Details of the Target

General Information of Target

Target ID LDTP04958
Target Name Small ribosomal subunit protein eS7 (RPS7)
Gene Name RPS7
Gene ID 6201
Synonyms
Small ribosomal subunit protein eS7; 40S ribosomal protein S7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAI
IIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSR
TLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKL
TGKDVNFEFPEFQL
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eS7 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Required for rRNA maturation. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Uniprot ID
P62081
Ensemble ID
ENST00000403564.5
HGNC ID
HGNC:10440

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
A-EBA
 Probe Info  		3.60  LDD0215  [1]
ILS-1
 Probe Info  		2.06  LDD0415  [2]
AZ-9
 Probe Info  		2.02  LDD0393  [3]
C-Sul
 Probe Info  		6.62  LDD0066  [4]
TH211
 Probe Info  		Y177(12.56)  LDD0257  [5]
TH214
 Probe Info  		Y177(6.11)  LDD0258  [5]
TH216
 Probe Info  		Y177(11.92)  LDD0259  [5]
ONAyne
 Probe Info  		K103(0.00); K155(0.00); K142(0.00); K169(0.00)  LDD0273  [6]
Probe 1
 Probe Info  		Y177(9.13)  LDD3495  [7]
HHS-482
 Probe Info  		Y177(0.88)  LDD0285  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		K155(0.00); K49(0.00); K169(0.00); K178(0.00)  LDD0199  [10]
m-APA
 Probe Info  		H168(0.00); H91(0.00); H126(0.00)  LDD2231  [9]
ATP probe
 Probe Info  		K74(0.00); K147(0.00); K155(0.00); K142(0.00)  LDD0035  [11]
1d-yne
 Probe Info  		N.A.  LDD0356  [12]
NHS
 Probe Info  		K178(0.00); K58(0.00); K49(0.00)  LDD0010  [13]
OSF
 Probe Info  		N.A.  LDD0029  [14]
SF
 Probe Info  		K147(0.00); K160(0.00); K49(0.00); K74(0.00)  LDD0028  [14]
STPyne
 Probe Info  		K160(0.00); K49(0.00)  LDD0009  [13]
1c-yne
 Probe Info  		K10(0.00); K142(0.00)  LDD0228  [12]
Acrolein
 Probe Info  		H126(0.00); H168(0.00)  LDD0217  [15]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ILS-1 PP
 Probe Info  		2.99  LDD0417  [2]
STS-2
 Probe Info  		N.A.  LDD0138  [16]
STS-1
 Probe Info  		N.A.  LDD0068  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa H157(0.00); H168(0.00)  LDD0222  [15]
 LDCM0107  IAA HeLa H126(0.00); H168(0.00)  LDD0221  [15]
 LDCM0123  JWB131 DM93 Y177(0.88)  LDD0285  [8]
 LDCM0124  JWB142 DM93 Y177(0.45)  LDD0286  [8]
 LDCM0125  JWB146 DM93 Y177(0.91)  LDD0287  [8]
 LDCM0126  JWB150 DM93 Y177(2.10)  LDD0288  [8]
 LDCM0127  JWB152 DM93 Y177(1.60)  LDD0289  [8]
 LDCM0128  JWB198 DM93 Y177(0.73)  LDD0290  [8]
 LDCM0129  JWB202 DM93 Y177(0.43)  LDD0291  [8]
 LDCM0130  JWB211 DM93 Y177(0.69)  LDD0292  [8]
 LDCM0109  NEM HeLa H126(0.00); H168(0.00)  LDD0223  [15]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
NEDD8 (NEDD8) Ubiquitin family Q15843

References

1 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
2 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
12 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
17 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.