Details of the Target

General Information of Target

Target ID LDTP09949
Target Name Transportin-1 (TNPO1)
Gene Name TNPO1
Gene ID 3842
Synonyms
KPNB2; MIP1; TRN; Transportin-1; Importin beta-2; Karyopherin beta-2; M9 region interaction protein; MIP
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MASQPPPPPKPWETRRIPGAGPGPGPGPTFQSADLGPTLMTRPGQPALTRVPPPILPRPS
QQTGSSSVNTFRPAYSSFSSGYGAYGNSFYGGYSPYSYGYNGLGYNRLRVDDLPPSRFVQ
QAEESSRGAFQSIESIVHAFASVSMMMDATFSAVYNSFRAVLDVANHFSRLKIHFTKVFS
AFALVRTIRYLYRRLQRMLGLRRGSENEDLWAESEGTVACLGAEDRAATSAKSWPIFLFF
AVILGGPYLIWKLLSTHSDEVTDSINWASGEDDHVVARAEYDFAAVSEEEISFRAGDMLN
LALKEQQPKVRGWLLASLDGQTTGLIPANYVKILGKRKGRKTVESSKVSKQQQSFTNPTL
TKGATVADSLDEQEAAFESVFVETNKVPVAPDSIGKDGEKQDL
Target Bioclass
Transporter and channel
Family
Importin beta family, Importin beta-2 subfamily
Subcellular location
Cytoplasm
Function
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. May mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in nuclear import of M9-containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Involved in hnRNP A1/A2 nuclear export. Mediates the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In vitro, mediates nuclear import of SRP19. Mediates nuclear import of ADAR/ADAR1 isoform 1 and isoform 5 in a RanGTP-dependent manner.; (Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev.
Uniprot ID
Q92973
Ensemble ID
ENST00000337273.10
HGNC ID
HGNC:6401

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 SNV: p.L809V DBIA    Probe Info 
COLO829 SNV: p.Q38H DBIA    Probe Info 
HCC70 SNV: p.L679V DBIA    Probe Info 
HEC1 SNV: p.C597Y DBIA    Probe Info 
HEC1B SNV: p.C597Y .
HT SNV: p.T514A .
J82 SNV: p.W805Ter DBIA    Probe Info 
JURKAT Deletion: p.C844VfsTer45 Compound 10    Probe Info 
OVCAR8 SNV: p.R351S DBIA    Probe Info 
SKMEL2 SNV: p.P196S DBIA    Probe Info 
SNU1196 Deletion: p.T555FfsTer29 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 47 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.30  LDD0402  [1]
A-EBA
 Probe Info  		2.74  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
TH211
 Probe Info  		Y51(11.03)  LDD0257  [4]
TH216
 Probe Info  		Y51(20.00)  LDD0259  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
YN-4
 Probe Info  		100.00  LDD0445  [5]
BTD
 Probe Info  		C806(5.07)  LDD1699  [6]
ONAyne
 Probe Info  		N.A.  LDD0273  [7]
OPA-S-S-alkyne
 Probe Info  		K889(1.10)  LDD3494  [8]
JZ128-DTB
 Probe Info  		C285(0.00); C790(0.00); C142(0.00); C103(0.00)  LDD0462  [9]
THZ1-DTB
 Probe Info  		C103(1.10); C285(1.08); C790(1.06); C142(1.02)  LDD0460  [9]
AZ-9
 Probe Info  		10.00  LDD2154  [10]
AHL-Pu-1
 Probe Info  		C164(3.13)  LDD0169  [11]
EA-probe
 Probe Info  		N.A.  LDD0440  [12]
HHS-475
 Probe Info  		Y51(0.74); Y788(0.75)  LDD0264  [13]
DBIA
 Probe Info  		C467(1.53); C205(0.89)  LDD0078  [14]
ATP probe
 Probe Info  		K85(0.00); K869(0.00); K889(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C386(0.00); C620(0.00); C164(0.00); C806(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		C142(0.00); C103(0.00); C683(0.00)  LDD0032  [17]
IPIAA_L
 Probe Info  		C164(0.00); C103(0.00)  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C386(0.00); C620(0.00); C164(0.00); C806(0.00)  LDD0037  [16]
JW-RF-010
 Probe Info  		C103(0.00); C164(0.00); C205(0.00)  LDD0026  [19]
NAIA_4
 Probe Info  		N.A.  LDD2226  [20]
TFBX
 Probe Info  		C467(0.00); C205(0.00); C620(0.00); C103(0.00)  LDD0027  [19]
WYneN
 Probe Info  		C164(0.00); C620(0.00); C386(0.00)  LDD0021  [21]
WYneO
 Probe Info  		C620(0.00); C103(0.00)  LDD0022  [21]
1d-yne
 Probe Info  		N.A.  LDD0356  [22]
Compound 10
 Probe Info  		N.A.  LDD2216  [23]
ENE
 Probe Info  		N.A.  LDD0006  [21]
IPM
 Probe Info  		C386(0.00); C683(0.00); C142(0.00); C205(0.00)  LDD0005  [21]
NHS
 Probe Info  		N.A.  LDD0010  [21]
PPMS
 Probe Info  		N.A.  LDD0008  [21]
STPyne
 Probe Info  		K889(0.00); K81(0.00); K869(0.00)  LDD0009  [21]
VSF
 Probe Info  		C164(0.00); C153(0.00); C103(0.00); C142(0.00)  LDD0007  [21]
Phosphinate-6
 Probe Info  		C862(0.00); C790(0.00); C103(0.00)  LDD0018  [24]
Ox-W18
 Probe Info  		W134(0.00); W878(0.00)  LDD2175  [25]
1c-yne
 Probe Info  		K487(0.00); K687(0.00)  LDD0228  [22]
Acrolein
 Probe Info  		C103(0.00); C164(0.00); C153(0.00); C142(0.00)  LDD0217  [26]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [26]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [26]
Methacrolein
 Probe Info  		C103(0.00); C142(0.00); C153(0.00)  LDD0218  [26]
W1
 Probe Info  		N.A.  LDD0236  [27]
AOyne
 Probe Info  		11.00  LDD0443  [28]
NAIA_5
 Probe Info  		C386(0.00); C862(0.00); C164(0.00); C205(0.00)  LDD2223  [20]
HHS-465
 Probe Info  		Y51(0.00); Y788(0.00); K64(0.00)  LDD2240  [29]
PAL-AfBPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		6.41  LDD1714  [30]
C017
 Probe Info  		7.01  LDD1725  [30]
C106
 Probe Info  		23.26  LDD1793  [30]
C108
 Probe Info  		9.06  LDD1795  [30]
