Details of the Target

General Information of Target

Target ID LDTP09294
Target Name Proton-coupled zinc antiporter SLC30A5 (SLC30A5)
Gene Name SLC30A5
Gene ID 64924
Synonyms
ZNT5; ZNTL1; ZTL1; Proton-coupled zinc antiporter SLC30A5; Solute carrier family 30 member 5; Zinc transporter 5; ZnT-5; ZnT-like transporter 1; hZTL1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEKYGGDVLAGPGGGGGLGPVDVPSARLTKYIVLLCFTKFLKAVGLFESYDLLKAVHIV
QFIFILKLGTAFFMVLFQKPFSSGKTITKHQWIKIFKHAVAGCIISLLWFFGLTLCGPLR
TLLLFEHSDIVVISLLSVLFTSSGGGPAKTRGAAFFIIAVICLLLFDNDDLMAKMAEHPE
GHHDSALTHMLYTAIAFLGVADHKGGVLLLVLALCCKVGFHTASRKLSVDVGGAKRLQAL
SHLVSVLLLCPWVIVLSVTTESKVESWFSLIMPFATVIFFVMILDFYVDSICSVKMEVSK
CARYGSFPIFISALLFGNFWTHPITDQLRAMNKAAHQESTEHVLSGGVVVSAIFFILSAN
ILSSPSKRGQKGTLIGYSPEGTPLYNFMGDAFQHSSQSIPRFIKESLKQILEESDSRQIF
YFLCLNLLFTFVELFYGVLTNSLGLISDGFHMLFDCSALVMGLFAALMSRWKATRIFSYG
YGRIEILSGFINGLFLIVIAFFVFMESVARLIDPPELDTHMLTPVSVGGLIVNLIGICAF
SHAHSHAHGASQGSCHSSDHSHSHHMHGHSDHGHGHSHGSAGGGMNANMRGVFLHVLADT
LGSIGVIVSTVLIEQFGWFIADPLCSLFIAILIFLSVVPLIKDACQVLLLRLPPEYEKEL
HIALEKIQKIEGLISYRDPHFWRHSASIVAGTIHIQVTSDVLEQRIVQQVTGILKDAGVN
NLTIQVEKEAYFQHMSGLSTGFHDVLAMTKQMESMKYCKDGTYIM
Target Bioclass
Transporter and channel
Family
Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily
Subcellular location
Endoplasmic reticulum membrane; Golgi apparatus, Golgi stack membrane
Function
Together with SLC30A6 forms a functional proton-coupled zinc ion antiporter mediating zinc entry into the lumen of organelles along the secretory pathway. By contributing to zinc ion homeostasis within the early secretory pathway, regulates the activation and folding of enzymes like alkaline phosphatases and enzymes involved in phosphatidylinositol glycan anchor biosynthesis. Through the transport of zinc into secretory granules of pancreatic beta-cells, plays an important role in the storage and secretion of insulin.; [Isoform 2]: Zinc ion:proton antiporter mediating influx and efflux of zinc at the plasma membrane.
Uniprot ID
Q8TAD4
Ensemble ID
ENST00000380860.8
HGNC ID
HGNC:19089

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.K149N .
IGROV1 Deletion: p.F73LfsTer47 .
JURKAT SNV: p.L191F .
MCC26 SNV: p.S557L .
P31FUJ SNV: p.I59V .
RVH421 SNV: p.L627F .
