Details of the Target

General Information of Target

Target ID LDTP05780
Target Name Syntaxin-5 (STX5)
Gene Name STX5
Gene ID 6811
Synonyms
STX5A; Syntaxin-5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIPRKRYGSKNTDQGVYLGLSKTQVLSPATAGSSSSDIAPLPPPVTLVPPPPDTMSCRDR
TQEFLSACKSLQTRQNGIQTNKPALRAVRQRSEFTLMAKRIGKDLSNTFAKLEKLTILAK
RKSLFDDKAVEIEELTYIIKQDINSLNKQIAQLQDFVRAKGSQSGRHLQTHSNTIVVSLQ
SKLASMSNDFKSVLEVRTENLKQQRSRREQFSRAPVSALPLAPNHLGGGAVVLGAESHAS
KDVAIDMMDSRTSQQLQLIDEQDSYIQSRADTMQNIESTIVELGSIFQQLAHMVKEQEET
IQRIDENVLGAQLDVEAAHSEILKYFQSVTSNRWLMVKIFLILIVFFIIFVVFLA
Target Bioclass
Transporter and channel
Family
Syntaxin family
Subcellular location
Endoplasmic reticulum-Golgi intermediate compartment membrane
Function
Mediates endoplasmic reticulum to Golgi transport. Together with p115/USO1 and GM130/GOLGA2, involved in vesicle tethering and fusion at the cis-Golgi membrane to maintain the stacked and inter-connected structure of the Golgi apparatus.; [Isoform 2]: Required for Golgi to endoplasmic reticulum retrogade transport, and for intra-Golgi transport.; (Microbial infection) Required for the efficient production of infectious virion during human cytomegalovirus infection. Mechanistically, participates in the formation of the cytoplasmic viral assembly compartment where tegument acquisition and envelopment occur.
Uniprot ID
Q13190
Ensemble ID
ENST00000294179.8
HGNC ID
HGNC:11440

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.L323P .
FTC133 SNV: p.L115P DBIA    Probe Info 
IGROV1 SNV: p.R207W DBIA    Probe Info 
JURKAT SNV: p.A235V .
KMRC1 SNV: p.N144S DBIA    Probe Info 
MOLT4 SNV: p.D59N IA-alkyne    Probe Info 
SW1990 SNV: p.D37V .
TOV21G SNV: p.R60L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K103(3.55); K114(10.00); K69(2.64); K99(1.44)  LDD0277  [1]
Probe 1
 Probe Info  		Y265(15.34)  LDD3495  [2]
m-APA
 Probe Info  		15.00  LDD0403  [3]
BTD
 Probe Info  		C68(1.44)  LDD1700  [4]
DA-P3
 Probe Info  		4.28  LDD0179  [5]
Alkyne-RA190
 Probe Info  		2.01  LDD0299  [6]
DBIA
 Probe Info  		C68(1.03)  LDD0531  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0025  [9]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
VSF
 Probe Info  		N.A.  LDD0007  [10]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
W1
 Probe Info  		N.A.  LDD0236  [13]
NAIA_5
 Probe Info  		C68(0.00); C57(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		8.28  LDD1728  [15]
C040
 Probe Info  		8.88  LDD1740  [15]
C106
 Probe Info  		16.11  LDD1793  [15]
C112
 Probe Info  		20.11  LDD1799  [15]
C163
 Probe Info  		5.82  LDD1843  [15]
C166
 Probe Info  		6.54  LDD1846  [15]
C169
 Probe Info  		29.65  LDD1849  [15]
C210
 Probe Info  		48.84  LDD1884  [15]
C213
 Probe Info  		15.24  LDD1887  [15]
C218
 Probe Info  		18.25  LDD1892  [15]
C220
 Probe Info  		14.12  LDD1894  [15]
C231
 Probe Info  		19.43  LDD1904  [15]
C232
 Probe Info  		41.93  LDD1905  [15]
C233
 Probe Info  		9.00  LDD1906  [15]
C235
 Probe Info  		25.46  LDD1908  [15]
C238
 Probe Info  		10.93  LDD1911  [15]
C278
 Probe Info  		80.45  LDD1948  [15]
C282
 Probe Info  		18.77  LDD1952  [15]
C284
 Probe Info  		25.28  LDD1954  [15]
C293
 Probe Info  		17.88  LDD1963  [15]
C296
 Probe Info  		15.03  LDD1966  [15]
C310
 Probe Info  		12.13  LDD1977  [15]
C350
 Probe Info  		25.81  LDD2011  [15]
C388
 Probe Info  		43.11  LDD2047  [15]
C403
 Probe Info  		15.03  LDD2061  [15]
C407
 Probe Info  		18.38  LDD2064  [15]
FFF probe11
 Probe Info  		20.00  LDD0471  [16]
FFF probe14
 Probe Info  		20.00  LDD0477  [16]
FFF probe2
 Probe Info  		20.00  LDD0463  [16]
OEA-DA
 Probe Info  		16.58  LDD0046  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C68(1.57)  LDD2112  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C68(1.46)  LDD2152  [4]
 LDCM0214  AC1 HCT 116 C68(1.03)  LDD0531  [7]
 LDCM0215  AC10 PaTu 8988t C57(1.01)  LDD1094  [7]
 LDCM0226  AC11 PaTu 8988t C57(1.03)  LDD1105  [7]
 LDCM0230  AC113 HCT 116 C68(0.90)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C68(0.98)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C68(1.07)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C68(0.97)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C68(1.08)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C68(1.13)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C68(1.08)  LDD0553  [7]
 LDCM0237  AC12 PaTu 8988t C57(1.00)  LDD1116  [7]
