Details of the Target

General Information of Target

Target ID LDTP18132
Target Name Protein FAM136A (FAM136A)
Gene Name FAM136A
Gene ID 84908
Synonyms
Protein FAM136A
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MSNPFLKQVFNKDKTFRPKRKFEPGTQRFELHKKAQASLNAGLDLRLAVQLPPGEDLNDW
VAVHVVDFFNRVNLIYGTISDGCTEQSCPVMSGGPKYEYRWQDEHKFRKPTALSAPRYMD
LLMDWIEAQINNEDLFPTNVGTPFPKNFLQTVRKILSRLFRVFVHVYIHHFDRIAQMGSE
AHVNTCYKHFYYFVKEFGLIDTKELEPLKEMTARMCH
Target Bioclass
Other
Family
FAM136 family
Uniprot ID
Q96C01
Ensemble ID
ENST00000037869.8
HGNC ID
HGNC:25911

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		12.80  LDD0402  [1]
YN-1
 Probe Info  		100.00  LDD0444  [2]
STPyne
 Probe Info  		K130(10.00); K18(10.00); K27(4.21); K89(5.98)  LDD0277  [3]
IPM
 Probe Info  		C57(0.00); C53(0.00)  LDD0241  [4]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [5]
BTD
 Probe Info  		C53(0.87)  LDD2097  [6]
Acrolein
 Probe Info  		N.A.  LDD0222  [7]
DBIA
 Probe Info  		C35(12.61); C40(12.61); C39(12.61)  LDD0080  [8]
5E-2FA
 Probe Info  		H58(0.00); H85(0.00); H120(0.00)  LDD2235  [9]
ATP probe
 Probe Info  		K99(0.00); K18(0.00); K104(0.00); K48(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C57(0.00); C53(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C53(0.00); C57(0.00)  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C57(0.00); C35(0.00); C39(0.00); C40(0.00)  LDD0037  [11]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
TFBX
 Probe Info  		C40(0.00); C35(0.00)  LDD0027  [14]
ENE
 Probe Info  		N.A.  LDD0006  [15]
NHS
 Probe Info  		K18(0.00); K99(0.00)  LDD0010  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [7]
AOyne
 Probe Info  		12.20  LDD0443  [16]
NAIA_5
 Probe Info  		C57(0.00); C82(0.00); C114(0.00); C110(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C064
 Probe Info  		7.41  LDD1761  [17]
C091
 Probe Info  		14.93  LDD1782  [17]
C092
 Probe Info  		30.27  LDD1783  [17]
C094
 Probe Info  		29.86  LDD1785  [17]
C201
 Probe Info  		23.92  LDD1877  [17]
C213
 Probe Info  		17.03  LDD1887  [17]
C229
 Probe Info  		7.21  LDD1902  [17]
C233
 Probe Info  		13.18  LDD1906  [17]
C235
 Probe Info  		23.92  LDD1908  [17]
C289
 Probe Info  		26.54  LDD1959  [17]
C322
 Probe Info  		5.66  LDD1988  [17]
C350
 Probe Info  		45.89  LDD2011  [17]
C399
 Probe Info  		6.68  LDD2058  [17]
C407
 Probe Info  		12.04  LDD2064  [17]
C419
 Probe Info  		18.77  LDD2074  [17]
C420
 Probe Info  		12.38  LDD2075  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C35(1.12); C39(1.22); C40(1.12)  LDD0812  [8]
 LDCM0215  AC10 HCT 116 C35(0.92); C39(0.92); C53(1.79)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C35(0.55); C39(0.62); C40(0.62); C53(0.93)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C35(0.64); C39(0.66); C40(0.75); C53(0.87)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C35(0.59); C39(0.60); C40(0.64); C53(0.87)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C35(0.61); C39(0.65); C40(0.68); C53(0.69)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C35(0.59); C39(0.58); C40(0.76); C53(0.70)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C35(0.64); C39(0.64); C40(0.80); C53(0.72)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C35(0.64); C39(0.73); C40(0.71); C53(0.65)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C35(0.72); C39(0.63); C40(0.96); C53(0.82)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C35(0.64); C39(0.65); C40(0.74); C53(0.83)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C35(0.61); C39(0.92); C40(0.71); C53(0.60)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C35(1.07); C39(1.07); C53(1.18)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C35(0.59); C39(0.79); C40(0.75); C53(0.67)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C35(0.68); C39(0.79); C40(0.77); C53(0.72)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C35(0.60); C39(0.60); C40(0.76); C53(0.72)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C35(0.95); C39(0.90); C40(0.66); C53(0.92)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C35(1.03); C39(1.10); C40(0.88); C53(0.85)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C35(1.03); C39(1.05); C40(0.97); C53(1.17)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C35(1.01); C39(1.09); C40(1.01); C53(1.32)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C35(1.02); C39(0.98); C40(0.92); C53(1.20)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C35(0.99); C39(1.05); C40(0.84); C53(1.00)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C35(1.12); C39(1.05); C40(0.93); C53(1.17)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C35(0.97); C39(0.97); C53(1.14)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