Details of the Target

General Information of Target

Target ID LDTP00886
Target Name Nardilysin (NRDC)
Gene Name NRDC
Gene ID 4898
Synonyms
NRD1; Nardilysin; EC 3.4.24.61; N-arginine dibasic convertase; NRD convertase; NRD-C; Nardilysin convertase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLRRVTVAAVCATRRKLCEAGRELAALWGIETRGRCEDSAAARPFPILAMPGRNKAKSTC
SCPDLQPNGQDLGENSRVARLGADESEEEGRRGSLSNAGDPEIVKSPSDPKQYRYIKLQN
GLQALLISDLSNMEGKTGNTTDDEEEEEVEEEEEDDDEDSGAEIEDDDEEGFDDEDEFDD
EHDDDLDTEDNELEELEERAEARKKTTEKQSAAALCVGVGSFADPDDLPGLAHFLEHMVF
MGSLKYPDENGFDAFLKKHGGSDNASTDCERTVFQFDVQRKYFKEALDRWAQFFIHPLMI
RDAIDREVEAVDSEYQLARPSDANRKEMLFGSLARPGHPMGKFFWGNAETLKHEPRKNNI
DTHARLREFWMRYYSSHYMTLVVQSKETLDTLEKWVTEIFSQIPNNGLPRPNFGHLTDPF
DTPAFNKLYRVVPIRKIHALTITWALPPQQQHYRVKPLHYISWLVGHEGKGSILSFLRKK
CWALALFGGNGETGFEQNSTYSVFSISITLTDEGYEHFYEVAYTVFQYLKMLQKLGPEKR
IFEEIRKIEDNEFHYQEQTDPVEYVENMCENMQLYPLQDILTGDQLLFEYKPEVIGEALN
QLVPQKANLVLLSGANEGKCDLKEKWFGTQYSIEDIENSWAELWNSNFELNPDLHLPAEN
KYIATDFTLKAFDCPETEYPVKIVNTPQGCLWYKKDNKFKIPKAYIRFHLISPLIQKSAA
NVVLFDIFVNILTHNLAEPAYEADVAQLEYKLVAGEHGLIIRVKGFNHKLPLLFQLIIDY
LAEFNSTPAVFTMITEQLKKTYFNILIKPETLAKDVRLLILEYARWSMIDKYQALMDGLS
LESLLSFVKEFKSQLFVEGLVQGNVTSTESMDFLKYVVDKLNFKPLEQEMPVQFQVVELP
SGHHLCKVKALNKGDANSEVTVYYQSGTRSLREYTLMELLVMHMEEPCFDFLRTKQTLGY
HVYPTCRNTSGILGFSVTVGTQATKYNSEVVDKKIEEFLSSFEEKIENLTEEAFNTQVTA
LIKLKECEDTHLGEEVDRNWNEVVTQQYLFDRLAHEIEALKSFSKSDLVNWFKAHRGPGS
KMLSVHVVGYGKYELEEDGTPSSEDSNSSCEVMQLTYLPTSPLLADCIIPITDIRAFTTT
LNLLPYHKIVK
Target Bioclass
Enzyme
Family
Peptidase M16 family
Subcellular location
Mitochondrion
Function
Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs. Is a critical activator of BACE1- and ADAM17-mediated pro-neuregulin ectodomain shedding, involved in the positive regulation of axonal maturation and myelination. Required for proper functioning of 2-oxoglutarate dehydrogenase (OGDH).
Uniprot ID
O43847
Ensemble ID
ENST00000352171.12
HGNC ID
HGNC:7995

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DOTC24510 SNV: p.F542L DBIA    Probe Info 
HCT15 SNV: p.Q1017H .
