Details of the Target

General Information of Target

Target ID LDTP03118
Target Name Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)
Gene Name TNFAIP3
Gene ID 7128
Synonyms
OTUD7C; Tumor necrosis factor alpha-induced protein 3; TNF alpha-induced protein 3; EC 2.3.2.-; EC 3.4.19.12; OTU domain-containing protein 7C; Putative DNA-binding protein A20; Zinc finger protein A20) [Cleaved into: A20p50; A20p37]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEQVLPQALYLSNMRKAVKIRERTPEDIFKPTNGIIHHFKTMHRYTLEMFRTCQFCPQF
REIIHKALIDRNIQATLESQKKLNWCREVRKLVALKTNGDGNCLMHATSQYMWGVQDTDL
VLRKALFSTLKETDTRNFKFRWQLESLKSQEFVETGLCYDTRNWNDEWDNLIKMASTDTP
MARSGLQYNSLEEIHIFVLCNILRRPIIVISDKMLRSLESGSNFAPLKVGGIYLPLHWPA
QECYRYPIVLGYDSHHFVPLVTLKDSGPEIRAVPLVNRDRGRFEDLKVHFLTDPENEMKE
KLLKEYLMVIEIPVQGWDHGTTHLINAAKLDEANLPKEINLVDDYFELVQHEYKKWQENS
EQGRREGHAQNPMEPSVPQLSLMDVKCETPNCPFFMSVNTQPLCHECSERRQKNQNKLPK
LNSKPGPEGLPGMALGASRGEAYEPLAWNPEESTGGPHSAPPTAPSPFLFSETTAMKCRS
PGCPFTLNVQHNGFCERCHNARQLHASHAPDHTRHLDPGKCQACLQDVTRTFNGICSTCF
KRTTAEASSSLSTSLPPSCHQRSKSDPSRLVRSPSPHSCHRAGNDAPAGCLSQAARTPGD
RTGTSKCRKAGCVYFGTPENKGFCTLCFIEYRENKHFAAASGKVSPTASRFQNTIPCLGR
ECGTLGSTMFEGYCQKCFIEAQNQRFHEAKRTEEQLRSSQRRDVPRTTQSTSRPKCARAS
CKNILACRSEELCMECQHPNQRMGPGAHRGEPAPEDPPKQRCRAPACDHFGNAKCNGYCN
ECFQFKQMYG
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Peptidase C64 family
Subcellular location
Cytoplasm
Function
Ubiquitin-editing enzyme that contains both ubiquitin ligase and deubiquitinase activities. Involved in immune and inflammatory responses signaled by cytokines, such as TNF-alpha and IL-1 beta, or pathogens via Toll-like receptors (TLRs) through terminating NF-kappa-B activity. Essential component of a ubiquitin-editing protein complex, comprising also RNF11, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. In cooperation with TAX1BP1 promotes disassembly of E2-E3 ubiquitin protein ligase complexes in IL-1R and TNFR-1 pathways; affected are at least E3 ligases TRAF6, TRAF2 and BIRC2, and E2 ubiquitin-conjugating enzymes UBE2N and UBE2D3. In cooperation with TAX1BP1 promotes ubiquitination of UBE2N and proteasomal degradation of UBE2N and UBE2D3. Upon TNF stimulation, deubiquitinates 'Lys-63'-polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Deubiquitinates TRAF6 probably acting on 'Lys-63'-linked polyubiquitin. Upon T-cell receptor (TCR)-mediated T-cell activation, deubiquitinates 'Lys-63'-polyubiquitin chains on MALT1 thereby mediating disassociation of the CBM (CARD11:BCL10:MALT1) and IKK complexes and preventing sustained IKK activation. Deubiquitinates NEMO/IKBKG; the function is facilitated by TNIP1 and leads to inhibition of NF-kappa-B activation. Upon stimulation by bacterial peptidoglycans, probably deubiquitinates RIPK2. Can also inhibit I-kappa-B-kinase (IKK) through a non-catalytic mechanism which involves polyubiquitin; polyubiquitin promotes association with IKBKG and prevents IKK MAP3K7-mediated phosphorylation. Targets TRAF2 for lysosomal degradation. In vitro able to deubiquitinate 'Lys-11'-, 'Lys-48'- and 'Lys-63' polyubiquitin chains. Inhibitor of programmed cell death. Has a role in the function of the lymphoid system. Required for LPS-induced production of pro-inflammatory cytokines and IFN beta in LPS-tolerized macrophages.