C35(0.95); C39(1.03); C40(0.95); C53(0.99)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C35(1.11); C39(1.01); C40(0.73); C53(1.19)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C35(1.05); C39(1.09); C40(0.95); C53(1.01)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C35(1.23); C39(0.97); C40(0.74); C53(1.09)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C35(1.09); C39(1.08); C40(0.77); C53(1.29)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C35(1.08); C39(1.12); C40(0.98); C53(0.91)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C35(0.89); C39(0.95); C40(0.92); C53(1.10)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C35(0.99); C39(1.08); C40(0.96); C53(1.01)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C35(0.74); C39(0.69); C40(0.84)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C35(0.93); C39(0.88); C40(0.91)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C35(0.94); C39(1.18); C40(1.03)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C35(0.91); C39(1.06); C40(0.90)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C35(0.84); C39(0.78); C40(0.90)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C35(0.79); C39(0.69); C40(0.88)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C35(0.77); C39(0.59); C40(0.84)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C35(0.71); C39(0.72); C40(0.83)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C35(0.73); C39(0.60); C40(0.83)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C35(0.78); C39(0.81); C40(0.81)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C35(0.71); C39(0.58); C40(0.77)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C35(0.79); C39(0.69); C40(0.83)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C35(0.97); C39(0.97); C53(1.40)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C35(0.73); C39(0.67); C40(0.80)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C35(0.83); C39(0.74); C40(0.89)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C35(0.91); C39(0.92); C40(0.91)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C35(1.02); C39(0.96); C40(0.99); C53(0.88)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C40(0.82); C53(0.83); C39(0.91); C35(0.93)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C40(0.75); C53(0.78); C39(0.84); C35(0.88)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C53(0.85); C40(0.93); C39(1.09); C35(1.11)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C40(0.74); C53(0.93); C39(0.94); C35(0.96)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C53(0.68); C40(0.70); C39(0.92); C35(1.00)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C53(0.73); C40(0.76); C39(0.96); C35(1.05)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C35(1.12); C39(1.12); C53(1.46)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C39(1.00); C35(1.01); C40(1.02); C53(1.06)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C53(1.10); C35(1.20); C39(1.20); C40(1.36)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C53(0.66); C40(0.71); C39(0.85); C35(0.86)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C53(0.64); C40(0.72); C39(0.89); C35(0.93)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C35(1.01); C39(1.00); C40(0.84); C53(0.90)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C35(1.08); C39(1.08); C40(1.05); C53(1.10)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C35(1.19); C39(1.31); C40(1.43); C53(0.79)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C35(1.20); C39(1.41); C40(1.59); C53(0.90)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C35(0.81); C39(0.90); C40(0.91); C53(0.92)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C53(0.70); C40(0.83); C35(0.84); C39(0.91)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C35(0.77); C39(0.89); C40(0.90); C53(1.34)  LDD0595  [8]
 LDCM0279  AC2 HEK-293T C35(1.07); C39(1.08); C40(1.07)  LDD0877  [8]
 LDCM0280  AC20 HCT 116 C35(0.79); C39(0.83); C40(0.85); C53(1.00)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C35(1.00); C39(1.08); C53(1.12); C40(1.14)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C35(0.88); C39(0.94); C40(0.99); C53(1.15)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C35(0.65); C40(0.72); C39(0.75); C53(0.88)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C35(0.84); C39(0.93); C53(1.02); C40(1.03)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C53(0.95); C35(1.15)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C53(0.85); C35(1.00)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C53(0.87); C35(1.35)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C35(1.30); C53(1.65)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C53(0.77); C35(1.06)  LDD0606  [8]
