Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name Backus_15  Probe Info 
Probe concentration 3 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name HOIPIN 11a  Competitor Info 
Competitor Concentration 30 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cell lysate (HEK-293T)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP10269  E3 ubiquitin-protein ligase RNF31 (RNF31) 4.9
 LDTP12744  Interleukin-1 receptor-associated kinase 4 (IRAK4) 3.2
 LDTP10320  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (TRMT61A) 2.5
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) 2.4
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) 2.3
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 2.2
 LDTP09961  Probable ubiquitin carboxyl-terminal hydrolase FAF-X (USP9X) 2.1
 LDTP03118  Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) 2.0
 LDTP12675  Ethanolamine kinase 2 (ETNK2) 2.0
 LDTP11841  ATP-dependent DNA/RNA helicase DHX36 (DHX36) 1.9
Other
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP11192  Death-inducer obliterator 1 (DIDO1) 2.0
 LDTP17715  S1 RNA-binding domain-containing protein 1 (SRBD1) 1.8

References

1 Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP. J Am Chem Soc. 2019 Feb 13;141(6):2703-2712. doi: 10.1021/jacs.8b13193. Epub 2019 Feb 4.