SNU1 Deletion: p.Q409HfsTer3 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0403  [1]
DBIA
 Probe Info  		C645(2.13)  LDD3312  [2]
AOyne
 Probe Info  		15.00  LDD0443  [3]
PAL-AfBPP Probe
Click To Hide/Show 51 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		16.80  LDD1728  [4]
C026
 Probe Info  		5.90  LDD1732  [4]
C091
 Probe Info  		25.99  LDD1782  [4]
C092
 Probe Info  		40.22  LDD1783  [4]
C094
 Probe Info  		35.26  LDD1785  [4]
C106
 Probe Info  		29.24  LDD1793  [4]
C107
 Probe Info  		10.56  LDD1794  [4]
C108
 Probe Info  		13.55  LDD1795  [4]
C112
 Probe Info  		36.00  LDD1799  [4]
C129
 Probe Info  		5.66  LDD1811  [4]
C134
 Probe Info  		33.36  LDD1816  [4]
C135
 Probe Info  		11.39  LDD1817  [4]
C139
 Probe Info  		11.16  LDD1821  [4]
C140
 Probe Info  		8.40  LDD1822  [4]
C159
 Probe Info  		10.63  LDD1839  [4]
C160
 Probe Info  		9.38  LDD1840  [4]
C161
 Probe Info  		16.34  LDD1841  [4]
C169
 Probe Info  		35.26  LDD1849  [4]
C186
 Probe Info  		12.64  LDD1864  [4]
C194
 Probe Info  		9.78  LDD1870  [4]
C196
 Probe Info  		11.55  LDD1872  [4]
C198
 Probe Info  		13.93  LDD1874  [4]
C210
 Probe Info  		62.25  LDD1884  [4]
C211
 Probe Info  		8.17  LDD1885  [4]
C213
 Probe Info  		16.22  LDD1887  [4]
C218
 Probe Info  		14.52  LDD1892  [4]
C219
 Probe Info  		6.68  LDD1893  [4]
C220
 Probe Info  		21.11  LDD1894  [4]
C225
 Probe Info  		7.62  LDD1898  [4]
C226
 Probe Info  		8.46  LDD1899  [4]
C228
 Probe Info  		24.42  LDD1901  [4]
C231
 Probe Info  		16.91  LDD1904  [4]
C243
 Probe Info  		13.93  LDD1916  [4]
C246
 Probe Info  		24.42  LDD1919  [4]
C249
 Probe Info  		11.88  LDD1922  [4]
C278
 Probe Info  		87.43  LDD1948  [4]
C280
 Probe Info  		14.22  LDD1950  [4]
C282
 Probe Info  		35.02  LDD1952  [4]
C284
 Probe Info  		30.27  LDD1954  [4]
C322
 Probe Info  		6.02  LDD1988  [4]
C348
 Probe Info  		20.68  LDD2009  [4]
C349
 Probe Info  		25.99  LDD2010  [4]
C350
 Probe Info  		49.52  LDD2011  [4]
C353
 Probe Info  		8.06  LDD2014  [4]
C390
 Probe Info  		35.51  LDD2049  [4]
C429
 Probe Info  		30.27  LDD2084  [4]
C431
 Probe Info  		24.25  LDD2086  [4]
C433
 Probe Info  		5.90  LDD2088  [4]
FFF probe11
 Probe Info  		20.00  LDD0471  [5]
FFF probe13
 Probe Info  		20.00  LDD0475  [5]
OEA-DA
 Probe Info  		20.00  LDD0046  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C645(0.84); C37(0.72)  LDD1507  [7]
