Details of the Target

General Information of Target

Target ID LDTP11737
Target Name Nonsense-mediated mRNA decay factor SMG9 (SMG9)
Gene Name SMG9
Gene ID 56006
Synonyms
C19orf61; Nonsense-mediated mRNA decay factor SMG9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLQIGEDVDYLLIPREVRLAGGVWRVISKPATKEAEFRERLTQFLEEEGRTLEDVARIME
KSTPHPPQPPKKPKEPRVRRRVQQMVTPPPRLVVGTYDSSNASDSEFSDFETSRDKSRQG
PRRGKKVRKMPVSYLGSKFLGSDLESEDDEELVEAFLRRQEKQPSAPPARRRVNLPVPMF
EDNLGPQLSKADRWREYVSQVSWGKLKRRVKGWAPRAGPGVGEARLASTAVESAGVSSAP
EGTSPGDRLGNAGDVCVPQASPRRWRPKINWASFRRRRKEQTAPTGQGADIEADQGGEAA
DSQREEAIADQREGAAGNQRAGAPADQGAEAADNQREEAADNQRAGAPAEEGAEAADNQR
EEAADNQRAEAPADQRSQGTDNHREEAADNQRAEAPADQGSEVTDNQREEAVHDQRERAP
AVQGADNQRAQARAGQRAEAAHNQRAGAPGIQEAEVSAAQGTTGTAPGARARKQVKTVRF
QTPGRFSWFCKRRRAFWHTPRLPTLPKRVPRAGEARNLRVLRAEARAEAEQGEQEDQL
Target Bioclass
Other
Family
SMG9 family
Function
Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited by release factors to stalled ribosomes together with SMG1 and SMG8 (forming the SMG1C protein kinase complex) and, in the SMG1C complex, is required for the efficient association between SMG1 and SMG8. Plays a role in brain, heart, and eye development.
Uniprot ID
Q9H0W8
Ensemble ID
ENST00000270066.11
HGNC ID
HGNC:25763

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.Ter521CextTer38 DBIA    Probe Info 
IGR1 SNV: p.K134N DBIA    Probe Info 
JURKAT SNV: p.A84T .
KMCH1 SNV: p.G115V DBIA    Probe Info 
NCIH23 SNV: p.Q144H .
REH SNV: p.S465N DBIA    Probe Info 
TE11 SNV: p.D203E DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
Alkylaryl probe 1
 Probe Info  		16.00  LDD0387  [2]
TG42
 Probe Info  		4.54; 4.48  LDD0326  [3]
STPyne
 Probe Info  		K178(10.00); K472(5.46)  LDD0277  [4]
Probe 1
 Probe Info  		Y147(16.04)  LDD3495  [5]
Backus_15
 Probe Info  		1.78  LDD0424  [6]
BTD
 Probe Info  		C380(1.21)  LDD2090  [7]
NAIA_5
 Probe Info  		C380(20.00)  LDD2227  [8]
DA-P3
 Probe Info  		4.86  LDD0181  [9]
DBIA
 Probe Info  		C380(606.28); C380(4.77)  LDD0209  [10]
BDBM50514113
 Probe Info  		1.81  LDD0041  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [12]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [8]
WYneN
 Probe Info  		N.A.  LDD0021  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
IA-alkyne
 Probe Info  		N.A.  LDD0149  [14]
IPM
 Probe Info  		N.A.  LDD0005  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C380(0.98)  LDD2142  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C380(1.20)  LDD2117  [7]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C380(1.05)  LDD2103  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C380(0.68)  LDD2132  [7]
 LDCM0214  AC1 HCT 116 C380(0.96)  LDD0531  [15]
 LDCM0215  AC10 HCT 116 C380(1.42)  LDD0532  [15]