C140
 Probe Info  		7.78  LDD1822  [30]
C161
 Probe Info  		11.00  LDD1841  [30]
C163
 Probe Info  		8.75  LDD1843  [30]
C178
 Probe Info  		15.24  LDD1857  [30]
C191
 Probe Info  		23.43  LDD1868  [30]
C220
 Probe Info  		17.51  LDD1894  [30]
C228
 Probe Info  		15.45  LDD1901  [30]
C277
 Probe Info  		14.83  LDD1947  [30]
C305
 Probe Info  		17.75  LDD1974  [30]
C310
 Probe Info  		8.57  LDD1977  [30]
C326
 Probe Info  		8.28  LDD1990  [30]
C337
 Probe Info  		5.24  LDD2000  [30]
C343
 Probe Info  		14.93  LDD2005  [30]
C376
 Probe Info  		8.17  LDD2036  [30]
FFF probe11
 Probe Info  		5.84  LDD0471  [31]
FFF probe13
 Probe Info  		20.00  LDD0475  [31]
FFF probe14
 Probe Info  		20.00  LDD0477  [31]
FFF probe15
 Probe Info  		12.50  LDD0490  [31]
FFF probe2
 Probe Info  		10.06  LDD0463  [31]
FFF probe3
 Probe Info  		7.33  LDD0464  [31]
JN0003
 Probe Info  		13.29  LDD0469  [31]
STS-1
 Probe Info  		7.33  LDD0136  [32]
STS-2
 Probe Info  		13.33  LDD0138  [32]
VE-P
 Probe Info  		N.A.  LDD0396  [33]
BD-F
 Probe Info  		N55(0.00); Q50(0.00); N49(0.00)  LDD0024  [34]
OEA-DA
 Probe Info  		6.75  LDD0046  [35]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C620(0.81)  LDD2112  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C620(1.02); C103(0.91)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C467(1.01); C103(0.88)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C467(0.85)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C806(1.07)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C103(0.34)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C620(0.80); C103(0.60)  LDD2131  [6]
 LDCM0025  4SU-RNA DM93 C164(2.75); C103(2.59)  LDD0170  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C164(3.13)  LDD0169  [11]
 LDCM0214  AC1 HCT 116 C142(0.79); C103(0.93); C153(0.88); C205(0.83)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C142(0.72); C103(0.76); C153(0.83); C205(0.80)  LDD0532  [14]
 LDCM0216  AC100 HCT 116 C142(0.38); C862(1.28); C103(0.98); C153(0.75)  LDD0533  [14]
 LDCM0217  AC101 HCT 116 C142(0.38); C862(2.19); C103(0.81); C153(0.76)  LDD0534  [14]
 LDCM0218  AC102 HCT 116 C142(0.46); C862(1.56); C103(0.86); C153(0.69)  LDD0535  [14]
 LDCM0219  AC103 HCT 116 C142(0.39); C862(2.38); C103(0.74); C153(0.58)  LDD0536  [14]
 LDCM0220  AC104 HCT 116 C142(0.35); C862(3.33); C103(0.81); C153(0.82)  LDD0537  [14]
 LDCM0221  AC105 HCT 116 C142(0.38); C862(1.41); C103(0.79); C153(0.74)  LDD0538  [14]
 LDCM0222  AC106 HCT 116 C142(0.38); C862(2.13); C103(0.88); C153(0.77)  LDD0539  [14]
 LDCM0223  AC107 HCT 116 C142(0.36); C862(2.70); C103(0.83); C153(0.70)  LDD0540  [14]
 LDCM0224  AC108 HCT 116 C142(0.45); C862(1.20); C103(0.86); C153(0.76)  LDD0541  [14]
 LDCM0225  AC109 HCT 116 C142(0.46); C862(2.11); C103(0.94); C153(0.92)  LDD0542  [14]
 LDCM0226  AC11 HCT 116 C142(0.72); C103(0.91); C153(0.82); C205(0.78)  LDD0543  [14]
 LDCM0227  AC110 HCT 116 C142(0.44); C862(1.57); C103(0.84); C153(0.62)  LDD0544  [14]
 LDCM0228  AC111 HCT 116 C142(0.40); C862(4.98); C103(0.72); C153(0.63)  LDD0545  [14]
 LDCM0229  AC112 HCT 116 C142(0.46); C862(2.68); C103(0.79); C153(0.72)  LDD0546  [14]
 LDCM0230  AC113 HCT 116 C862(0.93); C103(1.59); C205(1.03); C386(0.87)  LDD0547  [14]
 LDCM0231  AC114 HCT 116 C862(0.93); C103(0.85); C205(1.02); C386(1.25)  LDD0548  [14]
 LDCM0232  AC115 HCT 116 C862(0.91); C103(0.87); C205(1.00); C386(0.77)  LDD0549  [14]
 LDCM0233  AC116 HCT 116 C862(0.48); C103(0.92); C205(0.88); C386(0.74)  LDD0550  [14]
 LDCM0234  AC117 HCT 116 C862(0.30); C103(0.80); C205(0.97); C386(0.87)  LDD0551  [14]
 LDCM0235  AC118 HCT 116 C862(0.29); C103(1.03); C205(0.95); C386(0.97)  LDD0552  [14]
 LDCM0236  AC119 HCT 116 C862(0.19); C103(0.97); C205(0.79); C386(0.96)  LDD0553  [14]
 LDCM0237  AC12 HCT 116 C142(0.84); C103(0.94); C153(0.89); C205(0.81)  LDD0554  [14]
 LDCM0238  AC120 HCT 116 C862(1.14); C103(0.74); C205(0.93); C386(0.51)  LDD0555  [14]
 LDCM0239  AC121 HCT 116 C862(0.72); C103(0.97); C205(1.01); C386(0.92)  LDD0556  [14]
 LDCM0240  AC122 HCT 116 C862(0.21); C103(0.92); C205(0.92); C386(0.90)  LDD0557  [14]
 LDCM0241  AC123 HCT 116 C862(0.65); C103(0.84); C205(0.92); C386(0.85)  LDD0558  [14]
 LDCM0242  AC124 HCT 116 C862(0.46); C103(1.02); C205(0.94); C386(1.16)  LDD0559  [14]
 LDCM0243  AC125 HCT 116 C862(0.79); C103(0.82); C205(0.84); C386(1.26)  LDD0560  [14]
 LDCM0244  AC126 HCT 116 C862(0.77); C103(0.82); C205(0.89); C386(1.18)  LDD0561  [14]
 LDCM0245  AC127 HCT 116 C862(0.24); C103(0.94); C205(0.85); C386(1.19)  LDD0562  [14]
 LDCM0246  AC128 HCT 116 C103(1.15); C205(0.96); C386(1.66); C467(1.45)  LDD0563  [14]
 LDCM0247  AC129 HCT 116 C103(1.47); C205(1.52); C386(1.58); C467(1.47)  LDD0564  [14]
 LDCM0249  AC130 HCT 116 C103(1.23); C205(1.02); C386(1.63); C467(1.21)  LDD0566  [14]
 LDCM0250  AC131 HCT 116 C103(1.23); C205(1.76); C386(1.27); C467(1.63)  LDD0567  [14]