TTD ID
T56474
Uniprot ID
P21580
DrugMap ID
TT5W0IO
Ensemble ID
ENST00000237289.8
HGNC ID
HGNC:11896
ChEMBL ID
CHEMBL4523200

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
Backus_15
 Probe Info  		2.05  LDD0423  [2]
DBIA
 Probe Info  		C536(1.12); C539(1.12); C387(1.04); C392(1.04)  LDD0078  [3]
4-Iodoacetamidophenylacetylene
 Probe Info  		C767(0.00); C677(0.00); C158(0.00); C243(0.00)  LDD0038  [4]
IA-alkyne
 Probe Info  		C767(0.00); C677(0.00)  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		C657(0.00); C243(0.00)  LDD0037  [4]
NAIA_4
 Probe Info  		C559(0.00); C590(0.00)  LDD2226  [5]
TFBX
 Probe Info  		C677(0.00); C590(0.00)  LDD0027  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C54(1.09); C57(1.11)  LDD0812  [3]
 LDCM0215  AC10 HCT 116 C54(1.22); C57(1.22); C662(0.94); C674(0.94)  LDD0532  [3]
 LDCM0216  AC100 HEK-293T C57(1.09); C624(0.93); C627(0.93)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C57(1.12); C624(0.91); C627(0.91)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C57(1.25); C624(0.98); C627(0.98)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C57(1.14); C624(1.02); C627(1.02)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C57(1.23); C624(1.02); C627(1.02)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C57(0.98); C624(0.86); C627(0.86)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C57(0.86); C624(0.90); C627(0.90)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C57(1.09); C624(0.88); C627(0.88)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C57(1.03); C624(1.19); C627(1.19)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C57(1.13); C624(1.07); C627(1.07)  LDD0823  [3]
 LDCM0226  AC11 HCT 116 C54(1.27); C57(1.27); C662(1.00); C674(1.00)  LDD0543  [3]
 LDCM0227  AC110 HEK-293T C57(1.18); C624(0.89); C627(0.89)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C57(1.32); C624(0.94); C627(0.94)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C57(1.25); C624(0.87); C627(0.87)  LDD0827  [3]
 LDCM0230  AC113 HEK-293T C54(1.05); C57(1.15); C612(1.28); C662(1.05)  LDD0828  [3]
 LDCM0231  AC114 HEK-293T C54(1.00); C57(0.98); C612(1.48); C662(0.99)  LDD0829  [3]
 LDCM0232  AC115 HEK-293T C54(1.12); C57(1.29); C612(1.03); C662(1.14)  LDD0830  [3]
 LDCM0233  AC116 HEK-293T C54(1.23); C57(1.48); C612(1.54); C662(0.75)  LDD0831  [3]
 LDCM0234  AC117 HEK-293T C54(1.08); C57(1.22); C612(1.01); C662(0.91)  LDD0832  [3]
 LDCM0235  AC118 HEK-293T C54(0.92); C57(0.89); C612(1.24); C662(1.09)  LDD0833  [3]
 LDCM0236  AC119 HEK-293T C54(1.01); C57(1.01); C612(1.32); C662(1.06)  LDD0834  [3]
 LDCM0237  AC12 HCT 116 C54(1.10); C57(1.10); C662(0.79); C674(0.79)  LDD0554  [3]
 LDCM0238  AC120 HEK-293T C54(0.93); C57(0.96); C612(1.31); C662(1.24)  LDD0836  [3]
 LDCM0239  AC121 HEK-293T C54(1.16); C57(1.40); C612(1.10); C662(1.24)  LDD0837  [3]
 LDCM0240  AC122 HEK-293T C54(1.10); C57(1.25); C612(1.87); C662(1.37)  LDD0838  [3]
 LDCM0241  AC123 HEK-293T C54(1.08); C57(1.18); C612(1.38); C662(1.01)  LDD0839  [3]