 LDCM0238  AC120 HCT 116 C68(0.78)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C68(1.12)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C68(0.91)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C68(1.11)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C68(1.01)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C68(0.90)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C68(0.94)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C68(1.05)  LDD0562  [7]
 LDCM0246  AC128 PaTu 8988t C68(1.09)  LDD1125  [7]
 LDCM0247  AC129 PaTu 8988t C68(0.79)  LDD1126  [7]
 LDCM0249  AC130 PaTu 8988t C68(0.82)  LDD1128  [7]
 LDCM0250  AC131 PaTu 8988t C68(0.78)  LDD1129  [7]
 LDCM0251  AC132 PaTu 8988t C68(0.85)  LDD1130  [7]
 LDCM0252  AC133 PaTu 8988t C68(1.24)  LDD1131  [7]
 LDCM0253  AC134 PaTu 8988t C68(1.08)  LDD1132  [7]
 LDCM0254  AC135 PaTu 8988t C68(1.03)  LDD1133  [7]
 LDCM0255  AC136 PaTu 8988t C68(1.08)  LDD1134  [7]
 LDCM0256  AC137 PaTu 8988t C68(0.90)  LDD1135  [7]
 LDCM0257  AC138 PaTu 8988t C68(0.87)  LDD1136  [7]
 LDCM0258  AC139 PaTu 8988t C68(0.85)  LDD1137  [7]
 LDCM0259  AC14 PaTu 8988t C57(1.06)  LDD1138  [7]
 LDCM0260  AC140 PaTu 8988t C68(1.30)  LDD1139  [7]
 LDCM0261  AC141 PaTu 8988t C68(0.94)  LDD1140  [7]
 LDCM0262  AC142 PaTu 8988t C68(0.92)  LDD1141  [7]
 LDCM0263  AC143 HCT 116 C68(0.95)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C68(0.84)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C68(0.80)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C68(0.72)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C68(1.08)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C68(0.63)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C68(0.67)  LDD0586  [7]
 LDCM0270  AC15 PaTu 8988t C57(0.92)  LDD1149  [7]
 LDCM0271  AC150 HCT 116 C68(0.96)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C68(0.86)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C68(0.81)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C68(0.60)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C68(0.83)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C68(0.73)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C68(0.84)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C68(0.78)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C68(0.97)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C68(0.56)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C68(1.00)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C68(0.82)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C68(0.89)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C68(0.97)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C68(1.28)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C68(0.91)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C68(1.05)  LDD0601  [7]
 LDCM0285  AC25 HEK-293T C68(0.97)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C68(1.02)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C68(0.95)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C68(0.94)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C68(0.96)  LDD1528  [18]
 LDCM0290  AC3 HCT 116 C68(1.28)  LDD0607  [7]
 LDCM0291  AC30 HEK-293T C68(0.94); C57(0.91)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C68(1.01); C57(0.92)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C68(1.04)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C68(1.00)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C68(0.97)  LDD1534  [18]
 LDCM0296  AC35 PaTu 8988t C57(1.08)  LDD1175  [7]
 LDCM0297  AC36 PaTu 8988t C57(0.98)  LDD1176  [7]
 LDCM0298  AC37 PaTu 8988t C57(1.00)  LDD1177  [7]
 LDCM0299  AC38 PaTu 8988t C57(0.88)  LDD1178  [7]
 LDCM0300  AC39 PaTu 8988t C57(1.24)  LDD1179  [7]
 LDCM0301  AC4 HCT 116 C68(1.14)  LDD0618  [7]
 LDCM0302  AC40 PaTu 8988t C57(1.15)  LDD1181  [7]
 LDCM0303  AC41 PaTu 8988t C57(0.99)  LDD1182  [7]
 LDCM0304  AC42 PaTu 8988t C57(1.01)  LDD1183  [7]
 LDCM0305  AC43 PaTu 8988t C57(1.10)  LDD1184  [7]
 LDCM0306  AC44 PaTu 8988t C57(1.16)  LDD1185  [7]
 LDCM0307  AC45 PaTu 8988t C57(1.07)  LDD1186  [7]
 LDCM0308  AC46 HCT 116 C68(1.43)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C68(0.97)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C68(1.24)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C68(0.98)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C68(1.15)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C68(1.15)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C68(1.32)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C68(0.98)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C68(0.87)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C68(1.09)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C68(1.15)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C68(1.05)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C68(1.37)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C68(1.05)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C68(1.23)  LDD0639  [7]