 LDCM0251  AC132 HCT 116 C103(1.42); C205(0.91); C386(1.46); C467(0.96)  LDD0568  [14]
 LDCM0252  AC133 HCT 116 C103(1.21); C205(0.90); C386(1.60); C467(1.02)  LDD0569  [14]
 LDCM0253  AC134 HCT 116 C103(1.32); C205(0.97); C386(1.63); C467(0.99)  LDD0570  [14]
 LDCM0254  AC135 HCT 116 C103(1.41); C205(0.86); C386(1.65); C467(0.96)  LDD0571  [14]
 LDCM0255  AC136 HCT 116 C103(1.21); C205(0.89); C386(1.18); C467(0.97)  LDD0572  [14]
 LDCM0256  AC137 HCT 116 C103(1.32); C205(1.03); C386(1.28); C467(1.05)  LDD0573  [14]
 LDCM0257  AC138 HCT 116 C103(1.42); C205(0.84); C386(1.51); C467(0.96)  LDD0574  [14]
 LDCM0258  AC139 HCT 116 C103(1.45); C205(0.83); C386(1.46); C467(1.09)  LDD0575  [14]
 LDCM0259  AC14 HCT 116 C142(0.78); C103(0.72); C153(0.80); C205(0.86)  LDD0576  [14]
 LDCM0260  AC140 HCT 116 C103(1.32); C205(0.78); C386(1.85); C467(1.03)  LDD0577  [14]
 LDCM0261  AC141 HCT 116 C103(1.42); C205(0.88); C386(1.46); C467(1.01)  LDD0578  [14]
 LDCM0262  AC142 HCT 116 C103(1.41); C205(0.86); C386(1.39); C467(0.90)  LDD0579  [14]
 LDCM0263  AC143 HCT 116 C706(0.65); C153(0.68); C683(0.73); C620(0.76)  LDD0580  [14]
 LDCM0264  AC144 HCT 116 C153(0.52); C683(0.58); C620(0.69); C205(0.83)  LDD0581  [14]
 LDCM0265  AC145 HCT 116 C683(0.60); C153(0.70); C790(0.74); C620(0.74)  LDD0582  [14]
 LDCM0266  AC146 HCT 116 C683(0.53); C620(0.60); C790(0.61); C205(0.71)  LDD0583  [14]
 LDCM0267  AC147 HCT 116 C683(0.56); C153(0.58); C790(0.67); C620(0.76)  LDD0584  [14]
 LDCM0268  AC148 HCT 116 C620(0.61); C683(0.66); C153(0.84); C205(0.85)  LDD0585  [14]
 LDCM0269  AC149 HCT 116 C683(0.56); C620(0.58); C153(0.66); C205(0.74)  LDD0586  [14]
 LDCM0270  AC15 HCT 116 C706(0.68); C103(0.69); C142(0.69); C153(0.77)  LDD0587  [14]
 LDCM0271  AC150 HCT 116 C683(0.64); C153(0.67); C790(0.67); C620(0.69)  LDD0588  [14]
 LDCM0272  AC151 HCT 116 C683(0.67); C153(0.68); C620(0.79); C467(0.86)  LDD0589  [14]
 LDCM0273  AC152 HCT 116 C620(0.61); C683(0.64); C153(0.79); C806(0.85)  LDD0590  [14]
 LDCM0274  AC153 HCT 116 C620(0.50); C683(0.67); C205(0.89); C103(0.91)  LDD0591  [14]
 LDCM0621  AC154 HCT 116 C103(0.97); C153(0.58); C205(0.82); C386(0.98)  LDD2158  [14]
 LDCM0622  AC155 HCT 116 C103(0.89); C153(0.58); C205(0.77); C386(0.86)  LDD2159  [14]
 LDCM0623  AC156 HCT 116 C103(0.96); C153(0.72); C205(0.85); C386(0.93)  LDD2160  [14]
 LDCM0624  AC157 HCT 116 C103(0.78); C153(0.99); C205(1.30); C386(1.02)  LDD2161  [14]
 LDCM0276  AC17 HCT 116 C620(0.88); C683(0.92); C103(0.94); C706(0.95)  LDD0593  [14]
 LDCM0277  AC18 HCT 116 C467(0.75); C103(0.84); C620(0.85); C683(0.86)  LDD0594  [14]
 LDCM0278  AC19 HCT 116 C153(0.86); C683(0.89); C103(0.91); C467(0.97)  LDD0595  [14]
 LDCM0279  AC2 HCT 116 C706(0.75); C142(0.80); C153(0.80); C205(0.81)  LDD0596  [14]
 LDCM0280  AC20 HCT 116 C683(0.80); C386(0.82); C806(0.91); C620(0.93)  LDD0597  [14]
 LDCM0281  AC21 HCT 116 C683(0.77); C620(0.84); C103(0.88); C205(0.89)  LDD0598  [14]
 LDCM0282  AC22 HCT 116 C706(0.82); C467(0.84); C620(0.84); C683(0.89)  LDD0599  [14]
 LDCM0283  AC23 HCT 116 C683(0.76); C806(0.81); C620(0.81); C386(0.84)  LDD0600  [14]
 LDCM0284  AC24 HCT 116 C706(0.74); C386(0.87); C683(0.92); C153(1.02)  LDD0601  [14]
 LDCM0285  AC25 HCT 116 C683(0.74); C467(0.75); C205(0.80); C620(0.84)  LDD0602  [14]
 LDCM0286  AC26 HCT 116 C683(0.65); C205(0.68); C790(0.70); C467(0.74)  LDD0603  [14]
 LDCM0287  AC27 HCT 116 C683(0.65); C205(0.65); C467(0.65); C790(0.84)  LDD0604  [14]
 LDCM0288  AC28 HCT 116 C683(0.66); C467(0.67); C205(0.69); C790(0.80)  LDD0605  [14]
 LDCM0289  AC29 HCT 116 C683(0.61); C205(0.63); C467(0.72); C790(0.75)  LDD0606  [14]
 LDCM0290  AC3 HCT 116 C706(0.76); C205(0.82); C285(0.86); C297(0.86)  LDD0607  [14]
 LDCM0291  AC30 HCT 116 C467(0.68); C205(0.72); C683(0.75); C790(0.76)  LDD0608  [14]
 LDCM0292  AC31 HCT 116 C683(0.62); C467(0.70); C205(0.71); C790(0.75)  LDD0609  [14]
 LDCM0293  AC32 HCT 116 C683(0.55); C205(0.64); C706(0.75); C103(0.79)  LDD0610  [14]
 LDCM0294  AC33 HCT 116 C683(0.64); C706(0.66); C205(0.70); C790(0.76)  LDD0611  [14]
 LDCM0295  AC34 HCT 116 C683(0.64); C706(0.67); C103(0.76); C205(0.77)  LDD0612  [14]
 LDCM0296  AC35 HCT 116 C790(0.64); C706(0.84); C806(0.87); C142(0.98)  LDD0613  [14]
 LDCM0297  AC36 HCT 116 C790(0.76); C142(0.82); C153(0.82); C706(0.84)  LDD0614  [14]
 LDCM0298  AC37 HCT 116 C790(0.61); C706(0.85); C806(0.88); C205(0.94)  LDD0615  [14]
 LDCM0299  AC38 HCT 116 C790(0.52); C806(0.64); C706(0.65); C683(0.97)  LDD0616  [14]
 LDCM0300  AC39 HCT 116 C790(0.54); C205(0.73); C706(0.84); C806(0.86)  LDD0617  [14]
 LDCM0301  AC4 HCT 116 C142(0.78); C706(0.79); C285(0.81); C297(0.81)  LDD0618  [14]
 LDCM0302  AC40 HCT 116 C386(0.61); C790(0.65); C706(0.80); C806(0.81)  LDD0619  [14]
 LDCM0303  AC41 HCT 116 C790(0.53); C386(0.59); C706(0.59); C806(0.74)  LDD0620  [14]
 LDCM0304  AC42 HCT 116 C790(0.50); C706(0.59); C806(0.77); C142(0.86)  LDD0621  [14]