 LDCM0242  AC124 HEK-293T C54(1.15); C57(1.38); C612(1.39); C662(1.39)  LDD0840  [3]
 LDCM0243  AC125 HEK-293T C54(1.04); C57(1.15); C612(1.37); C662(1.34)  LDD0841  [3]
 LDCM0244  AC126 HEK-293T C54(2.23); C57(3.41); C612(1.38); C662(1.31)  LDD0842  [3]
 LDCM0245  AC127 HEK-293T C54(1.87); C57(2.55); C612(1.46); C662(1.38)  LDD0843  [3]
 LDCM0246  AC128 HEK-293T C624(1.33); C627(1.33)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C624(1.13); C627(1.13)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C624(1.01); C627(1.01)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C624(1.17); C627(1.17)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C624(0.93); C627(0.93)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C624(1.11); C627(1.11)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C624(1.43); C627(1.43)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C624(1.42); C627(1.42)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C624(1.33); C627(1.33)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C624(1.36); C627(1.36)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C624(1.27); C627(1.27)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C624(1.23); C627(1.23)  LDD0856  [3]
 LDCM0259  AC14 HCT 116 C54(1.67); C57(1.67); C662(1.08); C674(1.08)  LDD0576  [3]
 LDCM0260  AC140 HEK-293T C624(1.38); C627(1.38)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C624(1.33); C627(1.33)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C624(1.19); C627(1.19)  LDD0860  [3]
 LDCM0263  AC143 HCT 116 C54(1.21); C57(1.21)  LDD0580  [3]
 LDCM0264  AC144 HCT 116 C54(1.00); C57(1.00)  LDD0581  [3]
 LDCM0265  AC145 HCT 116 C54(0.98); C57(0.98)  LDD0582  [3]
 LDCM0266  AC146 HCT 116 C54(0.98); C57(0.98)  LDD0583  [3]
 LDCM0267  AC147 HCT 116 C54(1.06); C57(1.06)  LDD0584  [3]
 LDCM0268  AC148 HCT 116 C54(1.09); C57(1.09)  LDD0585  [3]
 LDCM0269  AC149 HCT 116 C54(1.29); C57(1.29)  LDD0586  [3]
 LDCM0270  AC15 HCT 116 C662(0.87); C674(0.87); C54(1.56); C57(1.56)  LDD0587  [3]
 LDCM0271  AC150 HCT 116 C54(0.72); C57(0.72)  LDD0588  [3]
 LDCM0272  AC151 HCT 116 C54(1.02); C57(1.02)  LDD0589  [3]
 LDCM0273  AC152 HCT 116 C54(0.88); C57(0.88)  LDD0590  [3]
 LDCM0274  AC153 HCT 116 C54(0.83); C57(0.83)  LDD0591  [3]
 LDCM0621  AC154 HCT 116 C54(0.83); C57(0.83)  LDD2158  [3]
 LDCM0622  AC155 HCT 116 C54(0.91); C57(0.91)  LDD2159  [3]
 LDCM0623  AC156 HCT 116 C54(0.93); C57(0.93)  LDD2160  [3]
 LDCM0624  AC157 HCT 116 C54(0.88); C57(0.88)  LDD2161  [3]
 LDCM0276  AC17 HEK-293T C54(1.12); C57(0.91); C612(0.59)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C54(2.59); C57(1.71); C612(0.74)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C54(1.07); C57(0.92); C612(0.67)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C54(1.05); C57(1.03)  LDD0877  [3]
