Details of the Target

General Information of Target

Target ID LDTP17633
Target Name Beta-galactosidase-1-like protein 2 (GLB1L2)
Gene Name GLB1L2
Gene ID 89944
Synonyms
Beta-galactosidase-1-like protein 2; EC 3.2.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSPPGSAAGESAAGGGGGGGGPGVSEELTAAAAAAAADEGPAREEQRPIQPSFTKSLCRE
SHWKCLLLSLLMYGCLGAVAWCHVTTVTRLTFSSAYQGNSLMYHDSPCSNGYVYIPLAFL
LMLYAVYLVECWHCQARHELQHRVDVSSVRERVGRMQQATPCIWWKAISYHYVRRTRQVT
RYRNGDAYTTTQVYHERVNTHVAEAEFDYARCGVRDVSKTLVGLEGAPATRLRFTKCFSF
ASVEAENAYLCQRARFFAENEGLDDYMEAREGMHLKNVDFREFMVAFPDPARPPWYACSS
AFWAAALLTLSWPLRVLAEYRTAYAHYHVEKLFGLEGPGSASSAGGGLSPSDELLPPLTH
RLPRVNTVDSTELEWHIRSNQQLVPSYSEAVLMDLAGLGTRCGGAGGGYAPSCRYGGVGG
PGAAGVAPYRRSCEHCQRAVSSSSIFSRSALSICASPRAGPGPGGGAGCGGSRFSLGRLY
GSRRSCLWRSRSGSVNEASCPTEQTRLSSQASMGDDEDDDEEEAGPPPPYHDALYFPVLI
VHRQEGCLGHSHRPLHRHGSCVETSL
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 35 family
Subcellular location
Secreted
Uniprot ID
Q8IW92
Ensemble ID
ENST00000535456.7
HGNC ID
HGNC:25129