LS180 Deletion: p.G261VfsTer38 DBIA    Probe Info 
MDAMB468 SNV: p.E31K DBIA    Probe Info 
MEWO SNV: p.S462F DBIA    Probe Info 
MIAPACA2 SNV: p.I663V DBIA    Probe Info 
MV411 SNV: p.R540I DBIA    Probe Info 
NCIH358 SNV: p.A42P DBIA    Probe Info 
REH SNV: p.C1127G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.79  LDD0402  [1]
A-EBA
 Probe Info  		3.99  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
STPyne
 Probe Info  		K326(6.87)  LDD0277  [4]
Probe 1
 Probe Info  		Y986(95.03)  LDD3495  [5]
DBIA
 Probe Info  		C758(4.10); C966(1.77)  LDD3310  [6]
AHL-Pu-1
 Probe Info  		C62(2.59)  LDD0168  [7]
HHS-475
 Probe Info  		Y960(3.11)  LDD0264  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
ATP probe
 Probe Info  		K808(0.00); K682(0.00)  LDD0199  [10]
IA-alkyne
 Probe Info  		C948(0.00); C269(0.00); C674(0.00); C966(0.00)  LDD0162  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [12]
BTD
 Probe Info  		N.A.  LDD0004  [13]
IPM
 Probe Info  		C60(0.00); C62(0.00)  LDD0025  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [14]
TFBX
 Probe Info  		C60(0.00); C62(0.00)  LDD0027  [14]
PF-06672131
 Probe Info  		N.A.  LDD0152  [15]
VSF
 Probe Info  		C60(0.00); C62(0.00)  LDD0007  [13]
Acrolein
 Probe Info  		C1027(0.00); C269(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [16]
Methacrolein
 Probe Info  		C1027(0.00); C674(0.00); C269(0.00); C690(0.00)  LDD0218  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]
AOyne
 Probe Info  		8.70  LDD0443  [18]
NAIA_5
 Probe Info  		C674(0.00); C620(0.00); C269(0.00); C690(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
PARPYnD
 Probe Info  		1.35  LDD0374  [20]
C161
 Probe Info  		10.63  LDD1841  [21]
C166
 Probe Info  		9.19  LDD1846  [21]
C174
 Probe Info  		4.92  LDD1854  [21]
C186
 Probe Info  		13.55  LDD1864  [21]
C215
 Probe Info  		5.03  LDD1889  [21]
C239
 Probe Info  		7.67  LDD1912  [21]
C269
 Probe Info  		5.86  LDD1939  [21]
C270
 Probe Info  		6.45  LDD1940  [21]
C282
 Probe Info  		15.67  LDD1952  [21]
C286
 Probe Info  		6.73  LDD1956  [21]
C288
 Probe Info  		6.50  LDD1958  [21]
C339
 Probe Info  		7.01  LDD2002  [21]
C348
 Probe Info  		9.99  LDD2009  [21]
C353
 Probe Info  		6.41  LDD2014  [21]
C407
 Probe Info  		11.55  LDD2064  [21]
FFF probe11
 Probe Info  		20.00  LDD0471  [22]
FFF probe12
 Probe Info  		13.81  LDD0473  [22]
FFF probe13
 Probe Info  		15.13  LDD0475  [22]
FFF probe14
 Probe Info  		12.38  LDD0477  [22]
FFF probe3
 Probe Info  		20.00  LDD0464  [22]
FFF probe6
 Probe Info  		9.74  LDD0467  [22]
FFF probe9
 Probe Info  		19.20  LDD0470  [22]
JN0003
 Probe Info  		20.00  LDD0469  [22]
STS-1
 Probe Info  		N.A.  LDD0136  [23]
STS-2
 Probe Info  		1.00  LDD0139  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C1027(0.88)  LDD2112  [24]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C1027(0.88)  LDD2130  [24]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C1027(2.13); C620(0.93)  LDD2117  [24]
 LDCM0025  4SU-RNA HEK-293T C62(2.59)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C268(2.67); C62(2.80)  LDD0169  [7]
 LDCM0214  AC1 HEK-293T C1027(0.97); C674(0.96); C690(0.93); C966(1.03)  LDD1507  [25]
 LDCM0215  AC10 HEK-293T C269(0.90); C1027(1.07); C674(0.94); C690(1.12)  LDD1508  [25]
 LDCM0226  AC11 HEK-293T C674(1.03); C690(1.00); C966(1.12)  LDD1509  [25]
 LDCM0237  AC12 HEK-293T C1027(0.98); C674(0.96); C690(1.05)  LDD1510  [25]