 LDCM0280  AC20 HEK-293T C54(1.02); C57(0.86); C612(0.49)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C54(1.27); C57(1.01); C612(0.63)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C54(1.21); C57(1.00); C612(0.63)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C54(2.32); C57(1.48); C612(0.70)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C54(1.23); C57(1.06); C612(0.60)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C54(0.99); C57(0.76)  LDD0883  [3]
 LDCM0286  AC26 HEK-293T C54(0.76); C57(0.69)  LDD0884  [3]
 LDCM0287  AC27 HEK-293T C54(0.90); C57(0.94)  LDD0885  [3]
 LDCM0288  AC28 HEK-293T C54(1.10); C57(1.46)  LDD0886  [3]
 LDCM0289  AC29 HEK-293T C54(0.90); C57(0.82)  LDD0887  [3]
 LDCM0290  AC3 HEK-293T C54(1.04); C57(1.02)  LDD0888  [3]
 LDCM0291  AC30 HEK-293T C54(0.85); C57(0.72)  LDD0889  [3]
 LDCM0292  AC31 HEK-293T C54(0.86); C57(0.67)  LDD0890  [3]
 LDCM0293  AC32 HEK-293T C54(0.94); C57(0.98)  LDD0891  [3]
 LDCM0294  AC33 HEK-293T C54(0.89); C57(0.79)  LDD0892  [3]
 LDCM0295  AC34 HEK-293T C54(0.93); C57(0.72)  LDD0893  [3]
 LDCM0297  AC36 HEK-293T C767(1.03)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C767(1.07)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C767(1.18); C158(1.15)  LDD1538  [7]
 LDCM0301  AC4 HEK-293T C54(0.96); C57(0.78)  LDD0899  [3]
 LDCM0304  AC42 HEK-293T C767(1.09)  LDD1543  [7]
 LDCM0306  AC44 HEK-293T C767(1.07)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C767(0.99)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C612(0.73)  LDD0906  [3]
 LDCM0309  AC47 HEK-293T C612(0.55)  LDD0907  [3]
 LDCM0310  AC48 HEK-293T C612(0.62)  LDD0908  [3]
 LDCM0311  AC49 HEK-293T C612(0.62)  LDD0909  [3]
 LDCM0312  AC5 HEK-293T C54(1.09); C57(1.13)  LDD0910  [3]
 LDCM0313  AC50 HEK-293T C612(0.71)  LDD0911  [3]
 LDCM0314  AC51 HEK-293T C612(0.84)  LDD0912  [3]
 LDCM0315  AC52 HEK-293T C612(0.60)  LDD0913  [3]
 LDCM0316  AC53 HEK-293T C612(0.64)  LDD0914  [3]
 LDCM0317  AC54 HEK-293T C612(0.68)  LDD0915  [3]
 LDCM0318  AC55 HEK-293T C612(0.51)  LDD0916  [3]
 LDCM0319  AC56 HEK-293T C612(0.67)  LDD0917  [3]
 LDCM0320  AC57 HCT 116 C54(1.59); C57(1.59)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C54(3.43); C57(3.43)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C54(2.19); C57(2.19)  LDD0639  [3]
 LDCM0323  AC6 HCT 116 C662(1.10); C674(1.10); C54(1.77); C57(1.77)  LDD0640  [3]
 LDCM0324  AC60 HCT 116 C54(1.86); C57(1.86)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C54(1.53); C57(1.53)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C54(1.69); C57(1.69)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C54(6.00); C57(6.00)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C54(1.74); C57(1.74)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C54(2.33); C57(2.33)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C54(2.13); C57(2.13)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C54(2.43); C57(2.43)  LDD0648  [3]
 LDCM0332  AC68 HCT 116 C662(0.73); C674(0.73)  LDD0649  [3]
 LDCM0333  AC69 HCT 116 C662(0.75); C674(0.75)  LDD0650  [3]
 LDCM0334  AC7 HCT 116 C662(0.88); C674(0.88); C54(1.93); C57(1.93)  LDD0651  [3]
 LDCM0335  AC70 HCT 116 C662(0.95); C674(0.95)  LDD0652  [3]
