Details of the Target

General Information of Target

Target ID LDTP11841
Target Name ATP-dependent DNA/RNA helicase DHX36 (DHX36)
Gene Name DHX36
Gene ID 170506
Synonyms
DDX36; KIAA1488; MLEL1; RHAU; ATP-dependent DNA/RNA helicase DHX36; EC 3.6.4.12; EC 3.6.4.13; DEAD/H box polypeptide 36; DEAH-box protein 36; G4-resolvase-1; G4R1; MLE-like protein 1; RNA helicase associated with AU-rich element protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHTPPALPRRFQGGGRVRTPGSHRQGKDNLERDPSGGCVPDFLPQAQDSNHFIMESLFCE
SSGDSSLEKEFLGAPVGPSVSTPNSQHSSPSRSLSANSIKVEMYSDEESSRLLGPDERLL
EKDDSVIVEDSLSEPLGYCDGSGPEPHSPGGIRLPNGKLKCDVCGMVCIGPNVLMVHKRS
HTGERPFHCNQCGASFTQKGNLLRHIKLHSGEKPFKCPFCNYACRRRDALTGHLRTHSVS
SPTVGKPYKCNYCGRSYKQQSTLEEHKERCHNYLQSLSTEAQALAGQPGDEIRDLEMVPD
SMLHSSSERPTFIDRLANSLTKRKRSTPQKFVGEKQMRFSLSDLPYDVNSGGYEKDVELV
AHHSLEPGFGSSLAFVGAEHLRPLRLPPTNCISELTPVISSVYTQMQPLPGRLELPGSRE
AGEGPEDLADGGPLLYRPRGPLTDPGASPSNGCQDSTDTESNHEDRVAGVVSLPQGPPPQ
PPPTIVVGRHSPAYAKEDPKPQEGLLRGTPGPSKEVLRVVGESGEPVKAFKCEHCRILFL
DHVMFTIHMGCHGFRDPFECNICGYHSQDRYEFSSHIVRGEHKVG
Target Bioclass
Enzyme
Family
DEAD box helicase family, DEAH subfamily
Subcellular location
Nucleus
Function
Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures. Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses. G4 structures correspond to helical structures containing guanine tetrads. Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) . Plays a role in genomic integrity. Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription . Plays a role in transcriptional regulation. Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression. Plays a role in post-transcriptional regulation. Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage. Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment. Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size. Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability. Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression. Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively. Binds also to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation. Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1. Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification.
Uniprot ID
Q9H2U1
Ensemble ID
ENST00000308361.10
HGNC ID
HGNC:14410
ChEMBL ID
CHEMBL2040704

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C4II SNV: p.G570E DBIA    Probe Info 
HCC1395 Deletion: p.D681EfsTer16
SNV: p.G690E		 DBIA    Probe Info 
HCC44 SNV: p.G35V DBIA    Probe Info 
HCT15 SNV: p.G44W; p.D499V .
HEC1 SNV: p.G125S DBIA    Probe Info 
KYSE30 Deletion: p.P496QfsTer7 DBIA    Probe Info 
L428 SNV: p.Y888C DBIA    Probe Info 
MCC13 SNV: p.S161L DBIA    Probe Info 
MV411 Substitution: p.Q430_E431delinsHTer DBIA    Probe Info 
NCIH1666 SNV: p.Q535L DBIA    Probe Info 
OAW42 SNV: p.I984T DBIA    Probe Info 
SUPT1 SNV: p.V493L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y22(11.12)  LDD0260  [2]
STPyne
 Probe Info  		K68(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y169(40.16); Y210(15.54)  LDD3495  [4]
Backus_15
 Probe Info  		1.86  LDD0423  [5]
AHL-Pu-1
 Probe Info  		C135(2.21)  LDD0168  [6]
HHS-475
 Probe Info  		Y22(0.57)  LDD0264  [7]
DBIA
 Probe Info  		C135(0.88)  LDD0078  [8]
ATP probe
 Probe Info  		K139(0.00); K947(0.00); K573(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C284(0.00); C836(0.00); C781(0.00); C234(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		C284(0.00); C836(0.00); C977(0.00); C781(0.00)  LDD0037  [10]
BTD
 Probe Info  		N.A.  LDD0004  [12]
IPM
 Probe Info  		N.A.  LDD0025  [13]
NAIA_4
 Probe Info  		N.A.  LDD2226  [14]
WYneO
 Probe Info  		N.A.  LDD0022  [12]
ENE
 Probe Info  		N.A.  LDD0006  [12]
TFBX
 Probe Info  		N.A.  LDD0148  [13]
VSF
 Probe Info  		N.A.  LDD0007  [12]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]
AOyne
 Probe Info  		4.60  LDD0443  [18]
NAIA_5
 Probe Info  		C284(0.00); C611(0.00); C836(0.00); C977(0.00)  LDD2223  [14]
HHS-482
 Probe Info  		Y22(1.31)  LDD2239  [19]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C158
 Probe Info  		15.03  LDD1838  [20]
C193
 Probe Info  		6.19  LDD1869  [20]
FFF probe12
 Probe Info  		20.00  LDD0473  [21]
FFF probe13
 Probe Info  		20.00  LDD0475  [21]
FFF probe6
 Probe Info  		12.36  LDD0467  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C135(0.56)  LDD2142  [22]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C135(1.03)  LDD2112  [22]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C135(0.92)  LDD2095  [22]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C135(1.32)  LDD2130  [22]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C611(1.44)  LDD2117  [22]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C135(0.72)  LDD2132  [22]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C135(0.62)  LDD2131  [22]