 LDCM0216  AC100 HCT 116 C380(1.31)  LDD0533  [15]
 LDCM0217  AC101 HCT 116 C380(1.69)  LDD0534  [15]
 LDCM0218  AC102 HCT 116 C380(1.40)  LDD0535  [15]
 LDCM0219  AC103 HCT 116 C380(1.65)  LDD0536  [15]
 LDCM0220  AC104 HCT 116 C380(1.15)  LDD0537  [15]
 LDCM0221  AC105 HCT 116 C380(1.46)  LDD0538  [15]
 LDCM0222  AC106 HCT 116 C380(1.41)  LDD0539  [15]
 LDCM0223  AC107 HCT 116 C380(1.29)  LDD0540  [15]
 LDCM0224  AC108 HCT 116 C380(1.20)  LDD0541  [15]
 LDCM0225  AC109 HCT 116 C380(1.13)  LDD0542  [15]
 LDCM0226  AC11 HCT 116 C380(0.79)  LDD0543  [15]
 LDCM0227  AC110 HCT 116 C380(1.64)  LDD0544  [15]
 LDCM0228  AC111 HCT 116 C380(1.20)  LDD0545  [15]
 LDCM0229  AC112 HCT 116 C380(1.17)  LDD0546  [15]
 LDCM0230  AC113 HCT 116 C380(1.15)  LDD0547  [15]
 LDCM0231  AC114 HCT 116 C380(0.91)  LDD0548  [15]
 LDCM0232  AC115 HCT 116 C380(1.01)  LDD0549  [15]
 LDCM0233  AC116 HCT 116 C380(1.16)  LDD0550  [15]
 LDCM0234  AC117 HCT 116 C380(1.29)  LDD0551  [15]
 LDCM0235  AC118 HCT 116 C380(0.94)  LDD0552  [15]
 LDCM0236  AC119 HCT 116 C380(1.03)  LDD0553  [15]
 LDCM0237  AC12 HCT 116 C380(0.89)  LDD0554  [15]
 LDCM0238  AC120 HCT 116 C380(1.10)  LDD0555  [15]
 LDCM0239  AC121 HCT 116 C380(1.32)  LDD0556  [15]
 LDCM0240  AC122 HCT 116 C380(0.97)  LDD0557  [15]
 LDCM0241  AC123 HCT 116 C380(1.01)  LDD0558  [15]
 LDCM0242  AC124 HCT 116 C380(0.96)  LDD0559  [15]
 LDCM0243  AC125 HCT 116 C380(0.91)  LDD0560  [15]
 LDCM0244  AC126 HCT 116 C380(1.03)  LDD0561  [15]
 LDCM0245  AC127 HCT 116 C380(1.04)  LDD0562  [15]
 LDCM0246  AC128 HCT 116 C380(0.85)  LDD0563  [15]
 LDCM0247  AC129 HCT 116 C380(0.82)  LDD0564  [15]
 LDCM0249  AC130 HCT 116 C380(0.99)  LDD0566  [15]
 LDCM0250  AC131 HCT 116 C380(0.89)  LDD0567  [15]
 LDCM0251  AC132 HCT 116 C380(1.28)  LDD0568  [15]
 LDCM0252  AC133 HCT 116 C380(0.88)  LDD0569  [15]
 LDCM0253  AC134 HCT 116 C380(0.98)  LDD0570  [15]
 LDCM0254  AC135 HCT 116 C380(0.89)  LDD0571  [15]
 LDCM0255  AC136 HCT 116 C380(0.80)  LDD0572  [15]
 LDCM0256  AC137 HCT 116 C380(1.50)  LDD0573  [15]
 LDCM0257  AC138 HCT 116 C380(1.07)  LDD0574  [15]
 LDCM0258  AC139 HCT 116 C380(1.00)  LDD0575  [15]
 LDCM0259  AC14 HCT 116 C380(0.68)  LDD0576  [15]
 LDCM0260  AC140 HCT 116 C380(1.50)  LDD0577  [15]
 LDCM0261  AC141 HCT 116 C380(1.40)  LDD0578  [15]
 LDCM0262  AC142 HCT 116 C380(0.98)  LDD0579  [15]
 LDCM0263  AC143 HCT 116 C380(1.15)  LDD0580  [15]
 LDCM0264  AC144 HCT 116 C380(1.39)  LDD0581  [15]
 LDCM0265  AC145 HCT 116 C380(0.97)  LDD0582  [15]
 LDCM0266  AC146 HCT 116 C380(1.67)  LDD0583  [15]
 LDCM0267  AC147 HCT 116 C380(1.55)  LDD0584  [15]
 LDCM0268  AC148 HCT 116 C380(1.54)  LDD0585  [15]
 LDCM0269  AC149 HCT 116 C380(1.87)  LDD0586  [15]
 LDCM0270  AC15 HCT 116 C380(0.84)  LDD0587  [15]