 LDCM0290  AC3 HEK-293T C35(1.06); C39(1.18); C40(1.06)  LDD0888  [8]
 LDCM0291  AC30 HCT 116 C53(0.67); C35(1.23)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C53(0.69); C35(1.23)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C53(0.95); C35(1.16)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C53(0.94); C35(1.18)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C53(0.73); C35(1.24)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C53(0.52); C35(1.03)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C53(0.63); C35(1.30)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C53(0.83); C35(1.00)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C53(0.64); C35(1.04)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C53(0.69); C35(1.54)  LDD0617  [8]
 LDCM0301  AC4 HEK-293T C35(1.01); C39(0.98); C40(1.01)  LDD0899  [8]
 LDCM0302  AC40 HCT 116 C53(0.80); C35(0.91)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C53(0.74); C35(1.47)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C53(0.60); C35(1.37)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C53(0.88); C35(1.58)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C53(0.85); C35(1.67)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C53(0.89); C35(1.25)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C35(0.68); C53(0.80); C40(0.88)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C35(0.71); C40(0.97); C53(1.07)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C53(0.89); C35(1.14); C40(1.24)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C53(0.80); C35(0.83); C40(1.56)  LDD0628  [8]
 LDCM0312  AC5 HEK-293T C35(1.32); C39(1.63); C40(1.32)  LDD0910  [8]
 LDCM0313  AC50 HCT 116 C53(0.82); C35(0.88); C40(1.11)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C53(0.80); C35(0.85); C40(0.92)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C35(0.88); C53(0.95); C40(1.03)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C35(0.80); C53(0.81); C40(1.17)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C53(1.10); C35(1.38); C40(1.60)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C53(0.72); C35(0.80); C40(1.17)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C53(0.60); C35(0.62); C40(1.16)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C40(0.78); C39(1.10); C35(1.14); C53(1.22)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C40(0.65); C39(0.98); C35(1.02); C53(1.19)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C40(0.67); C35(0.95); C39(0.95); C53(1.22)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C35(0.88); C39(0.88); C53(1.25)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C40(0.98); C35(1.12); C39(1.13); C53(1.26)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C40(1.33); C53(1.46); C35(1.49); C39(1.49)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C40(0.71); C39(0.85); C35(0.96); C53(1.37)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C40(0.91); C39(1.00); C35(1.06); C53(1.42)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C40(0.82); C39(0.92); C35(0.98); C53(1.24)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C40(0.36); C39(0.54); C35(0.61); C53(0.85)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C40(0.45); C39(0.56); C35(0.61); C53(0.92)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C40(0.29); C39(0.40); C35(0.43); C53(0.63)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C53(0.93); C39(0.93); C35(1.03); C40(1.21)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C39(0.87); C53(1.03); C35(1.16); C40(1.46)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C35(0.87); C39(0.87); C53(1.31)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C39(0.73); C53(0.86); C35(1.07); C40(1.30)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C53(0.89); C39(1.01); C35(1.32); C40(1.63)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C53(0.90); C39(0.91); C35(1.28); C40(1.57)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C53(0.66); C39(0.81); C35(1.13); C40(1.27)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C53(0.69); C39(0.72); C35(0.93); C40(1.05)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C53(0.72); C39(0.77); C35(1.04); C40(1.24)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C53(0.77); C39(0.82); C35(1.03); C40(1.28)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C53(0.75); C39(0.80); C35(1.04); C40(1.27)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C39(1.03); C53(1.14); C35(1.38); C40(1.54)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C39(0.94); C53(0.97); C35(1.14); C40(1.47)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C35(1.11); C39(1.11); C53(1.42)