 LDCM0025  4SU-RNA HEK-293T C135(2.21)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C135(2.14)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C135(0.70); C234(1.01); C261(0.97); C284(1.35)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C135(1.74); C234(0.75); C257(1.15); C261(1.20)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C135(1.33); C234(1.00); C284(0.49)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C135(1.36); C234(0.91); C284(0.65)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C135(1.16); C234(0.90); C284(0.59)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C135(1.33); C234(0.83); C284(0.42)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C135(1.00); C234(0.86); C284(0.51)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C135(1.43); C234(0.84); C284(0.41)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C135(1.53); C234(0.81); C284(0.38)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C135(1.26); C234(0.87); C284(0.53)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C135(1.19); C234(0.78); C284(0.35)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C135(1.01); C234(0.82); C284(0.46)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C135(1.08); C234(0.86); C257(1.64); C261(1.07)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C135(1.39); C234(0.75); C284(0.46)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C135(1.39); C234(0.85); C284(0.37)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C135(1.28); C234(0.89); C284(0.48)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C135(0.99); C261(1.27)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C135(1.06); C261(0.89)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C135(1.07); C261(1.04)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C135(1.12); C261(1.11)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C135(1.06); C261(1.12)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C135(1.07); C261(0.82)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C135(1.18); C261(1.02)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C135(1.10); C234(0.98); C257(1.62); C261(1.05)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C135(1.11); C261(1.10)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C135(1.00); C261(0.99)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C135(1.15); C261(1.05)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C135(0.99); C261(0.86)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C135(1.05); C261(1.03)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C135(1.09); C261(1.09)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C135(1.17); C261(0.87)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C135(1.15); C261(0.93)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C135(0.19); C234(0.82)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C135(0.32); C234(0.86)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C135(0.29); C234(0.85)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C135(0.28); C234(0.92)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C135(0.28); C234(1.03)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C135(0.35); C234(0.93)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C135(0.31); C234(0.99)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C135(0.26); C234(0.91)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C135(0.30); C234(1.04)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C135(0.30); C234(1.01)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C135(0.30); C234(0.95)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C135(0.32); C234(0.93)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C135(1.17); C234(0.69); C257(1.33); C261(0.96)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C135(0.38); C234(1.00)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C135(0.27); C234(0.93)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C135(0.27); C234(0.88)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C135(1.10); C284(1.01)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C135(1.12); C284(1.12)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C284(0.96); C135(1.14)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C284(0.78); C135(1.01)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C284(0.98); C135(1.23)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C284(0.73); C135(1.25)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C284(0.76); C135(1.08)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C234(0.58); C135(0.93); C261(0.95); C284(1.31)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C284(0.90); C135(0.95)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C135(0.81); C284(1.23)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C135(0.98); C284(0.99)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C284(0.79); C135(1.36)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C135(1.04); C284(1.04)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C135(1.04); C284(1.13)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C135(0.97); C284(0.77)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C135(0.94); C284(1.11)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C135(0.77); C284(0.95); C261(1.19)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C261(0.46); C135(0.78); C284(0.88)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C135(0.73); C261(0.84); C284(0.96)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C135(0.79); C234(0.99); C261(1.01); C284(1.08)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C261(0.71); C135(0.85); C284(0.87)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C261(0.68); C135(0.75); C284(0.91)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C261(0.59); C135(0.81); C284(1.01)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C261(0.55); C135(0.77); C284(0.94)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C135(0.74); C284(0.95); C261(1.20)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C261(0.85); C284(1.03); C135(1.65)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C284(0.82); C261(1.26); C135(1.78)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C284(0.80); C261(1.01); C135(1.97)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C284(0.78); C261(1.00); C135(2.39)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C284(0.73); C261(1.18); C135(2.30)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C135(0.89); C261(0.90); C234(0.93); C284(1.21)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C284(0.78); C261(1.27); C135(1.97)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C284(0.68); C261(0.93); C135(1.50)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C284(0.79); C261(1.31); C135(1.69)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C284(0.75); C261(0.90); C135(2.78)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C284(0.81); C261(0.83); C135(2.46)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C234(0.78); C284(1.16); C261(1.29)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C284(0.97); C234(0.98); C261(1.19)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C234(0.83); C284(1.06); C261(1.43)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C284(0.94); C234(0.97); C261(1.36)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C234(0.82); C284(1.00); C261(1.43)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C135(0.69); C234(0.93); C261(1.16); C284(1.22)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C234(0.65); C284(0.94); C261(1.19)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C234(0.92); C284(0.96); C261(1.30)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C234(0.83); C284(1.05); C261(1.26)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C234(0.72); C284(0.95); C261(1.19)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C234(0.97); C284(1.03); C261(1.20)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C234(0.76); C261(0.96); C284(0.98)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C234(0.69); C284(0.82); C257(0.95); C261(1.34)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C234(0.87); C284(0.91); C257(1.04); C261(1.06)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C284(0.81); C234(1.03); C261(1.04); C257(1.06)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C284(0.72); C261(0.75); C234(0.77); C257(0.93)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C135(0.65); C261(1.01); C234(1.05); C284(1.24)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C284(0.78); C261(0.93); C135(0.99); C234(1.00)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C284(0.96); C234(0.98); C257(1.04); C135(1.09)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C234(0.85); C257(0.98); C284(0.99); C135(1.49)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C284(0.79); C234(0.86); C261(0.90); C257(0.97)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C234(0.77); C257(0.93); C284(0.96); C261(1.05)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C284(0.63); C234(0.86); C261(0.98); C257(1.46)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C284(0.58); C261(0.68); C234(0.86); C257(1.13)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C284(0.80); C261(0.84)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C284(0.83); C261(0.84)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C284(0.80); C261(0.93)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C234(0.64); C261(0.93); C284(1.00); C257(1.05)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C261(0.72); C284(0.74)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C261(0.66); C284(0.69)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C284(0.79); C261(0.85)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C261(0.71); C284(0.81)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C284(0.76); C261(0.88)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C284(0.77); C261(0.85)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C261(0.75); C284(0.77)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C284(0.62); C261(0.64)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C261(0.65); C284(0.79); C135(0.85); C234(1.03)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C261(0.55); C135(0.76); C284(0.84); C234(1.09)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C234(0.79); C284(0.99); C257(1.12); C135(1.16)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C261(0.50); C284(0.71); C135(0.74); C234(1.03)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C135(0.82); C261(0.88); C284(1.04); C234(1.08)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C284(0.85); C261(0.88); C234(0.98); C135(1.15)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C261(0.51); C284(0.64); C234(1.13); C135(1.20)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C261(0.60); C284(0.78); C135(0.84); C234(1.34)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C261(0.54); C284(0.57); C234(1.13); C135(1.17)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C261(0.61); C284(1.03); C234(1.11); C135(1.22)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C261(0.69); C284(0.82); C135(0.84); C234(1.04)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C135(0.82); C261(0.86); C284(0.89); C234(0.95)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C135(0.82); C284(0.95); C261(0.95); C234(1.12)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C234(0.68); C135(0.94); C284(1.04); C261(1.10)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C261(0.95); C284(1.02); C135(1.11); C234(1.29)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C284(0.73); C135(0.79); C261(0.94); C234(1.02)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C261(0.43); C284(0.78); C135(0.90); C234(1.00)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C284(0.56); C261(1.03); C135(1.52)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C284(0.69); C261(0.96); C135(1.32)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C284(0.74); C261(1.06); C135(1.22)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C284(0.73); C261(0.91); C135(1.20)