 LDCM0215  AC10 HEK-293T C37(0.84)  LDD1508  [7]
 LDCM0226  AC11 HEK-293T C645(0.84); C37(0.95)  LDD1509  [7]
 LDCM0237  AC12 HEK-293T C645(0.83); C37(0.77)  LDD1510  [7]
 LDCM0259  AC14 HEK-293T C645(0.86); C37(0.82)  LDD1512  [7]
 LDCM0270  AC15 HEK-293T C645(0.82); C37(0.96)  LDD1513  [7]
 LDCM0276  AC17 HEK-293T C645(0.90); C37(0.77)  LDD1515  [7]
 LDCM0277  AC18 HEK-293T C37(0.72)  LDD1516  [7]
 LDCM0278  AC19 HEK-293T C645(0.78); C37(0.77)  LDD1517  [7]
 LDCM0279  AC2 HEK-293T C37(0.86)  LDD1518  [7]
 LDCM0280  AC20 HEK-293T C645(0.76); C37(0.84)  LDD1519  [7]
 LDCM0281  AC21 HEK-293T C645(0.99); C37(0.95)  LDD1520  [7]
 LDCM0282  AC22 HEK-293T C645(0.84); C37(0.86)  LDD1521  [7]
 LDCM0283  AC23 HEK-293T C645(1.19); C37(1.07)  LDD1522  [7]
 LDCM0284  AC24 HEK-293T C645(0.91); C37(0.99)  LDD1523  [7]
 LDCM0285  AC25 HEK-293T C645(0.88); C37(0.72)  LDD1524  [7]
 LDCM0286  AC26 HEK-293T C37(0.83)  LDD1525  [7]
 LDCM0287  AC27 HEK-293T C645(0.93); C37(0.96)  LDD1526  [7]
 LDCM0288  AC28 HEK-293T C645(0.90); C37(0.97)  LDD1527  [7]
 LDCM0289  AC29 HEK-293T C645(0.96); C37(0.90)  LDD1528  [7]
 LDCM0290  AC3 HEK-293T C645(0.99); C37(1.06)  LDD1529  [7]
 LDCM0291  AC30 HEK-293T C645(0.83); C37(0.98)  LDD1530  [7]
 LDCM0292  AC31 HEK-293T C645(1.18); C37(1.07)  LDD1531  [7]
 LDCM0293  AC32 HEK-293T C645(0.86); C37(1.00)  LDD1532  [7]
 LDCM0294  AC33 HEK-293T C645(0.89); C37(0.99)  LDD1533  [7]
 LDCM0295  AC34 HEK-293T C37(1.01)  LDD1534  [7]
 LDCM0296  AC35 HEK-293T C645(0.89); C37(1.08)  LDD1535  [7]
 LDCM0297  AC36 HEK-293T C645(0.94); C37(0.87)  LDD1536  [7]
 LDCM0298  AC37 HEK-293T C645(1.02); C37(0.92)  LDD1537  [7]
 LDCM0299  AC38 HEK-293T C645(0.88); C37(0.87)  LDD1538  [7]
 LDCM0300  AC39 HEK-293T C645(1.12); C37(1.30)  LDD1539  [7]
 LDCM0301  AC4 HEK-293T C645(0.90); C37(0.96)  LDD1540  [7]
 LDCM0302  AC40 HEK-293T C645(1.07); C37(0.97)  LDD1541  [7]
 LDCM0303  AC41 HEK-293T C645(0.93); C37(0.75)  LDD1542  [7]
 LDCM0304  AC42 HEK-293T C37(0.79)  LDD1543  [7]
 LDCM0305  AC43 HEK-293T C645(1.02); C37(1.11)  LDD1544  [7]
 LDCM0306  AC44 HEK-293T C645(0.78); C37(0.76)  LDD1545  [7]
 LDCM0307  AC45 HEK-293T C645(1.04); C37(1.02)  LDD1546  [7]
 LDCM0308  AC46 HEK-293T C645(0.99); C37(0.82)  LDD1547  [7]
 LDCM0309  AC47 HEK-293T C645(1.06); C37(0.86)  LDD1548  [7]
 LDCM0310  AC48 HEK-293T C645(1.11); C37(0.99)  LDD1549  [7]
