Details of the Target

General Information of Target

Target ID LDTP09961
Target Name Probable ubiquitin carboxyl-terminal hydrolase FAF-X (USP9X)
Gene Name USP9X
Gene ID 8239
Synonyms
DFFRX; FAM; USP9; Probable ubiquitin carboxyl-terminal hydrolase FAF-X; EC 3.4.19.12; Deubiquitinating enzyme FAF-X; Fat facets in mammals; hFAM; Fat facets protein-related, X-linked; Ubiquitin thioesterase FAF-X; Ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-X
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGETKIIYHLDGQETPYLVKLPLPAERVTLADFKGVLQRPSYKFFFKSMDDDFGVVKEEI
SDDNAKLPCFNGRVVSWLVSAEGSHPDPAPFCADNPSELPPPMERTGGIGDSRPPSFHPH
AGGGSQENLDNDTETDSLVSAQRERPRRRDGPEHATRLNGTAKGERRREPGGYDSSSTLM
SSELETTSFFDSDEDDSTSRFSSSTEQSSASRLMRRHKRRRRKQKVSRIERSSSFSSITD
STMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLL
QVNEINFENMSNDDAVRVLREIVHKPGPITLTVAKCWDPSPRGCFTLPRSEPIRPIDPAA
WVSHTAAMTGTFPAYGMSPSLSTITSTSSSITSSIPDTERLDDFHLSIHSDMAAIVKAMA
SPESGLEVRDRMWLKITIPNAFIGSDVVDWLYHNVEGFTDRREARKYASNLLKAGFIRHT
VNKITFSEQCYYIFGDLCGNMANLSLHDHDGSSGASDQDTLAPLPHPGAAPWPMAFPYQY
PPPPHPYNPHPGFPELGYSYGGGSASSQHSEGSRSSGSNRSGSDRRKEKDPKAGDSKSGG
SGSESDHTTRSSLRGPRERAPSERSGPAASEHSHRSHHSLASSLRSHHTHPSYGPPGVPP
LYGPPMLMMPPPPAAMGPPGAPPGRDLASVPPELTASRQSFRMAMGNPSEFFVDVM
Target Bioclass
Enzyme
Family
Peptidase C19 family
Subcellular location
Cytoplasm, cytosol
Function
Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-63'-, 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions. Deubiquitinates mTORC2 complex component RICTOR at 'Lys-294' by removing 'Lys-63'-linked polyubiquitin chains, stabilizing RICTOR and enhancing its binding to MTOR, thus promoting mTORC2 complex assembly. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Involved in axonal growth and neuronal cell migration. Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein BMAL1 via its deubiquitinating activity. Acts as a regulator of peroxisome import by mediating deubiquitination of PEX5: specifically deubiquitinates PEX5 monoubiquitinated at 'Cys-11' following its retrotranslocation into the cytosol, resetting PEX5 for a subsequent import cycle. Deubiquitinates PEG10.
Uniprot ID
Q93008
Ensemble ID
ENST00000324545.9
HGNC ID
HGNC:12632
ChEMBL ID
CHEMBL2406899

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.R2282I DBIA    Probe Info 
8305C SNV: p.I1795K DBIA    Probe Info 
A431 SNV: p.H69Y DBIA    Probe Info 
CAL51 SNV: p.R849Ter DBIA    Probe Info 
HEC1 SNV: p.R385Ter; p.R2085H DBIA    Probe Info 
HEC1B SNV: p.R385Ter .
IGROV1 SNV: p.H595R DBIA    Probe Info 
KMRC20 SNV: p.N2274I DBIA    Probe Info 
KP4 SNV: p.E1428D DBIA    Probe Info 
LNCaP clone FGC SNV: p.L2034M DBIA    Probe Info 
LOXIMVI Insertion: p.T1534NfsTer4 DBIA    Probe Info 
MCAS SNV: p.I2404V DBIA    Probe Info 
MCC13 SNV: p.M1044I DBIA    Probe Info 
MFE319 SNV: p.K2389E .