 LDCM0271  AC150 HCT 116 C380(1.14)  LDD0588  [15]
 LDCM0272  AC151 HCT 116 C380(1.52)  LDD0589  [15]
 LDCM0273  AC152 HCT 116 C380(1.23)  LDD0590  [15]
 LDCM0274  AC153 HCT 116 C380(1.68)  LDD0591  [15]
 LDCM0621  AC154 HCT 116 C380(1.41)  LDD2158  [15]
 LDCM0622  AC155 HCT 116 C380(1.28)  LDD2159  [15]
 LDCM0623  AC156 HCT 116 C380(1.27)  LDD2160  [15]
 LDCM0624  AC157 HCT 116 C380(1.21)  LDD2161  [15]
 LDCM0276  AC17 HEK-293T C380(1.16)  LDD0874  [15]
 LDCM0277  AC18 HEK-293T C380(1.03)  LDD0875  [15]
 LDCM0278  AC19 HEK-293T C380(1.07)  LDD0876  [15]
 LDCM0279  AC2 HCT 116 C380(1.01)  LDD0596  [15]
 LDCM0280  AC20 HEK-293T C380(1.16)  LDD0878  [15]
 LDCM0281  AC21 HEK-293T C380(0.97)  LDD0879  [15]
 LDCM0282  AC22 HEK-293T C380(1.20)  LDD0880  [15]
 LDCM0283  AC23 HEK-293T C380(1.39)  LDD0881  [15]
 LDCM0284  AC24 HEK-293T C380(1.09)  LDD0882  [15]
 LDCM0285  AC25 HCT 116 C380(1.40)  LDD0602  [15]
 LDCM0286  AC26 HCT 116 C380(1.26)  LDD0603  [15]
 LDCM0287  AC27 HCT 116 C380(1.10)  LDD0604  [15]
 LDCM0288  AC28 HCT 116 C380(1.30)  LDD0605  [15]
 LDCM0289  AC29 HCT 116 C380(1.76)  LDD0606  [15]
 LDCM0290  AC3 HCT 116 C380(1.25)  LDD0607  [15]
 LDCM0291  AC30 HCT 116 C380(1.50)  LDD0608  [15]
 LDCM0292  AC31 HCT 116 C380(1.04)  LDD0609  [15]
 LDCM0293  AC32 HCT 116 C380(1.26)  LDD0610  [15]
 LDCM0294  AC33 HCT 116 C380(1.27)  LDD0611  [15]
 LDCM0295  AC34 HCT 116 C380(1.54)  LDD0612  [15]
 LDCM0296  AC35 HCT 116 C380(0.83)  LDD0613  [15]
 LDCM0297  AC36 HCT 116 C380(0.91)  LDD0614  [15]
 LDCM0298  AC37 HCT 116 C380(0.85)  LDD0615  [15]
 LDCM0299  AC38 HCT 116 C380(1.05)  LDD0616  [15]
 LDCM0300  AC39 HCT 116 C380(1.14)  LDD0617  [15]
 LDCM0301  AC4 HCT 116 C380(1.14)  LDD0618  [15]
 LDCM0302  AC40 HCT 116 C380(1.28)  LDD0619  [15]
 LDCM0303  AC41 HCT 116 C380(1.03)  LDD0620  [15]
 LDCM0304  AC42 HCT 116 C380(1.22)  LDD0621  [15]
 LDCM0305  AC43 HCT 116 C380(1.04)  LDD0622  [15]
 LDCM0306  AC44 HCT 116 C380(0.95)  LDD0623  [15]
 LDCM0307  AC45 HCT 116 C380(1.30)  LDD0624  [15]
 LDCM0308  AC46 HCT 116 C380(1.00)  LDD0625  [15]
 LDCM0309  AC47 HCT 116 C380(1.13)  LDD0626  [15]
 LDCM0310  AC48 HCT 116 C380(1.25)  LDD0627  [15]
 LDCM0311  AC49 HCT 116 C380(1.42)  LDD0628  [15]
 LDCM0312  AC5 HCT 116 C380(1.21)  LDD0629  [15]
 LDCM0313  AC50 HCT 116 C380(1.16)  LDD0630  [15]
 LDCM0314  AC51 HCT 116 C380(1.12)  LDD0631  [15]
 LDCM0315  AC52 HCT 116 C380(1.08)  LDD0632  [15]
 LDCM0316  AC53 HCT 116 C380(1.10)  LDD0633  [15]
 LDCM0317  AC54 HCT 116 C380(1.17)  LDD0634  [15]
 LDCM0318  AC55 HCT 116 C380(1.11)  LDD0635  [15]
 LDCM0319  AC56 HCT 116 C380(1.56)  LDD0636  [15]
 LDCM0320  AC57 HCT 116 C380(0.93)  LDD0637  [15]
 LDCM0321  AC58 HCT 116 C380(1.21)  LDD0638  [15]