 LDCM0311  AC49 HEK-293T C645(0.99); C37(0.86)  LDD1550  [7]
 LDCM0312  AC5 HEK-293T C645(0.96); C37(0.95)  LDD1551  [7]
 LDCM0313  AC50 HEK-293T C37(0.79)  LDD1552  [7]
 LDCM0314  AC51 HEK-293T C645(1.07); C37(0.97)  LDD1553  [7]
 LDCM0315  AC52 HEK-293T C645(0.83); C37(0.89)  LDD1554  [7]
 LDCM0316  AC53 HEK-293T C645(1.09); C37(0.88)  LDD1555  [7]
 LDCM0317  AC54 HEK-293T C645(0.89); C37(0.85)  LDD1556  [7]
 LDCM0318  AC55 HEK-293T C645(0.79); C37(0.96)  LDD1557  [7]
 LDCM0319  AC56 HEK-293T C645(1.04); C37(1.21)  LDD1558  [7]
 LDCM0320  AC57 HEK-293T C645(1.01); C37(1.01)  LDD1559  [7]
 LDCM0321  AC58 HEK-293T C37(0.85)  LDD1560  [7]
 LDCM0322  AC59 HEK-293T C645(1.26); C37(1.14)  LDD1561  [7]
 LDCM0323  AC6 HEK-293T C645(0.94); C37(0.91)  LDD1562  [7]
 LDCM0324  AC60 HEK-293T C645(0.91); C37(0.96)  LDD1563  [7]
 LDCM0325  AC61 HEK-293T C645(0.91); C37(0.93)  LDD1564  [7]
 LDCM0326  AC62 HEK-293T C645(0.99); C37(0.98)  LDD1565  [7]
 LDCM0327  AC63 HEK-293T C645(1.21); C37(1.04)  LDD1566  [7]
 LDCM0328  AC64 HEK-293T C645(0.90); C37(1.05)  LDD1567  [7]
 LDCM0334  AC7 HEK-293T C645(1.41); C37(0.98)  LDD1568  [7]
 LDCM0345  AC8 HEK-293T C645(0.93); C37(1.07)  LDD1569  [7]
 LDCM0248  AKOS034007472 HEK-293T C645(0.83); C37(0.86)  LDD1511  [7]
 LDCM0356  AKOS034007680 HEK-293T C645(0.93); C37(0.78)  LDD1570  [7]
 LDCM0275  AKOS034007705 HEK-293T C645(0.99); C37(0.94)  LDD1514  [7]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [1]
 LDCM0367  CL1 HEK-293T C645(1.03); C37(1.17)  LDD1571  [7]
 LDCM0368  CL10 HEK-293T C645(1.02); C37(0.86)  LDD1572  [7]
 LDCM0369  CL100 HEK-293T C37(0.67)  LDD1573  [7]
 LDCM0370  CL101 HEK-293T C645(0.97); C37(0.99)  LDD1574  [7]
 LDCM0371  CL102 HEK-293T C645(0.97); C37(0.78)  LDD1575  [7]
 LDCM0372  CL103 HEK-293T C645(0.91); C37(0.92)  LDD1576  [7]
 LDCM0373  CL104 HEK-293T C37(0.82)  LDD1577  [7]
 LDCM0374  CL105 HEK-293T C645(1.01); C37(0.98)  LDD1578  [7]
 LDCM0375  CL106 HEK-293T C645(0.91); C37(0.88)  LDD1579  [7]
 LDCM0376  CL107 HEK-293T C645(0.97); C37(0.84)  LDD1580  [7]
 LDCM0377  CL108 HEK-293T C37(0.96)  LDD1581  [7]
 LDCM0378  CL109 HEK-293T C645(0.90); C37(0.98)  LDD1582  [7]
 LDCM0379  CL11 HEK-293T C645(1.25); C37(1.17)  LDD1583  [7]
 LDCM0380  CL110 HEK-293T C645(0.84); C37(0.86)  LDD1584  [7]
 LDCM0381  CL111 HEK-293T C645(0.91); C37(0.72)  LDD1585  [7]
