [30]
 LDCM0323  AC6 HEK-293T C179(1.20); C128(1.07); C60(1.18)  LDD1562  [30]
 LDCM0324  AC60 HEK-293T C179(1.35); C128(1.06); C60(1.13)  LDD1563  [30]
 LDCM0325  AC61 HEK-293T C179(1.22); C128(1.06); C60(1.15)  LDD1564  [30]
 LDCM0326  AC62 HEK-293T C179(1.19); C128(1.07); C60(1.08)  LDD1565  [30]
 LDCM0327  AC63 HEK-293T C179(1.17); C128(0.95); C60(1.04)  LDD1566  [30]
 LDCM0328  AC64 HEK-293T C179(1.12); C128(1.23); C60(1.13)  LDD1567  [30]
 LDCM0334  AC7 HEK-293T C179(1.20); C128(1.00); C60(1.08)  LDD1568  [30]
 LDCM0345  AC8 HEK-293T C179(1.03); C128(1.09); C60(1.08)  LDD1569  [30]
 LDCM0545  Acetamide MDA-MB-231 C179(0.58)  LDD2138  [29]
 LDCM0520  AKOS000195272 MDA-MB-231 C179(0.80)  LDD2113  [29]
 LDCM0248  AKOS034007472 HEK-293T C179(1.15); C128(1.04); C60(1.05)  LDD1511  [30]
 LDCM0356  AKOS034007680 HEK-293T C179(1.10); C128(0.91); C60(1.16)  LDD1570  [30]
 LDCM0275  AKOS034007705 HEK-293T C179(1.01); C128(1.14); C60(0.94)  LDD1514  [30]
 LDCM0156  Aniline NCI-H1299 11.76  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C179(0.71)  LDD2091  [29]
 LDCM0630  CCW28-3 231MFP C60(1.36)  LDD2214  [31]
 LDCM0108  Chloroacetamide HeLa H208(0.00); H11(0.00); H195(0.00); C179(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C179(20.00); C179(2.46); C128(2.02); C179(0.78)  LDD2227  [17]
 LDCM0367  CL1 HEK-293T C179(1.47); C128(0.91); C60(1.05)  LDD1571  [30]
 LDCM0368  CL10 HEK-293T C179(0.34); C128(0.84); C60(0.61)  LDD1572  [30]
 LDCM0369  CL100 HEK-293T C128(1.01); C60(1.43)  LDD1573  [30]
 LDCM0370  CL101 HEK-293T C179(1.27); C128(0.94); C60(1.22)  LDD1574  [30]
 LDCM0371  CL102 HEK-293T C179(0.97); C128(0.94); C60(1.09)  LDD1575  [30]
 LDCM0372  CL103 HEK-293T C179(1.14); C128(1.03); C60(0.98)  LDD1576  [30]
 LDCM0373  CL104 HEK-293T C128(1.04); C60(1.10)  LDD1577  [30]
 LDCM0374  CL105 HEK-293T C179(1.21); C128(0.96); C60(1.07)  LDD1578  [30]
 LDCM0375  CL106 HEK-293T C179(0.91); C128(1.01); C60(0.97)  LDD1579  [30]
 LDCM0376  CL107 HEK-293T C179(0.95); C128(1.04); C60(1.02)  LDD1580  [30]
 LDCM0377  CL108 HEK-293T C128(1.07); C60(1.20)  LDD1581  [30]
 LDCM0378  CL109 HEK-293T C179(1.16); C128(1.01); C60(1.07)  LDD1582  [30]
 LDCM0379  CL11 HEK-293T C179(0.47); C128(1.03); C60(0.68)  LDD1583  [30]
 LDCM0380  CL110 HEK-293T C179(0.91); C128(0.94); C60(0.92)  LDD1584  [30]
 LDCM0381  CL111 HEK-293T C179(0.95); C128(0.96); C60(1.02)  LDD1585  [30]
 LDCM0382  CL112 HEK-293T C128(1.08); C60(1.23)  LDD1586  [30]
 LDCM0383  CL113 HEK-293T C179(1.32); C128(1.01); C60(1.23)  LDD1587  [30]
 LDCM0384  CL114 HEK-293T C179(1.00); C128(0.95); C60(0.96)  LDD1588  [30]
 LDCM0385  CL115 HEK-293T C179(1.04); C128(1.08); C60(1.03)  LDD1589  [30]
 LDCM0386  CL116 HEK-293T C128(1.06); C60(1.18)  LDD1590  [30]
 LDCM0387  CL117 HEK-293T C179(1.24); C128(1.01); C60(1.24)  LDD1591  [30]
 LDCM0388  CL118 HEK-293T C179(1.05); C128(1.08); C60(0.98)  LDD1592  [30]
 LDCM0389  CL119 HEK-293T C179(1.04); C128(1.05); C60(1.03)  LDD1593  [30]
 LDCM0390  CL12 HEK-293T C179(0.38); C128(1.03); C60(0.82)  LDD1594  [30]
 LDCM0391  CL120 HEK-293T C128(1.11); C60(1.23)  LDD1595  [30]
 LDCM0392  CL121 HEK-293T C179(1.33); C128(1.04); C60(1.14)  LDD1596  [30]
 LDCM0393  CL122 HEK-293T C179(1.11); C128(1.03); C60(0.97)  LDD1597  [30]
 LDCM0394  CL123 HEK-293T C179(0.92); C128(0.91); C60(1.02)  LDD1598  [30]