 LDCM0322  AC59 HCT 116 C380(1.11)  LDD0639  [15]
 LDCM0323  AC6 HCT 116 C380(1.42)  LDD0640  [15]
 LDCM0324  AC60 HCT 116 C380(1.13)  LDD0641  [15]
 LDCM0325  AC61 HCT 116 C380(1.03)  LDD0642  [15]
 LDCM0326  AC62 HCT 116 C380(1.08)  LDD0643  [15]
 LDCM0327  AC63 HCT 116 C380(1.22)  LDD0644  [15]
 LDCM0328  AC64 HCT 116 C380(1.14)  LDD0645  [15]
 LDCM0329  AC65 HCT 116 C380(1.09)  LDD0646  [15]
 LDCM0330  AC66 HCT 116 C380(1.07)  LDD0647  [15]
 LDCM0331  AC67 HCT 116 C380(0.96)  LDD0648  [15]
 LDCM0332  AC68 HCT 116 C380(0.87)  LDD0649  [15]
 LDCM0333  AC69 HCT 116 C380(1.02)  LDD0650  [15]
 LDCM0334  AC7 HCT 116 C380(1.70)  LDD0651  [15]
 LDCM0335  AC70 HCT 116 C380(1.35)  LDD0652  [15]
 LDCM0336  AC71 HCT 116 C380(0.87)  LDD0653  [15]
 LDCM0337  AC72 HCT 116 C380(1.14)  LDD0654  [15]
 LDCM0338  AC73 HCT 116 C380(1.17)  LDD0655  [15]
 LDCM0339  AC74 HCT 116 C380(0.99)  LDD0656  [15]
 LDCM0340  AC75 HCT 116 C380(1.21)  LDD0657  [15]
 LDCM0341  AC76 HCT 116 C380(1.18)  LDD0658  [15]
 LDCM0342  AC77 HCT 116 C380(0.89)  LDD0659  [15]
 LDCM0343  AC78 HCT 116 C380(0.93)  LDD0660  [15]
 LDCM0344  AC79 HCT 116 C380(0.96)  LDD0661  [15]
 LDCM0345  AC8 HCT 116 C380(1.37)  LDD0662  [15]
 LDCM0346  AC80 HCT 116 C380(0.99)  LDD0663  [15]
 LDCM0347  AC81 HCT 116 C380(0.96)  LDD0664  [15]
 LDCM0348  AC82 HCT 116 C380(0.99)  LDD0665  [15]
 LDCM0349  AC83 HCT 116 C380(1.68)  LDD0666  [15]
 LDCM0350  AC84 HCT 116 C380(1.56)  LDD0667  [15]
 LDCM0351  AC85 HCT 116 C380(1.56)  LDD0668  [15]
 LDCM0352  AC86 HCT 116 C380(1.25)  LDD0669  [15]
 LDCM0353  AC87 HCT 116 C380(1.08)  LDD0670  [15]
 LDCM0354  AC88 HCT 116 C380(1.25)  LDD0671  [15]
 LDCM0355  AC89 HCT 116 C380(1.22)  LDD0672  [15]
 LDCM0357  AC90 HCT 116 C380(1.14)  LDD0674  [15]
 LDCM0358  AC91 HCT 116 C380(1.64)  LDD0675  [15]
 LDCM0359  AC92 HCT 116 C380(1.57)  LDD0676  [15]
 LDCM0360  AC93 HCT 116 C380(1.45)  LDD0677  [15]
 LDCM0361  AC94 HCT 116 C380(1.18)  LDD0678  [15]
 LDCM0362  AC95 HCT 116 C380(1.39)  LDD0679  [15]
 LDCM0363  AC96 HCT 116 C380(1.47)  LDD0680  [15]
 LDCM0364  AC97 HCT 116 C380(1.60)  LDD0681  [15]
 LDCM0365  AC98 HCT 116 C380(1.36)  LDD0682  [15]
 LDCM0366  AC99 HCT 116 C380(1.79)  LDD0683  [15]
 LDCM0248  AKOS034007472 HCT 116 C380(0.81)  LDD0565  [15]
 LDCM0356  AKOS034007680 HCT 116 C380(1.55)  LDD0673  [15]
 LDCM0275  AKOS034007705 HCT 116 C380(1.06)  LDD0592  [15]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0405  [1]
 LDCM0630  CCW28-3 231MFP C411(1.32)  LDD2214  [16]
 LDCM0632  CL-Sc Hep-G2 C380(20.00)  LDD2227  [8]
 LDCM0367  CL1 HCT 116 C380(2.46)  LDD0684  [15]
 LDCM0368  CL10 HCT 116 C380(1.15)  LDD0685  [15]
 LDCM0369  CL100 HCT 116 C380(1.30)  LDD0686  [15]
 LDCM0370  CL101 HCT 116 C380(1.43)  LDD0687  [15]