NALM6 SNV: p.Q952R DBIA    Probe Info 
NCIH1155 SNV: p.H238Y; p.S1872N DBIA    Probe Info 
NCIH1703 SNV: p.G233W DBIA    Probe Info 
OVK18 Insertion: p.F1447IfsTer6 DBIA    Probe Info 
PF382 SNV: p.Y648H; p.R2237H DBIA    Probe Info 
RKO SNV: p.R320M DBIA    Probe Info 
RL952 Deletion: p.Y1953MfsTer7
SNV: p.R492H		 DBIA    Probe Info 
SW1573 SNV: p.E2309D DBIA    Probe Info 
SW620 SNV: p.E1924D DBIA    Probe Info 
TOV21G Deletion: p.L28SfsTer51 DBIA    Probe Info 
WM2664 Insertion: p.E1541Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		9.31  LDD0402  [1]
A-EBA
 Probe Info  		4.66  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y648(11.75); Y1477(10.70); Y2455(8.98)  LDD0257  [4]
STPyne
 Probe Info  		K1045(7.02); K1056(6.49); K112(5.44); K1370(9.72)  LDD0277  [5]
BTD
 Probe Info  		C116(4.18)  LDD1699  [6]
Probe 1
 Probe Info  		Y598(11.29); Y1620(13.54); Y2540(7.06)  LDD3495  [7]
Backus_15
 Probe Info  		2.15  LDD0423  [8]
Johansson_61
 Probe Info  		_(20.00)  LDD1485  [9]
AHL-Pu-1
 Probe Info  		C842(2.74); C831(2.47); C673(3.51); C540(2.95)  LDD0168  [10]
HHS-465
 Probe Info  		Y367(2.99)  LDD2237  [11]
DBIA
 Probe Info  		C673(1.08); C1237(1.04); C842(0.99); C540(0.89)  LDD0078  [12]
ATP probe
 Probe Info  		K1370(0.00); K1993(0.00); K1627(0.00); K1632(0.00)  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C147(0.00); C673(0.00); C577(0.00); C1908(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C159(0.00); C1237(0.00); C831(0.00); C864(0.00)  LDD0032  [15]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [16]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C1061(0.00); C147(0.00); C673(0.00); C864(0.00)  LDD0037  [14]
NAIA_5
 Probe Info  		C673(0.00); C1237(0.00); C540(0.00); C674(0.00)  LDD2225  [17]
TFBX
 Probe Info  		N.A.  LDD0027  [18]
WYneN
 Probe Info  		C1451(0.00); C159(0.00); C1237(0.00); C540(0.00)  LDD0021  [19]
aHNE
 Probe Info  		N.A.  LDD0001  [19]
ENE
 Probe Info  		C116(0.00); C842(0.00)  LDD0006  [19]
IPM
 Probe Info  		C842(0.00); C193(0.00); C2238(0.00); C1237(0.00)  LDD0005  [19]
SF
 Probe Info  		Y367(0.00); Y1620(0.00)  LDD0028  [20]
VSF
 Probe Info  		C2238(0.00); C842(0.00); C673(0.00)  LDD0007  [19]
Acrolein
 Probe Info  		C864(0.00); C577(0.00); C1061(0.00)  LDD0217  [21]
Methacrolein
 Probe Info  		C864(0.00); C2293(0.00)  LDD0218  [21]
W1
 Probe Info  		C1908(0.00); C1237(0.00); C842(0.00); C540(0.00)  LDD0236  [22]
AOyne
 Probe Info  		6.70  LDD0443  [23]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [24]
Staurosporine capture compound
 Probe Info  		2.00  LDD0083  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C1724(0.54); C1061(2.17)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1061(1.54)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C1724(0.66)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1724(0.99)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1724(1.46); C1061(1.43); C1451(0.99); C116(1.13)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C1724(1.18); C1061(1.69)  LDD2152  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C1724(0.63); C147(0.92)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C1724(0.68); C1061(1.05)  LDD2131  [6]
 LDCM0025  4SU-RNA HEK-293T C842(2.74); C831(2.47); C673(3.51); C540(2.95)  LDD0168  [10]
 LDCM0026  4SU-RNA+native RNA HEK-293T C193(2.16); C842(2.84); C831(2.52); C673(3.33)  LDD0169  [10]
 LDCM0214  AC1 HCT 116 C673(0.73); C1061(0.94); C1237(0.99); C1340(0.77)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C673(1.46); C1061(1.00); C1237(0.87); C1340(1.04)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C673(0.96); C1061(0.60); C1237(0.97); C1340(0.86)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C673(0.98); C1061(0.68); C1237(1.05); C1340(0.74)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C673(0.96); C1061(0.64); C1237(0.97); C1340(0.76)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C673(1.07); C1061(0.68); C1237(1.18); C1340(0.71)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C673(1.22); C1061(0.69); C1237(1.06); C1340(0.81)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C673(1.05); C1061(0.67); C1237(1.06); C1340(0.76)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C673(1.01); C1061(0.66); C1237(1.12); C1340(0.67)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C673(1.24); C1061(0.71); C1237(1.41); C1340(0.79)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C673(0.93); C1061(0.69); C1237(0.94); C1340(0.84)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C673(0.95); C1061(0.73); C1237(0.91); C1340(0.90)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C673(1.00); C1061(0.89); C1237(1.09); C1340(0.99)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C673(0.91); C1061(0.62); C1237(1.00); C1340(1.42)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C673(1.05); C1061(0.69); C1237(0.99); C1340(0.80)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C673(1.07); C1061(0.68); C1237(1.16); C1340(0.72)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C673(1.08); C1237(1.05); C1340(1.05); C147(0.87)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C673(1.25); C1237(1.14); C1340(0.73); C147(0.89)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C673(1.37); C1237(1.30); C1340(0.80); C147(0.93)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C673(1.41); C1237(1.19); C1340(0.73); C147(0.87)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C673(1.13); C1237(0.99); C1340(0.85); C147(0.95)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C673(1.06); C1237(0.99); C1340(0.89); C147(0.78)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C673