 LDCM0323  AC6 PaTu 8988t C57(1.03)  LDD1202  [7]
 LDCM0324  AC60 HCT 116 C68(1.51)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C68(1.25)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C68(1.29)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C68(1.42)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C68(1.31)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C68(1.34)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C68(1.19)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C68(1.25)  LDD0648  [7]
 LDCM0334  AC7 PaTu 8988t C57(0.94)  LDD1213  [7]
 LDCM0345  AC8 PaTu 8988t C57(0.84)  LDD1224  [7]
 LDCM0349  AC83 HCT 116 C68(1.27)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C68(1.19)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C68(0.94)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C68(1.48)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C68(1.10)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C68(1.10)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C68(1.41)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C68(1.39)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C68(1.19)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C68(1.36)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C68(0.85)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C68(1.17)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C68(1.88)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C68(1.25)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C68(1.09)  LDD0681  [7]
 LDCM0248  AKOS034007472 PaTu 8988t C57(0.95)  LDD1127  [7]
 LDCM0356  AKOS034007680 PaTu 8988t C57(1.11)  LDD1235  [7]
 LDCM0275  AKOS034007705 PaTu 8988t C57(1.01)  LDD1154  [7]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [3]
 LDCM0020  ARS-1620 HCC44 C68(1.10)  LDD2171  [7]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0632  CL-Sc Hep-G2 C68(1.54); C68(0.93)  LDD2227  [14]
 LDCM0367  CL1 HCT 116 C68(0.88)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C68(1.14)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C68(0.94)  LDD0686  [7]
 LDCM0370  CL101 PaTu 8988t C57(1.03)  LDD1249  [7]
 LDCM0371  CL102 PaTu 8988t C57(1.02)  LDD1250  [7]
 LDCM0372  CL103 PaTu 8988t C57(1.03)  LDD1251  [7]
 LDCM0373  CL104 PaTu 8988t C57(1.04)  LDD1252  [7]
 LDCM0374  CL105 HCT 116 C68(0.77)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C68(0.74)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C68(0.70)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C68(0.61)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C68(0.97)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C68(1.02)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C68(0.76)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C68(0.75)  LDD0698  [7]
 LDCM0382  CL112 HEK-293T C68(0.95); C57(1.01)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C68(0.99); C57(0.90)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C68(0.89)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C68(0.97); C57(0.87)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C68(0.92); C57(0.95)  LDD1590  [18]
 LDCM0387  CL117 PaTu 8988t C57(0.91)  LDD1266  [7]
 LDCM0388  CL118 PaTu 8988t C57(1.18)  LDD1267  [7]
 LDCM0389  CL119 PaTu 8988t C57(1.04)  LDD1268  [7]
 LDCM0390  CL12 HCT 116 C68(1.25)  LDD0707  [7]
 LDCM0391  CL120 PaTu 8988t C57(1.01)  LDD1270  [7]