 LDCM0259  AC14 HEK-293T C1027(1.08); C674(0.99); C690(1.05); C966(1.03)  LDD1512  [25]
 LDCM0270  AC15 HEK-293T C269(4.09); C1027(0.96); C674(1.00); C690(1.05)  LDD1513  [25]
 LDCM0276  AC17 HEK-293T C1027(0.96); C674(1.00); C690(0.83); C966(1.11)  LDD1515  [25]
 LDCM0277  AC18 HEK-293T C269(0.80); C1027(1.05); C674(1.12); C690(1.10)  LDD1516  [25]
 LDCM0278  AC19 HEK-293T C674(0.90); C690(1.00); C966(1.00)  LDD1517  [25]
 LDCM0279  AC2 HEK-293T C269(0.99); C1027(1.02); C674(0.99); C690(1.22)  LDD1518  [25]
 LDCM0280  AC20 HEK-293T C1027(0.93); C674(0.97); C690(0.90)  LDD1519  [25]
 LDCM0281  AC21 HEK-293T C674(0.99); C690(1.01)  LDD1520  [25]
 LDCM0282  AC22 HEK-293T C1027(0.99); C674(1.01); C690(0.90); C966(0.94)  LDD1521  [25]
 LDCM0283  AC23 HEK-293T C269(4.09); C1027(1.12); C674(1.05); C690(0.92)  LDD1522  [25]
 LDCM0284  AC24 HEK-293T C674(1.00); C690(1.01); C966(1.09); C1110(1.34)  LDD1523  [25]
 LDCM0285  AC25 HEK-293T C1027(1.00); C674(1.01); C690(0.82); C966(1.08)  LDD1524  [25]
 LDCM0286  AC26 HEK-293T C269(0.86); C1027(1.03); C674(1.01); C690(1.11)  LDD1525  [25]
 LDCM0287  AC27 HEK-293T C674(1.11); C690(1.02); C966(0.99)  LDD1526  [25]
 LDCM0288  AC28 HEK-293T C1027(1.03); C674(1.03); C690(1.25)  LDD1527  [25]
 LDCM0289  AC29 HEK-293T C674(1.12); C690(0.94)  LDD1528  [25]
 LDCM0290  AC3 HEK-293T C674(0.94); C690(1.07); C966(1.06)  LDD1529  [25]
 LDCM0291  AC30 HEK-293T C1027(1.03); C674(1.05); C690(1.04); C966(1.01)  LDD1530  [25]
 LDCM0292  AC31 HEK-293T C269(3.11); C1027(1.07); C674(0.96); C690(0.95)  LDD1531  [25]
 LDCM0293  AC32 HEK-293T C674(0.96); C690(1.05); C966(1.05); C1110(1.02)  LDD1532  [25]
 LDCM0294  AC33 HEK-293T C1027(1.08); C674(0.97); C690(0.88); C966(1.12)  LDD1533  [25]
 LDCM0295  AC34 HEK-293T C269(0.87); C1027(0.99); C674(1.06); C690(1.07)  LDD1534  [25]
 LDCM0296  AC35 HEK-293T C674(0.92); C690(0.92); C966(1.00)  LDD1535  [25]
 LDCM0297  AC36 HEK-293T C1027(0.99); C674(0.90); C690(0.97)  LDD1536  [25]
 LDCM0298  AC37 HEK-293T C674(0.95); C690(0.93)  LDD1537  [25]
 LDCM0299  AC38 HEK-293T C1027(1.05); C674(1.10); C690(1.15); C966(1.24)  LDD1538  [25]
 LDCM0300  AC39 HEK-293T C269(4.12); C1027(0.99); C674(0.96); C690(1.14)  LDD1539  [25]
 LDCM0301  AC4 HEK-293T C1027(0.94); C674(0.93); C690(1.05)  LDD1540  [25]
 LDCM0302  AC40 HEK-293T C674(0.95); C690(0.97); C966(1.21); C1110(1.10)  LDD1541  [25]
 LDCM0303  AC41 HEK-293T C1027(1.06); C674(0.98); C690(0.83); C966(1.08)  LDD1542  [25]
 LDCM0304  AC42 HEK-293T C269(1.01); C1027(1.11); C674(0.99); C690(1.18)  LDD1543  [25]
 LDCM0305  AC43 HEK-293T C674(0.98); C690(0.90); C966(1.12)  LDD1544  [25]
 LDCM0306  AC44 HEK-293T C1027(1.03); C674(0.95); C690(0.96)  LDD1545  [25]
 LDCM0307  AC45 HEK-293T C674(0.90); C690(1.00)  LDD1546  [25]
 LDCM0308  AC46 HEK-293T C1027(1.02); C674(1.02); C690(1.00); C966(1.06)  LDD1547  [25]
 LDCM0309  AC47 HEK-293T C269(3.06); C1027(0.93); C674(1.02); C690(1.02)  LDD1548  [25]
 LDCM0310  AC48 HEK-293T C674(0.98); C690(0.99); C966(1.11); C1110(1.36)  LDD1549  [25]
 LDCM0311  AC49 HEK-293T C1027(1.08); C674(1.03); C690(0.77); C966(1.17)  LDD1550  [25]
 LDCM0312  AC5 HEK-293T C674(0.88); C690(0.96)  LDD1551  [25]
 LDCM0313  AC50 HEK-293T C269(1.38); C1027(1.13); C674(0.94); C690(1.07)  LDD1552  [25]
 LDCM0314  AC51 HEK-293T C674(1.01); C690(1.01); C966(1.02)  LDD1553  [25]
 LDCM0315  AC52 HEK-293T C1027(1.05); C674(0.97); C690(1.20)  LDD1554  [25]
 LDCM0316  AC53 HEK-293T C674(0.93); C690(0.90)  LDD1555  [25]