(1.03); C1237(1.15); C1340(0.74); C147(0.92)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C673(0.95); C1061(0.99); C1237(1.04); C1340(1.06)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C673(1.34); C1237(1.10); C1340(0.86); C147(0.80)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C673(0.98); C1237(0.88); C1340(1.02); C147(1.16)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C673(0.97); C1237(1.08); C1340(0.85); C147(0.87)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C673(1.03); C1237(0.99); C1340(1.08); C147(0.82)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C673(1.03); C1237(1.01); C1340(0.82); C147(1.02)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C673(1.07); C1237(0.91); C1340(0.87); C147(0.95)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C673(1.04); C1237(1.05); C1340(0.86); C147(0.96)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C673(0.95); C1237(1.04); C1340(0.79); C147(0.83)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C673(1.36); C1237(0.89); C147(1.08); C1724(1.42)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C673(1.22); C1237(1.10); C147(1.52); C1724(1.15)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C673(1.44); C1237(0.99); C147(1.67); C1724(1.13)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C673(1.01); C1237(0.88); C147(1.25); C1724(1.17)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C673(1.11); C1237(1.14); C147(1.78); C1724(0.93)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C673(2.19); C1237(1.02); C147(1.35); C1724(1.03)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C673(1.43); C1237(1.31); C147(1.49); C1724(0.88)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C673(1.56); C1237(1.04); C147(1.39); C1724(1.16)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C673(1.25); C1237(1.61); C147(1.53); C1724(1.04)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C673(1.25); C1237(1.24); C147(1.13); C1724(0.93)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C673(1.69); C1237(1.10); C147(1.08); C1724(0.70)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C673(1.07); C1237(1.12); C147(1.57); C1724(0.78)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C673(1.09); C1061(0.95); C1237(0.81); C1340(1.00)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C673(1.01); C1237(1.24); C147(1.72); C1724(0.73)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C673(1.33); C1237(1.23); C147(1.48); C1724(0.73)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C673(1.18); C1237(1.05); C147(1.53); C1724(0.82)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C673(1.27); C1237(0.82); C1908(0.83); C831(0.83)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C1920(0.72); C819(0.75); C1908(0.76); C692(0.78)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C1727(0.84); C831(0.90); C1340(0.93); C692(0.95)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C1340(0.77); C2390(0.79); C2398(0.79); C692(0.80)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C692(0.77); C683(0.77); C1920(0.78); C147(0.81)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C1340(0.79); C819(0.80); C1920(0.82); C2390(0.83)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C2390(0.67); C2398(0.67); C1340(0.67); C692(0.69)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C2390(0.74); C2398(0.74); C819(0.77); C147(0.78)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C2239(0.70); C683(0.71); C692(0.73); C2238(0.77)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C2239(0.71); C692(0.72); C683(0.73); C831(0.74)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C683(0.72); C692(0.73); C1920(0.79); C147(0.80)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C1920(0.73); C2390(0.80); C2398(0.80); C831(0.80)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C673(1.25); C1237(1.08); C1340(0.94); C147(0.79)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C673(1.23); C1237(1.09); C1340(0.98); C147(0.86)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C673(0.96); C1237(0.95); C1340(1.09); C147(0.88)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C673(1.13); C1237(0.89); C1340(1.01); C147(0.97)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C819(0.76); C1451(0.82); C1920(0.84); C673(0.94)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C819(0.73); C1451(0.77); C1340(0.82); C1724(0.89)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C1451(0.73); C1920(0.82); C819(0.85); C1340(0.88)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C2238(0.79); C673(0.83); C540(0.85); C1340(0.88)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C2238(0.79); C1920(0.82); C1451(0.83); C1340(0.84)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C1451(0.76); C1920(0.79); C819(0.80); C1727(0.87)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C1920(0.68); C842(0.88); C147(0.89); C1451(0.90)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C1920(0.74); C1451(0.76); C1724(0.92); C842(0.94)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C1451(0.82); C1727(0.87); C1920(0.90); C819(0.90)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C1237(0.73); C819(0.80); C1920(0.83); C692(0.87)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C1920(0.69); C1908(0.72); C1237(0.76); C683(0.78)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C1237(0.71); C1920(0.75); C819(0.75); C683(0.78)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C819(0.73); C1920(0.74); C2239(0.76); C1237(0.83)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C1908(0.62); C819(0.69); C683(0.81); C1920(0.83)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