 LDCM0392  CL121 HCT 116 C68(1.16)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C68(0.83)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C68(0.85)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C68(0.82)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C68(1.30)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C68(1.12)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C68(1.14)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C68(1.27)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C68(0.97)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C68(1.01)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C68(0.91)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C68(0.87)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C68(0.95)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C68(0.92)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C68(0.96)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C68(0.93)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C68(0.97)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C68(0.93)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C68(0.89)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C68(0.89)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C68(1.01)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C68(0.92)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C68(1.02)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C68(0.97)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C68(0.93)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C68(1.13)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C68(0.89)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C68(0.99)  LDD0736  [7]
 LDCM0420  CL31 PaTu 8988t C57(0.68)  LDD1299  [7]
 LDCM0421  CL32 PaTu 8988t C57(1.00)  LDD1300  [7]
 LDCM0422  CL33 PaTu 8988t C57(0.85)  LDD1301  [7]
 LDCM0423  CL34 PaTu 8988t C57(0.99)  LDD1302  [7]
 LDCM0424  CL35 PaTu 8988t C57(1.11)  LDD1303  [7]
 LDCM0425  CL36 PaTu 8988t C57(0.66)  LDD1304  [7]
 LDCM0426  CL37 PaTu 8988t C57(0.98)  LDD1305  [7]
 LDCM0428  CL39 PaTu 8988t C57(0.84)  LDD1307  [7]
 LDCM0429  CL4 HCT 116 C68(0.95)  LDD0746  [7]
 LDCM0430  CL40 PaTu 8988t C57(0.74)  LDD1309  [7]
 LDCM0431  CL41 PaTu 8988t C57(0.89)  LDD1310  [7]
 LDCM0432  CL42 PaTu 8988t C57(1.38)  LDD1311  [7]
 LDCM0433  CL43 PaTu 8988t C57(0.93)  LDD1312  [7]
 LDCM0434  CL44 PaTu 8988t C57(0.99)  LDD1313  [7]
 LDCM0435  CL45 PaTu 8988t C57(0.94)  LDD1314  [7]
 LDCM0436  CL46 PaTu 8988t C57(1.11)  LDD1315  [7]
 LDCM0437  CL47 PaTu 8988t C57(1.07)  LDD1316  [7]
 LDCM0438  CL48 PaTu 8988t C57(1.23)  LDD1317  [7]
 LDCM0439  CL49 PaTu 8988t C57(1.11)  LDD1318  [7]
 LDCM0440  CL5 HCT 116 C68(0.95)  LDD0757  [7]
 LDCM0441  CL50 PaTu 8988t C57(1.03)  LDD1320  [7]
 LDCM0442  CL51 PaTu 8988t C57(1.11)  LDD1321  [7]
 LDCM0443  CL52 PaTu 8988t C57(1.19)  LDD1322  [7]
 LDCM0444  CL53 PaTu 8988t C57(1.33)  LDD1323  [7]
 LDCM0445  CL54 PaTu 8988t C57(1.11)  LDD1324  [7]
 LDCM0446  CL55 PaTu 8988t C57(1.33)  LDD1325  [7]
 LDCM0447  CL56 PaTu 8988t C57(1.02)  LDD1326  [7]
 LDCM0448  CL57 PaTu 8988t C57(1.18)  LDD1327  [7]
 LDCM0449  CL58 PaTu 8988t C57(1.20)  LDD1328  [7]
 LDCM0450  CL59 PaTu 8988t C57(1.06)  LDD1329  [7]
 LDCM0451  CL6 HCT 116 C68(0.99)  LDD0768  [7]
 LDCM0452  CL60 PaTu 8988t C57(1.19)  LDD1331  [7]
 LDCM0453  CL61 PaTu 8988t C57(1.08)  LDD1332  [7]
 LDCM0454  CL62 PaTu 8988t C57(0.89)  LDD1333  [7]
 LDCM0455  CL63 PaTu 8988t C57(0.82)  LDD1334  [7]
 LDCM0456  CL64 PaTu 8988t C57(0.99)  LDD1335  [7]
 LDCM0457  CL65 PaTu 8988t C57(0.96)  LDD1336  [7]
 LDCM0458  CL66 PaTu 8988t C57(0.88)  LDD1337  [7]
 LDCM0459  CL67 PaTu 8988t C57(1.05)  LDD1338  [7]
 LDCM0460  CL68 PaTu 8988t C57(1.19)  LDD1339  [7]
 LDCM0461  CL69 PaTu 8988t C57(1.21)  LDD1340  [7]
 LDCM0462  CL7 HCT 116 C68(1.13)  LDD0779  [7]
 LDCM0463  CL70 PaTu 8988t C57(1.12)  LDD1342  [7]
 LDCM0464  CL71 PaTu 8988t C57(0.86)  LDD1343  [7]
 LDCM0465  CL72 PaTu 8988t C57(0.93)  LDD1344  [7]
 LDCM0466  CL73 PaTu 8988t C57(1.12)  LDD1345  [7]
 LDCM0467  CL74 PaTu 8988t C57(1.11)  LDD1346  [7]
 LDCM0469  CL76 HCT 116 C68(1.00)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C68(0.87)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C68(0.83)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C68(0.99)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C68(0.80)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C68(1.06)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C68(1.06)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C68(1.14)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C68(0.86)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C68(0.89)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C68(0.80)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C68(1.02)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C68(0.90)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C68(1.07)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C68(0.99)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C68(1.04)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C68(0.96)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C68(1.09)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C68(0.97)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C68(0.99)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C68(1.17)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C68(0.92)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C68(1.09)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C68(1.09)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C68(0.92)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C68(0.90)  LDD0811  [7]
