Details of the Target

General Information of Target

Target ID LDTP08577
Target Name SURP and G-patch domain-containing protein 1 (SUGP1)
Gene Name SUGP1
Gene ID 57794
Synonyms
SF4; SURP and G-patch domain-containing protein 1; RNA-binding protein RBP; Splicing factor 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSLKMDNRDVAGKANRWFGVAPPKSGKMNMNILHQEELIAQKKREIEAKMEQKAKQNQVA
SPQPPHPGEITNAHNSSCISNKFANDGSFLQQFLKLQKAQTSTDAPTSAPSAPPSTPTPS
AGKRSLLISRRTGLGLASLPGPVKSYSHAKQLPVAHRPSVFQSPDEDEEEDYEQWLEIKV
SPPEGAETRKVIEKLARFVAEGGPELEKVAMEDYKDNPAFAFLHDKNSREFLYYRKKVAE
IRKEAQKSQAASQKVSPPEDEEVKNLAEKLARFIADGGPEVETIALQNNRENQAFSFLYE
PNSQGYKYYRQKLEEFRKAKASSTGSFTAPDPGLKRKSPPEALSGSLPPATTCPASSTPA
PTIIPAPAAPGKPASAATVKRKRKSRWGPEEDKVELPPAELVQRDVDASPSPLSVQDLKG
LGYEKGKPVGLVGVTELSDAQKKQLKEQQEMQQMYDMIMQHKRAMQDMQLLWEKAVQQHQ
HGYDSDEEVDSELGTWEHQLRRMEMDKTREWAEQLTKMGRGKHFIGDFLPPDELEKFMET
FKALKEGREPDYSEYKEFKLTVENIGYQMLMKMGWKEGEGLGSEGQGIKNPVNKGTTTVD
GAGFGIDRPAELSKEDDEYEAFRKRMMLAYRFRPNPLNNPRRPYY
Target Bioclass
Other
Subcellular location
Nucleus
Function Plays a role in pre-mRNA splicing.
Uniprot ID
Q8IWZ8
Ensemble ID
ENST00000247001.10
HGNC ID
HGNC:18643

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 Deletion: p.Q249RfsTer26 .
A498 SNV: p.L413M .
IPC298 SNV: p.S438L .
MDST8 SNV: p.P397L .
NCIH2286 Substitution: p.R509I .
SKNSH SNV: p.P119T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH211
 Probe Info  		Y214(18.55)  LDD0257  [2]
STPyne
 Probe Info  		K194(7.59); K269(4.80)  LDD0277  [3]
Probe 1
 Probe Info  		Y214(88.06); Y423(60.80); Y552(37.41); Y619(30.26)  LDD3495  [4]
AHL-Pu-1
 Probe Info  		C78(2.64)  LDD0168  [5]
HPAP
 Probe Info  		4.49  LDD0062  [6]
IA-alkyne
 Probe Info  		C78(10.11)  LDD0371  [5]
DBIA
 Probe Info  		C78(1.17); C353(0.98)  LDD1492  [7]
Compound 10
 Probe Info  		N.A.  LDD2216  [8]
Compound 11
 Probe Info  		N.A.  LDD2213  [8]
IPM
 Probe Info  		N.A.  LDD2156  [9]
Phosphinate-6
 Probe Info  		C78(0.00); C353(0.00)  LDD0018  [10]
AOyne
 Probe Info  		11.10  LDD0443  [11]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C198
 Probe Info  		15.03  LDD1874  [12]
C213
 Probe Info  		15.67  LDD1887  [12]
FFF probe13
 Probe Info  		20.00  LDD0475  [13]
FFF probe2
 Probe Info  		20.00  LDD0463  [13]
FFF probe3
 Probe Info  		20.00  LDD0465  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C78(2.64)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C78(5.47)  LDD0169  [5]
 LDCM0214  AC1 HEK-293T C353(1.09)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C353(0.96); C78(1.13)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C353(0.99); C78(0.98)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C353(1.01); C78(1.06)  LDD1510  [7]
 LDCM0270  AC15 HEK-293T C353(0.76)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C353(1.07)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C353(0.82); C78(1.10)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C353(0.87); C78(1.13)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C353(0.86); C78(1.01)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C353(0.76); C78(1.07)  LDD1519  [7]
 LDCM0283  AC23 HEK-293T C353(1.15)  LDD1522  [7]
 LDCM0285  AC25 HEK-293T C353(1.06)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C353(0.79); C78(0.98)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C353(0.99); C78(0.68)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C353(0.91); C78(0.99)  LDD1527  [7]
 LDCM0290  AC3 HEK-293T C353(0.95); C78(1.06)  LDD1529  [7]
 LDCM0292  AC31 HEK-293T C353(1.38)  LDD1531  [7]
 LDCM0294  AC33 HEK-293T C353(1.03)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C353(0.77); C78(1.32)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C353(0.84); C78(1.01)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C353(0.78); C78(1.07)  LDD1536  [7]
 LDCM0300  AC39 HEK-293T C353(0.89)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C353(0.86); C78(1.01)  LDD1540  [7]