 LDCM0371  CL102 HCT 116 C380(1.35)  LDD0688  [15]
 LDCM0372  CL103 HCT 116 C380(1.01)  LDD0689  [15]
 LDCM0373  CL104 HCT 116 C380(1.08)  LDD0690  [15]
 LDCM0374  CL105 HEK-293T C380(1.14)  LDD0972  [15]
 LDCM0375  CL106 HEK-293T C380(1.08)  LDD0973  [15]
 LDCM0376  CL107 HEK-293T C380(0.85)  LDD0974  [15]
 LDCM0377  CL108 HEK-293T C380(1.23)  LDD0975  [15]
 LDCM0378  CL109 HEK-293T C380(1.00)  LDD0976  [15]
 LDCM0379  CL11 HCT 116 C380(2.43)  LDD0696  [15]
 LDCM0380  CL110 HEK-293T C380(1.02)  LDD0978  [15]
 LDCM0381  CL111 HEK-293T C380(0.90)  LDD0979  [15]
 LDCM0382  CL112 HCT 116 C380(2.50)  LDD0699  [15]
 LDCM0383  CL113 HCT 116 C380(1.54)  LDD0700  [15]
 LDCM0384  CL114 HCT 116 C380(4.06)  LDD0701  [15]
 LDCM0385  CL115 HCT 116 C380(2.17)  LDD0702  [15]
 LDCM0386  CL116 HCT 116 C380(1.39)  LDD0703  [15]
 LDCM0387  CL117 HCT 116 C380(8.38)  LDD0704  [15]
 LDCM0388  CL118 HCT 116 C380(1.39)  LDD0705  [15]
 LDCM0389  CL119 HCT 116 C380(1.18)  LDD0706  [15]
 LDCM0390  CL12 HCT 116 C380(1.52)  LDD0707  [15]
 LDCM0391  CL120 HCT 116 C380(0.95)  LDD0708  [15]
 LDCM0392  CL121 HCT 116 C380(1.33)  LDD0709  [15]
 LDCM0393  CL122 HCT 116 C380(2.57)  LDD0710  [15]
 LDCM0394  CL123 HCT 116 C380(11.53)  LDD0711  [15]
 LDCM0395  CL124 HCT 116 C380(2.91)  LDD0712  [15]
 LDCM0396  CL125 HCT 116 C380(1.28)  LDD0713  [15]
 LDCM0397  CL126 HCT 116 C380(5.52)  LDD0714  [15]
 LDCM0398  CL127 HCT 116 C380(1.80)  LDD0715  [15]
 LDCM0399  CL128 HCT 116 C380(0.96)  LDD0716  [15]
 LDCM0400  CL13 HCT 116 C380(2.01)  LDD0717  [15]
 LDCM0401  CL14 HCT 116 C380(1.66)  LDD0718  [15]
 LDCM0402  CL15 HCT 116 C380(2.67)  LDD0719  [15]
 LDCM0403  CL16 HCT 116 C380(1.25)  LDD0720  [15]
 LDCM0404  CL17 HCT 116 C380(1.86)  LDD0721  [15]
 LDCM0405  CL18 HCT 116 C380(1.42)  LDD0722  [15]
 LDCM0406  CL19 HCT 116 C380(1.15)  LDD0723  [15]
 LDCM0407  CL2 HCT 116 C380(3.97)  LDD0724  [15]
 LDCM0408  CL20 HCT 116 C380(0.80)  LDD0725  [15]
 LDCM0409  CL21 HCT 116 C380(2.81)  LDD0726  [15]
 LDCM0410  CL22 HCT 116 C380(2.38)  LDD0727  [15]
 LDCM0411  CL23 HCT 116 C380(1.18)  LDD0728  [15]
 LDCM0412  CL24 HCT 116 C380(1.24)  LDD0729  [15]
 LDCM0413  CL25 HCT 116 C380(1.71)  LDD0730  [15]
 LDCM0414  CL26 HCT 116 C380(1.30)  LDD0731  [15]
 LDCM0415  CL27 HCT 116 C380(1.23)  LDD0732  [15]
 LDCM0416  CL28 HCT 116 C380(3.05)  LDD0733  [15]
 LDCM0417  CL29 HCT 116 C380(1.16)  LDD0734  [15]
 LDCM0418  CL3 HCT 116 C380(4.30)  LDD0735  [15]
 LDCM0419  CL30 HCT 116 C380(0.97)  LDD0736  [15]
 LDCM0420  CL31 HCT 116 C380(1.33)  LDD0737  [15]
 LDCM0421  CL32 HCT 116 C380(1.54)  LDD0738  [15]
 LDCM0422  CL33 HCT 116 C380(1.20)  LDD0739  [15]
 LDCM0423  CL34 HCT 116 C380(1.20)  LDD0740  [15]
 LDCM0424  CL35 HCT 116 C380(1.20)  LDD0741  [15]