 LDCM0305  AC43 HCT 116 C790(0.54); C706(0.67); C386(0.68); C142(0.81)  LDD0622  [14]
 LDCM0306  AC44 HCT 116 C790(0.53); C706(0.57); C386(0.67); C806(0.77)  LDD0623  [14]
 LDCM0307  AC45 HCT 116 C386(0.53); C790(0.62); C706(0.68); C806(0.73)  LDD0624  [14]
 LDCM0308  AC46 HCT 116 C103(0.92); C790(0.93); C205(1.00); C620(1.01)  LDD0625  [14]
 LDCM0309  AC47 HCT 116 C790(0.82); C205(0.84); C806(0.88); C103(1.03)  LDD0626  [14]
 LDCM0310  AC48 HCT 116 C790(0.34); C205(0.67); C467(0.77); C620(0.83)  LDD0627  [14]
 LDCM0311  AC49 HCT 116 C103(0.85); C706(0.89); C620(0.96); C806(0.97)  LDD0628  [14]
 LDCM0312  AC5 HCT 116 C706(0.68); C205(0.74); C285(0.83); C297(0.83)  LDD0629  [14]
 LDCM0313  AC50 HCT 116 C706(0.77); C103(0.85); C620(0.96); C806(1.00)  LDD0630  [14]
 LDCM0314  AC51 HCT 116 C790(0.68); C706(0.72); C205(0.89); C103(0.92)  LDD0631  [14]
 LDCM0315  AC52 HCT 116 C790(0.80); C706(0.87); C205(0.90); C103(0.90)  LDD0632  [14]
 LDCM0316  AC53 HCT 116 C806(0.81); C706(0.88); C790(0.90); C103(0.92)  LDD0633  [14]
 LDCM0317  AC54 HCT 116 C706(0.73); C790(0.91); C806(0.93); C467(0.95)  LDD0634  [14]
 LDCM0318  AC55 HCT 116 C706(0.82); C467(0.94); C806(0.98); C103(1.01)  LDD0635  [14]
 LDCM0319  AC56 HCT 116 C806(0.80); C706(0.80); C103(0.89); C620(0.96)  LDD0636  [14]
 LDCM0320  AC57 HCT 116 C142(0.69); C153(0.74); C620(0.81); C205(0.87)  LDD0637  [14]
 LDCM0321  AC58 HCT 116 C142(0.65); C620(0.77); C153(0.79); C683(0.80)  LDD0638  [14]
 LDCM0322  AC59 HCT 116 C142(0.74); C706(0.77); C153(0.83); C205(0.84)  LDD0639  [14]
 LDCM0323  AC6 HCT 116 C142(0.65); C103(0.66); C205(0.77); C620(0.78)  LDD0640  [14]
 LDCM0324  AC60 HCT 116 C142(0.69); C620(0.70); C706(0.78); C153(0.80)  LDD0641  [14]
 LDCM0325  AC61 HCT 116 C142(0.65); C153(0.72); C706(0.74); C620(0.76)  LDD0642  [14]
 LDCM0326  AC62 HCT 116 C706(0.73); C142(0.76); C620(0.77); C153(0.79)  LDD0643  [14]
 LDCM0327  AC63 HCT 116 C142(0.69); C620(0.73); C153(0.78); C706(0.82)  LDD0644  [14]
 LDCM0328  AC64 HCT 116 C620(0.72); C142(0.73); C153(0.81); C205(0.85)  LDD0645  [14]
 LDCM0329  AC65 HCT 116 C790(0.58); C205(0.73); C806(0.73); C142(0.73)  LDD0646  [14]
 LDCM0330  AC66 HCT 116 C790(0.54); C142(0.78); C706(0.81); C205(0.81)  LDD0647  [14]
 LDCM0331  AC67 HCT 116 C790(0.58); C620(0.74); C706(0.75); C683(0.76)  LDD0648  [14]
 LDCM0332  AC68 HCT 116 C620(0.79); C683(0.79); C205(0.80); C386(0.80)  LDD0649  [14]
 LDCM0333  AC69 HCT 116 C142(0.76); C386(0.81); C683(0.83); C620(0.86)  LDD0650  [14]
 LDCM0334  AC7 HCT 116 C103(0.73); C142(0.74); C790(0.75); C153(0.78)  LDD0651  [14]
 LDCM0335  AC70 HCT 116 C862(0.26); C683(0.63); C205(0.80); C467(0.85)  LDD0652  [14]
 LDCM0336  AC71 HCT 116 C142(0.81); C683(0.81); C620(0.93); C153(0.97)  LDD0653  [14]
 LDCM0337  AC72 HCT 116 C862(0.35); C142(0.84); C386(0.87); C683(0.91)  LDD0654  [14]
 LDCM0338  AC73 HCT 116 C862(0.48); C142(0.92); C706(0.83); C620(0.95)  LDD0655  [14]
 LDCM0339  AC74 HCT 116 C706(0.79); C683(0.87); C620(0.91); C386(0.96)  LDD0656  [14]
 LDCM0340  AC75 HCT 116 C862(0.61); C103(0.96); C706(0.97); C205(1.06)  LDD0657  [14]
 LDCM0341  AC76 HCT 116 C862(0.76); C706(0.84); C142(0.84); C386(0.88)  LDD0658  [14]
 LDCM0342  AC77 HCT 116 C706(0.74); C683(0.83); C103(0.89); C142(0.91)  LDD0659  [14]
 LDCM0343  AC78 HCT 116 C142(0.69); C706(0.71); C683(0.75); C386(0.78)  LDD0660  [14]
 LDCM0344  AC79 HCT 116 C862(0.69); C706(0.74); C142(0.78); C683(0.84)  LDD0661  [14]
 LDCM0345  AC8 HCT 116 C103(0.75); C142(0.76); C205(0.78); C706(0.80)  LDD0662  [14]
 LDCM0346  AC80 HCT 116 C386(0.78); C706(0.79); C620(0.82); C683(0.84)  LDD0663  [14]
 LDCM0347  AC81 HCT 116 C862(0.63); C386(0.66); C806(0.77); C706(0.79)  LDD0664  [14]
 LDCM0348  AC82 HCT 116 C862(0.40); C706(0.77); C683(0.88); C103(0.96)  LDD0665  [14]
 LDCM0349  AC83 HCT 116 C706(0.70); C620(0.74); C205(0.80); C806(0.81)  LDD0666  [14]
 LDCM0350  AC84 HCT 116 C706(0.63); C620(0.76); C205(0.79); C806(0.81)  LDD0667  [14]
 LDCM0351  AC85 HCT 116 C706(0.73); C620(0.73); C205(0.75); C285(0.75)  LDD0668  [14]
 LDCM0352  AC86 HCT 116 C706(0.73); C285(0.73); C297(0.73); C103(0.74)  LDD0669  [14]
 LDCM0353  AC87 HCT 116 C706(0.83); C285(0.89); C297(0.89); C205(0.91)  LDD0670  [14]
 LDCM0354  AC88 HCT 116 C706(0.68); C205(0.90); C285(0.91); C297(0.91)  LDD0671  [14]
 LDCM0355  AC89 HCT 116 C706(0.57); C620(0.78); C205(0.82); C806(0.88)  LDD0672  [14]
 LDCM0357  AC90 HCT 116 C205(0.87); C706(0.92); C285(1.04); C297(1.04)  LDD0674  [14]
 LDCM0358  AC91 HCT 116 C706(0.66); C205(0.85); C103(0.87); C620(0.89)  LDD0675  [14]
 LDCM0359  AC92 HCT 116 C706(0.59); C620(0.80); C205(0.81); C683(0.83)  LDD0676  [14]
 LDCM0360  AC93 HCT 116 C706(0.58); C285(0.76); C297(0.76); C205(0.81)  LDD0677  [14]
 LDCM0361  AC94 HCT 116 C706(0.62); C620(0.82); C103(0.83); C683(0.88)  LDD0678  [14]
 LDCM0362  AC95 HCT 116 C706(0.64); C285(0.67); C297(0.67); C620(0.68)  LDD0679  [14]