 LDCM0317  AC54 HEK-293T C1027(1.08); C674(0.99); C690(1.02); C966(1.09)  LDD1556  [25]
 LDCM0318  AC55 HEK-293T C269(2.97); C1027(0.95); C674(0.99); C690(0.99)  LDD1557  [25]
 LDCM0319  AC56 HEK-293T C674(0.99); C690(1.03); C966(1.02); C1110(1.35)  LDD1558  [25]
 LDCM0320  AC57 HEK-293T C1027(0.98); C674(0.94); C690(0.90); C966(1.07)  LDD1559  [25]
 LDCM0321  AC58 HEK-293T C269(1.00); C1027(1.04); C674(0.99); C690(1.08)  LDD1560  [25]
 LDCM0322  AC59 HEK-293T C674(1.04); C690(0.99); C966(1.03)  LDD1561  [25]
 LDCM0323  AC6 HEK-293T C1027(0.96); C674(0.96); C690(1.07); C966(1.07)  LDD1562  [25]
 LDCM0324  AC60 HEK-293T C1027(0.95); C674(0.98); C690(0.93)  LDD1563  [25]
 LDCM0325  AC61 HEK-293T C674(0.95); C690(0.94)  LDD1564  [25]
 LDCM0326  AC62 HEK-293T C1027(1.01); C674(1.04); C690(1.01); C966(1.15)  LDD1565  [25]
 LDCM0327  AC63 HEK-293T C269(3.85); C1027(1.03); C674(0.99); C690(1.05)  LDD1566  [25]
 LDCM0328  AC64 HEK-293T C674(0.97); C690(1.01); C966(1.08); C1110(0.88)  LDD1567  [25]
 LDCM0334  AC7 HEK-293T C269(4.15); C1027(0.93); C674(0.96); C690(1.18)  LDD1568  [25]
 LDCM0345  AC8 HEK-293T C674(0.84); C690(1.04); C966(1.04); C1110(0.82)  LDD1569  [25]
 LDCM0248  AKOS034007472 HEK-293T C674(0.93); C690(0.85)  LDD1511  [25]
 LDCM0356  AKOS034007680 HEK-293T C1027(1.11); C674(0.97); C690(0.86); C966(1.02)  LDD1570  [25]
 LDCM0275  AKOS034007705 HEK-293T C674(0.95); C690(1.09); C966(1.09); C1110(1.14)  LDD1514  [25]
 LDCM0498  BS-3668 MDA-MB-231 C1027(0.70)  LDD2091  [24]
 LDCM0108  Chloroacetamide HeLa C1027(0.00); C269(0.00); C690(0.00); C674(0.00)  LDD0222  [16]
 LDCM0367  CL1 HEK-293T C269(1.24); C674(0.88); C690(0.94)  LDD1571  [25]
 LDCM0368  CL10 HEK-293T C1027(1.18); C674(0.88); C690(0.98); C966(0.95)  LDD1572  [25]
 LDCM0369  CL100 HEK-293T C1027(0.91); C674(0.98); C690(1.00); C1110(0.86)  LDD1573  [25]
 LDCM0370  CL101 HEK-293T C269(1.30); C674(0.94); C690(1.01)  LDD1574  [25]
 LDCM0371  CL102 HEK-293T C269(1.07); C1027(0.90); C674(0.82); C690(1.02)  LDD1575  [25]
 LDCM0372  CL103 HEK-293T C269(1.54); C674(0.86); C690(1.02)  LDD1576  [25]
 LDCM0373  CL104 HEK-293T C1027(1.07); C674(1.00); C690(0.97); C1110(0.94)  LDD1577  [25]
 LDCM0374  CL105 HEK-293T C269(1.32); C674(1.01); C690(0.95)  LDD1578  [25]
 LDCM0375  CL106 HEK-293T C269(1.30); C1027(0.95); C674(1.02); C690(1.08)  LDD1579  [25]
 LDCM0376  CL107 HEK-293T C269(1.22); C674(0.89); C690(1.02)  LDD1580  [25]
 LDCM0377  CL108 HEK-293T C1027(0.99); C674(0.94); C690(0.91); C1110(1.06)  LDD1581  [25]
 LDCM0378  CL109 HEK-293T C269(1.42); C674(0.96); C690(0.94)  LDD1582  [25]
 LDCM0379  CL11 HEK-293T C269(4.28); C1027(1.27); C674(0.96); C690(1.13)  LDD1583  [25]
 LDCM0380  CL110 HEK-293T C269(1.03); C1027(1.00); C674(0.86); C690(0.99)  LDD1584  [25]
 LDCM0381  CL111 HEK-293T C269(1.11); C674(0.96); C690(1.02)  LDD1585  [25]
 LDCM0382  CL112 HEK-293T C1027(1.04); C674(0.91); C690(1.06); C1110(0.89)  LDD1586  [25]
 LDCM0383  CL113 HEK-293T C269(1.30); C674(0.91); C690(0.95)  LDD1587  [25]
 LDCM0384  CL114 HEK-293T C269(1.00); C1027(1.05); C674(0.79); C690(1.03)  LDD1588  [25]
 LDCM0385  CL115 HEK-293T C269(1.60); C674(0.89); C690(0.98)  LDD1589  [25]
 LDCM0386  CL116 HEK-293T C1027(0.97); C674(0.88); C690(1.02); C1110(1.20)  LDD1590  [25]
 LDCM0387  CL117 HEK-293T C269(1.29); C674(0.94); C690(1.05)  LDD1591  [25]
 LDCM0388  CL118 HEK-293T C269(1.31); C1027(0.97); C674(0.88); C690(1.10)  LDD1592  [25]
 LDCM0389  CL119 HEK-293T C269(1.51); C674(0.88); C690(1.01)  LDD1593  [25]