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y493(5.91)  LDD3495  [1]
DBIA
 Probe Info  		C562(1.17)  LDD3364  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [3]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C063
 Probe Info  		9.92  LDD1760  [4]
C149
 Probe Info  		5.24  LDD1830  [4]
C208
 Probe Info  		18.13  LDD1883  [4]
C211
 Probe Info  		20.25  LDD1885  [4]
C213
 Probe Info  		15.35  LDD1887  [4]
C302
 Probe Info  		5.70  LDD1971  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C88(0.90)  LDD1507  [5]
 LDCM0215  AC10 HEK-293T C88(1.19)  LDD1508  [5]
 LDCM0276  AC17 HEK-293T C88(0.99)  LDD1515  [5]
 LDCM0277  AC18 HEK-293T C88(1.11)  LDD1516  [5]
 LDCM0279  AC2 HEK-293T C88(1.35)  LDD1518  [5]
 LDCM0285  AC25 HEK-293T C88(1.16)  LDD1524  [5]
 LDCM0286  AC26 HEK-293T C88(1.05)  LDD1525  [5]
 LDCM0294  AC33 HEK-293T C88(0.96)  LDD1533  [5]
 LDCM0295  AC34 HEK-293T C88(1.08)  LDD1534  [5]
 LDCM0303  AC41 HEK-293T C88(0.98)  LDD1542  [5]
 LDCM0304  AC42 HEK-293T C88(1.09)  LDD1543  [5]
 LDCM0311  AC49 HEK-293T C88(1.32)  LDD1550  [5]
 LDCM0313  AC50 HEK-293T C88(1.17)  LDD1552  [5]
 LDCM0320  AC57 HEK-293T C88(0.94)  LDD1559  [5]
 LDCM0321  AC58 HEK-293T C88(1.37)  LDD1560  [5]
 LDCM0356  AKOS034007680 HEK-293T C88(1.01)  LDD1570  [5]
 LDCM0369  CL100 HEK-293T C88(0.94)  LDD1573  [5]
 LDCM0371  CL102 HEK-293T C88(1.19)  LDD1575  [5]
 LDCM0372  CL103 HEK-293T C88(1.13)  LDD1576  [5]
 LDCM0373  CL104 HEK-293T C88(1.02)  LDD1577  [5]
 LDCM0375  CL106 HEK-293T C88(1.21)  LDD1579  [5]
 LDCM0376  CL107 HEK-293T C88(1.07)  LDD1580  [5]
 LDCM0377  CL108 HEK-293T C88(0.76)  LDD1581  [5]
 LDCM0380  CL110 HEK-293T C88(0.98)  LDD1584  [5]
 LDCM0381  CL111 HEK-293T C88(1.14)  LDD1585  [5]
 LDCM0382  CL112 HEK-293T C88(0.91)  LDD1586  [5]
 LDCM0384  CL114 HEK-293T C88(1.21)  LDD1588  [5]
 LDCM0385  CL115 HEK-293T C88(1.11)  LDD1589  [5]
 LDCM0386  CL116 HEK-293T C88(0.98)  LDD1590  [5]
 LDCM0388  CL118 HEK-293T C88(1.01)  LDD1592  [5]
 LDCM0389  CL119 HEK-293T C88(1.03)  LDD1593  [5]
 LDCM0391  CL120 HEK-293T C88(0.73)  LDD1595  [5]
 LDCM0393  CL122 HEK-293T C88(1.12)  LDD1597  [5]
 LDCM0394  CL123 HEK-293T C88(1.30)  LDD1598  [5]
 LDCM0395  CL124 HEK-293T C88(0.75)  LDD1599  [5]
 LDCM0397  CL126 HEK-293T C88(0.93)  LDD1601  [5]
 LDCM0398  CL127 HEK-293T C88(0.95)  LDD1602  [5]
 LDCM0399  CL128 HEK-293T C88(0.79)  LDD1603  [5]
 LDCM0401  CL14 HEK-293T C88(1.02)  LDD1605  [5]
 LDCM0402  CL15 HEK-293T C88(1.10)  LDD1606  [5]
 LDCM0403  CL16 HEK-293T C88(0.80)  LDD1607  [5]
 LDCM0404  CL17 HEK-293T C88(1.21)  LDD1608  [5]
 LDCM0405  CL18 HEK-293T C88(1.09)  LDD1609  [5]
 LDCM0407  CL2 HEK-293T C88(1.18)  LDD1611  [5]
 LDCM0414  CL26 HEK-293T C88(1.23)  LDD1618  [5]
 LDCM0415  CL27 HEK-293T C88(1.05)  LDD1619  [5]
 LDCM0416  CL28 HEK-293T C88(0.83)  LDD1620  [5]
 LDCM0417  CL29 HEK-293T C88(1.10)  LDD1621  [5]
 LDCM0418  CL3 HEK-293T C88(0.96)  LDD1622  [5]
 LDCM0419  CL30 HEK-293T C88(0.97)  LDD1623  [5]
 LDCM0428  CL39 HEK-293T C88(0.96)  LDD1632  [5]
 LDCM0429  CL4 HEK-293T C88(0.73)  LDD1633  [5]
 LDCM0430  CL40 HEK-293T C88(0.76)  LDD1634  [5]
 LDCM0431  CL41 HEK-293T C88(1.22)  LDD1635  [5]
 LDCM0432  CL42 HEK-293T C88(1.11)  LDD1636  [5]
 LDCM0440  CL5 HEK-293T C88(0.97)  LDD1644  [5]
 LDCM0441  CL50 HEK-293T C88(0.87)  LDD1645  [5]
 LDCM0443  CL52 HEK-293T C88(0.66)  LDD1646  [5]
 LDCM0444  CL53 HEK-293T C88(0.86)  LDD1647  [5]
 LDCM0445  CL54 HEK-293T C88(1.03)  LDD1648  [5]
 LDCM0451  CL6 HEK-293T C88(1.43)  LDD1654  [5]
 LDCM0454  CL62 HEK-293T C88(1.12)  LDD1657  [5]
 LDCM0455  CL63 HEK-293T C88(0.96)  LDD1658  [5]
 LDCM0456  CL64 HEK-293T C88(0.95)  LDD1659  [5]
 LDCM0457  CL65 HEK-293T C88(0.90)  LDD1660  [5]
 LDCM0458  CL66 HEK-293T C88(1.17)  LDD1661  [5]
 LDCM0467  CL74 HEK-293T C88(1.08)  LDD1670  [5]
 LDCM0469  CL76 HEK-293T C88(0.90)  LDD1672  [5]
 LDCM0470  CL77 HEK-293T C88(0.79)  LDD1673  [5]
 LDCM0471  CL78 HEK-293T C88(1.12)  LDD1674  [5]
 LDCM0480  CL86 HEK-293T C88(1.12)  LDD1683  [5]
 LDCM0481  CL87 HEK-293T C88(1.13)  LDD1684  [5]
 LDCM0482  CL88 HEK-293T C88(1.05)  LDD1685  [5]
 LDCM0483  CL89 HEK-293T C88(1.29)  LDD1686  [5]
 LDCM0485  CL90 HEK-293T C88(1.68)  LDD1688  [5]
 LDCM0493  CL98 HEK-293T C88(0.91)  LDD1696  [5]
 LDCM0494  CL99 HEK-293T C88(0.77)  LDD1697  [5]
 LDCM0495  E2913 HEK-293T C88(0.88)  LDD1698  [5]
 LDCM0468  Fragment33 HEK-293T C88(1.12)  LDD1671  [5]
 LDCM0427  Fragment51 HEK-293T C88(1.51)  LDD1631  [5]
 LDCM0022  KB02 A101D C562(0.74)  LDD2250  [2]
 LDCM0023  KB03 A204 C562(1.09)  LDD2669  [2]
 LDCM0024  KB05 NCI-N87 C562(1.17)  LDD3364  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A) CAMK Ser/Thr protein kinase family Q9UQM7
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cysteine-rich tail protein 1 (CYSRT1) CYSRT1 family A8MQ03

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402