Details of the Target

General Information of Target

Target ID LDTP06105
Target Name Protein FAM50A (FAM50A)
Gene Name FAM50A
Gene ID 9130
Synonyms
DXS9928E; HXC26; XAP5; Protein FAM50A; Protein HXC-26; Protein XAP-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAQYKGAASEAGRAMHLMKKREKQREQMEQMKQRIAEENIMKSNIDKKFSAHYDAVEAEL
KSSTVGLVTLNDMKAKQEALVKEREKQLAKKEQSKELQMKLEKLREKERKKEAKRKISSL
SFTLEEEEEGGEEEEEAAMYEEEMEREEITTKKRKLGKNPDVDTSFLPDRDREEEENRLR
EELRQEWEAKQEKIKSEEIEITFSYWDGSGHRRTVKMRKGNTMQQFLQKALEILRKDFSE
LRSAGVEQLMYIKEDLIIPHHHSFYDFIVTKARGKSGPLFNFDVHDDVRLLSDATVEKDE
SHAGKVVLRSWYEKNKHIFPASRWEPYDPEKKWDKYTIR
Target Bioclass
Other
Family
FAM50 family
Subcellular location
Nucleus
Function Probably involved in the regulation of pre-mRNA splicing.
Uniprot ID
Q14320
Ensemble ID
ENST00000393600.8
HGNC ID
HGNC:18786

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 12 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Alkylaryl probe 1
 Probe Info  		5.00  LDD0387  [1]
ONAyne
 Probe Info  		K236(6.67)  LDD0274  [2]
STPyne
 Probe Info  		K100(1.18); K19(2.08); K219(10.00); K236(10.00)  LDD0277  [2]
HHS-475
 Probe Info  		Y53(0.68)  LDD0264  [3]
HHS-465
 Probe Info  		Y53(10.00)  LDD2237  [4]
5E-2FA
 Probe Info  		H260(0.00); H52(0.00)  LDD2235  [5]
ATP probe
 Probe Info  		K305(0.00); K298(0.00); K275(0.00); K76(0.00)  LDD0199  [6]
m-APA
 Probe Info  		H260(0.00); H52(0.00); H285(0.00); H302(0.00)  LDD2231  [5]
NHS
 Probe Info  		K305(0.00); K5(0.00)  LDD0010  [7]
SF
 Probe Info  		Y53(0.00); K305(0.00)  LDD0028  [8]
1d-yne
 Probe Info  		N.A.  LDD0357  [9]
Acrolein
 Probe Info  		N.A.  LDD0217  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H302(0.00); H285(0.00)  LDD0222  [10]
 LDCM0116  HHS-0101 DM93 Y53(0.68)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y53(0.54)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y53(0.84)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y53(0.63)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y53(0.57)  LDD0268  [3]
 LDCM0107  IAA HeLa H285(0.00); H302(0.00)  LDD0221  [10]
 LDCM0109  NEM HeLa H285(0.00); H302(0.00)  LDD0223  [10]

References

1 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
8 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
9 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.