Details of the Target

General Information of Target

Target ID LDTP12207
Target Name Putative divalent cation/proton antiporter TMEM165 (TMEM165)
Gene Name TMEM165
Gene ID 55858
Synonyms
TPARL; Putative divalent cation/proton antiporter TMEM165; Transmembrane protein 165; Transmembrane protein PT27; Transmembrane protein TPARL
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATPAAVNPPEMASDIPGSVTLPVAPMAATGQVRMAGAMPARGGKRRSGMDFDDEDGEGP
SKFSRENHSEIERRRRNKMTQYITELSDMVPTCSALARKPDKLTILRMAVSHMKSMRGTG
NKSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYVSDSVTPVLNQPQSEWFG
STLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQQSSMRMCMGSRRSFICR
MRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCTGYIKAWPPAGMTIPEED
ADVGQGSKYCLVAIGRLQVTSSPVCMDMNGMSVPTEFLSRHNSDGIITFVDPRCISVIGY
QPQDLLGKDILEFCHPEDQSHLRESFQQVVKLKGQVLSVMYRFRTKNREWMLIRTSSFTF
QNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRDGLSSYDLSQVPVPNLPAGVHEAGKSV
EKADAIFSQERDPRFAEMFAGISASEKKMMSSASAAGTQQIYSQGSPFPSGHSGKAFSSS
VVHVPGVNDIQSSSSTGQNMSQISRQLNQSQVAWTGSRPPFPGQQIPSQSSKTQSSPFGI
GTSHTYPADPSSYSPLSSPATSSPSGNAYSSLANRTPGFAESGQSSGQFQGRPSEVWSQW
QSQHHGQQSGEQHSHQQPGQTEVFQDMLPMPGDPTQGTGNYNIEDFADLGMFPPFSE
Target Bioclass
Transporter and channel
Family
GDT1 family
Subcellular location
Golgi apparatus membrane
Function
Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway. Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk. The transport mechanism and stoichiometry remains to be elucidated.
Uniprot ID
Q9HC07
Ensemble ID
ENST00000381334.10
HGNC ID
HGNC:30760

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.L309WfsTer10 .
BT549 SNV: p.A99P .
HCT15 SNV: p.R42L; p.P65T .
KYSE180 SNV: p.A27V; p.G92V .
LNCaP clone FGC SNV: p.H95R .
MFE319 SNV: p.W229R; p.V285A .
NALM6 Deletion: p.L309WfsTer10 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.69  LDD0402  [1]
FBPP2
 Probe Info  		3.05  LDD0318  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
ONAyne
 Probe Info  		K200(0.91)  LDD0274  [5]
Acrolein
 Probe Info  		N.A.  LDD0229  [6]
DBIA
 Probe Info  		C278(0.97); C280(0.97)  LDD0531  [7]
ATP probe
 Probe Info  		N.A.  LDD0035  [8]
IPM
 Probe Info  		N.A.  LDD2156  [9]
STPyne
 Probe Info  		N.A.  LDD0009  [10]
AOyne
 Probe Info  		15.00  LDD0443  [11]
PAL-AfBPP Probe
Click To Hide/Show 75 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		14.93  LDD1728  [12]
C055
 Probe Info  		15.45  LDD1752  [12]
C056
 Probe Info  		24.93  LDD1753  [12]
C063
 Probe Info  		12.91  LDD1760  [12]
C064
 Probe Info  		6.50  LDD1761  [12]
C070
 Probe Info  		19.29  LDD1766  [12]
C072
 Probe Info  		10.48  LDD1768  [12]
C106
 Probe Info  		63.56  LDD1793  [12]
C107
 Probe Info  		12.04  LDD1794  [12]
C108
 Probe Info  		21.56  LDD1795  [12]
C112
 Probe Info  		27.67  LDD1799  [12]
C129
 Probe Info  		5.54  LDD1811  [12]
C134
 Probe Info  		23.26  LDD1816  [12]
C141
 Probe Info  		15.56  LDD1823  [12]
C143
 Probe Info  		25.81  LDD1825  [12]
C147
 Probe Info  		7.11  LDD1829  [12]
C153
 Probe Info  		18.77  LDD1834  [12]
C159
 Probe Info  		13.45  LDD1839  [12]
C160
 Probe Info  		11.55  LDD1840  [12]
C161
 Probe Info  		18.00  LDD1841  [12]
C163
 Probe Info  		5.66  LDD1843  [12]
C166
 Probe Info  		7.67  LDD1846  [12]
C178
 Probe Info  		26.17  LDD1857  [12]
C186
 Probe Info  		8.34  LDD1864  [12]
C210
 Probe Info  		84.45  LDD1884  [12]
C213
 Probe Info  		19.03  LDD1887  [12]
C214
 Probe Info  		6.73  LDD1888  [12]
C217
 Probe Info  		4.92  LDD1891  [12]
C218
 Probe Info  		45.57  LDD1892  [12]
C219
 Probe Info  		12.73  LDD1893  [12]
C220
 Probe Info  		48.17  LDD1894  [12]
C229
 Probe Info  		18.00  LDD1902  [12]
C231
 Probe Info  		65.80  LDD1904  [12]
C232
 Probe Info  		99.73  LDD1905  [12]
C233
 Probe Info  		25.81  LDD1906  [12]
C234
 Probe Info  		12.73  LDD1907  [12]
C235
 Probe Info  		99.73  LDD1908  [12]
C238
 Probe Info  		14.83  LDD1911  [12]
C240
 Probe Info  		9.06  LDD1913  [12]
C246
 Probe Info  		14.12  LDD1919  [12]
C285
 Probe Info  		21.41  LDD1955  [12]
C287
 Probe Info  		12.64  LDD1957  [12]
C288
 Probe Info  		8.17  LDD1958  [12]
C289
 Probe Info  		44.32  LDD1959  [12]
C293
 Probe Info  		34.54  LDD1963  [12]
C296
 Probe Info  		23.75  LDD1966  [12]
C310
 Probe Info  		17.63  LDD1977  [12]
C313
 Probe Info  		17.15  LDD1980  [12]
C314
 Probe Info  		18.64  LDD1981  [12]
C343
 Probe Info  		18.13  LDD2005  [12]
