Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Backus_15  Probe Info 
Probe concentration 3 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name HOIPIN 11a  Competitor Info 
Competitor Concentration 30 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Invasive breast carcinoma [ICD-11:2C60]
Model Name Human invasive breast carcinoma cell lysate (MCF-7)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12744  Interleukin-1 receptor-associated kinase 4 (IRAK4) 3.0
 LDTP10269  E3 ubiquitin-protein ligase RNF31 (RNF31) 2.5
 LDTP09961  Probable ubiquitin carboxyl-terminal hydrolase FAF-X (USP9X) 2.3
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) 2.0
 LDTP11841  ATP-dependent DNA/RNA helicase DHX36 (DHX36) 1.9
 LDTP04185  Glutamate--cysteine ligase catalytic subunit (GCLC) 1.8
Other
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11192  Death-inducer obliterator 1 (DIDO1) 2.4
 LDTP11737  Nonsense-mediated mRNA decay factor SMG9 (SMG9) 1.8
 LDTP17715  S1 RNA-binding domain-containing protein 1 (SRBD1) 1.7

References

1 Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP. J Am Chem Soc. 2019 Feb 13;141(6):2703-2712. doi: 10.1021/jacs.8b13193. Epub 2019 Feb 4.