 LDCM0303  AC41 HEK-293T C353(1.09)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C353(0.93); C78(1.31)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C353(1.07); C78(1.03)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C353(0.93); C78(1.03)  LDD1545  [7]
 LDCM0309  AC47 HEK-293T C353(0.83)  LDD1548  [7]
 LDCM0311  AC49 HEK-293T C353(0.94)  LDD1550  [7]
 LDCM0313  AC50 HEK-293T C353(0.93); C78(1.18)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C353(0.82); C78(0.75)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C353(0.82); C78(1.05)  LDD1554  [7]
 LDCM0318  AC55 HEK-293T C353(0.99)  LDD1557  [7]
 LDCM0320  AC57 HEK-293T C353(1.14)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C353(0.85); C78(1.00)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C353(0.87); C78(0.81)  LDD1561  [7]
 LDCM0324  AC60 HEK-293T C353(0.84); C78(1.08)  LDD1563  [7]
 LDCM0327  AC63 HEK-293T C353(1.01)  LDD1566  [7]
 LDCM0334  AC7 HEK-293T C353(0.79)  LDD1568  [7]
 LDCM0356  AKOS034007680 HEK-293T C353(1.02)  LDD1570  [7]
 LDCM0156  Aniline NCI-H1299 12.17  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C353(0.75); C78(1.20)  LDD1571  [7]
 LDCM0370  CL101 HEK-293T C353(0.93); C78(1.10)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C353(0.97); C78(1.06)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C78(1.01)  LDD1576  [7]
 LDCM0374  CL105 HEK-293T C353(0.84); C78(1.00)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C353(0.95); C78(1.25)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C78(0.89)  LDD1580  [7]
 LDCM0378  CL109 HEK-293T C353(0.79); C78(0.97)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C353(0.79)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C353(0.83); C78(1.25)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C78(0.99)  LDD1585  [7]
 LDCM0383  CL113 HEK-293T C353(0.83); C78(1.22)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C353(0.83); C78(1.05)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C78(0.94)  LDD1589  [7]
 LDCM0387  CL117 HEK-293T C353(0.87); C78(0.93)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C353(0.92); C78(1.07)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C78(1.11)  LDD1593  [7]
 LDCM0392  CL121 HEK-293T C353(0.75); C78(0.95)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C353(0.97); C78(1.23)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C78(0.89)  LDD1598  [7]
 LDCM0396  CL125 HEK-293T C353(0.76); C78(0.83)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C353(1.06); C78(1.03)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C78(0.94)  LDD1602  [7]
 LDCM0400  CL13 HEK-293T C353(0.83); C78(0.85)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C353(0.85); C78(1.27)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C78(0.95)  LDD1606  [7]
 LDCM0404  CL17 HEK-293T C353(1.10)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C353(0.99); C78(1.23)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C353(1.16); C78(0.80)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C353(0.98); C78(1.15)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C353(1.16); C78(0.94)  LDD1612  [7]
 LDCM0411  CL23 HEK-293T C353(1.30)  LDD1615  [7]
 LDCM0413  CL25 HEK-293T C353(0.68); C78(1.22)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C353(1.01); C78(1.23)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C78(0.90)  LDD1619  [7]
 LDCM0417  CL29 HEK-293T C353(1.00)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C78(0.89)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C353(1.05); C78(1.21)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C353(1.11); C78(1.20)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C353(1.40); C78(0.94)  LDD1625  [7]
 LDCM0424  CL35 HEK-293T C353(1.35)  LDD1628  [7]
 LDCM0426  CL37 HEK-293T C353(0.80); C78(0.94)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C78(0.96)  LDD1632  [7]