C348
 Probe Info  		39.67  LDD2009  [12]
C349
 Probe Info  		46.21  LDD2010  [12]
C350
 Probe Info  		99.73  LDD2011  [12]
C353
 Probe Info  		14.72  LDD2014  [12]
C354
 Probe Info  		14.03  LDD2015  [12]
C362
 Probe Info  		99.73  LDD2023  [12]
C363
 Probe Info  		47.84  LDD2024  [12]
C364
 Probe Info  		50.56  LDD2025  [12]
C366
 Probe Info  		21.71  LDD2027  [12]
C367
 Probe Info  		14.93  LDD2028  [12]
C376
 Probe Info  		9.65  LDD2036  [12]
C380
 Probe Info  		5.70  LDD2039  [12]
C382
 Probe Info  		14.42  LDD2041  [12]
C399
 Probe Info  		10.48  LDD2058  [12]
C403
 Probe Info  		40.22  LDD2061  [12]
C407
 Probe Info  		20.68  LDD2064  [12]
C413
 Probe Info  		12.73  LDD2069  [12]
FFF probe11
 Probe Info  		20.00  LDD0471  [13]
FFF probe13
 Probe Info  		20.00  LDD0475  [13]
FFF probe14
 Probe Info  		20.00  LDD0477  [13]
FFF probe2
 Probe Info  		20.00  LDD0463  [13]
FFF probe3
 Probe Info  		20.00  LDD0465  [13]
FFF probe4
 Probe Info  		10.16  LDD0466  [13]
VE-P
 Probe Info  		N.A.  LDD0396  [14]
OEA-DA
 Probe Info  		18.74  LDD0046  [15]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C278(0.97); C280(0.97)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C278(0.90); C280(0.90)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C278(0.99); C280(0.99)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C278(0.66); C280(0.66)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C278(0.74); C280(0.74)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C278(0.71); C280(0.71)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C278(1.10); C280(1.10)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C278(0.65); C280(0.65)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C278(0.74); C280(0.74)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C278(0.74); C280(0.74)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C278(1.25); C280(1.25)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C278(0.96); C280(0.96)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C278(0.95); C280(0.95)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C278(0.82); C280(0.82)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C278(0.76); C280(0.76)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C278(0.99); C280(0.99)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C278(0.99); C280(0.99)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C278(0.96); C280(0.96)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C278(0.90); C280(0.90)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C278(0.99); C280(0.99)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C278(1.20); C280(1.20)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C278(0.96); C280(0.96)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C278(1.13); C280(1.13)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C278(0.90); C280(0.90)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C278(0.88); C280(0.88)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C278(0.84); C280(0.84)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C278(0.87); C280(0.87)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C278(0.99); C280(0.99)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C278(0.80); C280(0.80)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C278(0.85); C280(0.85)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C278(0.93); C280(0.93)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C278(0.84); C280(0.84)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C278(1.01); C280(1.01)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C278(1.02); C280(1.02)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C278(0.88); C280(0.88)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C278(0.90); C280(0.90)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C278(1.05); C280(1.05)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C278(0.93); C280(0.93)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C278(0.89); C280(0.89)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C278(0.98); C280(0.98)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C278(0.93); C280(0.93)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C278(0.95); C280(0.95)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C278(0.87); C280(0.87)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C278(0.91); C280(0.91)