 LDCM0390  CL12 HEK-293T C674(0.92); C690(1.03); C966(0.99); C1110(0.99)  LDD1594  [25]
 LDCM0391  CL120 HEK-293T C1027(0.97); C674(0.93); C690(0.99); C1110(0.83)  LDD1595  [25]
 LDCM0392  CL121 HEK-293T C269(1.22); C674(0.93); C690(0.96)  LDD1596  [25]
 LDCM0393  CL122 HEK-293T C269(1.10); C1027(0.91); C674(0.94); C690(1.07)  LDD1597  [25]
 LDCM0394  CL123 HEK-293T C269(1.09); C674(0.86); C690(1.00)  LDD1598  [25]
 LDCM0395  CL124 HEK-293T C1027(0.98); C674(0.89); C690(1.04); C1110(0.86)  LDD1599  [25]
 LDCM0396  CL125 HEK-293T C269(1.44); C674(0.96); C690(0.90)  LDD1600  [25]
 LDCM0397  CL126 HEK-293T C269(1.21); C1027(1.03); C674(0.87); C690(0.86)  LDD1601  [25]
 LDCM0398  CL127 HEK-293T C269(1.17); C674(0.87); C690(1.00)  LDD1602  [25]
 LDCM0399  CL128 HEK-293T C1027(0.96); C674(0.91); C690(0.96); C1110(1.16)  LDD1603  [25]
 LDCM0400  CL13 HEK-293T C269(1.17); C674(0.88); C690(0.95)  LDD1604  [25]
 LDCM0401  CL14 HEK-293T C269(1.04); C1027(0.97); C674(0.91); C690(1.05)  LDD1605  [25]
 LDCM0402  CL15 HEK-293T C269(1.12); C674(0.83); C690(0.99)  LDD1606  [25]
 LDCM0403  CL16 HEK-293T C1027(1.11); C674(0.87); C690(1.09); C1110(1.15)  LDD1607  [25]
 LDCM0404  CL17 HEK-293T C1027(0.99); C674(0.88); C690(0.80); C966(1.00)  LDD1608  [25]
 LDCM0405  CL18 HEK-293T C269(0.77); C1027(1.12); C674(1.09); C690(1.23)  LDD1609  [25]
 LDCM0406  CL19 HEK-293T C674(0.99); C690(1.13); C966(1.20)  LDD1610  [25]
 LDCM0407  CL2 HEK-293T C269(1.04); C1027(1.06); C674(0.97); C690(1.07)  LDD1611  [25]
 LDCM0408  CL20 HEK-293T C1027(1.17); C674(1.03); C690(1.14)  LDD1612  [25]
 LDCM0409  CL21 HEK-293T C674(0.95); C690(0.45)  LDD1613  [25]
 LDCM0410  CL22 HEK-293T C1027(1.26); C674(1.06); C690(1.01); C966(1.00)  LDD1614  [25]
 LDCM0411  CL23 HEK-293T C269(4.60); C1027(1.45); C674(0.95); C690(1.06)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C674(1.00); C690(1.14); C966(1.01); C1110(1.28)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C269(1.23); C674(0.95); C690(1.00)  LDD1617  [25]
 LDCM0414  CL26 HEK-293T C269(1.02); C1027(0.92); C674(1.05); C690(1.04)  LDD1618  [25]
 LDCM0415  CL27 HEK-293T C269(1.64); C674(0.91); C690(0.99)  LDD1619  [25]
 LDCM0416  CL28 HEK-293T C1027(1.00); C674(0.88); C690(0.97); C1110(0.84)  LDD1620  [25]
 LDCM0417  CL29 HEK-293T C1027(1.16); C674(1.14); C690(0.77); C966(1.01)  LDD1621  [25]
 LDCM0418  CL3 HEK-293T C269(1.46); C674(0.88); C690(1.10)  LDD1622  [25]
 LDCM0419  CL30 HEK-293T C269(0.92); C1027(1.14); C674(1.01); C690(1.07)  LDD1623  [25]
 LDCM0420  CL31 HEK-293T C674(0.88); C690(1.04); C966(1.17)  LDD1624  [25]
 LDCM0421  CL32 HEK-293T C1027(1.24); C674(1.04); C690(1.02)  LDD1625  [25]
 LDCM0422  CL33 HEK-293T C674(0.79); C690(0.97)  LDD1626  [25]
 LDCM0423  CL34 HEK-293T C1027(1.20); C674(1.04); C690(1.12); C966(0.93)  LDD1627  [25]
 LDCM0424  CL35 HEK-293T C269(4.87); C1027(1.54); C674(0.96); C690(0.96)  LDD1628  [25]
 LDCM0425  CL36 HEK-293T C674(0.96); C690(1.08); C966(1.01); C1110(1.19)  LDD1629  [25]
 LDCM0426  CL37 HEK-293T C269(1.38); C674(1.05); C690(1.00)  LDD1630  [25]
 LDCM0428  CL39 HEK-293T C269(1.22); C674(0.88); C690(1.02)  LDD1632  [25]
 LDCM0429  CL4 HEK-293T C1027(1.01); C674(0.89); C690(1.06); C1110(1.47)  LDD1633  [25]
 LDCM0430  CL40 HEK-293T C1027(1.03); C674(0.97); C690(1.01); C1110(0.96)  LDD1634  [25]
 LDCM0431  CL41 HEK-293T C1027(0.99); C674(0.97); C690(0.94); C966(0.94)  LDD1635  [25]
