Details of the Target

General Information of Target

Target ID LDTP04247
Target Name Protein farnesyltransferase subunit beta (FNTB)
Gene Name FNTB
Gene ID 100529261
Synonyms
Protein farnesyltransferase subunit beta; FTase-beta; EC 2.5.1.58; CAAX farnesyltransferase subunit beta; Ras proteins prenyltransferase subunit beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS
SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
IVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQY
LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
GVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF
YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPV
PGFEELKDETSAEPATD
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein prenyltransferase subunit beta family
Function
Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.
TTD ID
T86428
Uniprot ID
P49356
DrugMap ID
TT7WZIJ
Ensemble ID
ENST00000246166.3
HGNC ID
HGNC:3785
ChEMBL ID
CHEMBL272

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.G139S .
KASUMI1 SNV: p.S357A .
KMCH1 SNV: p.Q88K .
MOLT4 SNV: p.R266H IA-alkyne    Probe Info 
OVCAR8 SNV: p.Y147C .
SKMEL28 SNV: p.S3F DBIA    Probe Info 
SKNSH SNV: p.P346H .
SW756 SNV: p.I172V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y300(9.89)  LDD0257  [1]
STPyne
 Probe Info  		K83(8.79)  LDD0277  [2]
m-APA
 Probe Info  		15.00  LDD0403  [3]
AHL-Pu-1
 Probe Info  		C299(3.31)  LDD0170  [4]
HHS-482
 Probe Info  		Y300(0.85)  LDD0286  [5]
DBIA
 Probe Info  		C299(1.09)  LDD0532  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [7]
IPM
 Probe Info  		N.A.  LDD2156  [9]
PAL-AfBPP Probe
Click To Hide/Show 29 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		7.01  LDD1740  [10]
C085
 Probe Info  		6.11  LDD1777  [10]
C092
 Probe Info  		29.04  LDD1783  [10]
C139
 Probe Info  		11.63  LDD1821  [10]
C147
 Probe Info  		6.68  LDD1829  [10]
C158
 Probe Info  		9.00  LDD1838  [10]
C159
 Probe Info  		9.58  LDD1839  [10]
C161
 Probe Info  		11.63  LDD1841  [10]
C196
 Probe Info  		21.11  LDD1872  [10]
C213
 Probe Info  		22.01  LDD1887  [10]
C225
 Probe Info  		6.82  LDD1898  [10]
C226
 Probe Info  		6.02  LDD1899  [10]
C228
 Probe Info  		30.27  LDD1901  [10]
C275
 Probe Info  		5.50  LDD1945  [10]
C286
 Probe Info  		8.75  LDD1956  [10]
C288
 Probe Info  		6.87  LDD1958  [10]
C289
 Probe Info  		36.00  LDD1959  [10]
C290
 Probe Info  		5.03  LDD1960  [10]
C293
 Probe Info  		66.26  LDD1963  [10]
C310
 Probe Info  		13.55  LDD1977  [10]
C322
 Probe Info  		22.63  LDD1988  [10]
C338
 Probe Info  		15.24  LDD2001  [10]
C349
 Probe Info  		11.96  LDD2010  [10]
C350
 Probe Info  		22.16  LDD2011  [10]
C353
 Probe Info  		7.78  LDD2014  [10]
C426
 Probe Info  		17.88  LDD2081  [10]
C428
 Probe Info  		6.11  LDD2083  [10]
C429
 Probe Info  		29.24  LDD2084  [10]
Kambe_22
 Probe Info  		3.45  LDD0132  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C299(3.31)  LDD0170  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C299(2.61)  LDD0171  [4]
 LDCM0215  AC10 HCT 116 C299(1.09)  LDD0532  [6]
 LDCM0226  AC11 HCT 116 C299(0.94)  LDD0543  [6]
 LDCM0237  AC12 HCT 116 C299(0.89)  LDD0554  [6]
 LDCM0246  AC128 HCT 116 C299(0.69)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C299(0.64)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C299(0.92)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C299(1.15)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C299(0.83)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C299(0.71)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C299(0.77)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C299(0.67)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C299(0.81)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C299(0.91)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C299(0.59)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C299(0.69)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C299(0.87)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C299(0.79)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C299(0.73)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C299(1.00)  LDD0579  [6]
 LDCM0270  AC15 HCT 116 C299(1.00)  LDD0587  [6]
 LDCM0276  AC17 HCT 116 C299(1.35)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C299(1.55)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C299(1.30)  LDD0595  [6]
 LDCM0280  AC20 HCT 116 C299(1.49)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C299(1.27)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C299(1.18)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C299(1.00)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C299(1.40)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C299(0.89)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C299(0.84)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C299(1.08)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C299(0.94)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C299(0.77)  LDD0606  [6]