 LDCM0382  CL112 HEK-293T C37(0.77)  LDD1586  [7]
 LDCM0383  CL113 HEK-293T C645(1.04); C37(1.00)  LDD1587  [7]
 LDCM0384  CL114 HEK-293T C645(1.02); C37(0.96)  LDD1588  [7]
 LDCM0385  CL115 HEK-293T C645(0.94); C37(0.93)  LDD1589  [7]
 LDCM0386  CL116 HEK-293T C37(0.82)  LDD1590  [7]
 LDCM0387  CL117 HEK-293T C645(1.03); C37(1.03)  LDD1591  [7]
 LDCM0388  CL118 HEK-293T C645(1.19); C37(0.81)  LDD1592  [7]
 LDCM0389  CL119 HEK-293T C645(1.04); C37(0.93)  LDD1593  [7]
 LDCM0390  CL12 HEK-293T C645(1.18); C37(1.11)  LDD1594  [7]
 LDCM0391  CL120 HEK-293T C37(0.88)  LDD1595  [7]
 LDCM0392  CL121 HEK-293T C645(1.10); C37(0.98)  LDD1596  [7]
 LDCM0393  CL122 HEK-293T C645(0.95); C37(0.90)  LDD1597  [7]
 LDCM0394  CL123 HEK-293T C645(1.15); C37(0.75)  LDD1598  [7]
 LDCM0395  CL124 HEK-293T C37(0.70)  LDD1599  [7]
 LDCM0396  CL125 HEK-293T C645(1.04); C37(1.32)  LDD1600  [7]
 LDCM0397  CL126 HEK-293T C645(0.96); C37(1.05)  LDD1601  [7]
 LDCM0398  CL127 HEK-293T C645(1.10); C37(1.15)  LDD1602  [7]
 LDCM0399  CL128 HEK-293T C37(0.89)  LDD1603  [7]
 LDCM0400  CL13 HEK-293T C645(1.01); C37(0.85)  LDD1604  [7]
 LDCM0401  CL14 HEK-293T C645(0.98); C37(1.05)  LDD1605  [7]
 LDCM0402  CL15 HEK-293T C645(1.09); C37(0.82)  LDD1606  [7]
 LDCM0403  CL16 HEK-293T C37(0.79)  LDD1607  [7]
 LDCM0404  CL17 HEK-293T C645(0.85); C37(0.65)  LDD1608  [7]
 LDCM0405  CL18 HEK-293T C37(0.84)  LDD1609  [7]
 LDCM0406  CL19 HEK-293T C645(1.15); C37(0.91)  LDD1610  [7]
 LDCM0407  CL2 HEK-293T C645(1.09); C37(0.89)  LDD1611  [7]
 LDCM0408  CL20 HEK-293T C645(1.14); C37(0.85)  LDD1612  [7]
 LDCM0409  CL21 HEK-293T C645(1.10); C37(0.77)  LDD1613  [7]
 LDCM0410  CL22 HEK-293T C645(0.83); C37(0.98)  LDD1614  [7]
 LDCM0411  CL23 HEK-293T C645(1.21); C37(1.38)  LDD1615  [7]
 LDCM0412  CL24 HEK-293T C645(1.06); C37(1.12)  LDD1616  [7]
 LDCM0413  CL25 HEK-293T C645(1.09); C37(1.15)  LDD1617  [7]
 LDCM0414  CL26 HEK-293T C645(0.99); C37(1.14)  LDD1618  [7]
 LDCM0415  CL27 HEK-293T C645(0.83); C37(0.97)  LDD1619  [7]
 LDCM0416  CL28 HEK-293T C37(0.70)  LDD1620  [7]
 LDCM0417  CL29 HEK-293T C645(0.98); C37(1.28)  LDD1621  [7]
 LDCM0418  CL3 HEK-293T C645(0.89); C37(0.80)  LDD1622  [7]
 LDCM0419  CL30 HEK-293T C37(0.84)  LDD1623  [7]
 LDCM0420  CL31 HEK-293T C645(0.85); C37(0.98)  LDD1624  [7]
 LDCM0421  CL32 HEK-293T C645(1.10); C37(0.83)  LDD1625  [7]
