Details of the Target

General Information of Target

Target ID LDTP04789
Target Name Synaptojanin-2-binding protein (SYNJ2BP)
Gene Name SYNJ2BP
Gene ID 55333
Synonyms
OMP25; Synaptojanin-2-binding protein; Mitochondrial outer membrane protein 25
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNGRVDYLVTEEEINLTRGPSGLGFNIVGGTDQQYVSNDSGIYVSRIKENGAAALDGRLQ
EGDKILSVNGQDLKNLLHQDAVDLFRNAGYAVSLRVQHRLQVQNGPIGHRGEGDPSGIPI
FMVLVPVFALTMVAAWAFMRYRQQL
Target Bioclass
Transporter and channel
Subcellular location
Mitochondrion outer membrane
Function Regulates endocytosis of activin type 2 receptor kinases through the Ral/RALBP1-dependent pathway and may be involved in suppression of activin-induced signal transduction.
Uniprot ID
P57105
Ensemble ID
ENST00000256366.6
HGNC ID
HGNC:18955

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K48(4.04)  LDD0277  [1]
Acrolein
 Probe Info  		N.A.  LDD0224  [2]
5E-2FA
 Probe Info  		H109(0.00); H78(0.00)  LDD2235  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [3]
SF
 Probe Info  		N.A.  LDD0028  [4]
PAL-AfBPP Probe
Click To Hide/Show 66 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		5.98  LDD1714  [5]
C022
 Probe Info  		9.06  LDD1728  [5]
C040
 Probe Info  		15.24  LDD1740  [5]
C041
 Probe Info  		6.06  LDD1741  [5]
C055
 Probe Info  		27.28  LDD1752  [5]
C056
 Probe Info  		49.87  LDD1753  [5]
C082
 Probe Info  		6.82  LDD1774  [5]
C087
 Probe Info  		9.38  LDD1779  [5]
C091
 Probe Info  		28.05  LDD1782  [5]
C092
 Probe Info  		41.93  LDD1783  [5]
C094
 Probe Info  		99.73  LDD1785  [5]
C106
 Probe Info  		43.71  LDD1793  [5]
C107
 Probe Info  		6.96  LDD1794  [5]
C108
 Probe Info  		12.91  LDD1795  [5]
C134
 Probe Info  		37.27  LDD1816  [5]
C135
 Probe Info  		11.08  LDD1817  [5]
C153
 Probe Info  		16.80  LDD1834  [5]
C159
 Probe Info  		8.17  LDD1839  [5]
C160
 Probe Info  		6.87  LDD1840  [5]
C161
 Probe Info  		14.32  LDD1841  [5]
C201
 Probe Info  		83.29  LDD1877  [5]
C206
 Probe Info  		36.00  LDD1881  [5]
C210
 Probe Info  		99.73  LDD1884  [5]
C211
 Probe Info  		16.00  LDD1885  [5]
C212
 Probe Info  		7.06  LDD1886  [5]
C213
 Probe Info  		37.01  LDD1887  [5]
C214
 Probe Info  		8.46  LDD1888  [5]
C218
 Probe Info  		20.39  LDD1892  [5]
C220
 Probe Info  		22.32  LDD1894  [5]
C225
 Probe Info  		6.02  LDD1898  [5]
C226
 Probe Info  		5.78  LDD1899  [5]
C228
 Probe Info  		43.41  LDD1901  [5]
C229
 Probe Info  		7.78  LDD1902  [5]
C231
 Probe Info  		27.10  LDD1904  [5]
C232
 Probe Info  		56.49  LDD1905  [5]
C233
 Probe Info  		10.06  LDD1906  [5]
C234
 Probe Info  		6.23  LDD1907  [5]
C235
 Probe Info  		62.25  LDD1908  [5]
C246
 Probe Info  		15.03  LDD1919  [5]
C264
 Probe Info  		17.51  LDD1935  [5]
C285
 Probe Info  		33.59  LDD1955  [5]
C287
 Probe Info  		12.73  LDD1957  [5]
C288
 Probe Info  		8.17  LDD1958  [5]
C289
 Probe Info  		81.01  LDD1959  [5]
C292
 Probe Info  		5.43  LDD1962  [5]
C293
 Probe Info  		66.26  LDD1963  [5]
C296
 Probe Info  		32.67  LDD1966  [5]
C299
 Probe Info  		5.82  LDD1968  [5]
C313
 Probe Info  		15.14  LDD1980  [5]
C314
 Probe Info  		18.90  LDD1981  [5]
C343
 Probe Info  		16.56  LDD2005  [5]
C349
 Probe Info  		10.70  LDD2010  [5]
C350
 Probe Info  		31.12  LDD2011  [5]
C362
 Probe Info  		66.72  LDD2023  [5]
C363
 Probe Info  		18.77  LDD2024  [5]
C364
 Probe Info  		20.68  LDD2025  [5]
C366
 Probe Info  		7.57  LDD2027  [5]
C367
 Probe Info  		5.39  LDD2028  [5]
C376
 Probe Info  		7.57  LDD2036  [5]
C382
 Probe Info  		12.91  LDD2041  [5]
C388
 Probe Info  		91.14  LDD2047  [5]
C390
 Probe Info  		49.18  LDD2049  [5]
C403
 Probe Info  		14.83  LDD2061  [5]
C407
 Probe Info  		17.15  LDD2064  [5]
C429
 Probe Info  		13.00  LDD2084  [5]
C431
 Probe Info  		24.42  LDD2086  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0224  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Very long chain fatty acid elongase 5 (ELOVL5) ELO family Q9NYP7
Very long chain fatty acid elongase 7 (ELOVL7) ELO family A1L3X0
Acyl-coenzyme A thioesterase THEM5 (THEM5) THEM4/THEM5 thioesterase family Q8N1Q8
TLC domain-containing protein 4 (TLCD4) TLCD4 family Q96MV1
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Large neutral amino acids transporter small subunit 2 (SLC7A8) L-type amino acid transporter (LAT) (TC 2.A.3.8) family Q9UHI5
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 242 (TMEM242) TMEM242 family Q9NWH2
Transmembrane protein 101 (TMEM101) . Q96IK0
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Receptor expression-enhancing protein 4 (REEP4) DP1 family Q9H6H4
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Delta-like protein 4 (DLL4) . Q9NR61
Mesenteric estrogen-dependent adipogenesis protein (MEDAG) . Q5VYS4

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
5 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587