C2238(0.70); C540(0.74); C673(0.78); C1340(0.86)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C1908(0.60); C819(0.68); C577(0.76); C1237(0.77)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C1920(0.71); C1237(0.71); C1908(0.76); C819(0.77)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C1908(0.63); C819(0.64); C1920(0.69); C1237(0.71)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C1920(0.70); C819(0.73); C683(0.77); C577(0.85)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C1451(0.62); C819(0.68); C1920(0.69); C2239(0.73)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C1920(0.85); C1237(0.93); C831(0.94); C2238(0.98)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C1340(0.91); C2239(0.92); C1237(0.93); C2238(0.94)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C577(0.77); C2238(0.79); C2239(0.80); C1340(0.81)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C2238(0.86); C2239(0.89); C673(0.90); C831(0.91)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C673(0.80); C1451(0.88); C1237(0.95); C1920(0.96)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C673(0.76); C540(0.81); C683(0.81); C692(0.81)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C2239(0.68); C1340(0.78); C831(0.80); C2107(0.87)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C2239(0.52); C577(0.73); C2238(0.78); C831(0.80)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C2239(0.73); C1451(0.82); C831(0.82); C2238(0.91)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C577(0.75); C2239(0.81); C831(0.82); C673(0.88)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C2239(0.69); C831(0.84); C577(0.91); C2238(0.92)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C2239(0.61); C2238(0.70); C1340(0.75); C577(0.84)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C1727(0.81); C577(0.84); C540(0.89); C1340(0.89)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C1727(0.74); C577(0.84); C2239(0.86); C1340(0.89)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C673(0.73); C1727(0.78); C1340(0.80); C1237(0.95)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C1727(0.78); C577(0.78); C2239(0.84); C819(0.90)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C2238(0.70); C1340(0.75); C673(0.81); C683(0.84)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C1920(0.80); C1727(0.81); C1340(0.85); C577(0.85)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C1727(0.70); C673(0.76); C692(0.85); C577(0.97)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C1727(0.69); C577(0.87); C2239(0.93); C819(0.95)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C1727(0.74); C540(0.92); C577(0.94); C1724(0.96)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C1727(0.79); C819(0.86); C1724(0.88); C1340(0.92)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C1727(0.70); C2239(0.71); C1920(0.80); C1724(0.88)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C1727(0.64); C2239(0.81); C1724(0.82); C1920(0.89)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C683(0.76); C692(0.76); C831(0.76); C1451(0.84)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C1451(0.79); C831(0.82); C1908(0.83); C683(0.84)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C1920(0.67); C831(0.69); C683(0.75); C692(0.75)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C2075(0.74); C577(0.80); C1724(0.81); C1727(0.81)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C1920(0.70); C683(0.73); C692(0.73); C1908(0.79)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C683(0.80); C692(0.80); C1451(0.82); C1908(0.88)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C1908(0.76); C1451(0.79); C683(0.83); C692(0.83)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C683(0.78); C692(0.78); C1908(0.78); C1920(0.79)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C1727(0.74); C1908(0.79); C683(0.84); C692(0.84)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C683(0.78); C692(0.78); C831(0.83); C1340(0.85)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C683(0.87); C692(0.87); C1340(0.88); C1237(0.88)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C1908(0.74); C1920(0.75); C683(0.75); C692(0.75)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C1727(0.75); C842(0.80); C540(0.81); C819(0.83)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C1237(0.90); C2238(0.90); C1727(0.91); C2239(0.93)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C2075(0.64); C1451(0.76); C577(0.83); C2238(0.84)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C831(0.62); C1340(0.68); C2239(0.78); C819(0.81)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C842(0.80); C819(0.80); C1237(0.83); C540(0.93)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C1340(0.82); C819(0.90); C831(0.92); C577(0.92)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C673(1.61); C2239(0.75); C2238(0.81); C540(0.81)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C842(0.91); C819(0.95); C1237(0.95); C1727(0.97)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C1727(0.85); C577(0.92); C1724(0.92); C1237(0.99)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C819(0.81); C540(0.89); C1340(0.92); C2239(0.94)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C819(0.78); C1340(0.79); C1727(0.83); C842(0.84)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C1727(0.86); C819(0.91); C1340(0.91); C2238(0.92)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C1727(0.81); C819(0.86); C1340(0.86); C540(0.88)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C1451(0.75); C1724(0.80); C1727(0.80); C1920(0.84)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