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C284(0.77); C261(1.07); C135(1.21)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C284(0.76); C261(1.03); C135(1.17)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C284(0.68); C261(0.88); C135(1.25)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C261(0.78); C135(1.55); C284(1.58)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C284(0.58); C135(1.07); C261(1.16)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C284(0.70); C261(1.13); C135(1.14)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C284(0.78); C135(1.10); C261(1.12)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C284(0.72); C135(0.77); C261(1.16)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C284(0.54); C261(1.25); C135(1.28)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C284(0.65); C135(0.85); C261(1.24)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C284(0.75); C135(1.29); C261(1.30)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C284(0.19); C234(0.62); C135(1.32)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C284(0.56); C234(0.91); C135(1.24)  LDD0683  [8]
 LDCM0545  Acetamide MDA-MB-231 C135(0.37)  LDD2138  [22]
 LDCM0248  AKOS034007472 HCT 116 C135(1.00); C234(0.68); C257(1.38); C261(1.04)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C284(0.82); C135(0.86); C261(0.98); C234(1.03)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C234(0.63); C261(1.04); C284(1.38); C257(1.45)  LDD0592  [8]
 LDCM0020  ARS-1620 HCC44 C135(0.88)  LDD0078  [8]
 LDCM0498  BS-3668 MDA-MB-231 C135(0.37)  LDD2091  [22]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C135(20.00)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C284(0.91); C234(0.97); C135(1.07); C261(1.08)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C284(0.77); C261(0.94); C234(1.11); C135(1.23)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C135(0.70); C261(0.95); C234(1.03); C284(1.34)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C257(0.85); C261(0.91); C284(1.07); C135(1.08)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C234(0.70); C257(0.78); C135(0.97); C261(1.06)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C284(0.94); C261(1.01); C234(1.10); C135(1.11)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C135(1.01); C234(1.08); C284(1.11); C261(1.11)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C261(0.59); C135(0.67); C284(0.87)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C261(0.35); C135(0.60); C284(0.87)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C261(0.57); C135(0.71); C284(0.91)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C261(0.47); C135(0.63); C284(0.85)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C261(0.64); C284(0.84); C135(0.92)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C284(0.72); C261(0.88); C234(0.99); C135(1.13)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C261(0.51); C284(0.70); C135(0.74)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C261(0.60); C135(0.80); C284(0.88)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C284(0.89); C261(1.16); C135(1.42)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C284(0.75); C261(1.29); C135(1.82)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C284(0.70); C261(1.51); C135(2.20)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C284(0.76); C261(1.23); C135(3.01)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C284(0.89); C261(1.15); C135(2.47)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C234(0.69); C284(0.75); C261(0.78)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C284(1.01); C234(1.13); C261(1.32)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C284(1.01); C234(1.10); C261(1.20)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C284(0.90); C261(0.99); C234(1.09); C135(1.23)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C234(0.93); C284(1.14); C261(1.28)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C284(0.72); C234(0.78); C261(0.95); C257(1.18)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C284(0.75); C234(0.91); C257(1.17); C261(1.33)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C284(0.78); C257(0.91); C261(0.97); C234(1.09)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C284(0.71); C257(0.86); C234(0.86); C261(1.01)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C284(0.95); C261(1.43)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C284(0.85); C261(1.11)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C284(0.77); C261(1.01)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C261(0.84); C284(0.88)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C284(0.75); C135(1.00); C261(1.08); C234(1.11)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C135(1.00); C284(1.02); C261(1.11); C234(1.11)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C261(0.81); C284(0.82); C135(0.89); C234(1.05)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C284(0.81); C257(1.21); C135(1.43); C261(2.07)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C257(0.85); C135(1.02); C284(1.15); C261(1.16)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C284(0.91); C257(1.09); C135(1.32); C261(1.72)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C284(0.88); C135(1.11); C257(1.33); C261(2.34)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C234(0.80); C261(0.84); C284(0.94); C135(1.03)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C284(0.97); C135(1.11); C257(1.33); C261(1.81)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C284(0.98); C135(1.14); C257(1.27); C261(2.38)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C284