 LDCM0395  CL124 HEK-293T C128(1.16); C60(1.17)  LDD1599  [30]
 LDCM0396  CL125 HEK-293T C179(1.51); C128(1.04); C60(1.28)  LDD1600  [30]
 LDCM0397  CL126 HEK-293T C179(1.38); C128(0.99); C60(1.04)  LDD1601  [30]
 LDCM0398  CL127 HEK-293T C179(1.24); C128(1.07); C60(1.15)  LDD1602  [30]
 LDCM0399  CL128 HEK-293T C128(1.15); C60(1.24)  LDD1603  [30]
 LDCM0400  CL13 HEK-293T C179(1.54); C128(0.85); C60(1.07)  LDD1604  [30]
 LDCM0401  CL14 HEK-293T C179(1.04); C128(1.01); C60(0.94)  LDD1605  [30]
 LDCM0402  CL15 HEK-293T C179(0.90); C128(0.80); C60(0.83)  LDD1606  [30]
 LDCM0403  CL16 HEK-293T C128(1.11); C60(0.99)  LDD1607  [30]
 LDCM0404  CL17 HEK-293T C179(0.84); C128(0.69); C60(0.86)  LDD1608  [30]
 LDCM0405  CL18 HEK-293T C128(0.97); C60(0.88)  LDD1609  [30]
 LDCM0406  CL19 HEK-293T C179(0.85); C128(0.99); C60(0.88)  LDD1610  [30]
 LDCM0407  CL2 HEK-293T C179(1.09); C128(0.89); C60(0.90)  LDD1611  [30]
 LDCM0408  CL20 HEK-293T C179(0.87); C128(1.00); C60(0.84)  LDD1612  [30]
 LDCM0409  CL21 HEK-293T C179(0.43); C128(0.96); C60(0.70)  LDD1613  [30]
 LDCM0410  CL22 HEK-293T C179(0.37); C128(1.01); C60(0.72)  LDD1614  [30]
 LDCM0411  CL23 HEK-293T C179(0.33); C128(1.00); C60(0.76)  LDD1615  [30]
 LDCM0412  CL24 HEK-293T C179(0.25); C128(1.02); C60(0.78)  LDD1616  [30]
 LDCM0413  CL25 HEK-293T C179(1.34); C128(0.91); C60(1.09)  LDD1617  [30]
 LDCM0414  CL26 HEK-293T C179(1.06); C128(0.98); C60(0.92)  LDD1618  [30]
 LDCM0415  CL27 HEK-293T C179(0.99); C128(1.05); C60(1.02)  LDD1619  [30]
 LDCM0416  CL28 HEK-293T C128(1.00); C60(1.03)  LDD1620  [30]
 LDCM0417  CL29 HEK-293T C179(0.89); C128(0.97); C60(0.98)  LDD1621  [30]
 LDCM0418  CL3 HEK-293T C179(1.00); C128(0.96); C60(0.92)  LDD1622  [30]
 LDCM0419  CL30 HEK-293T C128(0.98); C60(0.88)  LDD1623  [30]
 LDCM0420  CL31 HEK-293T C179(0.82); C128(0.90); C60(0.80)  LDD1624  [30]
 LDCM0421  CL32 HEK-293T C179(0.81); C128(1.02); C60(0.83)  LDD1625  [30]
 LDCM0422  CL33 HEK-293T C179(0.36); C128(0.93); C60(0.61)  LDD1626  [30]
 LDCM0423  CL34 HEK-293T C179(0.32); C128(1.13); C60(0.68)  LDD1627  [30]
 LDCM0424  CL35 HEK-293T C179(0.31); C128(1.00); C60(0.75)  LDD1628  [30]
 LDCM0425  CL36 HEK-293T C179(0.22); C128(1.14); C60(0.74)  LDD1629  [30]
 LDCM0426  CL37 HEK-293T C179(1.36); C128(0.95); C60(1.24)  LDD1630  [30]
 LDCM0428  CL39 HEK-293T C179(0.97); C128(1.04); C60(0.97)  LDD1632  [30]
 LDCM0429  CL4 HEK-293T C128(0.87); C60(1.02)  LDD1633  [30]
 LDCM0430  CL40 HEK-293T C128(1.07); C60(1.06)  LDD1634  [30]
 LDCM0431  CL41 HEK-293T C179(0.86); C128(0.98); C60(1.00)  LDD1635  [30]
 LDCM0432  CL42 HEK-293T C128(1.03); C60(0.90)  LDD1636  [30]
 LDCM0433  CL43 HEK-293T C179(0.76); C128(1.18); C60(0.82)  LDD1637  [30]
 LDCM0434  CL44 HEK-293T C179(0.89); C128(1.06); C60(0.87)  LDD1638  [30]
 LDCM0435  CL45 HEK-293T C179(0.49); C128(0.98); C60(0.74)  LDD1639  [30]
 LDCM0436  CL46 HEK-293T C179(0.30); C128(1.16); C60(0.74)  LDD1640  [30]
 LDCM0437  CL47 HEK-293T C179(0.29); C128(1.01); C60(0.76)  LDD1641  [30]
 LDCM0438  CL48 HEK-293T C179(0.16); C128(1.07); C60(0.75)  LDD1642  [30]
 LDCM0439  CL49 HEK-293T C179(1.43); C128(0.97); C60(1.28)  LDD1643  [30]
 LDCM0440  CL5 HEK-293T C179(1.09); C128(0.84); C60(1.00)  LDD1644  [30]
 LDCM0441  CL50 HEK-293T C179(1.13); C128(0.97); C60(0.89)  LDD1645  [30]
 LDCM0443  CL52 HEK-293T C128(1.02); C60(1.03)  LDD1646  [30]