C819(0.85); C831(0.92); C540(1.01); C1451(1.01)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C2075(0.26); C819(0.84); C1727(0.89); C831(0.91)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C819(0.83); C842(0.96); C540(0.98); C1724(1.02)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C577(0.63); C1340(0.73); C831(0.81); C683(0.82)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C577(0.68); C1340(0.73); C683(0.75); C692(0.75)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C577(0.65); C1340(0.67); C831(0.73); C683(0.80)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C577(0.72); C1908(0.79); C1340(0.80); C1920(0.85)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C1340(0.78); C1920(0.86); C2238(0.90); C683(0.93)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C831(0.77); C1340(0.77); C1920(0.81); C577(0.89)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C1340(0.72); C577(0.73); C1061(0.83); C1920(0.86)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C673(0.77); C577(0.84); C2238(0.92); C540(0.95)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C1340(0.65); C1908(0.66); C831(0.74); C1920(0.78)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C1340(0.79); C831(0.79); C683(0.81); C692(0.81)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C1920(0.73); C1340(0.75); C577(0.76); C831(0.77)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C683(0.65); C692(0.65); C1340(0.76); C1061(0.82)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C1340(0.72); C1908(0.72); C577(0.74); C831(0.82)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C1340(0.67); C1061(0.80); C683(0.85); C692(0.85)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C1908(0.56); C577(0.64); C1340(0.66); C683(0.66)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C1340(0.68); C683(0.71); C1908(0.76); C1061(0.76)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C1061(0.72); C1908(0.80); C1724(0.81); C1727(0.81)  LDD0683  [12]
 LDCM0545  Acetamide MDA-MB-231 C1724(0.46); C1061(0.50)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C1724(0.87); C1061(0.96)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C673(0.92); C1061(1.13); C1237(0.96); C1340(0.97)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C1451(0.63); C577(0.79); C683(0.83); C2390(0.84)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C2390(0.71); C2398(0.71); C1724(0.74); C1727(0.74)  LDD0592  [12]
 LDCM0020  ARS-1620 HCC44 C673(1.08); C1237(1.04); C842(0.99); C540(0.89)  LDD0078  [12]
 LDCM0498  BS-3668 MDA-MB-231 C1724(0.70); C1061(0.83)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C864(0.00); H372(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C673(20.00); C1237(20.00); C831(5.40); C673(1.75)  LDD2227  [17]
 LDCM0367  CL1 HCT 116 C2107(0.80); C1061(0.86); C683(0.88); C692(0.88)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C2107(0.65); C1061(0.74); C683(0.82); C692(0.82)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C540(0.64); C1340(0.71); C2238(0.73); C673(0.75)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C1451(0.68); C2390(0.69); C2398(0.69); C1237(0.72)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C1451(0.74); C1237(0.79); C2075(0.81); C673(0.86)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C2390(0.77); C2398(0.77); C673(0.77); C1451(0.78)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C1451(0.68); C2390(0.81); C2398(0.81); C1237(0.83)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C1920(0.67); C1451(0.70); C819(0.78); C1724(0.90)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C1451(0.72); C819(0.76); C1920(0.77); C1724(0.87)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C1920(0.75); C819(0.76); C1340(0.79); C1451(0.80)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C819(0.75); C1451(0.77); C1920(0.90); C2238(0.92)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C1920(0.66); C1451(0.67); C819(0.79); C1340(0.82)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C2107(0.66); C1061(0.69); C2390(0.76); C2398(0.76)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C1451(0.65); C819(0.75); C1920(0.79); C1724(0.83)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C1451(0.73); C1920(0.77); C819(0.79); C1340(0.84)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C1237(0.74); C819(0.82); C1908(0.84); C540(0.91)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C1908(0.60); C1451(0.65); C1920(0.66); C819(0.66)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C1451(0.52); C1908(0.55); C819(0.71); C1727(0.73)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C1908(0.65); C1451(0.67); C819(0.69); C683(0.71)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C683(0.70); C819(0.77); C1451(0.79); C1920(0.79)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C831(0.81); C1920(0.89); C2239(0.92); C1451(0.95)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C577(0.77); C2239(0.82); C831(0.83); C1920(0.88)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C577(0.79); C673(0.88); C1451(0.92); C1340(0.93)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C2107(0.41); C2390(0.73); C2398(0.73); C1061(0.77)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C577(0.74); C2239(0.80); C673(0.85); C2238(0.88)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C831(0.44); C1724(0.53); C692(0.62); C683(0.67)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C2239(0.61); C1727(0.71); C1340(0.88); C2238(0.91)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C1727(0.75); C831(0.77); C1724(0.83); C2239(0.86)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