(0.94); C135(1.01); C261(1.49); C257(1.87)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C284(0.90); C135(1.26); C257(1.27); C261(1.52)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C284(0.85); C257(1.35); C135(1.43); C261(1.66)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C135(1.35); C257(1.27); C261(2.20); C284(0.72)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C135(2.06); C257(1.71); C261(1.74); C284(0.91)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C135(1.51); C257(1.49); C261(2.05); C284(0.86)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C135(1.47); C257(1.08); C261(1.78); C284(0.71)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C135(1.38); C257(1.27); C261(2.40); C284(0.83)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C135(0.97); C234(1.09); C261(1.17); C284(1.15)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C135(1.42); C257(1.60); C261(1.74); C284(0.97)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C135(2.04)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C135(1.59); C257(1.98)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C135(1.86); C257(1.08)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C135(1.99); C257(1.70)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C135(1.66); C257(2.08)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C135(1.98); C257(1.72)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C135(2.26); C257(2.11)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C135(2.65); C257(1.33)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C135(1.06); C234(0.85); C261(1.10); C284(0.91)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C135(1.67); C257(1.23)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C135(2.04); C257(1.53)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C135(1.90); C257(2.25)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C135(2.48); C257(1.57)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C135(1.79); C257(1.96)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C135(1.72); C257(1.88)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C135(1.36); C284(0.84)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C135(1.11); C284(0.79)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C135(0.96); C284(0.92)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C135(0.76); C284(0.87)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C135(0.94); C234(1.07); C261(1.14); C284(1.01)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C135(0.95); C284(0.82)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C135(0.88); C284(0.89)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C135(1.59); C284(0.82)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C135(0.92); C284(0.91)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C135(1.33); C284(0.79)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C135(1.36); C284(0.87)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C135(0.89); C284(0.86)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C135(1.16); C284(0.82)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C135(1.20); C284(0.87)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C135(1.20); C284(0.91)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C135(1.13); C234(0.91); C261(0.99); C284(0.82)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C135(1.29); C284(0.79)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C284(0.90)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C284(0.88)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C284(0.74)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C284(0.85)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C284(0.93)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C284(0.89)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C284(0.94)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C284(0.89)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C284(0.82)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C135(1.09); C234(0.93); C261(1.09); C284(0.92)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C284(0.83)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C284(0.86)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C284(0.92)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C284(0.96)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C284(0.92)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C284(0.84)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C284(1.06)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C284(1.11)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C284(1.06)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C135(1.27); C234(1.06); C261(0.82); C284(0.84)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C284(1.26)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C284(0.96)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C284(1.11)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C284(0.85)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C284(0.81)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C284(0.89)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C284(0.94)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C284(1.01)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C284(1.05)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C284(1.05)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C135(1.27); C234(0.87); C261(1.05); C284(0.89)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C284(1.05)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C135(0.84); C234(0.99); C261(0.88); C284(0.88)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C135(0.76); C234(0.93); C261(0.95); C284(1.11)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C135(0.65); C234(1.00); C261(1.00); C284(1.34)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C135(0.87); C234(1.06); C261(0.88); C284(1.59)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C135(0.63); C234(0.97); C261(1.16); C284(0.99)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C135(0.58); C234(0.86); C261(1.02); C284(0.88)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C135(0.80); C234(0.83); C261(1.07); C284(0.94)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C135(1.00); C234(0.91); C261(0.94); C284(0.89)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C135(0.62); C234(0.96); C261(0.99); C284(1.10)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C135(1.00); C284(0.80); C836(0.94); C234(0.96)  