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C53(0.90); C39(0.94); C35(1.04); C40(1.15)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C39(0.95); C53(1.10); C35(1.20); C40(1.44)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C53(0.61); C39(0.67); C35(0.90); C40(1.02)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C53(0.82); C39(0.86); C35(0.94); C40(0.96)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C39(0.74); C35(0.79); C40(0.92); C53(0.96)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C39(0.87); C35(0.89); C53(1.13); C40(1.20)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C39(1.03); C35(1.06); C53(1.07); C40(1.10)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C35(0.93); C53(0.97); C39(1.00); C40(1.10)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C35(0.93); C40(0.96); C39(1.00); C53(2.08)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C35(0.91); C39(0.91); C40(1.07); C53(1.16)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C53(0.82); C35(1.04); C39(1.12); C40(1.21)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C53(0.80); C39(0.99); C35(1.01); C40(1.15)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C35(0.93); C39(0.94); C53(0.97); C40(1.20)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C35(0.85); C39(0.88); C40(1.05); C53(1.39)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C39(1.01); C35(1.01); C53(1.06); C40(1.14)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C40(0.98); C35(1.03); C39(1.09); C53(1.37)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C35(1.04); C39(1.09); C40(1.13); C53(1.36)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C35(0.93); C39(0.94); C53(1.03); C40(1.04)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C53(0.44); C35(0.52); C39(0.57); C40(0.62)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C35(0.55); C39(0.60); C40(0.68); C53(0.87)  LDD0683  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C110(0.87); C53(0.96)  LDD2113  [6]
 LDCM0248  AKOS034007472 HCT 116 C35(0.96); C39(0.96); C53(1.20)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C35(1.19); C39(1.19); C53(1.53)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C35(1.01); C39(1.01); C53(1.48)  LDD0592  [8]
 LDCM0020  ARS-1620 HCC44 C110(1.24); C53(1.14); C39(1.23); C40(1.23)  LDD2171  [8]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 HCT 116 C35(0.98); C40(0.98); C53(1.19)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C53(0.95); C35(1.22); C40(1.22)  LDD0685  [8]
 LDCM0369  CL100 HEK-293T C35(0.92); C39(0.91); C40(0.92)  LDD0967  [8]
 LDCM0370  CL101 HCT 116 C35(0.89); C39(0.89); C53(1.20)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C35(0.75); C39(0.75); C53(1.27)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C35(1.00); C39(1.00); C53(1.74)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C35(0.99); C39(0.99); C53(1.54)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C35(0.81); C40(0.85); C39(0.95); C53(0.97)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C35(0.80); C40(0.95); C53(0.98); C39(0.99)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C35(0.84); C53(0.90); C39(1.01); C40(1.10)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C35(0.89); C40(1.01); C53(1.01); C39(1.01)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C35(0.93); C53(0.97); C39(1.04); C40(1.09)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C35(0.88); C40(0.88); C53(1.26)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C35(0.79); C40(0.80); C39(0.81); C53(0.95)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C35(0.79); C39(0.84); C40(0.84); C53(0.93)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C53(0.93); C35(1.04)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C53(0.82); C35(0.97)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C53(0.76); C35(0.94)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C53(1.06); C35(1.14)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C53(0.93); C35(1.27)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C53(0.70); C35(1.38)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C53(0.84); C35(1.62)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C53(0.78); C35(1.79)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C53(0.86); C35(1.45); C40(1.45)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C53(0.88); C35(1.46)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C35(0.70); C53(0.94); C40(1.09)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C53(1.00); C40(1.16); C35(1.27)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C53(0.78); C35(0.86); C40(1.14)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C53(0.84); C35(0.93); C40(1.21)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