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C278(0.98); C280(0.98)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C278(0.93); C280(0.93)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C278(0.89); C280(0.89)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C278(0.96); C280(0.96)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C278(0.82); C280(0.82)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C278(0.84); C280(0.92)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C278(0.67); C280(0.86)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C280(0.68); C278(0.74)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C280(0.78); C278(0.86)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C280(0.90); C278(0.99)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C278(0.82); C280(0.88)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C278(0.84); C280(0.84)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C278(0.89); C280(0.94)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C280(0.67); C278(0.81)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C280(0.83); C278(0.92)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C280(0.94); C278(1.28)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C278(0.76); C280(0.72)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C278(0.91); C280(0.82)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C278(0.78); C280(0.87)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C278(0.95); C280(0.78)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C278(0.83); C280(0.83)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C278(1.29); C280(1.29)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C278(0.87); C280(0.87)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C278(1.06); C280(1.06)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C278(0.91); C280(0.91)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C278(0.98); C280(0.98)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C278(0.87); C280(0.87)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C278(0.86); C280(0.86)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C278(0.85); C280(0.85)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C278(0.99); C280(0.99)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C278(0.92); C280(0.92)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C278(0.94); C280(0.94)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C278(0.89); C280(0.89)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C278(1.02); C280(1.02)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C278(1.07); C280(1.07)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C278(1.07); C280(1.07)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C278(1.04); C280(1.04)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C278(0.88); C280(0.88)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C278(1.01); C280(1.01)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C278(0.98); C280(0.98)  LDD0612  [7]
 LDCM0296  AC35 PaTu 8988t C278(0.91); C280(0.91)  LDD1175  [7]
 LDCM0297  AC36 PaTu 8988t C278(0.92); C280(0.92)  LDD1176  [7]
 LDCM0298  AC37 PaTu 8988t C278(1.06); C280(1.06)  LDD1177  [7]
 LDCM0299  AC38 PaTu 8988t C278(0.98); C280(0.98)  LDD1178  [7]
 LDCM0300  AC39 PaTu 8988t C278(1.00); C280(1.00)  LDD1179  [7]
 LDCM0301  AC4 HCT 116 C278(1.05); C280(1.05)  LDD0618  [7]
 LDCM0302  AC40 PaTu 8988t C278(0.95); C280(0.95)  LDD1181  [7]
 LDCM0303  AC41 PaTu 8988t C278(1.12); C280(1.12)  LDD1182  [7]
 LDCM0304  AC42 PaTu 8988t C278(1.18); C280(1.18)  LDD1183  [7]
 LDCM0305  AC43 PaTu 8988t C278(1.03); C280(1.03)  LDD1184  [7]
 LDCM0306  AC44 PaTu 8988t C278(1.09); C280(1.09)  LDD1185  [7]
 LDCM0307  AC45 PaTu 8988t C278(0.99); C280(0.99)  LDD1186  [7]
 LDCM0308  AC46 HCT 116 C278(0.91); C280(0.91)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C278(0.81); C280(0.81)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C278(0.86); C280(0.86)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C278(0.97); C280(0.97)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C278(1.06); C280(1.06)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C278(1.00); C280(1.00)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C278(0.94); C280(0.94)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C278(0.98); C280(0.98)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C278(0.98); C280(0.98)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C278(1.01); C280(1.01)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C278(1.14); C280(1.14)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C278(1.03); C280(1.03)  LDD0636  [7]