LDD1698  [23]
 LDCM0625  F8 Ramos C135(1.14)  LDD2187  [24]
 LDCM0572  Fragment10 Ramos C135(1.29)  LDD2189  [24]
 LDCM0574  Fragment12 Ramos C135(0.62)  LDD2191  [24]
 LDCM0575  Fragment13 Ramos C135(0.84)  LDD2192  [24]
 LDCM0576  Fragment14 Ramos C135(0.56)  LDD2193  [24]
 LDCM0579  Fragment20 Ramos C135(0.52)  LDD2194  [24]
 LDCM0580  Fragment21 Ramos C135(1.15)  LDD2195  [24]
 LDCM0582  Fragment23 Ramos C135(0.62)  LDD2196  [24]
 LDCM0578  Fragment27 Ramos C135(1.03)  LDD2197  [24]
 LDCM0586  Fragment28 Ramos C135(0.64)  LDD2198  [24]
 LDCM0588  Fragment30 Ramos C135(1.14)  LDD2199  [24]
 LDCM0589  Fragment31 Ramos C135(0.71)  LDD2200  [24]
 LDCM0590  Fragment32 Ramos C135(1.31)  LDD2201  [24]
 LDCM0468  Fragment33 HCT 116 C284(0.91)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C135(0.85)  LDD2203  [24]
 LDCM0566  Fragment4 Ramos C135(0.62)  LDD2184  [24]
 LDCM0427  Fragment51 HCT 116 C135(1.69); C257(1.43)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C135(0.78)  LDD2204  [24]
 LDCM0614  Fragment56 Ramos C135(0.85)  LDD2205  [24]
 LDCM0569  Fragment7 Ramos C135(0.63)  LDD2186  [24]
 LDCM0571  Fragment9 Ramos C135(0.73)  LDD2188  [24]
 LDCM0116  HHS-0101 DM93 Y22(0.57)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y22(1.24)  LDD0265  [7]
 LDCM0120  HHS-0701 DM93 Y22(0.92)  LDD0268  [7]
 LDCM0167  HOIPIN 11a HEK-293T 1.86  LDD0423  [5]
 LDCM0022  KB02 HEK-293T C135(0.67); C284(0.70); C611(1.18); C836(0.92)  LDD1492  [23]
 LDCM0023  KB03 HEK-293T C135(0.92); C284(1.08); C611(1.06); C836(1.07)  LDD1497  [23]
 LDCM0024  KB05 G361 C284(2.10); C627(3.42); C611(2.55)  LDD3311  [25]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C135(0.35)  LDD2121  [22]
 LDCM0109  NEM HeLa N.A.  LDD0226  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C135(0.61)  LDD2089  [22]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C135(0.90)  LDD2090  [22]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C135(0.96)  LDD2092  [22]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C135(1.80)  LDD2094  [22]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C135(0.66)  LDD2096  [22]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C135(1.21)  LDD2098  [22]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C135(0.86)  LDD2100  [22]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C135(1.75)  LDD2105  [22]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C135(0.67)  LDD2106  [22]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C135(0.94)  LDD2107  [22]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C135(0.83)  LDD2108  [22]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C135(0.53)  LDD2109  [22]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C135(2.71)  LDD2110  [22]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C135(1.00)  LDD2114  [22]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C135(0.88)  LDD2118  [22]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C135(0.93)  LDD2122  [22]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C135(0.83)  LDD2124  [22]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C135(0.61)  LDD2125  [22]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C135(0.77); C261(3.35)  LDD2126  [22]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C135(0.75); C284(2.13)  LDD2127  [22]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C135(0.68)  LDD2128  [22]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C135(0.38)  LDD2135  [22]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C135(0.93); C611(1.57); C284(1.88)  LDD2136  [22]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C135(1.01)  LDD2137  [22]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C135(0.77)  LDD2141  [22]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C135(0.89)  LDD2149  [22]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C135(0.31)  LDD2150  [22]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C135(0.94)  LDD2153  [22]
 LDCM0627  NUDT7-COV-1 HEK-293T C135(0.51)  LDD2206  [26]
 LDCM0628  OTUB2-COV-1 HEK-293T C135(0.88)  LDD2207  [26]
 LDCM0131  RA190 MM1.R C135(1.24)  LDD0304  [27]
 LDCM0021  THZ1 HCT 116 C135(1.06)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heme oxygenase 2 (HMOX2) Heme oxygenase family P30519
GTP-binding nuclear protein Ran (RAN) Ran family P62826

References

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2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Fragment-Based Covalent Ligand Screening Enables Rapid Discovery of Inhibitors for the RBR E3 Ubiquitin Ligase HOIP. J Am Chem Soc. 2019 Feb 13;141(6):2703-2712. doi: 10.1021/jacs.8b13193. Epub 2019 Feb 4.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
26 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
27 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.