 LDCM0432  CL42 HEK-293T C269(1.29); C1027(1.10); C674(1.08); C690(1.19)  LDD1636  [25]
 LDCM0433  CL43 HEK-293T C674(1.04); C690(1.11); C966(1.12)  LDD1637  [25]
 LDCM0434  CL44 HEK-293T C1027(1.33); C674(0.96); C690(1.03)  LDD1638  [25]
 LDCM0435  CL45 HEK-293T C674(0.92); C690(0.90)  LDD1639  [25]
 LDCM0436  CL46 HEK-293T C1027(1.45); C674(1.03); C690(1.05); C966(1.05)  LDD1640  [25]
 LDCM0437  CL47 HEK-293T C269(4.53); C1027(1.37); C674(1.04); C690(0.93)  LDD1641  [25]
 LDCM0438  CL48 HEK-293T C674(0.97); C690(1.00); C966(0.94); C1110(1.40)  LDD1642  [25]
 LDCM0439  CL49 HEK-293T C269(1.37); C674(0.91); C690(0.97)  LDD1643  [25]
 LDCM0440  CL5 HEK-293T C1027(1.20); C674(1.03); C690(0.96); C966(1.05)  LDD1644  [25]
 LDCM0441  CL50 HEK-293T C269(1.06); C1027(1.08); C674(0.87); C690(1.03)  LDD1645  [25]
 LDCM0443  CL52 HEK-293T C1027(1.01); C674(0.95); C690(1.15); C1110(0.77)  LDD1646  [25]
 LDCM0444  CL53 HEK-293T C1027(1.06); C674(0.97); C690(0.80); C966(1.00)  LDD1647  [25]
 LDCM0445  CL54 HEK-293T C269(0.99); C1027(1.01); C674(0.90); C690(1.12)  LDD1648  [25]
 LDCM0446  CL55 HEK-293T C674(0.88); C690(1.06); C966(1.19)  LDD1649  [25]
 LDCM0447  CL56 HEK-293T C1027(1.30); C674(0.88); C690(1.07)  LDD1650  [25]
 LDCM0448  CL57 HEK-293T C674(0.77); C690(0.94)  LDD1651  [25]
 LDCM0449  CL58 HEK-293T C1027(1.23); C674(0.98); C690(1.04); C966(0.94)  LDD1652  [25]
 LDCM0450  CL59 HEK-293T C269(4.46); C1027(1.50); C674(0.96); C690(1.02)  LDD1653  [25]
 LDCM0451  CL6 HEK-293T C269(0.89); C1027(1.17); C674(1.02); C690(1.02)  LDD1654  [25]
 LDCM0452  CL60 HEK-293T C674(0.96); C690(1.14); C966(1.03); C1110(1.19)  LDD1655  [25]
 LDCM0453  CL61 HEK-293T C269(1.12); C674(0.97); C690(0.95)  LDD1656  [25]
 LDCM0454  CL62 HEK-293T C269(1.27); C1027(1.06); C674(0.91); C690(1.05)  LDD1657  [25]
 LDCM0455  CL63 HEK-293T C269(1.31); C674(0.93); C690(1.03)  LDD1658  [25]
 LDCM0456  CL64 HEK-293T C1027(1.02); C674(0.81); C690(0.98); C1110(0.74)  LDD1659  [25]
 LDCM0457  CL65 HEK-293T C1027(0.99); C674(1.14); C690(0.95); C966(1.07)  LDD1660  [25]
 LDCM0458  CL66 HEK-293T C269(1.00); C1027(1.19); C674(0.98); C690(1.18)  LDD1661  [25]
 LDCM0459  CL67 HEK-293T C674(0.92); C690(1.00); C966(1.17)  LDD1662  [25]
 LDCM0460  CL68 HEK-293T C1027(1.29); C674(1.00); C690(1.08)  LDD1663  [25]
 LDCM0461  CL69 HEK-293T C674(0.65); C690(1.03)  LDD1664  [25]
 LDCM0462  CL7 HEK-293T C674(0.93); C690(1.15); C966(1.10)  LDD1665  [25]
 LDCM0463  CL70 HEK-293T C1027(1.31); C674(1.01); C690(1.15); C966(0.96)  LDD1666  [25]
 LDCM0464  CL71 HEK-293T C269(4.28); C1027(1.37); C674(0.96); C690(1.00)  LDD1667  [25]
 LDCM0465  CL72 HEK-293T C674(0.93); C690(1.02); C966(1.03); C1110(1.42)  LDD1668  [25]
 LDCM0466  CL73 HEK-293T C269(1.58); C674(0.97); C690(0.94)  LDD1669  [25]
 LDCM0467  CL74 HEK-293T C269(1.32); C1027(0.99); C674(0.91); C690(1.11)  LDD1670  [25]
 LDCM0469  CL76 HEK-293T C1027(0.94); C674(0.89); C690(1.09); C1110(1.47)  LDD1672  [25]
 LDCM0470  CL77 HEK-293T C1027(1.11); C674(1.03); C690(0.89); C966(1.00)  LDD1673  [25]
 LDCM0471  CL78 HEK-293T C269(1.10); C1027(1.16); C674(1.01); C690(1.15)  LDD1674  [25]
 LDCM0472  CL79 HEK-293T C674(0.96); C690(1.03); C966(1.13)  LDD1675  [25]
 LDCM0473  CL8 HEK-293T C1027(1.08); C674(0.86); C690(0.80)  LDD1676  [25]
 LDCM0474  CL80 HEK-293T C1027(1.26); C674(1.04); C690(1.06)  LDD1677  [25]
 LDCM0475  CL81 HEK-293T C674(0.97); C690(0.98)  LDD1678  [25]
 LDCM0476  CL82 HEK-293T C1027(1.26); C674(0.94); C690(1.19); C966(0.99)  LDD1679  [25]