 LDCM0027  Dopamine HEK-293T 4.28  LDD0179  [5]
 LDCM0495  E2913 HEK-293T C68(1.08); C57(0.90)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C68(1.30)  LDD1702  [4]
 LDCM0572  Fragment10 Ramos C68(1.20)  LDD2189  [19]
 LDCM0573  Fragment11 Ramos C68(1.07)  LDD2190  [19]
 LDCM0574  Fragment12 Ramos C68(1.16)  LDD2191  [19]
 LDCM0575  Fragment13 Ramos C68(1.02)  LDD2192  [19]
 LDCM0576  Fragment14 Ramos C68(0.81)  LDD2193  [19]
 LDCM0579  Fragment20 Ramos C68(2.65)  LDD2194  [19]
 LDCM0580  Fragment21 Ramos C68(1.11)  LDD2195  [19]
 LDCM0582  Fragment23 Ramos C68(2.97)  LDD2196  [19]
 LDCM0578  Fragment27 Ramos C68(0.83)  LDD2197  [19]
 LDCM0586  Fragment28 Ramos C68(0.75)  LDD2198  [19]
 LDCM0588  Fragment30 Ramos C68(1.10)  LDD2199  [19]
 LDCM0589  Fragment31 Ramos C68(1.00)  LDD2200  [19]
 LDCM0590  Fragment32 Ramos C68(1.00)  LDD2201  [19]
 LDCM0468  Fragment33 PaTu 8988t C57(1.02)  LDD1347  [7]
 LDCM0596  Fragment38 Ramos C68(0.92)  LDD2203  [19]
 LDCM0427  Fragment51 PaTu 8988t C57(1.20)  LDD1306  [7]
 LDCM0610  Fragment52 Ramos C68(1.08)  LDD2204  [19]
 LDCM0614  Fragment56 Ramos C68(1.34)  LDD2205  [19]
 LDCM0571  Fragment9 Ramos C68(1.20)  LDD2188  [19]
 LDCM0022  KB02 HEK-293T C57(1.15)  LDD1492  [18]
 LDCM0023  KB03 HEK-293T C57(1.18)  LDD1497  [18]
 LDCM0024  KB05 HMCB C68(3.98)  LDD3312  [20]
 LDCM0109  NEM HeLa N.A.  LDD0223  [12]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C68(1.28)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C68(1.12)  LDD2100  [4]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C68(1.08)  LDD2104  [4]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C68(1.19)  LDD2106  [4]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C68(1.06)  LDD2108  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C68(0.86)  LDD2109  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C68(1.10)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C68(0.96)  LDD2127  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C68(1.44)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C68(1.00)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C68(1.07)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C68(2.03)  LDD2144  [4]
 LDCM0131  RA190 MM1.R 2.01  LDD0299  [6]
 LDCM0021  THZ1 HCT 116 C68(1.10)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Amyloid-beta precursor protein (APP) APP family P05067
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Stimulator of interferon genes protein (STING1) STING family Q86WV6
Syntaxin-binding protein 1 (STXBP1) STXBP/unc-18/SEC1 family P61764
Syntaxin-1A (STX1A) Syntaxin family Q16623
Syntaxin-3 (STX3) Syntaxin family Q13277
Syntaxin-4 (STX4) Syntaxin family Q12846
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 3 (CREB3L3) BZIP family Q68CJ9
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Probable G-protein coupled receptor 152 (GPR152) G-protein coupled receptor 1 family Q8TDT2
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Leucine-rich repeat-containing protein 4C (LRRC4C) . Q9HCJ2
Other
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Conserved oligomeric Golgi complex subunit 4 (COG4) COG4 family Q9H9E3
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Golgi SNAP receptor complex member 2 (GOSR2) GOSR2 family O14653
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Beta-soluble NSF attachment protein (NAPB) SNAP family Q9H115
Vesicle-associated membrane protein 5 (VAMP5) Synaptobrevin family O95183
Syntaxin-8 (STX8) Syntaxin family Q9UNK0
Transforming acidic coiled-coil-containing protein 1 (TACC1) TACC family O75410
Alanine and arginine-rich domain-containing protein (AARD) . Q4LEZ3
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) . O95872
Melanoma-associated antigen 6 (MAGEA6) . P43360
Protein KASH5 (KASH5) . Q8N6L0

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
6 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840