 LDCM0336  AC71 HCT 116 C662(0.62); C674(0.62)  LDD0653  [3]
 LDCM0337  AC72 HCT 116 C662(0.71); C674(0.71)  LDD0654  [3]
 LDCM0338  AC73 HCT 116 C662(0.78); C674(0.78)  LDD0655  [3]
 LDCM0339  AC74 HCT 116 C662(0.66); C674(0.66)  LDD0656  [3]
 LDCM0340  AC75 HCT 116 C662(0.82); C674(0.82)  LDD0657  [3]
 LDCM0341  AC76 HCT 116 C662(0.73); C674(0.73)  LDD0658  [3]
 LDCM0342  AC77 HCT 116 C662(0.71); C674(0.71)  LDD0659  [3]
 LDCM0343  AC78 HCT 116 C662(0.60); C674(0.60)  LDD0660  [3]
 LDCM0344  AC79 HCT 116 C662(0.59); C674(0.59)  LDD0661  [3]
 LDCM0345  AC8 HCT 116 C662(0.90); C674(0.90); C54(1.06); C57(1.06)  LDD0662  [3]
 LDCM0346  AC80 HCT 116 C662(0.79); C674(0.79)  LDD0663  [3]
 LDCM0347  AC81 HCT 116 C662(0.68); C674(0.68)  LDD0664  [3]
 LDCM0348  AC82 HCT 116 C662(0.82); C674(0.82)  LDD0665  [3]
 LDCM0349  AC83 HCT 116 C54(1.59); C57(1.59)  LDD0666  [3]
 LDCM0350  AC84 HCT 116 C54(1.45); C57(1.45)  LDD0667  [3]
 LDCM0351  AC85 HCT 116 C54(1.46); C57(1.46)  LDD0668  [3]
 LDCM0352  AC86 HCT 116 C54(1.30); C57(1.30)  LDD0669  [3]
 LDCM0353  AC87 HCT 116 C54(1.25); C57(1.25)  LDD0670  [3]
 LDCM0354  AC88 HCT 116 C54(1.42); C57(1.42)  LDD0671  [3]
 LDCM0355  AC89 HCT 116 C54(1.44); C57(1.44)  LDD0672  [3]
 LDCM0357  AC90 HCT 116 C54(1.24); C57(1.24)  LDD0674  [3]
 LDCM0358  AC91 HCT 116 C54(1.12); C57(1.12)  LDD0675  [3]
 LDCM0359  AC92 HCT 116 C54(1.21); C57(1.21)  LDD0676  [3]
 LDCM0360  AC93 HCT 116 C54(1.23); C57(1.23)  LDD0677  [3]
 LDCM0361  AC94 HCT 116 C54(1.13); C57(1.13)  LDD0678  [3]
 LDCM0362  AC95 HCT 116 C54(1.26); C57(1.26)  LDD0679  [3]
 LDCM0363  AC96 HCT 116 C54(1.04); C57(1.04)  LDD0680  [3]
 LDCM0364  AC97 HCT 116 C54(1.66); C57(1.66)  LDD0681  [3]
 LDCM0365  AC98 HEK-293T C57(1.10); C624(1.00); C627(1.00)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C57(1.15); C624(0.86); C627(0.86)  LDD0964  [3]
 LDCM0248  AKOS034007472 HCT 116 C54(1.45); C57(1.45); C662(0.81); C674(0.81)  LDD0565  [3]
 LDCM0356  AKOS034007680 HCT 116 C662(1.05); C674(1.05); C54(1.33); C57(1.33)  LDD0673  [3]
 LDCM0275  AKOS034007705 HCT 116 C662(0.92); C674(0.92); C54(2.96); C57(2.96)  LDD0592  [3]
 LDCM0020  ARS-1620 HCC44 C536(1.12); C539(1.12); C387(1.04); C392(1.04)  LDD0078  [3]
 LDCM0367  CL1 HEK-293T C612(0.79); C624(1.23); C627(1.23)  LDD0965  [3]
 LDCM0368  CL10 HEK-293T C612(0.84); C624(1.16); C627(1.16)  LDD0966  [3]
 LDCM0369  CL100 HEK-293T C54(1.04); C57(1.03)  LDD0967  [3]
 LDCM0370  CL101 HCT 116 C662(1.39); C674(1.39); C54(2.34); C57(2.34)  LDD0687  [3]
 LDCM0371  CL102 HCT 116 C662(1.17); C674(1.17); C54(1.65); C57(1.65)  LDD0688  [3]
 LDCM0372  CL103 HCT 116 C662(1.05); C674(1.05); C54(2.39); C57(2.39)  LDD0689  [3]
 LDCM0373  CL104 HCT 116 C662(1.06); C674(1.06); C54(1.57); C57(1.57)  LDD0690  [3]
 LDCM0374  CL105 HEK-293T C54(1.59); C57(1.25); C612(0.78)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C54(1.22); C57(1.06); C612(0.66)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C54(1.22); C57(0.95); C612(0.74)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C54(1.07); C57(0.98); C612(0.72)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C54(2.25); C57(1.56); C612(0.76)  LDD0976  [3]