 LDCM0477  CL83 HEK-293T C269(4.26); C1027(1.27); C674(0.97); C690(0.73)  LDD1680  [25]
 LDCM0478  CL84 HEK-293T C674(0.86); C690(1.04); C966(1.02); C1110(1.39)  LDD1681  [25]
 LDCM0479  CL85 HEK-293T C269(1.18); C674(0.87); C690(0.96)  LDD1682  [25]
 LDCM0480  CL86 HEK-293T C269(1.33); C1027(0.94); C674(0.93); C690(1.11)  LDD1683  [25]
 LDCM0481  CL87 HEK-293T C269(1.51); C674(0.82); C690(0.76)  LDD1684  [25]
 LDCM0482  CL88 HEK-293T C1027(1.03); C674(0.98); C690(1.01); C1110(0.94)  LDD1685  [25]
 LDCM0483  CL89 HEK-293T C1027(1.12); C674(1.05); C690(0.90); C966(1.03)  LDD1686  [25]
 LDCM0484  CL9 HEK-293T C674(1.05); C690(1.13)  LDD1687  [25]
 LDCM0485  CL90 HEK-293T C269(0.95); C1027(1.05); C674(0.83); C690(1.09)  LDD1688  [25]
 LDCM0486  CL91 HEK-293T C674(0.92); C690(1.13); C966(1.14)  LDD1689  [25]
 LDCM0487  CL92 HEK-293T C1027(1.08); C674(1.00); C690(0.96)  LDD1690  [25]
 LDCM0488  CL93 HEK-293T C674(0.87); C690(0.91)  LDD1691  [25]
 LDCM0489  CL94 HEK-293T C1027(1.17); C674(1.01); C690(0.98); C966(0.95)  LDD1692  [25]
 LDCM0490  CL95 HEK-293T C269(4.39); C1027(0.94); C674(0.77); C690(0.94)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C674(0.82); C690(1.01); C966(0.97); C1110(1.26)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C269(1.23); C674(0.82); C690(0.96)  LDD1695  [25]
 LDCM0493  CL98 HEK-293T C269(1.06); C1027(0.88); C674(0.85); C690(1.09)  LDD1696  [25]
 LDCM0494  CL99 HEK-293T C269(1.27); C674(0.87); C690(1.01)  LDD1697  [25]
 LDCM0191  Compound 21 HEK-293T 10.70  LDD0508  [22]
 LDCM0190  Compound 34 HEK-293T 9.43  LDD0510  [22]
 LDCM0192  Compound 35 HEK-293T 7.07  LDD0509  [22]
 LDCM0193  Compound 36 HEK-293T 8.55  LDD0511  [22]
 LDCM0634  CY-0357 Hep-G2 C674(1.02)  LDD2228  [19]
 LDCM0495  E2913 HEK-293T C269(1.32); C674(0.82); C690(0.98)  LDD1698  [25]
 LDCM0625  F8 Ramos 0.76; C674(1.12); C269(1.01)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos 1.51; C674(0.51); C269(0.44)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos 8.45; C674(1.16)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos 1.01; C674(0.32); C269(0.38)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos 1.09; C269(0.81)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos 1.02; C674(0.54); C269(0.66)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos 0.79; C674(0.37); C269(0.29)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos 0.90; C674(0.57); C269(0.79)  LDD2195  [26]
 LDCM0582  Fragment23 Ramos 1.35; C674(0.89); C269(0.83)  LDD2196  [26]
 LDCM0578  Fragment27 Ramos 0.94; C674(1.45); C269(0.64)  LDD2197  [26]
 LDCM0586  Fragment28 Ramos 1.27; C269(0.51)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos 1.16; C674(0.75); C269(0.93)  LDD2199  [26]
 LDCM0589  Fragment31 Ramos 1.17; C269(0.79)  LDD2200  [26]
 LDCM0590  Fragment32 Ramos 2.57; C674(0.29); C269(0.52)  LDD2201  [26]
 LDCM0468  Fragment33 HEK-293T C269(1.64); C674(0.95); C690(1.03)  LDD1671  [25]
 LDCM0596  Fragment38 Ramos 0.91; C674(0.36); C269(0.95)  LDD2203  [26]
 LDCM0566  Fragment4 Ramos 0.91; C269(0.61)  LDD2184  [26]
 LDCM0427  Fragment51 HEK-293T C269(1.16); C1027(1.02); C674(0.91); C690(0.98)  LDD1631  [25]
 LDCM0610  Fragment52 Ramos 1.39; C269(0.86)  LDD2204  [26]
 LDCM0614  Fragment56 Ramos 1.70; C674(1.56); C269(1.17)  LDD2205  [26]
 LDCM0569  Fragment7 Ramos 0.99; C674(0.69); C269(0.49)  LDD2186  [26]
 LDCM0571  Fragment9 Ramos 1.12; C674(0.63); C269(0.39)  LDD2188  [26]