C40(0.76); C35(1.07); C39(1.10); C53(1.14)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C40(0.71); C35(0.86); C39(0.87); C53(1.12)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C40(0.89); C39(0.94); C35(1.01); C53(1.31)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C40(0.96); C39(1.01); C35(1.09); C53(1.34)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C53(1.05); C35(1.11); C40(1.11)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C53(0.91); C35(1.10); C40(1.10)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C53(0.82); C35(0.90); C40(0.90)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C40(1.08); C35(1.12); C39(1.12); C53(1.42)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C35(0.97); C39(0.97); C53(0.98); C40(0.98)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C35(1.16); C39(1.16); C53(1.39); C40(1.50)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C35(1.19); C39(1.19); C53(1.38); C40(1.41)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C35(1.03); C40(1.03); C53(1.22)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C53(0.87); C35(1.20); C39(1.20); C40(1.51)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C35(0.99); C39(0.99); C53(1.19); C40(1.67)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C53(0.95); C35(1.08); C39(1.08); C40(1.54)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C53(1.02); C35(1.32); C39(1.32); C40(1.42)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C53(1.15); C35(1.35); C39(1.35); C40(1.68)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C35(1.36); C39(1.36); C40(1.76); C53(1.21)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C35(1.36); C39(1.36); C40(1.43); C53(1.21)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C35(1.19); C39(1.19); C40(1.48); C53(1.56)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C35(1.29); C39(1.29); C40(1.57); C53(1.13)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C35(1.50); C39(1.50); C40(1.99); C53(1.34)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C35(1.22); C40(1.22); C53(0.81)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C35(1.37); C39(1.37); C40(1.63); C53(1.24)  LDD0736  [8]
 LDCM0420  CL31 HEK-293T C35(1.05); C39(1.10); C40(1.15)  LDD1018  [8]
 LDCM0421  CL32 HCT 116 C35(0.86); C39(0.86); C40(0.64)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C35(1.12); C39(1.12); C40(1.36)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C35(0.81); C39(0.81); C40(0.66)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C35(0.92); C39(0.92); C40(0.74)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C35(0.87); C39(0.87); C40(0.84)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C35(0.91); C39(0.91); C40(0.66)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C35(0.89); C39(0.89); C40(0.75)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C35(1.10); C40(1.10); C53(0.95)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C35(0.91); C39(0.91); C40(0.91)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C35(0.96); C39(0.96); C40(0.93)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C35(0.93); C39(0.93); C40(0.96)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C35(0.97); C39(0.97); C40(0.84)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C35(1.03); C39(1.03); C40(0.88)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C35(1.01); C39(1.01); C40(0.95)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C35(0.92); C40(0.92)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C35(1.00); C40(1.00)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C35(1.00); C40(1.00)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C35(1.04); C40(1.04)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C35(1.00); C40(1.00); C53(1.24)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C35(1.10); C40(1.10)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C35(0.93); C40(0.93)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C35(0.98); C40(0.98)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C35(0.99); C40(0.99)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C35(0.98); C40(0.98)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C35(0.91); C40(0.91)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C35(0.88); C40(0.88)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C35(0.96); C40(0.96)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C35(1.08); C40(1.08)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C35(1.01); C40(1.01)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C35(1.14); C40(1.14); C53(1.00)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C35(1.04); C40(1.04)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