 LDCM0422  CL33 HEK-293T C645(0.81); C37(0.94)  LDD1626  [7]
 LDCM0423  CL34 HEK-293T C645(1.09); C37(1.11)  LDD1627  [7]
 LDCM0424  CL35 HEK-293T C645(1.00); C37(1.11)  LDD1628  [7]
 LDCM0425  CL36 HEK-293T C645(0.93); C37(1.28)  LDD1629  [7]
 LDCM0426  CL37 HEK-293T C645(1.03); C37(1.55)  LDD1630  [7]
 LDCM0428  CL39 HEK-293T C645(1.12); C37(0.89)  LDD1632  [7]
 LDCM0429  CL4 HEK-293T C37(0.84)  LDD1633  [7]
 LDCM0430  CL40 HEK-293T C37(0.70)  LDD1634  [7]
 LDCM0431  CL41 HEK-293T C645(0.86); C37(0.71)  LDD1635  [7]
 LDCM0432  CL42 HEK-293T C37(1.04)  LDD1636  [7]
 LDCM0433  CL43 HEK-293T C645(1.00); C37(1.02)  LDD1637  [7]
 LDCM0434  CL44 HEK-293T C645(0.93); C37(0.86)  LDD1638  [7]
 LDCM0435  CL45 HEK-293T C645(0.90); C37(0.83)  LDD1639  [7]
 LDCM0436  CL46 HEK-293T C645(1.01); C37(0.98)  LDD1640  [7]
 LDCM0437  CL47 HEK-293T C645(1.24); C37(1.10)  LDD1641  [7]
 LDCM0438  CL48 HEK-293T C645(1.00); C37(1.30)  LDD1642  [7]
 LDCM0439  CL49 HEK-293T C645(1.27); C37(1.20)  LDD1643  [7]
 LDCM0440  CL5 HEK-293T C645(1.01); C37(1.02)  LDD1644  [7]
 LDCM0441  CL50 HEK-293T C645(0.84); C37(1.03)  LDD1645  [7]
 LDCM0443  CL52 HEK-293T C37(0.79)  LDD1646  [7]
 LDCM0444  CL53 HEK-293T C645(0.89); C37(0.78)  LDD1647  [7]
 LDCM0445  CL54 HEK-293T C37(0.90)  LDD1648  [7]
 LDCM0446  CL55 HEK-293T C645(1.01); C37(1.02)  LDD1649  [7]
 LDCM0447  CL56 HEK-293T C645(0.78); C37(0.89)  LDD1650  [7]
 LDCM0448  CL57 HEK-293T C645(1.07); C37(0.81)  LDD1651  [7]
 LDCM0449  CL58 HEK-293T C645(1.05); C37(1.03)  LDD1652  [7]
 LDCM0450  CL59 HEK-293T C645(0.96); C37(0.96)  LDD1653  [7]
 LDCM0451  CL6 HEK-293T C37(0.93)  LDD1654  [7]
 LDCM0452  CL60 HEK-293T C645(1.10); C37(1.14)  LDD1655  [7]
 LDCM0453  CL61 HEK-293T C645(1.16); C37(1.36)  LDD1656  [7]
 LDCM0454  CL62 HEK-293T C645(1.02); C37(0.89)  LDD1657  [7]
 LDCM0455  CL63 HEK-293T C645(0.92); C37(0.76)  LDD1658  [7]
 LDCM0456  CL64 HEK-293T C37(0.65)  LDD1659  [7]
 LDCM0457  CL65 HEK-293T C645(0.85); C37(0.65)  LDD1660  [7]
 LDCM0458  CL66 HEK-293T C37(0.77)  LDD1661  [7]
 LDCM0459  CL67 HEK-293T C645(1.02); C37(1.01)  LDD1662  [7]
 LDCM0460  CL68 HEK-293T C645(0.92); C37(0.82)  LDD1663  [7]
 LDCM0461  CL69 HEK-293T C645(1.06); C37(0.96)  LDD1664  [7]
 LDCM0462  CL7 HEK-293T C645(1.06); C37(1.08)  LDD1665  [7]
 LDCM0463  CL70 HEK-293T C645(0.90); C37(0.87)  LDD1666  [7]
 LDCM0464  CL71 HEK-293T C645(1.27); C37(1.10)  LDD1667  [7]