 LDCM0444  CL53 HEK-293T C179(0.82); C128(0.81); C60(0.89)  LDD1647  [30]
 LDCM0445  CL54 HEK-293T C128(0.94); C60(0.78)  LDD1648  [30]
 LDCM0446  CL55 HEK-293T C179(0.77); C128(1.03); C60(0.78)  LDD1649  [30]
 LDCM0447  CL56 HEK-293T C179(0.82); C128(1.03); C60(0.83)  LDD1650  [30]
 LDCM0448  CL57 HEK-293T C179(0.43); C128(0.91); C60(0.66)  LDD1651  [30]
 LDCM0449  CL58 HEK-293T C179(0.39); C128(1.12); C60(0.70)  LDD1652  [30]
 LDCM0450  CL59 HEK-293T C179(0.32); C128(0.97); C60(0.74)  LDD1653  [30]
 LDCM0451  CL6 HEK-293T C128(0.79); C60(0.87)  LDD1654  [30]
 LDCM0452  CL60 HEK-293T C179(0.22); C128(1.07); C60(0.78)  LDD1655  [30]
 LDCM0453  CL61 HEK-293T C179(1.59); C128(0.98); C60(1.28)  LDD1656  [30]
 LDCM0454  CL62 HEK-293T C179(1.14); C128(1.00); C60(1.02)  LDD1657  [30]
 LDCM0455  CL63 HEK-293T C179(1.04); C128(1.06); C60(1.04)  LDD1658  [30]
 LDCM0456  CL64 HEK-293T C128(0.98); C60(1.01)  LDD1659  [30]
 LDCM0457  CL65 HEK-293T C179(1.00); C128(0.94); C60(1.05)  LDD1660  [30]
 LDCM0458  CL66 HEK-293T C128(0.96); C60(0.93)  LDD1661  [30]
 LDCM0459  CL67 HEK-293T C179(0.87); C128(1.04); C60(0.81)  LDD1662  [30]
 LDCM0460  CL68 HEK-293T C179(0.83); C128(1.08); C60(0.82)  LDD1663  [30]
 LDCM0461  CL69 HEK-293T C179(0.47); C128(1.04); C60(0.72)  LDD1664  [30]
 LDCM0462  CL7 HEK-293T C179(1.00); C128(0.94); C60(0.86)  LDD1665  [30]
 LDCM0463  CL70 HEK-293T C179(0.38); C128(1.10); C60(0.71)  LDD1666  [30]
 LDCM0464  CL71 HEK-293T C179(0.34); C128(0.99); C60(0.80)  LDD1667  [30]
 LDCM0465  CL72 HEK-293T C179(0.32); C128(1.02); C60(0.76)  LDD1668  [30]
 LDCM0466  CL73 HEK-293T C179(1.58); C128(1.02); C60(1.19)  LDD1669  [30]
 LDCM0467  CL74 HEK-293T C179(1.28); C128(1.07); C60(1.01)  LDD1670  [30]
 LDCM0469  CL76 HEK-293T C128(1.04); C60(1.10)  LDD1672  [30]
 LDCM0470  CL77 HEK-293T C179(0.87); C128(0.82); C60(0.95)  LDD1673  [30]
 LDCM0471  CL78 HEK-293T C128(1.10); C60(0.96)  LDD1674  [30]
 LDCM0472  CL79 HEK-293T C179(0.98); C128(1.12); C60(0.87)  LDD1675  [30]
 LDCM0473  CL8 HEK-293T C179(0.53); C128(0.82); C60(0.73)  LDD1676  [30]
 LDCM0474  CL80 HEK-293T C179(0.87); C128(1.17); C60(0.88)  LDD1677  [30]
 LDCM0475  CL81 HEK-293T C179(0.58); C128(1.06); C60(0.77)  LDD1678  [30]
 LDCM0476  CL82 HEK-293T C179(0.46); C128(1.27); C60(0.77)  LDD1679  [30]
 LDCM0477  CL83 HEK-293T C179(0.38); C128(1.10); C60(0.74)  LDD1680  [30]
 LDCM0478  CL84 HEK-293T C179(0.38); C128(1.10); C60(0.76)  LDD1681  [30]
 LDCM0479  CL85 HEK-293T C179(1.59); C128(0.95); C60(1.49)  LDD1682  [30]
 LDCM0480  CL86 HEK-293T C179(1.78); C128(1.01); C60(1.29)  LDD1683  [30]
 LDCM0481  CL87 HEK-293T C179(1.40); C128(1.02); C60(1.25)  LDD1684  [30]
 LDCM0482  CL88 HEK-293T C128(1.04); C60(1.31)  LDD1685  [30]
 LDCM0483  CL89 HEK-293T C179(1.59); C128(0.92); C60(1.08)  LDD1686  [30]
 LDCM0484  CL9 HEK-293T C179(0.51); C128(0.93); C60(0.74)  LDD1687  [30]
 LDCM0485  CL90 HEK-293T C128(0.77); C60(0.77)  LDD1688  [30]
 LDCM0486  CL91 HEK-293T C179(0.97); C128(1.15); C60(0.92)  LDD1689  [30]
 LDCM0487  CL92 HEK-293T C179(0.98); C128(0.93); C60(0.85)  LDD1690  [30]
 LDCM0488  CL93 HEK-293T C179(0.56); C128(1.03); C60(0.71)  LDD1691  [30]
 LDCM0489  CL94 HEK-293T C179(0.53); C128(1.12); C60(0.82)  LDD1692  [30]
 LDCM0490  CL95 HEK-293T C179(0.45); C128(0.86); C60(0.84)  LDD1693  [30]
 LDCM0491  CL96 HEK-293T C179(0.55); C128(1.02); C60(0.82)  LDD1694  [30]