 LDCM0363  AC96 HCT 116 C706(0.65); C467(0.79); C620(0.80); C285(0.81)  LDD0680  [14]
 LDCM0364  AC97 HCT 116 C706(0.55); C285(0.70); C297(0.70); C620(0.75)  LDD0681  [14]
 LDCM0365  AC98 HCT 116 C683(0.33); C142(0.42); C285(0.50); C297(0.50)  LDD0682  [14]
 LDCM0366  AC99 HCT 116 C285(0.38); C297(0.38); C683(0.44); C142(0.51)  LDD0683  [14]
 LDCM0520  AKOS000195272 MDA-MB-231 C706(1.17)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C142(0.83); C103(0.81); C153(0.88); C205(0.91)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C706(0.68); C142(0.75); C205(0.76); C103(0.82)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C706(0.63); C142(0.70); C153(0.76); C103(0.76)  LDD0592  [14]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0405  [1]
 LDCM0020  ARS-1620 HCC44 C467(1.53); C205(0.89)  LDD0078  [14]
 LDCM0151  AZ-11 HeLa 10.00  LDD2154  [10]
 LDCM0498  BS-3668 MDA-MB-231 C467(0.96); C103(0.74)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C103(0.00); C164(0.00); C620(0.00); H87(0.00)  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C467(20.00); C205(1.76); C683(1.06); C862(0.30)  LDD2227  [20]
 LDCM0367  CL1 HCT 116 C620(0.77); C386(0.91); C706(0.92); C103(0.94)  LDD0684  [14]
 LDCM0368  CL10 HCT 116 C620(0.69); C706(0.72); C683(0.92); C142(0.98)  LDD0685  [14]
 LDCM0369  CL100 HCT 116 C706(0.78); C790(0.79); C285(0.80); C297(0.80)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C142(0.66); C103(0.69); C153(0.71); C285(0.78)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C103(0.74); C806(0.77); C142(0.85); C285(0.88)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C806(0.71); C103(0.86); C153(0.92); C142(0.93)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C706(0.75); C142(0.80); C103(0.81); C153(0.83)  LDD0690  [14]
 LDCM0374  CL105 HCT 116 C467(0.74); C683(0.75); C205(0.83); C620(0.86)  LDD0691  [14]
 LDCM0375  CL106 HCT 116 C683(0.67); C620(0.78); C467(0.88); C153(0.93)  LDD0692  [14]
 LDCM0376  CL107 HCT 116 C683(0.70); C205(0.78); C620(0.79); C467(0.88)  LDD0693  [14]
 LDCM0377  CL108 HCT 116 C467(0.73); C683(0.79); C205(0.87); C620(0.89)  LDD0694  [14]
 LDCM0378  CL109 HCT 116 C683(0.72); C706(0.85); C386(0.85); C153(0.88)  LDD0695  [14]
 LDCM0379  CL11 HCT 116 C620(0.79); C706(0.80); C683(1.06); C103(1.08)  LDD0696  [14]
 LDCM0380  CL110 HCT 116 C683(0.66); C467(0.74); C620(0.84); C706(0.85)  LDD0697  [14]
 LDCM0381  CL111 HCT 116 C806(0.64); C683(0.81); C153(0.83); C706(0.85)  LDD0698  [14]
 LDCM0382  CL112 HCT 116 C205(0.73); C683(0.75); C467(0.78); C790(0.87)  LDD0699  [14]
 LDCM0383  CL113 HCT 116 C683(0.62); C467(0.65); C706(0.77); C205(0.78)  LDD0700  [14]
 LDCM0384  CL114 HCT 116 C467(0.54); C706(0.64); C683(0.66); C386(0.72)  LDD0701  [14]
 LDCM0385  CL115 HCT 116 C683(0.60); C467(0.61); C706(0.62); C205(0.70)  LDD0702  [14]
 LDCM0386  CL116 HCT 116 C706(0.61); C683(0.64); C205(0.67); C467(0.78)  LDD0703  [14]
 LDCM0387  CL117 HCT 116 C790(0.68); C806(0.77); C706(0.82); C386(0.84)  LDD0704  [14]
 LDCM0388  CL118 HCT 116 C790(0.57); C706(0.74); C142(0.82); C153(0.82)  LDD0705  [14]
 LDCM0389  CL119 HCT 116 C790(0.70); C706(0.77); C205(0.85); C806(0.88)  LDD0706  [14]
 LDCM0390  CL12 HCT 116 C620(0.80); C706(0.83); C142(0.97); C153(0.97)  LDD0707  [14]
 LDCM0391  CL120 HCT 116 C790(0.72); C706(0.76); C205(0.77); C467(0.85)  LDD0708  [14]
 LDCM0392  CL121 HCT 116 C467(0.71); C806(0.76); C790(0.77); C153(0.83)  LDD0709  [14]
 LDCM0393  CL122 HCT 116 C467(0.81); C806(0.81); C706(0.82); C103(0.84)  LDD0710  [14]
 LDCM0394  CL123 HCT 116 C806(0.79); C620(0.88); C467(0.90); C706(0.92)  LDD0711  [14]
 LDCM0395  CL124 HCT 116 C706(0.82); C806(0.85); C103(0.85); C620(0.96)  LDD0712  [14]
 LDCM0396  CL125 HCT 116 C467(0.90); C153(0.95); C142(0.95); C205(0.96)  LDD0713  [14]
 LDCM0397  CL126 HCT 116 C142(0.79); C153(0.85); C620(0.89); C706(0.95)  LDD0714  [14]
 LDCM0398  CL127 HCT 116 C620(0.80); C683(0.81); C142(0.82); C153(0.85)  LDD0715  [14]
 LDCM0399  CL128 HCT 116 C142(0.79); C683(0.79); C205(0.83); C153(0.85)  LDD0716  [14]
 LDCM0400  CL13 HCT 116 C706(0.67); C620(0.71); C142(0.92); C153(0.92)  LDD0717  [14]
 LDCM0401  CL14 HCT 116 C706(0.62); C620(0.63); C142(0.85); C153(0.85)  LDD0718  [14]
 LDCM0402  CL15 HCT 116 C620(0.71); C706(0.73); C386(0.95); C285(1.00)  LDD0719  [14]
 LDCM0403  CL16 HCT 116 C153(0.79); C142(0.87); C467(0.88); C706(0.92)  LDD0720  [14]
 LDCM0404  CL17 HCT 116 C862(0.44); C706(0.67); C142(0.89); C620(0.89)  LDD0721  [14]
 LDCM0405  CL18 HCT 116 C862(0.51); C706(0.53); C153(0.72); C620(0.75)  LDD0722  [14]
 LDCM0406  CL19 HCT 116 C706(0.68); C862(0.76); C620(0.80); C683(0.88)  LDD0723  [14]
 LDCM0407  CL2 HCT 116 C386(0.80); C620(0.81); C706(0.85); C103(1.01)  LDD0724  [14]
 LDCM0408  CL20 HCT 116 C706(0.56); C862(0.70); C620(0.84); C142(0.85)  LDD0725  [14]
 LDCM0409  CL21 HCT 116 C706(0.59); C862(0.65); C620(0.75); C153(0.83)  LDD0726  [14]