C1727(0.69); C1340(0.89); C819(0.92); C1724(0.92)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C831(0.62); C673(0.88); C683(0.89); C692(0.89)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C683(0.68); C692(0.68); C1920(0.79); C1908(0.83)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C683(0.76); C692(0.76); C1727(0.79); C831(0.81)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C831(0.73); C1451(0.76); C683(0.81); C692(0.81)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C2107(0.44); C1061(0.72); C1451(0.89); C683(0.91)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C2107(0.67); C1061(0.68); C2075(0.79); C1451(0.81)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C2107(0.50); C2075(0.71); C2390(0.79); C2398(0.79)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C2238(0.79); C2239(0.81); C1451(0.81); C1920(0.85)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C1920(0.77); C540(0.82); C819(0.87); C2390(0.93)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C1920(0.71); C683(0.78); C692(0.78); C1451(0.83)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C1920(0.77); C2390(0.83); C2398(0.83); C819(0.83)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C2107(0.59); C683(0.80); C692(0.80); C1451(0.91)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C1920(0.72); C819(0.78); C683(0.81); C692(0.81)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C1920(0.75); C673(0.87); C577(0.89); C1451(0.90)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C2390(0.74); C2398(0.74); C1724(0.78); C1727(0.78)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C1920(0.68); C819(0.82); C1451(0.82); C1724(0.89)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C673(1.13); C1237(1.10); C1340(0.96); C1451(0.87)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C673(0.96); C1237(1.20); C1340(0.88); C1451(0.86)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C673(1.18); C1237(1.29); C1340(1.03); C1451(0.83)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C673(1.09); C1237(1.02); C1340(1.02); C1451(0.90)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C673(1.00); C1237(1.16); C1340(1.05); C1451(0.84)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C673(1.21); C1237(1.09); C1340(0.96); C1451(0.83)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C673(1.01); C1061(0.95); C1237(0.90); C1340(0.96)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C673(1.01); C1237(1.20); C1340(0.96); C1451(0.92)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C673(1.22); C1237(1.07); C1340(0.89); C1451(0.98)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C673(1.64); C1237(1.11); C1340(0.77); C1451(0.95)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C673(2.59); C1237(1.27); C1340(1.00); C1451(0.81)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C673(1.61); C1237(0.98); C1340(1.16); C1451(1.01)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C673(1.83); C1237(1.09); C1340(1.02); C1451(0.72)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C673(1.57); C1237(1.07); C1340(1.08); C1451(0.76)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C673(1.72); C1237(1.15); C1340(0.99); C1451(0.83)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C673(4.01); C1237(1.14); C1340(0.95); C1451(0.84)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C673(1.29); C1061(0.68); C1237(1.09); C1340(1.01)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C673(3.79); C1237(2.00); C1340(0.95); C1451(0.76)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C673(1.49); C1237(1.04); C1340(0.97); C1451(0.79)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C673(1.88); C1237(1.28); C1340(1.08); C1451(0.87)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C673(1.67); C1237(1.10); C1340(1.12); C1451(0.87)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C673(2.21); C1237(1.20); C1340(0.92); C1451(0.77)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C673(1.93); C1237(1.05); C1340(0.93); C1451(0.78)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C673(1.18); C1237(1.20); C1340(1.29); C1451(0.95)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C673(0.80); C1237(1.04); C1340(1.13); C1451(0.94)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C673(0.78); C1237(1.15); C1340(1.16); C1451(0.89)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C673(0.81); C1237(1.07); C1340(1.47); C1451(1.02)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C673(1.05); C1061(0.88); C1237(0.95); C1340(0.91)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C673(0.78); C1237(1.12); C1340(1.10); C1451(0.89)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C673(0.70); C1237(1.04); C1340(1.09); C1451(1.01)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C673(0.84); C1237(1.12); C1340(1.05); C1451(0.89)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C673(1.10); C1237(0.85); C1340(1.34); C1451(0.92)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C673(0.74); C1237(1.07); C1340(1.20); C1451(0.77)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C673(0.75); C1237(1.05); C1340(1.29); C1451(0.91)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C673(0.90); C1237(1.11); C1340(0.96); C1451(0.77)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C673(0.85); C1237(0.97); C1340(1.13); C1451(0.88)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C673(0.76); C1237(1.05); C1340(1.19); C1451(0.78)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C673(0.94); C1237(1.02); C1340(1.04); C1451(0.79)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C673(0.93); C1061(0.75); C1237(1.02); C1340(0.98)