 LDCM0291  AC30 HCT 116 C299(1.12)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C299(1.26)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C299(1.06)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C299(1.11)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C299(1.39)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C299(1.14)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C299(1.29)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C299(1.47)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C299(1.08)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C299(1.28)  LDD0617  [6]
 LDCM0302  AC40 HCT 116 C299(1.05)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C299(1.03)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C299(1.24)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C299(0.96)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C299(1.43)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C299(1.38)  LDD0624  [6]
 LDCM0323  AC6 HCT 116 C299(1.07)  LDD0640  [6]
 LDCM0334  AC7 HCT 116 C299(1.04)  LDD0651  [6]
 LDCM0345  AC8 HCT 116 C299(1.10)  LDD0662  [6]
 LDCM0248  AKOS034007472 HCT 116 C299(0.98)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C299(0.99)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C299(0.83)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 15.00  LDD0403  [3]
 LDCM0370  CL101 HCT 116 C299(1.10)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C299(0.79)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C299(0.98)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C299(1.31)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C299(1.10)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C299(1.31)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C299(1.36)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C299(1.24)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C299(1.26)  LDD0695  [6]
 LDCM0380  CL110 HCT 116 C299(1.05)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C299(1.17)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C299(0.85)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C299(0.96)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C299(0.80)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C299(0.74)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C299(1.17)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C299(1.29)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C299(0.89)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C299(1.17)  LDD0706  [6]
 LDCM0391  CL120 HCT 116 C299(1.05)  LDD0708  [6]
 LDCM0469  CL76 HCT 116 C299(0.82)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C299(0.80)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C299(0.50)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C299(0.78)  LDD0789  [6]
 LDCM0474  CL80 HCT 116 C299(0.50)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C299(0.54)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C299(1.11)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C299(0.55)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C299(0.53)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C299(0.87)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C299(0.64)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C299(0.54)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C299(0.54)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C299(0.53)  LDD0800  [6]
 LDCM0485  CL90 HCT 116 C299(0.62)  LDD0802  [6]
 LDCM0124  JWB142 DM93 Y300(0.85)  LDD0286  [5]
 LDCM0125  JWB146 DM93 Y300(1.31)  LDD0287  [5]
 LDCM0126  JWB150 DM93 Y300(3.43)  LDD0288  [5]
 LDCM0127  JWB152 DM93 Y300(1.79)  LDD0289  [5]
 LDCM0128  JWB198 DM93 Y300(1.12)  LDD0290  [5]
 LDCM0130  JWB211 DM93 Y300(1.22)  LDD0292  [5]
 LDCM0076  kambe_cp71 PC-3 3.45  LDD0132  [11]
 LDCM0022  KB02 42-MG-BA C299(1.73)  LDD2244  [12]
 LDCM0023  KB03 42-MG-BA C299(2.14)  LDD2661  [12]
 LDCM0024  KB05 COLO792 C299(2.03)  LDD3310  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alanine--glyoxylate aminotransferase (AGXT) Class-V pyridoxal-phosphate-dependent aminotransferase family P21549
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (FNTA) Protein prenyltransferase subunit alpha family P49354
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-C8 (HOXC8) Antp homeobox family P31273
T-cell leukemia homeobox protein 3 (TLX3) . O43711
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein L6 (APOL6) Apolipoprotein L family Q9BWW8
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) ATP12 family Q8N5M1
Nonsense-mediated mRNA decay factor SMG9 (SMG9) SMG9 family Q9H0W8
Coiled-coil domain-containing protein 24 (CCDC24) . Q8N4L8
Sprouty-related, EVH1 domain-containing protein 1 (SPRED1) . Q7Z699