 LDCM0116  HHS-0101 DM93 Y960(3.11)  LDD0264  [8]
 LDCM0117  HHS-0201 DM93 Y960(3.43)  LDD0265  [8]
 LDCM0118  HHS-0301 DM93 Y960(2.88)  LDD0266  [8]
 LDCM0119  HHS-0401 DM93 Y960(3.86)  LDD0267  [8]
 LDCM0120  HHS-0701 DM93 Y960(2.23)  LDD0268  [8]
 LDCM0107  IAA HeLa C1027(0.00); C674(0.00); H259(0.00); C690(0.00)  LDD0221  [16]
 LDCM0022  KB02 HEK-293T C269(0.96); C1027(0.94); C674(0.99); C690(1.06)  LDD1492  [25]
 LDCM0023  KB03 HEK-293T C269(0.99); C1027(0.88); C674(1.01); C690(1.11)  LDD1497  [25]
 LDCM0024  KB05 COLO792 C758(4.10); C966(1.77)  LDD3310  [6]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1027(0.97)  LDD2102  [24]
 LDCM0109  NEM HeLa N.A.  LDD0223  [16]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C1027(0.98)  LDD2092  [24]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C620(0.85)  LDD2093  [24]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C1027(0.94)  LDD2098  [24]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C1027(1.52); C620(1.08)  LDD2099  [24]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C1027(0.83); C269(0.27)  LDD2100  [24]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C620(0.50)  LDD2104  [24]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C1027(1.57)  LDD2105  [24]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C1027(0.72); C620(0.46)  LDD2106  [24]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C1027(1.85)  LDD2107  [24]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C1027(1.09); C620(0.86)  LDD2108  [24]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C1027(1.05); C620(0.69)  LDD2109  [24]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C1027(0.73)  LDD2110  [24]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1027(1.74)  LDD2111  [24]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C1027(0.55)  LDD2114  [24]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C1027(2.16)  LDD2119  [24]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C269(0.75)  LDD2120  [24]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C1027(1.55)  LDD2122  [24]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C620(0.87)  LDD2123  [24]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C620(0.88)  LDD2125  [24]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C1027(1.69); C620(0.86)  LDD2127  [24]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C1027(0.84)  LDD2128  [24]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C1027(1.05)  LDD2129  [24]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C620(0.49)  LDD2134  [24]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C1027(2.06)  LDD2135  [24]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C1027(1.93)  LDD2136  [24]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C1027(1.22)  LDD2137  [24]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C1027(1.28)  LDD2140  [24]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C1027(2.36)  LDD2144  [24]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C1027(1.34); C620(1.04)  LDD2146  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cellular tumor antigen p53 (TP53) P53 family P04637

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Structure-Guided Design and In-Cell Target Profiling of a Cell-Active Target Engagement Probe for PARP Inhibitors. ACS Chem Biol. 2020 Feb 21;15(2):325-333. doi: 10.1021/acschembio.9b00963. Epub 2020 Feb 10.
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578