 LDCM0379  CL11 HEK-293T C612(0.78); C624(1.21); C627(1.21)  LDD0977  [3]
 LDCM0380  CL110 HEK-293T C54(2.34); C57(1.60); C612(0.79)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C54(2.23); C57(1.56); C612(0.73)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C54(1.23); C57(1.51)  LDD0980  [3]
 LDCM0383  CL113 HEK-293T C54(0.97); C57(0.98)  LDD0981  [3]
 LDCM0384  CL114 HEK-293T C54(1.30); C57(1.72)  LDD0982  [3]
 LDCM0385  CL115 HEK-293T C54(1.17); C57(1.36)  LDD0983  [3]
 LDCM0386  CL116 HEK-293T C54(0.88); C57(0.84)  LDD0984  [3]
 LDCM0390  CL12 HEK-293T C612(0.65); C624(1.19); C627(1.19)  LDD0988  [3]
 LDCM0392  CL121 HEK-293T C612(0.46)  LDD0990  [3]
 LDCM0393  CL122 HEK-293T C612(0.50)  LDD0991  [3]
 LDCM0394  CL123 HEK-293T C612(0.56)  LDD0992  [3]
 LDCM0395  CL124 HEK-293T C612(0.63)  LDD0993  [3]
 LDCM0396  CL125 HCT 116 C54(1.26); C57(1.26)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C54(1.49); C57(1.49)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C54(2.88); C57(2.88)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C54(1.42); C57(1.42)  LDD0716  [3]
 LDCM0400  CL13 HEK-293T C612(0.76); C624(1.02); C627(1.02)  LDD0998  [3]
 LDCM0401  CL14 HEK-293T C612(0.64); C624(1.22); C627(1.22)  LDD0999  [3]
 LDCM0402  CL15 HEK-293T C612(0.63); C624(1.60); C627(1.60)  LDD1000  [3]
 LDCM0403  CL16 HCT 116 C662(0.97); C674(0.97)  LDD0720  [3]
 LDCM0404  CL17 HCT 116 C662(0.99); C674(0.99)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C662(1.40); C674(1.40)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C662(0.96); C674(0.96)  LDD0723  [3]
 LDCM0407  CL2 HEK-293T C612(1.10); C624(1.10); C627(1.10)  LDD1005  [3]
 LDCM0408  CL20 HCT 116 C662(1.13); C674(1.13)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C662(1.22); C674(1.22)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C662(1.85); C674(1.85)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C662(1.07); C674(1.07)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C662(1.16); C674(1.16)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C662(1.62); C674(1.62)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C662(0.97); C674(0.97)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C662(1.12); C674(1.12)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C662(1.10); C674(1.10)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C662(1.15); C674(1.15)  LDD0734  [3]
 LDCM0418  CL3 HEK-293T C612(0.87); C624(1.15); C627(1.15)  LDD1016  [3]
 LDCM0419  CL30 HCT 116 C662(1.07); C674(1.07)  LDD0736  [3]
 LDCM0420  CL31 HEK-293T C54(1.98); C57(1.98); C612(0.81); C624(0.81)  LDD1018  [3]
 LDCM0421  CL32 HEK-293T C54(1.48); C57(1.48); C612(0.71); C624(0.87)  LDD1019  [3]
 LDCM0422  CL33 HEK-293T C54(3.58); C57(3.58); C612(0.80); C624(0.76)  LDD1020  [3]
 LDCM0423  CL34 HEK-293T C54(3.27); C57(3.27); C612(0.91); C624(0.87)  LDD1021  [3]
 LDCM0424  CL35 HEK-293T C54(1.81); C57(1.81); C612(0.91); C624(0.88)  LDD1022  [3]