 LDCM0320  AC57 HEK-293T C278(1.12)  LDD0918  [7]
 LDCM0321  AC58 HEK-293T C278(1.09)  LDD0919  [7]
 LDCM0322  AC59 HEK-293T C278(1.09)  LDD0920  [7]
 LDCM0323  AC6 HCT 116 C278(0.85); C280(0.85)  LDD0640  [7]
 LDCM0324  AC60 HEK-293T C278(1.06)  LDD0922  [7]
 LDCM0325  AC61 HEK-293T C278(1.07)  LDD0923  [7]
 LDCM0326  AC62 HEK-293T C278(1.06)  LDD0924  [7]
 LDCM0327  AC63 HEK-293T C278(1.14)  LDD0925  [7]
 LDCM0328  AC64 HEK-293T C278(1.15)  LDD0926  [7]
 LDCM0329  AC65 HEK-293T C278(1.12)  LDD0927  [7]
 LDCM0330  AC66 HEK-293T C278(0.97)  LDD0928  [7]
 LDCM0331  AC67 HEK-293T C278(1.17)  LDD0929  [7]
 LDCM0332  AC68 HCT 116 C278(0.79); C280(0.79)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C278(0.76); C280(0.76)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C278(0.90); C280(0.90)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C278(0.72); C280(0.72)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C278(0.74); C280(0.74)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C278(0.88); C280(0.88)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C278(0.82); C280(0.82)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C278(0.90); C280(0.90)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C278(0.90); C280(0.90)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C278(0.84); C280(0.84)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C278(0.74); C280(0.74)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C278(0.69); C280(0.69)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C278(0.86); C280(0.86)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C278(0.91); C280(0.91)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C278(0.87); C280(0.87)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C278(0.96); C280(0.96)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C278(0.92); C280(0.92)  LDD0665  [7]
 LDCM0349  AC83 HEK-293T C278(1.06)  LDD0947  [7]
 LDCM0350  AC84 HEK-293T C278(1.34)  LDD0948  [7]
 LDCM0351  AC85 HEK-293T C278(1.15)  LDD0949  [7]
 LDCM0352  AC86 HEK-293T C278(1.10)  LDD0950  [7]
 LDCM0353  AC87 HEK-293T C278(1.17)  LDD0951  [7]
 LDCM0354  AC88 HEK-293T C278(1.07)  LDD0952  [7]
 LDCM0355  AC89 HEK-293T C278(1.16)  LDD0953  [7]
 LDCM0357  AC90 HEK-293T C278(1.26)  LDD0955  [7]
 LDCM0358  AC91 HEK-293T C278(1.23)  LDD0956  [7]
 LDCM0359  AC92 HEK-293T C278(1.20)  LDD0957  [7]
 LDCM0360  AC93 HEK-293T C278(1.25)  LDD0958  [7]
 LDCM0361  AC94 HEK-293T C278(0.97)  LDD0959  [7]
 LDCM0362  AC95 HEK-293T C278(1.11)  LDD0960  [7]
 LDCM0363  AC96 HEK-293T C278(1.18)  LDD0961  [7]
 LDCM0364  AC97 HEK-293T C278(1.59)  LDD0962  [7]
 LDCM0365  AC98 HCT 116 C278(0.83); C280(0.83)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C278(0.69); C280(0.69)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C278(0.98); C280(0.98)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C278(0.89); C280(0.89)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C278(0.91); C280(0.91)  LDD0592  [7]
 LDCM0367  CL1 HCT 116 C278(1.35); C280(1.35)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C278(0.91); C280(0.91)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C278(0.90); C280(0.90)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C278(0.80); C280(0.80)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C278(0.78); C280(0.78)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C278(0.90); C280(0.90)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C278(0.90); C280(0.90)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C278(0.81); C280(0.81)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C278(0.73); C280(0.73)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C278(0.84); C280(0.84)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C278(0.97); C280(0.97)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C278(0.83); C280(0.83)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C278(1.22); C280(1.22)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C278(0.78); C280(0.78)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C278(1.02); C280(1.02)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C278(1.07); C280(1.07)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C278(1.13); C280(1.13)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C278(1.14); C280(1.14)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C278(1.15); C280(1.15)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C278(1.06); C280(1.06)  LDD0703  [7]