 LDCM0431  CL41 HEK-293T C353(0.99)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C353(1.08); C78(1.08)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C353(0.97); C78(0.93)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C353(1.06); C78(1.05)  LDD1638  [7]
 LDCM0437  CL47 HEK-293T C353(1.14)  LDD1641  [7]
 LDCM0439  CL49 HEK-293T C353(0.79); C78(0.93)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C353(1.19)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C353(0.81); C78(1.31)  LDD1645  [7]
 LDCM0444  CL53 HEK-293T C353(1.07)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C353(0.89); C78(1.30)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C353(1.59); C78(0.90)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C353(1.35); C78(0.95)  LDD1650  [7]
 LDCM0450  CL59 HEK-293T C353(1.35)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C353(0.78); C78(0.94)  LDD1654  [7]
 LDCM0453  CL61 HEK-293T C353(0.71); C78(1.10)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C353(0.95); C78(1.10)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C78(1.27)  LDD1658  [7]
 LDCM0457  CL65 HEK-293T C353(1.08)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C353(0.98); C78(1.15)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C353(1.11); C78(0.82)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C353(1.26); C78(1.00)  LDD1663  [7]
 LDCM0462  CL7 HEK-293T C353(1.18); C78(0.88)  LDD1665  [7]
 LDCM0464  CL71 HEK-293T C353(1.13)  LDD1667  [7]
 LDCM0466  CL73 HEK-293T C353(0.76); C78(1.02)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C353(1.07); C78(1.08)  LDD1670  [7]
 LDCM0470  CL77 HEK-293T C353(1.18)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C353(0.97); C78(1.14)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C353(0.94); C78(0.74)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C353(0.90); C78(0.75)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C353(1.17); C78(0.94)  LDD1677  [7]
 LDCM0477  CL83 HEK-293T C353(1.26)  LDD1680  [7]
 LDCM0479  CL85 HEK-293T C353(0.78); C78(0.81)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C353(1.01); C78(0.94)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C78(0.81)  LDD1684  [7]
 LDCM0483  CL89 HEK-293T C353(1.07)  LDD1686  [7]
 LDCM0485  CL90 HEK-293T C353(0.73); C78(0.84)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C353(1.12); C78(0.66)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C353(0.90); C78(0.89)  LDD1690  [7]
 LDCM0490  CL95 HEK-293T C353(1.46)  LDD1693  [7]
 LDCM0492  CL97 HEK-293T C353(0.73); C78(1.02)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C353(0.99); C78(1.01)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C78(0.96)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C78(1.01)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C78(0.96)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C353(1.09); C78(0.90)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C78(1.17); C353(0.98)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C78(1.04); C353(1.30)  LDD1497  [7]
 LDCM0024  KB05 HEK-293T C78(1.17); C353(1.17)  LDD1502  [7]
 LDCM0014  Panhematin HEK-293T 4.49  LDD0062  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-dependent RNA helicase DHX15 (DHX15) DEAD box helicase family O43143
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Splicing factor U2AF 65 kDa subunit (U2AF2) Splicing factor SR family P26368
RNA-binding protein 10 (RBM10) . P98175
Splicing factor 45 (RBM17) . Q96I25

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 A Chemical Proteomic Map of Heme-Protein Interactions. J Am Chem Soc. 2022 Aug 24;144(33):15013-15019. doi: 10.1021/jacs.2c06104. Epub 2022 Aug 12.
Mass spectrometry data entry: PXD034651
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
8 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.