 LDCM0410  CL22 HCT 116 C706(0.63); C103(0.90); C205(0.98); C620(0.98)  LDD0727  [14]
 LDCM0411  CL23 HCT 116 C706(0.54); C153(0.71); C142(0.81); C620(0.84)  LDD0728  [14]
 LDCM0412  CL24 HCT 116 C142(0.95); C862(0.95); C103(1.22); C153(0.85)  LDD0729  [14]
 LDCM0413  CL25 HCT 116 C142(0.95); C862(0.79); C103(1.23); C153(0.79)  LDD0730  [14]
 LDCM0414  CL26 HCT 116 C142(1.01); C862(0.65); C103(1.12); C153(0.82)  LDD0731  [14]
 LDCM0415  CL27 HCT 116 C142(0.84); C862(0.93); C103(1.24); C153(0.77)  LDD0732  [14]
 LDCM0416  CL28 HCT 116 C142(0.86); C862(0.54); C103(1.21); C153(0.74)  LDD0733  [14]
 LDCM0417  CL29 HCT 116 C142(0.89); C862(0.82); C103(0.97); C153(0.84)  LDD0734  [14]
 LDCM0418  CL3 HCT 116 C142(0.95); C103(0.99); C153(0.95); C205(0.92)  LDD0735  [14]
 LDCM0419  CL30 HCT 116 C142(0.91); C862(0.34); C103(0.72); C153(0.78)  LDD0736  [14]
 LDCM0420  CL31 HCT 116 C142(0.74); C862(0.56); C103(1.24); C153(0.74)  LDD0737  [14]
 LDCM0421  CL32 HCT 116 C142(0.62); C103(1.04); C153(0.62); C205(1.05)  LDD0738  [14]
 LDCM0422  CL33 HCT 116 C142(0.63); C103(1.20); C153(0.63); C205(0.93)  LDD0739  [14]
 LDCM0423  CL34 HCT 116 C142(0.78); C103(1.09); C153(0.78); C205(1.17)  LDD0740  [14]
 LDCM0424  CL35 HCT 116 C142(0.81); C103(1.05); C153(0.81); C205(1.27)  LDD0741  [14]
 LDCM0425  CL36 HCT 116 C142(0.72); C103(1.02); C153(0.72); C205(1.17)  LDD0742  [14]
 LDCM0426  CL37 HCT 116 C142(0.72); C103(1.15); C153(0.72); C205(1.22)  LDD0743  [14]
 LDCM0428  CL39 HCT 116 C142(0.74); C103(1.26); C153(0.74); C205(1.00)  LDD0745  [14]
 LDCM0429  CL4 HCT 116 C142(1.04); C103(0.94); C153(1.04); C205(1.15)  LDD0746  [14]
 LDCM0430  CL40 HCT 116 C142(0.76); C103(1.01); C153(0.76); C205(1.14)  LDD0747  [14]
 LDCM0431  CL41 HCT 116 C142(0.66); C103(0.95); C153(0.66); C205(1.07)  LDD0748  [14]
 LDCM0432  CL42 HCT 116 C142(0.89); C103(1.03); C153(0.89); C205(1.19)  LDD0749  [14]
 LDCM0433  CL43 HCT 116 C142(0.72); C103(1.07); C153(0.72); C205(1.20)  LDD0750  [14]
 LDCM0434  CL44 HCT 116 C142(0.63); C103(1.06); C153(0.63); C205(1.12)  LDD0751  [14]
 LDCM0435  CL45 HCT 116 C142(0.75); C103(1.11); C153(0.75); C205(0.94)  LDD0752  [14]
 LDCM0436  CL46 HCT 116 C142(1.12); C103(0.98); C153(0.98); C205(1.11)  LDD0753  [14]
 LDCM0437  CL47 HCT 116 C142(1.00); C103(0.88); C153(0.95); C205(1.07)  LDD0754  [14]
 LDCM0438  CL48 HCT 116 C142(1.02); C103(0.96); C153(1.07); C205(1.23)  LDD0755  [14]
 LDCM0439  CL49 HCT 116 C142(0.99); C103(1.11); C153(0.93); C205(1.19)  LDD0756  [14]
 LDCM0440  CL5 HCT 116 C142(1.03); C103(1.00); C153(1.03); C205(0.95)  LDD0757  [14]
 LDCM0441  CL50 HCT 116 C142(0.91); C103(1.05); C153(0.92); C205(1.17)  LDD0758  [14]
 LDCM0442  CL51 HCT 116 C142(0.98); C103(1.32); C153(1.00); C205(1.13)  LDD0759  [14]
 LDCM0443  CL52 HCT 116 C142(1.02); C103(1.04); C153(0.92); C205(1.06)  LDD0760  [14]
 LDCM0444  CL53 HCT 116 C142(1.01); C103(1.11); C153(0.95); C205(1.33)  LDD0761  [14]
 LDCM0445  CL54 HCT 116 C142(1.05); C103(1.02); C153(0.84); C205(0.93)  LDD0762  [14]
 LDCM0446  CL55 HCT 116 C142(1.09); C103(0.97); C153(0.89); C205(1.35)  LDD0763  [14]
 LDCM0447  CL56 HCT 116 C142(0.93); C103(1.24); C153(0.85); C205(1.06)  LDD0764  [14]
 LDCM0448  CL57 HCT 116 C142(0.89); C103(0.83); C153(0.76); C205(1.11)  LDD0765  [14]
 LDCM0449  CL58 HCT 116 C142(1.04); C103(0.87); C153(1.01); C205(1.13)  LDD0766  [14]
 LDCM0450  CL59 HCT 116 C142(0.97); C103(1.10); C153(0.98); C205(0.99)  LDD0767  [14]
 LDCM0451  CL6 HCT 116 C142(0.94); C103(0.92); C153(0.94); C205(0.82)  LDD0768  [14]
 LDCM0452  CL60 HCT 116 C142(1.00); C103(1.02); C153(0.95); C205(1.20)  LDD0769  [14]
 LDCM0453  CL61 HCT 116 C142(1.13); C103(0.80); C153(1.04); C205(0.89)  LDD0770  [14]
 LDCM0454  CL62 HCT 116 C142(1.18); C103(0.81); C153(1.02); C205(0.82)  LDD0771  [14]
 LDCM0455  CL63 HCT 116 C142(0.93); C103(0.67); C153(0.85); C205(0.76)  LDD0772  [14]
 LDCM0456  CL64 HCT 116 C142(1.23); C103(0.71); C153(1.17); C205(0.71)  LDD0773  [14]
 LDCM0457  CL65 HCT 116 C142(1.03); C103(0.86); C153(0.98); C205(0.84)  LDD0774  [14]
 LDCM0458  CL66 HCT 116 C142(1.24); C103(0.80); C153(1.04); C205(0.80)  LDD0775  [14]
 LDCM0459  CL67 HCT 116 C142(0.94); C103(0.71); C153(1.09); C205(0.82)  LDD0776  [14]
 LDCM0460  CL68 HCT 116 C142(0.77); C103(0.73); C153(0.83); C205(0.81)  LDD0777  [14]
 LDCM0461  CL69 HCT 116 C142(0.78); C103(0.66); C153(0.83); C205(0.80)  LDD0778  [14]
 LDCM0462  CL7 HCT 116 C142(1.03); C103(1.05); C153(1.03); C205(1.00)  LDD0779  [14]
 LDCM0463  CL70 HCT 116 C142(0.98); C103(0.79); C153(0.91); C205(0.88)  LDD0780  [14]
 LDCM0464  CL71 HCT 116 C142(0.86); C103(0.84); C153(0.88); C205(0.81)  LDD0781  [14]
 LDCM0465  CL72 HCT 116 C142(1.19); C103(0.75); C153(1.24); C205(0.82)  LDD0782  [14]
 LDCM0466  CL73 HCT 116 C142(0.96); C103(0.79); C153(1.04); C205(0.78)  LDD0783  [14]
 LDCM0467  CL74 HCT 116 C142(0.84); C103(0.76); C153(0.99); C205(0.84)  LDD0784  [14]
 LDCM0469  CL76 HCT 116 C142(0.82); C103(0.73); C153(0.86); C205(0.95)  LDD0786  [14]