 LDCM0425  CL36 HEK-293T C54(1.52); C57(1.52); C612(0.78); C624(1.01)  LDD1023  [3]
 LDCM0426  CL37 HEK-293T C54(2.12); C57(2.12); C612(0.70); C624(0.92)  LDD1024  [3]
 LDCM0428  CL39 HEK-293T C54(3.80); C57(3.80); C612(0.77); C624(0.93)  LDD1026  [3]
 LDCM0429  CL4 HEK-293T C612(0.83); C624(1.31); C627(1.31)  LDD1027  [3]
 LDCM0430  CL40 HEK-293T C54(1.24); C57(1.24); C612(0.83); C624(0.87)  LDD1028  [3]
 LDCM0431  CL41 HEK-293T C54(2.73); C57(2.73); C612(0.89); C624(0.79)  LDD1029  [3]
 LDCM0432  CL42 HEK-293T C54(1.38); C57(1.38); C612(0.92); C624(0.89)  LDD1030  [3]
 LDCM0433  CL43 HEK-293T C54(1.77); C57(1.77); C612(0.84); C624(0.97)  LDD1031  [3]
 LDCM0434  CL44 HEK-293T C54(1.39); C57(1.39); C612(0.94); C624(0.88)  LDD1032  [3]
 LDCM0435  CL45 HEK-293T C54(3.31); C57(3.31); C612(0.92); C624(0.83)  LDD1033  [3]
 LDCM0436  CL46 HCT 116 C54(1.08); C57(1.08); C662(0.73); C674(0.73)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C54(1.10); C57(1.10); C662(0.78); C674(0.78)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C54(0.99); C57(0.99); C662(0.63); C674(0.63)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C54(0.95); C57(0.95); C662(0.60); C674(0.60)  LDD0756  [3]
 LDCM0440  CL5 HEK-293T C612(0.78); C624(0.88); C627(0.88)  LDD1038  [3]
 LDCM0441  CL50 HCT 116 C54(1.17); C57(1.17); C662(0.73); C674(0.73)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C54(1.00); C57(1.00); C662(0.80); C674(0.80)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C54(1.01); C57(1.01); C662(0.86); C674(0.86)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C54(0.86); C57(0.86); C662(0.99); C674(0.99)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C54(1.12); C57(1.12); C662(1.00); C674(1.00)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C54(1.11); C57(1.11); C662(1.04); C674(1.04)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C54(0.98); C57(0.98); C662(0.78); C674(0.78)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C54(1.06); C57(1.06); C662(0.77); C674(0.77)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C54(1.15); C57(1.15); C662(0.90); C674(0.90)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C54(1.08); C57(1.08); C662(0.84); C674(0.84)  LDD0767  [3]
 LDCM0451  CL6 HEK-293T C612(0.72); C624(1.20); C627(1.20)  LDD1049  [3]
 LDCM0452  CL60 HCT 116 C54(1.13); C57(1.13); C662(0.90); C674(0.90)  LDD0769  [3]
 LDCM0458  CL66 HEK-293T C767(1.21)  LDD1661  [7]
 LDCM0460  CL68 HEK-293T C767(1.09)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C767(1.03)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C612(0.76); C624(1.07); C627(1.07)  LDD1060  [3]
 LDCM0463  CL70 HEK-293T C767(1.34); C158(1.24)  LDD1666  [7]
 LDCM0469  CL76 HCT 116 C54(1.36); C57(1.36)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C54(1.49); C57(1.49)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C54(1.74); C57(1.74)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C54(1.02); C57(1.02)  LDD0789  [3]
 LDCM0473  CL8 HEK-293T C612(1.13); C627(2.01)  LDD1071  [3]