 LDCM0492  CL97 HEK-293T C179(1.36); C128(0.95); C60(1.19)  LDD1695  [30]
 LDCM0493  CL98 HEK-293T C179(1.06); C128(0.97); C60(1.00)  LDD1696  [30]
 LDCM0494  CL99 HEK-293T C179(1.02); C128(0.96); C60(1.16)  LDD1697  [30]
 LDCM0028  Dobutamine HEK-293T 5.28  LDD0180  [10]
 LDCM0495  E2913 HEK-293T C179(1.04); C128(0.91); C60(1.08)  LDD1698  [30]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C179(0.50)  LDD1702  [29]
 LDCM0625  F8 Ramos C179(2.86); C128(1.12)  LDD2187  [32]
 LDCM0572  Fragment10 Ramos C179(1.01); C128(0.60)  LDD2189  [32]
 LDCM0573  Fragment11 Ramos C179(0.13); C128(0.20)  LDD2190  [32]
 LDCM0574  Fragment12 Ramos C179(0.55); C128(0.96)  LDD2191  [32]
 LDCM0575  Fragment13 Ramos C179(1.28); C128(1.33)  LDD2192  [32]
 LDCM0576  Fragment14 Ramos C179(0.54); C128(0.66)  LDD2193  [32]
 LDCM0579  Fragment20 Ramos C179(0.60); C128(0.72)  LDD2194  [32]
 LDCM0580  Fragment21 Ramos C179(0.65); C128(0.87)  LDD2195  [32]
 LDCM0582  Fragment23 Ramos C179(1.36); C128(1.05)  LDD2196  [32]
 LDCM0578  Fragment27 Ramos C179(1.74); C128(0.98)  LDD2197  [32]
 LDCM0586  Fragment28 Ramos C179(0.70); C128(1.17)  LDD2198  [32]
 LDCM0588  Fragment30 Ramos C179(0.79); C128(1.53)  LDD2199  [32]
 LDCM0589  Fragment31 Ramos C179(1.02); C128(1.45)  LDD2200  [32]
 LDCM0590  Fragment32 Ramos C179(1.07); C128(0.67)  LDD2201  [32]
 LDCM0468  Fragment33 HEK-293T C179(1.10); C128(1.08); C60(1.02)  LDD1671  [30]
 LDCM0596  Fragment38 Ramos C179(1.72); C128(1.24)  LDD2203  [32]
 LDCM0566  Fragment4 Ramos C179(0.79); C128(0.73)  LDD2184  [32]
 LDCM0427  Fragment51 HEK-293T C179(1.08); C128(1.04); C60(0.96)  LDD1631  [30]
 LDCM0610  Fragment52 Ramos C179(0.92); C128(1.90)  LDD2204  [32]
 LDCM0614  Fragment56 Ramos C179(1.09); C128(1.57)  LDD2205  [32]
 LDCM0569  Fragment7 Ramos C179(0.70); C128(0.69)  LDD2186  [32]
 LDCM0571  Fragment9 Ramos C179(0.39); C128(0.59)  LDD2188  [32]
 LDCM0107  IAA HeLa H208(0.00); H11(0.00); H163(0.00); C179(0.00)  LDD0221  [22]
 LDCM0022  KB02 HEK-293T C179(1.03); C128(0.97); C60(1.00)  LDD1492  [30]
 LDCM0023  KB03 HEK-293T C179(0.94); C128(0.94); C60(1.04)  LDD1497  [30]
 LDCM0024  KB05 G361 C128(1.50)  LDD3311  [9]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C179(0.97); C128(0.91)  LDD2102  [29]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C179(0.72)  LDD2121  [29]
 LDCM0109  NEM HeLa H208(0.00); H163(0.00); H11(0.00); H195(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C179(0.70)  LDD2089  [29]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C179(1.37)  LDD2090  [29]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C179(0.89); C128(1.17)  LDD2092  [29]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C179(1.54); C128(1.23)  LDD2093  [29]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C179(1.77)  LDD2094  [29]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C179(2.39); C128(1.23)  LDD2096  [29]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C179(0.72); C128(0.89)  LDD2097  [29]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C179(0.55); C128(0.68)  LDD2098  [29]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C128(1.17)  LDD2099  [29]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C128(0.43)  LDD2100  [29]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C179(1.06); C128(0.87)  LDD2101  [29]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C179(0.55); C128(0.51)  