 LDCM0425  CL36 HCT 116 C380(1.23)  LDD0742  [15]
 LDCM0426  CL37 HCT 116 C380(0.92)  LDD0743  [15]
 LDCM0428  CL39 HCT 116 C380(0.93)  LDD0745  [15]
 LDCM0429  CL4 HCT 116 C380(4.22)  LDD0746  [15]
 LDCM0430  CL40 HCT 116 C380(1.08)  LDD0747  [15]
 LDCM0431  CL41 HCT 116 C380(0.97)  LDD0748  [15]
 LDCM0432  CL42 HCT 116 C380(0.72)  LDD0749  [15]
 LDCM0433  CL43 HCT 116 C380(1.01)  LDD0750  [15]
 LDCM0434  CL44 HCT 116 C380(1.07)  LDD0751  [15]
 LDCM0435  CL45 HCT 116 C380(1.07)  LDD0752  [15]
 LDCM0436  CL46 HCT 116 C380(2.33)  LDD0753  [15]
 LDCM0437  CL47 HCT 116 C380(1.66)  LDD0754  [15]
 LDCM0438  CL48 HCT 116 C380(1.39)  LDD0755  [15]
 LDCM0439  CL49 HCT 116 C380(1.43)  LDD0756  [15]
 LDCM0440  CL5 HCT 116 C380(1.54)  LDD0757  [15]
 LDCM0441  CL50 HCT 116 C380(1.74)  LDD0758  [15]
 LDCM0442  CL51 HCT 116 C380(0.78)  LDD0759  [15]
 LDCM0443  CL52 HCT 116 C380(1.37)  LDD0760  [15]
 LDCM0444  CL53 HCT 116 C380(1.66)  LDD0761  [15]
 LDCM0445  CL54 HCT 116 C380(2.20)  LDD0762  [15]
 LDCM0446  CL55 HCT 116 C380(1.02)  LDD0763  [15]
 LDCM0447  CL56 HCT 116 C380(2.05)  LDD0764  [15]
 LDCM0448  CL57 HCT 116 C380(1.95)  LDD0765  [15]
 LDCM0449  CL58 HCT 116 C380(1.53)  LDD0766  [15]
 LDCM0450  CL59 HCT 116 C380(1.45)  LDD0767  [15]
 LDCM0451  CL6 HCT 116 C380(2.70)  LDD0768  [15]
 LDCM0452  CL60 HCT 116 C380(1.48)  LDD0769  [15]
 LDCM0453  CL61 HCT 116 C380(1.48)  LDD0770  [15]
 LDCM0454  CL62 HCT 116 C380(1.67)  LDD0771  [15]
 LDCM0455  CL63 HCT 116 C380(2.04)  LDD0772  [15]
 LDCM0456  CL64 HCT 116 C380(2.57)  LDD0773  [15]
 LDCM0457  CL65 HCT 116 C380(1.51)  LDD0774  [15]
 LDCM0458  CL66 HCT 116 C380(2.70)  LDD0775  [15]
 LDCM0459  CL67 HCT 116 C380(1.74)  LDD0776  [15]
 LDCM0460  CL68 HCT 116 C380(3.49)  LDD0777  [15]
 LDCM0461  CL69 HCT 116 C380(4.24)  LDD0778  [15]
 LDCM0462  CL7 HCT 116 C380(1.78)  LDD0779  [15]
 LDCM0463  CL70 HCT 116 C380(1.62)  LDD0780  [15]
 LDCM0464  CL71 HCT 116 C380(1.73)  LDD0781  [15]
 LDCM0465  CL72 HCT 116 C380(1.29)  LDD0782  [15]
 LDCM0466  CL73 HCT 116 C380(1.76)  LDD0783  [15]
 LDCM0467  CL74 HCT 116 C380(1.71)  LDD0784  [15]
 LDCM0469  CL76 HCT 116 C380(2.88)  LDD0786  [15]
 LDCM0470  CL77 HCT 116 C380(12.54)  LDD0787  [15]
 LDCM0471  CL78 HCT 116 C380(1.96)  LDD0788  [15]
 LDCM0472  CL79 HCT 116 C380(1.23)  LDD0789  [15]
 LDCM0473  CL8 HCT 116 C380(2.52)  LDD0790  [15]
 LDCM0474  CL80 HCT 116 C380(0.95)  LDD0791  [15]
 LDCM0475  CL81 HCT 116 C380(1.49)  LDD0792  [15]
 LDCM0476  CL82 HCT 116 C380(1.47)  LDD0793  [15]
 LDCM0477  CL83 HCT 116 C380(4.53)  LDD0794  [15]
 LDCM0478  CL84 HCT 116 C380(2.74)  LDD0795  [15]
 LDCM0479  CL85 HCT 116 C380(1.50)  LDD0796  [15]
 LDCM0480  CL86 HCT 116 C380(1.53)  LDD0797  [15]
 LDCM0481  CL87 HCT 116 C380(2.10)  LDD0798  [15]