 LDCM0470  CL77 HCT 116 C142(0.86); C103(0.75); C153(0.90); C205(1.22)  LDD0787  [14]
 LDCM0471  CL78 HCT 116 C142(0.93); C103(1.23); C153(0.97); C205(0.91)  LDD0788  [14]
 LDCM0472  CL79 HCT 116 C142(0.88); C103(0.90); C153(0.98); C205(1.04)  LDD0789  [14]
 LDCM0473  CL8 HCT 116 C142(0.97); C103(0.93); C153(0.97); C205(1.20)  LDD0790  [14]
 LDCM0474  CL80 HCT 116 C142(0.87); C103(0.80); C153(0.89); C205(0.97)  LDD0791  [14]
 LDCM0475  CL81 HCT 116 C142(0.85); C103(0.90); C153(0.95); C205(1.04)  LDD0792  [14]
 LDCM0476  CL82 HCT 116 C142(0.94); C103(0.90); C153(0.98); C205(1.12)  LDD0793  [14]
 LDCM0477  CL83 HCT 116 C142(0.93); C103(0.82); C153(0.95); C205(1.03)  LDD0794  [14]
 LDCM0478  CL84 HCT 116 C142(1.04); C103(0.89); C153(1.05); C205(0.97)  LDD0795  [14]
 LDCM0479  CL85 HCT 116 C142(0.85); C103(0.75); C153(0.89); C205(0.99)  LDD0796  [14]
 LDCM0480  CL86 HCT 116 C142(0.89); C103(0.98); C153(0.97); C205(1.03)  LDD0797  [14]
 LDCM0481  CL87 HCT 116 C142(0.95); C103(1.02); C153(0.95); C205(0.97)  LDD0798  [14]
 LDCM0482  CL88 HCT 116 C142(0.91); C103(0.89); C153(0.92); C205(1.09)  LDD0799  [14]
 LDCM0483  CL89 HCT 116 C142(1.26); C103(1.16); C153(1.17); C205(1.21)  LDD0800  [14]
 LDCM0484  CL9 HCT 116 C142(0.96); C103(0.95); C153(0.96); C205(1.04)  LDD0801  [14]
 LDCM0485  CL90 HCT 116 C142(1.03); C103(1.16); C153(0.96); C205(1.19)  LDD0802  [14]
 LDCM0486  CL91 HCT 116 C142(0.80); C103(0.92); C153(0.83); C205(0.76)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C142(0.85); C103(0.93); C153(0.87); C205(0.85)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C142(0.95); C103(0.99); C153(0.90); C205(1.02)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C142(0.80); C103(0.85); C153(0.87); C205(0.81)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C142(0.78); C103(0.87); C153(0.79); C205(0.83)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C142(0.71); C103(0.94); C153(0.84); C205(0.82)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C142(0.81); C103(0.84); C153(0.87); C205(0.84)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C142(0.76); C103(0.89); C153(0.83); C205(0.79)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C142(0.81); C103(0.94); C153(0.82); C205(0.78)  LDD0811  [14]
 LDCM0185  Compound 17 HEK-293T 4.14  LDD0512  [31]
 LDCM0191  Compound 21 HEK-293T 4.05  LDD0508  [31]
 LDCM0190  Compound 34 HEK-293T 3.86  LDD0510  [31]
 LDCM0192  Compound 35 HEK-293T 3.08  LDD0509  [31]
 LDCM0193  Compound 36 HEK-293T 3.63  LDD0511  [31]
 LDCM0495  E2913 HEK-293T C706(0.94); C620(1.01); C806(0.78); C205(0.92)  LDD1698  [36]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C467(12.35); C205(8.33); C386(7.26); C103(3.56)  LDD1702  [6]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [12]
 LDCM0625  F8 Ramos C862(1.15); C467(1.34); C620(1.08); C205(1.42)  LDD2187  [37]
 LDCM0572  Fragment10 Ramos C862(9.40); C467(8.34); C620(1.28); C205(1.77)  LDD2189  [37]
 LDCM0573  Fragment11 Ramos C862(0.20); C467(0.55); C205(0.63); C683(20.00)  LDD2190  [37]
 LDCM0574  Fragment12 Ramos C862(5.63); C467(7.54); C620(1.34); C683(1.81)  LDD2191  [37]
 LDCM0575  Fragment13 Ramos C862(1.00); C467(1.39); C620(1.05); C205(0.57)  LDD2192  [37]
 LDCM0576  Fragment14 Ramos C862(6.49); C467(8.66); C620(3.44); C205(11.30)  LDD2193  [37]
 LDCM0579  Fragment20 Ramos C862(20.00); C467(14.01); C620(2.85); C103(20.00)  LDD2194  [37]
 LDCM0580  Fragment21 Ramos C862(1.18); C467(1.93); C620(0.86); C205(1.23)  LDD2195  [37]
 LDCM0582  Fragment23 Ramos C862(2.52); C467(1.11); C620(3.08); C103(2.78)  LDD2196  [37]
 LDCM0578  Fragment27 Ramos C862(0.85); C467(1.01); C620(0.97); C205(0.61)  LDD2197  [37]
 LDCM0586  Fragment28 Ramos C862(0.81); C467(1.05); C620(0.77); C205(1.93)  LDD2198  [37]
 LDCM0588  Fragment30 Ramos C862(1.35); C467(1.30); C620(1.39); C205(0.19)  LDD2199  [37]
 LDCM0589  Fragment31 Ramos C862(1.36); C467(2.01); C620(1.21); C205(1.86)  LDD2200  [37]
 LDCM0590  Fragment32 Ramos C862(2.89); C467(3.64); C620(0.76); C205(1.26)  LDD2201  [37]
 LDCM0468  Fragment33 HCT 116 C142(0.90); C103(0.68); C153(0.98); C205(0.76)  LDD0785  [14]
 LDCM0596  Fragment38 Ramos C862(3.18); C467(3.91); C620(1.20); C205(0.51)  LDD2203  [37]
 LDCM0566  Fragment4 Ramos C862(5.50); C467(5.25); C620(1.07); C205(3.29)  LDD2184  [37]
 LDCM0427  Fragment51 HCT 116 C142(0.91); C103(1.12); C153(0.91); C205(1.17)  LDD0744  [14]
 LDCM0610  Fragment52 Ramos C862(1.31); C467(2.11); C620(1.41); C205(0.24)  LDD2204  [37]
 LDCM0614  Fragment56 Ramos C862(0.97); C467(1.22); C620(1.78); C205(0.32)  LDD2205  [37]
 LDCM0569  Fragment7 Ramos C862(3.82); C467(4.83); C620(1.26); C205(2.66)  LDD2186  [37]
 LDCM0571  Fragment9 Ramos C862(17.46); C467(20.00); C620(2.70); C103(20.00)  LDD2188  [37]