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C673(0.97); C1237(1.06); C1340(1.36); C1451(0.71)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C673(1.14); C1237(1.02); C1340(0.78); C1451(1.03)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C673(0.93); C1237(0.96); C1340(0.81); C1451(0.94)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C673(1.09); C1237(1.16); C1340(0.66); C1451(0.88)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C673(1.30); C1237(1.43); C1340(0.74); C1451(0.86)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C673(1.02); C1237(1.14); C1340(0.69); C1451(0.92)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C673(1.51); C1237(1.54); C1340(0.63); C1451(0.89)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C673(1.52); C1237(1.36); C1340(0.72); C1451(0.89)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C673(1.83); C1237(1.17); C1340(0.68); C1451(0.93)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C673(1.21); C1237(1.15); C1340(0.84); C1451(0.88)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C673(0.98); C1061(0.80); C1237(1.19); C1340(0.90)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C673(1.15); C1237(1.21); C1340(0.74); C1451(0.90)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C673(1.34); C1237(1.28); C1340(0.68); C1451(0.94)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C673(1.28); C1237(1.00); C1340(0.88); C1451(0.98)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C673(1.16); C1237(1.17); C1340(1.28); C1451(0.84)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C673(1.37); C1237(1.16); C1340(0.85); C1451(0.87)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C673(1.05); C1061(0.95); C1237(0.94); C1340(1.11)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C673(1.04); C1061(0.73); C1237(0.94); C1340(1.52)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C673(1.13); C1061(0.86); C1237(1.13); C1340(0.87)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C673(0.94); C1061(0.97); C1237(1.22); C1340(1.00)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C673(1.28); C1061(0.75); C1237(1.74); C1340(1.09)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C673(0.93); C1061(0.95); C1237(0.93); C1340(1.36)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C673(0.73); C1061(0.94); C1237(1.05); C1340(1.03)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C673(0.74); C1061(1.02); C1237(1.39); C1340(1.02)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C673(0.88); C1061(0.94); C1237(1.39); C1340(0.99)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C673(1.03); C1061(1.11); C1237(1.54); C1340(1.01)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C673(1.03); C1061(0.88); C1237(1.18); C1340(0.99)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C673(0.97); C1061(0.99); C1237(1.15); C1340(0.96)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C673(0.70); C1061(1.01); C1237(1.12); C1340(1.00)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C673(0.75); C1061(0.97); C1237(1.39); C1340(0.99)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C673(0.87); C1061(1.29); C1237(1.66); C1340(0.98)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C673(4.30); C1061(0.75); C1237(1.10); C1340(0.91)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C673(1.37); C1061(1.25); C1237(1.00); C1340(0.91)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C673(1.06); C1061(0.97); C1237(1.04); C1340(0.93)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C673(1.13); C1061(0.95); C1237(1.07); C1340(1.00)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C673(0.72); C1061(0.90); C1237(0.89); C1340(0.90)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C673(0.93); C1061(0.95); C1237(0.88); C1340(0.70)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C673(0.84); C1061(0.89); C1237(0.97); C1340(0.89)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C673(0.94); C1061(0.92); C1237(0.95); C1340(0.81)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C673(0.94); C1061(0.78); C1237(1.05); C1340(0.81)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C673(1.20); C1061(0.96); C1237(1.04); C1340(0.73)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C673(1.36); C1061(0.95); C1237(0.89); C1340(0.95)  LDD0811  [12]
 LDCM0634  CY-0357 Hep-G2 C673(0.55)  LDD2228  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C1451(9.43); C1061(3.77)  LDD1702  [6]
 LDCM0625  F8 Ramos C2293(1.25); C159(0.78); C147(1.42); C1237(0.94)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C2293(0.98); C1451(2.40); C159(0.91); C673(0.95)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C2293(4.18); C1451(1.27); C147(16.12); C673(0.84)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C2293(1.73); C159(1.53); C1237(5.10); C673(0.69)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C2293(0.93); C1451(1.66); C159(0.81); C1237(1.30)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C2293(1.52); C159(2.91); C147(0.96); C1237(1.71)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C2293(2.79); C159(1.80); C2107(2.20); C540(4.82)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C2293(1.07); C159(1.13); C1237(0.62); C673(0.90)  LDD2195  [26]
 LDCM0582  Fragment23 Ramos C2293(1.89); C1451(1.39); C159(1.66); C1237(2.31)  LDD2196  [26]
 LDCM0578  Fragment27 Ramos C2293(0.96); C1451(3.76); C159(0.90); C1237(1.09)  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C2293(0.70); C1451(0.48); C159(0.88); C147(0.27)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C2293(1.11); C1451(1.92); C159(0.85); C1237(1.97)  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C2293(1.09); C159(0.94); C673(1.02); 1.20  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C2293(0.98); C159(0.96); C673(0.57); C2107(1.47)  LDD2201  [26]