 LDCM0474  CL80 HCT 116 C54(1.15); C57(1.15)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C54(0.96); C57(0.96)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C54(0.98); C57(0.98)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C54(0.88); C57(0.88)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C54(1.40); C57(1.40)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C54(1.25); C57(1.25)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C54(1.23); C57(1.23)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C54(1.85); C57(1.85)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C54(1.24); C57(1.24)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C54(1.16); C57(1.16)  LDD0800  [3]
 LDCM0484  CL9 HEK-293T C612(0.89); C627(1.47)  LDD1082  [3]
 LDCM0485  CL90 HCT 116 C54(1.92); C57(1.92)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C54(1.34); C57(1.25)  LDD1084  [3]
 LDCM0487  CL92 HEK-293T C54(2.10); C57(2.72)  LDD1085  [3]
 LDCM0488  CL93 HEK-293T C54(2.43); C57(3.68)  LDD1086  [3]
 LDCM0489  CL94 HEK-293T C54(2.64); C57(3.87)  LDD1087  [3]
 LDCM0490  CL95 HEK-293T C54(1.93); C57(2.70)  LDD1088  [3]
 LDCM0491  CL96 HEK-293T C54(1.26); C57(1.18)  LDD1089  [3]
 LDCM0492  CL97 HEK-293T C54(1.51); C57(1.79)  LDD1090  [3]
 LDCM0493  CL98 HEK-293T C54(1.96); C57(2.72)  LDD1091  [3]
 LDCM0494  CL99 HEK-293T C54(1.53); C57(1.80)  LDD1092  [3]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C767(1.02); C657(0.89)  LDD1702  [8]
 LDCM0427  Fragment51 HEK-293T C54(1.45); C57(1.45); C612(0.69); C624(0.74)  LDD1025  [3]
 LDCM0167  HOIPIN 11a HEK-293T 2.05  LDD0423  [2]
 LDCM0022  KB02 HCT 116 C54(20.00); C57(20.00); C662(3.66); C674(3.66)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C54(20.00); C57(20.00); C662(2.94); C674(2.94)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C54(20.00); C57(20.00); C662(3.21); C674(3.21)  LDD0082  [3]
 LDCM0021  THZ1 HCT 116 C733(1.15); C736(1.15)  LDD2173  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-8 (CASP8) Peptidase C14A family Q14790
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) Peptidase C64 family P21580
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase RNF216 (RNF216) . Q9NWF9
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Arrestin domain-containing protein 3 (ARRDC3) Arrestin family Q96B67
Other
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Dynein regulatory complex subunit 4 (GAS8) DRC4 family O95995
UV excision repair protein RAD23 homolog A (RAD23A) RAD23 family P54725
NF-kappa-B essential modulator (IKBKG) . Q9Y6K9
RING finger protein 11 (RNF11) . Q9Y3C5
Tax1-binding protein 1 (TAX1BP1) . Q86VP1
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
TNFAIP3-interacting protein 2 (TNIP2) . Q8NFZ5
TNFAIP3-interacting protein 3 (TNIP3) . Q96KP6

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP. J Am Chem Soc. 2019 Feb 13;141(6):2703-2712. doi: 10.1021/jacs.8b13193. Epub 2019 Feb 4.
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761