 LDCM0482  CL88 HCT 116 C380(1.03)  LDD0799  [15]
 LDCM0483  CL89 HCT 116 C380(1.18)  LDD0800  [15]
 LDCM0484  CL9 HCT 116 C380(6.07)  LDD0801  [15]
 LDCM0485  CL90 HCT 116 C380(3.87)  LDD0802  [15]
 LDCM0486  CL91 HCT 116 C380(1.39)  LDD0803  [15]
 LDCM0487  CL92 HCT 116 C380(2.28)  LDD0804  [15]
 LDCM0488  CL93 HCT 116 C380(1.60)  LDD0805  [15]
 LDCM0489  CL94 HCT 116 C380(1.85)  LDD0806  [15]
 LDCM0490  CL95 HCT 116 C380(1.94)  LDD0807  [15]
 LDCM0491  CL96 HCT 116 C380(1.96)  LDD0808  [15]
 LDCM0492  CL97 HCT 116 C380(1.89)  LDD0809  [15]
 LDCM0493  CL98 HCT 116 C380(1.53)  LDD0810  [15]
 LDCM0494  CL99 HCT 116 C380(1.66)  LDD0811  [15]
 LDCM0495  E2913 HEK-293T C380(3.30)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C380(3.66)  LDD1702  [7]
 LDCM0573  Fragment11 Ramos C380(0.64)  LDD2190  [18]
 LDCM0576  Fragment14 Ramos C380(1.18)  LDD2193  [18]
 LDCM0586  Fragment28 Ramos C380(0.47)  LDD2198  [18]
 LDCM0468  Fragment33 HCT 116 C380(4.51)  LDD0785  [15]
 LDCM0427  Fragment51 HCT 116 C380(1.03)  LDD0744  [15]
 LDCM0569  Fragment7 Ramos C380(0.98)  LDD2186  [18]
 LDCM0167  HOIPIN 11a MCF-7 1.78  LDD0424  [6]
 LDCM0022  KB02 T cell C380(18.52)  LDD1703  [19]
 LDCM0023  KB03 Jurkat C380(606.28); C380(4.77)  LDD0209  [10]
 LDCM0024  KB05 COLO792 C380(3.18)  LDD3310  [20]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C380(1.24)  LDD2102  [7]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C380(1.21)  LDD2090  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C380(0.88)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C380(1.22)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C380(1.00)  LDD2094  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C380(1.43)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C380(0.92)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C380(0.96)  LDD2100  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C380(1.24)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C380(0.93)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C380(0.78)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C380(0.87)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C380(0.97)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C380(1.00)  LDD2111  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C380(1.04)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C380(0.87)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C380(1.20)  LDD2127  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C380(0.97)  LDD2135  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C380(0.96)  LDD2137  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C380(0.91)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C380(0.69)  LDD2141  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C380(0.96)  LDD2146  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C380(0.89)  LDD2150  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C380(2.03)  LDD2153  [7]