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lonafarnib Small molecular drug DB06448
Investigative
Click To Hide/Show 32 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(Z)-2-methyl-3-tetradecyl-but-2-enedioic Acid Small molecular drug D0VD2C
A-313326 Small molecular drug D0T2SJ
Actinoplanic Acid A Small molecular drug D01OFD
Alpha-hydroxyfarnesylphosphonic Acid Small molecular drug D0TC4Z
Arteminolide Small molecular drug D00OMV
Azd3409 Small molecular drug DB04893
Bms-316810 Small molecular drug D0PK8Y
Bms-404683 Small molecular drug D00LAR
Clavarinone Small molecular drug D0R3PD
Cylindrol A Small molecular drug D04ETB
Farnesyl Small molecular drug D01DTW
Farnesyl Diphosphate Small molecular drug DB07780
Fti 276 Small molecular drug D0M5PB
Geranylgeranyl Diphosphate Small molecular drug D0QX6B
Geranylgeranyl Diphosphate Small molecular drug DB07841
H-smglpcvvm-oh Small molecular drug D0X5KQ
L-739750 Small molecular drug D07ZTG
L-778123 Small molecular drug DB07227
Lb42908 Small molecular drug D08VBE
Pb-27 Small molecular drug D06JMV
Pb-80 Small molecular drug D0H4QM
Pb-81 Small molecular drug D0L4RX
Pd-83176 Small molecular drug D06DSE
Preussomerin Small molecular drug D05IVD
Tipifarnib Small molecular drug DB04960
(11s)-8-chloro-11-[1-(Methylsulfonyl)Piperidin-4-yl]-6-piperazin-1-yl-11h-benzo[56]Cyclohepta[12-b]Pyridine . DB07216
(20s)-19202122-tetrahydro-19-oxo-5h-1820-ethano-1214-etheno-610-metheno-18h-benz[D]Imidazo[43-k][16912]Oxatriaza-cyclooctadecosine-9-carbonitrile . DB08674
(20s)-19202223-tetrahydro-19-oxo-5h21h-1820-ethano-1214-etheno-610-methenobenz[D]Imidazo[43-l][16913]Oxatriazacyclonoadecosine-9-carbonitrile . DB08676
2-chloro-5-(3-chloro-phenyl)-6-[(4-cyano-phenyl)-(3-methyl-3h-imidazol-4-yl)- Methoxymethyl]-nicotinonitrile . DB06953
F-12458 . D08SZO
Prenyl Pyrophosphate Analogue . D0OC3P
[(3711-trimethyl-dodeca-2610-trienyloxycarbamoyl)-methyl]-phosphonic Acid . DB07771
Discontinued
Click To Hide/Show 17 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Abt-100 Small molecular drug D05XTO
Abt-839 Small molecular drug D04DYZ
Fusidienol Small molecular drug D03FZA
L-731735 Small molecular drug D0W2ED
L-739749 Small molecular drug D09DLN
L-745631 Small molecular drug D03OLA
Manumycin A Small molecular drug D0C2UY
Rpr-113829 Small molecular drug D0H5VF
Rpr-114334 Small molecular drug D0L5AS
Sch-44342 Small molecular drug D0EY9P
B-956 . D07PAY
Bms-182566 . D0W3OQ
Bms-185857 . D0I9AR
Cp-663427 . D0E7BP
Sch-207758 . D0V3WQ
Xr-3005 . D0O1XU
Xr-3054 . D0H2AM

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells. J Am Chem Soc. 2014 Jul 30;136(30):10777-82. doi: 10.1021/ja505517t. Epub 2014 Jul 21.
12 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840