 LDCM0468  Fragment33 HCT 116 C673(1.59); C1237(1.22); C1340(0.75); C1451(0.88)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C2293(0.92); C1451(1.57); C159(0.92); C1237(1.33)  LDD2203  [26]
 LDCM0566  Fragment4 Ramos C2293(1.27); C159(1.36); C1237(1.68); C673(0.52)  LDD2184  [26]
 LDCM0427  Fragment51 HCT 116 C673(1.63); C1237(1.43); C1340(1.14); C1451(0.83)  LDD0744  [12]
 LDCM0610  Fragment52 Ramos C2293(1.37); C159(4.86); C673(0.93); 1.02  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C2293(1.39); C1451(1.62); C159(0.98); C1237(0.50)  LDD2205  [26]
 LDCM0569  Fragment7 Jurkat _(20.00)  LDD1485  [9]
 LDCM0571  Fragment9 Ramos C2293(3.89); C159(1.82); C864(2.26); C577(1.81)  LDD2188  [26]
 LDCM0167  HOIPIN 11a HEK-293T 2.15  LDD0423  [8]
 LDCM0022  KB02 HCT 116 C1724(1.67); C1727(1.67); C2238(6.93); C2239(6.93)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C1724(4.23); C1727(4.23); C2238(1.98); C2239(1.98)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C1724(3.72); C1727(3.72); C2238(2.46); C2239(2.46)  LDD0082  [12]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1724(1.12); C1061(1.02)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C1724(0.84); C1061(0.88)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0224  [21]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C1061(1.13)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C1061(1.40)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1724(1.16); C1061(1.15)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C1061(1.71); C1451(1.22)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C1724(1.30); C1061(0.59)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C1061(0.53)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C1724(1.40)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1724(1.40); C1061(1.00)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1724(1.43); C1451(0.97); C116(0.85)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1724(0.86)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C116(0.95)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C1724(0.62); C1061(1.34)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1724(1.02); C1061(1.61)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1724(1.09); C1061(1.40); C1451(1.14); C116(0.88)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1724(0.60)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1724(0.86); C2387(0.93)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1724(0.96); C1061(1.24)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1724(0.56)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C1724(0.64)  LDD2115  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1724(1.18); C1061(1.43)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C1724(0.52); C1061(0.70)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1061(0.57)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C1061(0.95)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C1061(0.56)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C1724(0.98); C1061(1.05); C1451(0.98); C116(0.75)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C1061(0.54)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1724(1.12); C116(0.99); C2387(1.02); C2239(1.18)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1724(0.42)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1724(0.94); C1061(1.39)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C1724(0.71)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C1061(0.53)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1724(0.98); C1061(1.52); C1451(1.37); C116(0.48)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1724(1.23); C116(1.18)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1061(1.27); C1451(1.20); C116(0.92); C2387(1.06)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C1061(2.77); C1724(1.93)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1724(1.11); C1061(1.33); C1451(1.06); C116(0.63)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C1724(0.82)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C1724(0.40); C1061(0.48)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1724(1.68); C1061(1.72); C116(0.87)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C1724(2.02)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1724(1.05); C1061(1.35); C1451(0.99); C116(0.83)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C1724(0.57)  LDD2147  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C1724(0.74); C1061(1.03); C116(0.28)  LDD2150  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C1061(2.27)  LDD2153  [6]
 LDCM0628  OTUB2-COV-1 HEK-293T C2293(0.70)  LDD2207  [27]
 LDCM0019  Staurosporine Hep-G2 2.00  LDD0083  [25]
 LDCM0021  THZ1 HCT 116 C1451(1.08); C1237(1.11); C540(1.03)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NUAK family SNF1-like kinase 1 (NUAK1) CAMK Ser/Thr protein kinase family O60285
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mothers against decapentaplegic homolog 4 (SMAD4) Dwarfin/SMAD family Q13485
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) Bcl-2 family Q07820

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP. J Am Chem Soc. 2019 Feb 13;141(6):2703-2712. doi: 10.1021/jacs.8b13193. Epub 2019 Feb 4.
9 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
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Mass spectrometry data entry: PXD027578
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