 LDCM0029  Quercetin HEK-293T 4.86  LDD0181  [9]
 LDCM0002  Ward_cp1 U2OS 1.81  LDD0041  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenylate kinase 8 (AK8) Adenylate kinase family Q96MA6
Diacylglycerol O-acyltransferase 2-like protein 6 (DGAT2L6) Diacylglycerol acyltransferase family Q6ZPD8
Protein farnesyltransferase subunit beta (FNTB) Protein prenyltransferase subunit beta family P49356
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (PPP2R3C) . Q969Q6
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Voltage-gated purine nucleotide uniporter SLC17A9 (SLC17A9) Sodium/anion cotransporter family Q9BYT1
Sugar transporter SWEET1 (SLC50A1) SWEET sugar transporter family Q9BRV3
Synaptophysin (SYP) Synaptophysin/synaptobrevin family P08247
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
NF-kappa-B inhibitor delta (NFKBID) NF-kappa-B inhibitor family Q8NI38
PHD finger protein 1 (PHF1) Polycomblike family O43189
Other
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) CAMP-dependent kinase regulatory chain family P31321
Centrosomal protein of 76 kDa (CEP76) CEP76 family Q8TAP6
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin-associated protein 10-8 (KRTAP10-8) KRTAP type 10 family P60410
Paraneoplastic antigen Ma3 (PNMA3) PNMA family Q9UL41
Prefoldin subunit 5 (PFDN5) Prefoldin subunit alpha family Q99471
Nonsense-mediated mRNA decay factor SMG8 (SMG8) SMG8 family Q8ND04
Nonsense-mediated mRNA decay factor SMG9 (SMG9) SMG9 family Q9H0W8
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) TTC19 family Q6DKK2
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Arfaptin-2 (ARFIP2) . P53365
Heat shock factor 2-binding protein (HSF2BP) . O75031
Puratrophin-1 (PLEKHG4) . Q58EX7
Ras association domain-containing protein 10 (RASSF10) . A6NK89
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
3 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP. J Am Chem Soc. 2019 Feb 13;141(6):2703-2712. doi: 10.1021/jacs.8b13193. Epub 2019 Feb 4.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
9 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
10 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
11 Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3268-3272. doi: 10.1021/acschembio.6b00766. Epub 2016 Oct 31.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
15 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
16 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
19 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840