 LDCM0116  HHS-0101 DM93 Y51(0.74); Y788(0.75)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y51(0.76); Y788(0.88)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y51(0.61); Y788(0.88)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y51(0.77); Y788(0.99)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y788(0.67); Y51(0.83)  LDD0268  [13]
 LDCM0015  HNE MDA-MB-231 C103(1.24); C862(1.66); C164(0.88)  LDD0346  [37]
 LDCM0107  IAA HeLa C103(0.00); H87(0.00); C153(0.00)  LDD0221  [26]
 LDCM0179  JZ128 PC-3 C285(0.00); C790(0.00); C142(0.00); C103(0.00)  LDD0462  [9]
 LDCM0022  KB02 HCT 116 C142(9.92); C153(9.92); C683(2.25); C467(2.79)  LDD0080  [14]
 LDCM0023  KB03 HCT 116 C142(14.44); C153(14.44); C683(2.86); C467(3.49)  LDD0081  [14]
 LDCM0024  KB05 HCT 116 C142(20.00); C153(20.00); C683(3.49); C467(2.56)  LDD0082  [14]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C103(0.71)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [26]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C620(1.13); C103(0.44)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C806(1.23)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C806(0.85)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C467(1.36)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C806(0.79)  LDD2094  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C205(1.04); C806(1.30)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C467(1.13); C103(1.02)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C806(2.25)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C706(1.32)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C620(0.58)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C205(0.92)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C467(0.97); C620(1.01); C103(1.01); C205(1.01)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C806(1.05)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C467(1.14); C103(1.01); C205(1.28)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C467(1.45); C103(1.02)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C620(0.51); C806(0.90)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C103(0.47); C706(0.76)  LDD2115  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C205(0.60); C862(0.29)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C467(1.39); C103(2.19)  LDD2119  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C706(0.83)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C205(0.74); C806(0.75); C386(1.22)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C205(1.05)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C467(0.91); C103(0.86); C205(0.79); C706(0.79)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C467(1.12); C205(1.21); C706(0.97)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C467(1.21)  LDD2129  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C467(1.34); C103(1.01)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C467(1.71); C103(0.99); C706(1.14)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C467(0.95); C103(0.90); C205(0.98); C706(0.74)  LDD2137  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C467(0.96); C103(0.68)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C806(0.95)  LDD2141  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C467(2.00)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C467(1.01); C103(1.24); C205(0.96)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C467(1.12); C806(0.58); C706(0.61)  LDD2148  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C620(0.95); C103(0.49)  LDD2150  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C683(0.99); C683(0.88); C467(0.77); C153(0.55)  LDD2206  [38]
 LDCM0628  OTUB2-COV-1 HEK-293T C862(1.33); C205(1.10); C103(1.04); C164(1.00)  LDD2207  [38]
 LDCM0131  RA190 MM1.R C142(1.42); C153(1.42)  LDD0304  [39]
 LDCM0021  THZ1 HeLa S3 C103(1.10); C285(1.08); C790(1.06); C142(1.02)  LDD0460  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
RNA-binding protein FUS (FUS) RRM TET family P35637
Heterogeneous nuclear ribonucleoprotein M (HNRNPM) . P52272

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
8 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
13 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
26 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
27 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
28 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
29 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
30 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
31 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
32 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
33 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
34 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
35 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
36 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
37 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
38 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
39 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.