 LDCM0465  CL72 HEK-293T C645(1.11); C37(1.05)  LDD1668  [7]
 LDCM0466  CL73 HEK-293T C645(0.97); C37(1.14)  LDD1669  [7]
 LDCM0467  CL74 HEK-293T C645(0.97); C37(0.77)  LDD1670  [7]
 LDCM0469  CL76 HEK-293T C37(0.91)  LDD1672  [7]
 LDCM0470  CL77 HEK-293T C645(0.97); C37(0.80)  LDD1673  [7]
 LDCM0471  CL78 HEK-293T C37(0.79)  LDD1674  [7]
 LDCM0472  CL79 HEK-293T C645(1.21); C37(1.07)  LDD1675  [7]
 LDCM0473  CL8 HEK-293T C645(1.22); C37(1.11)  LDD1676  [7]
 LDCM0474  CL80 HEK-293T C645(0.86); C37(0.83)  LDD1677  [7]
 LDCM0475  CL81 HEK-293T C645(1.13); C37(0.91)  LDD1678  [7]
 LDCM0476  CL82 HEK-293T C645(0.92); C37(0.94)  LDD1679  [7]
 LDCM0477  CL83 HEK-293T C645(1.08); C37(1.21)  LDD1680  [7]
 LDCM0478  CL84 HEK-293T C645(1.06); C37(1.03)  LDD1681  [7]
 LDCM0479  CL85 HEK-293T C645(1.24); C37(1.22)  LDD1682  [7]
 LDCM0480  CL86 HEK-293T C645(1.10); C37(1.24)  LDD1683  [7]
 LDCM0481  CL87 HEK-293T C645(1.27); C37(0.68)  LDD1684  [7]
 LDCM0482  CL88 HEK-293T C37(0.76)  LDD1685  [7]
 LDCM0483  CL89 HEK-293T C645(0.99); C37(1.38)  LDD1686  [7]
 LDCM0484  CL9 HEK-293T C645(1.15); C37(1.12)  LDD1687  [7]
 LDCM0485  CL90 HEK-293T C37(0.90)  LDD1688  [7]
 LDCM0486  CL91 HEK-293T C645(1.12); C37(1.25)  LDD1689  [7]
 LDCM0487  CL92 HEK-293T C645(0.98); C37(0.92)  LDD1690  [7]
 LDCM0488  CL93 HEK-293T C645(0.24); C37(1.10)  LDD1691  [7]
 LDCM0489  CL94 HEK-293T C645(1.14); C37(0.95)  LDD1692  [7]
 LDCM0490  CL95 HEK-293T C645(0.98); C37(0.99)  LDD1693  [7]
 LDCM0491  CL96 HEK-293T C645(1.09); C37(1.09)  LDD1694  [7]
 LDCM0492  CL97 HEK-293T C645(1.02); C37(1.10)  LDD1695  [7]
 LDCM0493  CL98 HEK-293T C645(0.91); C37(0.98)  LDD1696  [7]
 LDCM0494  CL99 HEK-293T C645(1.08); C37(1.10)  LDD1697  [7]
 LDCM0495  E2913 HEK-293T C645(1.12); C37(0.81)  LDD1698  [7]
 LDCM0468  Fragment33 HEK-293T C645(0.96); C37(0.88)  LDD1671  [7]
 LDCM0427  Fragment51 HEK-293T C645(0.98); C37(0.80)  LDD1631  [7]
 LDCM0022  KB02 HEK-293T C37(0.93)  LDD1492  [7]
 LDCM0023  KB03 HEK-293T C37(0.88)  LDD1497  [7]
 LDCM0024  KB05 HMCB C645(2.13)  LDD3312  [2]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Zinc Chloride . DB14533
Zinc Sulfate Unspecified Form . DB14548

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
6 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
7 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402