Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name FFF probe13  Probe Info 
Probe concentration Probe:20uM; negative probe:20uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
SILAC
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 45 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 20.0
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 20.0
 LDTP04437  Aldehyde dehydrogenase family 3 member A2 (ALDH3A2) 20.0
 LDTP02141  Alpha-galactosidase A (GLA) 20.0
 LDTP06618  ATP-dependent Clp protease proteolytic subunit, mitochondrial (CLPP) 20.0
 LDTP02837  Beta-galactosidase (GLB1) 20.0
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 20.0
 LDTP02198  Cathepsin D (CTSD) 20.0
 LDTP03189  Cytochrome b-c1 complex subunit 2, mitochondrial (UQCRC2) 20.0
 LDTP18087  Dephospho-CoA kinase domain-containing protein (DCAKD) 20.0
 LDTP01769  Dihydrofolate reductase (DHFR) 20.0
 LDTP00950  Dynamin-like 120 kDa protein, mitochondrial (OPA1) 20.0
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 20.0
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 20.0
 LDTP02651  Gamma-interferon-inducible lysosomal thiol reductase (IFI30) 20.0
 LDTP02359  Heme oxygenase 1 (HMOX1) 20.0
 LDTP03540  Heme oxygenase 2 (HMOX2) 20.0
 LDTP02602  Histidine--tRNA ligase, cytoplasmic (HARS1) 20.0
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 20.0
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 20.0
 LDTP09396  Minor histocompatibility antigen H13 (HM13) 20.0
 LDTP02848  NADPH--cytochrome P450 reductase (POR) 20.0
 LDTP04051  Nicotinamide phosphoribosyltransferase (NAMPT) 20.0
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 20.0
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 20.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 20.0
 LDTP07003  Presequence protease, mitochondrial (PITRM1) 20.0
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 20.0
 LDTP08979  Prostaglandin reductase 2 (PTGR2) 20.0
 LDTP03060  Proteasome subunit beta type-1 (PSMB1) 20.0
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 20.0
 LDTP03515  Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3) 20.0
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 20.0
 LDTP10318  Ubiquitin thioesterase OTUB1 (OTUB1) 20.0
 LDTP06901  Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12) 20.0
 LDTP06200  Delta(14)-sterol reductase LBR (LBR) 17.4
 LDTP06905  Acylglycerol kinase, mitochondrial (AGK) 14.3
 LDTP03689  Serine hydroxymethyltransferase, mitochondrial (SHMT2) 8.7
 LDTP02534  Endoplasmic reticulum chaperone BiP (HSPA5) 8.5
 LDTP02333  Glutathione S-transferase P (GSTP1) 7.3
 LDTP02188  Protein disulfide-isomerase (P4HB) 6.9
 LDTP12681  ATPase family AAA domain-containing protein 3A (ATAD3A) 6.9
 LDTP12954  Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 (HACD3) 6.5
 LDTP05724  Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1) 6.3
 LDTP02860  Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2) 5.6
Transporter and channel
Click to Show/Hide to Show 32 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP14511  ATP synthase subunit g, mitochondrial (ATP5MG) 20.0
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) 20.0
 LDTP02057  Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (RPN1) 20.0
 LDTP13393  Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13) 20.0
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 20.0
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 20.0
 LDTP00562  Membrane-associated progesterone receptor component 2 (PGRMC2) 20.0
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 20.0
 LDTP12909  Mitochondrial carrier homolog 1 (MTCH1) 20.0
 LDTP14235  Mitochondrial carrier homolog 2 (MTCH2) 20.0
 LDTP13174  Mitochondrial dicarboxylate carrier (SLC25A10) 20.0
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 20.0
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 20.0
 LDTP14200  Mitochondrial ornithine transporter 1 (SLC25A15) 20.0
 LDTP01525  Mitochondrial proton/calcium exchanger protein (LETM1) 20.0
 LDTP11213  Nucleoporin NDC1 (NDC1) 20.0
 LDTP04213  Phosphatidylinositol transfer protein beta isoform (PITPNB) 20.0
 LDTP02215  Prosaposin (PSAP) 20.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 20.0
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 20.0
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 20.0
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 20.0
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 20.0
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 20.0
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) 20.0
 LDTP04501  Importin subunit alpha-1 (KPNA2) 17.0
 LDTP00592  Surfeit locus protein 4 (SURF4) 16.0
 LDTP03405  Calnexin (CANX) 10.4
 LDTP00235  Membrane-associated progesterone receptor component 1 (PGRMC1) 8.9
 LDTP04293  Transmembrane emp24 domain-containing protein 10 (TMED10) 7.3
 LDTP12142  Exportin-5 (XPO5) 6.9
 LDTP05238  Solute carrier family 25 member 3 (SLC25A3) 6.5
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03772  Basigin (BSG) 14.4
Other
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 20.0
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 20.0
 LDTP08425  Hornerin (HRNR) 20.0
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 20.0
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 20.0
 LDTP13630  Neudesin (NENF) 20.0
 LDTP05375  Nucleobindin-1 (NUCB1) 20.0
 LDTP05160  Nucleobindin-2 (NUCB2) 20.0
 LDTP16323  Signal recognition particle receptor subunit beta (SRPRB) 20.0
 LDTP04684  Nucleosome assembly protein 1-like 1 (NAP1L1) 12.1
 LDTP03968  Lamina-associated polypeptide 2, isoforms beta/gamma (TMPO) 8.7
 LDTP17065  Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2) 8.7
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) 7.9
 LDTP02297  Vimentin (VIM) 7.8
 LDTP10684  RNA-binding protein 14 (RBM14) 7.2
 LDTP00500  Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL) 5.4
 LDTP03775  RNA-binding protein FUS (FUS) 5.3
 LDTP09881  TATA-binding protein-associated factor 2N (TAF15) 5.2

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.