LDD2104  [29]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C128(1.61)  LDD2105  [29]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C179(0.53)  LDD2106  [29]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C179(1.02); C128(0.98)  LDD2107  [29]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C179(0.62); C128(0.48)  LDD2108  [29]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C179(0.66); C128(0.73)  LDD2109  [29]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C179(0.98)  LDD2110  [29]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C179(1.81); C128(1.26)  LDD2111  [29]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C179(0.59); C128(0.55)  LDD2114  [29]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C179(0.44); C128(0.63)  LDD2115  [29]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C179(0.80); C128(1.07)  LDD2116  [29]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C128(1.72)  LDD2118  [29]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C179(2.13); C128(1.56)  LDD2119  [29]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C179(0.66); C128(0.85)  LDD2120  [29]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C128(1.06)  LDD2122  [29]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C179(0.90); C128(0.93)  LDD2123  [29]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C128(1.06)  LDD2124  [29]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C179(0.95); C128(0.95)  LDD2125  [29]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C179(1.27); C128(1.09)  LDD2126  [29]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C179(1.43); C128(1.24)  LDD2127  [29]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C128(1.15)  LDD2128  [29]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C179(1.04); C128(1.05)  LDD2129  [29]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C179(0.56); C128(0.50)  LDD2133  [29]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C179(0.38); C128(0.65)  LDD2134  [29]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C179(1.24); C128(1.19)  LDD2135  [29]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C179(1.58); C128(1.28)  LDD2136  [29]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C179(0.95); C128(1.08)  LDD2137  [29]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C179(3.19); C128(1.41)  LDD1700  [29]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C179(0.91); C128(0.60)  LDD2141  [29]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C128(1.12)  LDD2143  [29]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C179(2.47); C128(2.77)  LDD2144  [29]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C179(3.90); C128(0.81)  LDD2145  [29]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C179(0.76); C128(0.96)  LDD2146  [29]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C128(3.36)  LDD2147  [29]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C179(0.42); C128(0.53)  LDD2148  [29]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C179(4.32)  LDD2149  [29]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C179(0.56)  LDD2150  [29]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C179(1.67); C128(0.97)  LDD2151  [29]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C179(2.17)  LDD2153  [29]
 LDCM0627  NUDT7-COV-1 HEK-293T C60(1.21)  LDD2206  [33]