C35(0.91); C39(0.91)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C35(1.18); C39(1.18)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C35(1.14); C39(1.14)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C35(1.14); C39(1.14)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C35(0.98); C39(0.98)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C35(1.10); C39(1.10)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C35(1.02); C39(1.02)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C35(0.98); C39(0.98)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C35(1.00); C39(1.00)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C35(1.25); C40(1.25); C53(0.90)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C35(1.04); C39(1.04)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C35(0.94); C39(0.94)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C35(1.05); C39(1.05)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C35(1.21); C39(1.21)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C35(1.09); C39(1.09)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C35(0.82); C39(0.82)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C35(0.93); C39(0.93)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C35(0.98); C39(0.98)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C35(1.04); C39(1.04)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C35(0.78); C40(0.78); C53(1.01)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C35(1.12); C39(1.12)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C35(1.10); C39(1.10)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C35(1.01); C39(1.01)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C35(1.22); C39(1.22)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C35(1.00); C39(1.00)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C35(0.94); C39(0.94)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C35(0.97); C39(0.97)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C35(0.75); C39(0.75)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C35(0.91); C39(0.91)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C35(1.05); C39(1.05)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C35(1.07); C40(1.07); C53(1.09)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C35(0.83); C39(0.83)  LDD0802  [8]
 LDCM0486  CL91 HEK-293T C35(0.84); C39(0.67); C40(0.84)  LDD1084  [8]
 LDCM0487  CL92 HEK-293T C35(1.08); C39(1.39); C40(1.08)  LDD1085  [8]
 LDCM0488  CL93 HEK-293T C35(1.14); C39(1.25); C40(1.14)  LDD1086  [8]
 LDCM0489  CL94 HEK-293T C35(1.00); C39(1.05); C40(1.00)  LDD1087  [8]
 LDCM0490  CL95 HEK-293T C35(1.17); C39(1.49); C40(1.17)  LDD1088  [8]
 LDCM0491  CL96 HEK-293T C35(0.79); C39(0.86); C40(0.79)  LDD1089  [8]
 LDCM0492  CL97 HEK-293T C35(1.03); C39(1.11); C40(1.03)  LDD1090  [8]
 LDCM0493  CL98 HEK-293T C35(0.97); C39(1.18); C40(0.97)  LDD1091  [8]
 LDCM0494  CL99 HEK-293T C35(1.13); C39(1.24); C40(1.13)  LDD1092  [8]
 LDCM0495  E2913 HEK-293T C40(0.91)  LDD1698  [18]
 LDCM0468  Fragment33 HCT 116 C35(0.88); C39(0.88)  LDD0785  [8]
 LDCM0566  Fragment4 Ramos C57(1.22)  LDD2184  [19]
 LDCM0427  Fragment51 HCT 116 C35(0.84); C39(0.84); C40(0.74)  LDD0744  [8]
 LDCM0569  Fragment7 Ramos C57(0.99)  LDD2186  [19]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [5]
 LDCM0022  KB02 HCT 116 C35(12.61); C40(12.61); C39(12.61)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C35(12.88); C40(12.88); C39(12.88)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C35(13.68); C40(13.68); C39(13.68)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C53(0.87)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C53(0.23)  LDD2098  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C110(0.79); C53(1.22)  LDD2101  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C110(0.48); C53(0.53)  LDD2115  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C110(0.99); C53(0.63)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C53(0.57); C57(0.56)  LDD2134  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C110(0.49)  LDD2148  [6]
 LDCM0628  OTUB2-COV-1 HEK-293T C40(1.01)  LDD2207  [20]
 LDCM0021  THZ1 HCT 116 C110(1.24); C53(1.14); C39(1.23); C40(1.23)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) P4HA family Q7Z4N8
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein dpy-30 homolog (DPY30) Dpy-30 family Q9C005
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (SMARCD1) SMARCD family Q96GM5
Tetratricopeptide repeat protein 19, mitochondrial (TTC19) TTC19 family Q6DKK2
Melanoma-associated antigen B4 (MAGEB4) . O15481

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
20 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.