 LDCM0628  OTUB2-COV-1 HEK-293T C60(0.92); C179(0.77); C179(0.68)  LDD2207  [33]
 LDCM0131  RA190 MM1.R C128(1.08)  LDD0304  [34]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Signal peptidase complex catalytic subunit SEC11C (SEC11C) Peptidase S26B family Q9BY50
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2) RSAD2 family Q8WXG1
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Plasma membrane ascorbate-dependent reductase CYBRD1 (CYBRD1) . Q53TN4
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 11 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Membrane-associated progesterone receptor component 2 (PGRMC2) Cytochrome b5 family O15173
Novel acetylcholine receptor chaperone (TMEM35A) DoxX family Q53FP2
Gastrokine-1 (GKN1) Gastrokine family Q9NS71
Monocarboxylate transporter 2 (SLC16A7) Monocarboxylate porter (TC 2.A.1.13) family O60669
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Solute carrier family 35 member B1 (SLC35B1) Nucleotide-sugar transporter family P78383
Voltage-dependent calcium channel gamma-1 subunit (CACNG1) PMP-22/EMP/MP20 family Q06432
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Vesicle-associated membrane protein-associated protein B/C (VAPB) VAMP-associated protein (VAP) (TC 9.B.17) family O95292
Protrudin (ZFYVE27) . Q5T4F4
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 22 (ZBTB22) Krueppel C2H2-type zinc-finger protein family O15209
GPCR
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mu-type opioid receptor (OPRM1) G-protein coupled receptor 1 family P35372
Adhesion G-protein coupled receptor G7 (ADGRG7) G-protein coupled receptor 2 family Q96K78
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 10 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein D (APOD) Lipocalin family P05090
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
Oxysterol-binding protein 1 (OSBP) OSBP family P22059
Oxysterol-binding protein-related protein 1 (OSBPL1A) OSBP family Q9BXW6
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Regulator of microtubule dynamics protein 2 (RMDN2) RMDN family Q96LZ7
Transmembrane protein 229B (TMEM229B) TMEM229 family Q8NBD8
Protein YIF1A (YIF1A) YIF1 family O95070
Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) . O00559

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
9 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
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Mass spectrometry data entry: PXD043348
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Mass spectrometry data entry: PXD042377
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD041264
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD039931
20 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
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Mass spectrometry data entry: PXD041587
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
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Mass spectrometry data entry: PXD007570
29 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
30 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
31 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
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Mass spectrometry data entry: PXD027578
33 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
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