 LDCM0387  CL117 PaTu 8988t C278(0.96); C280(0.96)  LDD1266  [7]
 LDCM0388  CL118 PaTu 8988t C278(1.32); C280(1.32)  LDD1267  [7]
 LDCM0389  CL119 PaTu 8988t C278(0.95); C280(0.95)  LDD1268  [7]
 LDCM0390  CL12 HCT 116 C278(1.11); C280(1.11)  LDD0707  [7]
 LDCM0391  CL120 PaTu 8988t C278(1.03); C280(1.03)  LDD1270  [7]
 LDCM0392  CL121 HCT 116 C278(1.54); C280(1.54)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C278(0.87); C280(0.87)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C278(0.94); C280(0.94)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C278(0.91); C280(0.91)  LDD0712  [7]
 LDCM0396  CL125 HEK-293T C278(1.19)  LDD0994  [7]
 LDCM0397  CL126 HEK-293T C278(0.92)  LDD0995  [7]
 LDCM0398  CL127 HEK-293T C278(0.99)  LDD0996  [7]
 LDCM0399  CL128 HEK-293T C278(1.01)  LDD0997  [7]
 LDCM0400  CL13 HCT 116 C278(1.07); C280(1.07)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C278(1.04); C280(1.04)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C278(1.04); C280(1.04)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C278(1.05); C280(1.05)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C278(0.80); C280(0.80)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C278(0.80); C280(0.80)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C278(0.78); C280(0.78)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C278(1.11); C280(1.11)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C278(1.03); C280(1.03)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C278(0.91); C280(0.91)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C278(0.97); C280(0.97)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C278(1.06); C280(1.06)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C278(0.90); C280(0.90)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C278(0.82); C280(0.82)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C278(0.94); C280(0.94)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C278(1.08); C280(1.08)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C278(0.86); C280(0.86)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C278(0.75); C280(0.75)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C278(1.25); C280(1.25)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C278(0.83); C280(0.83)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C278(1.10); C280(1.10)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C278(0.82); C280(0.82)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C278(0.93); C280(0.93)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C278(1.11); C280(1.11)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C278(1.02); C280(1.02)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C278(0.96); C280(0.96)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C278(1.05); C280(1.05)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C278(1.03); C280(1.03)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C278(1.21); C280(1.21)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C278(1.08); C280(1.08)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C278(1.08); C280(1.08)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C278(0.88); C280(0.88)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C278(1.14); C280(1.14)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C278(1.05); C280(1.05)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C278(0.99); C280(0.99)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C278(1.02); C280(1.02)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C278(1.02); C280(1.02)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C278(0.98); C280(0.98)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C278(1.08); C280(1.08)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C278(1.21); C280(1.21)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C278(0.97); C280(0.97)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C278(1.06); C280(1.06)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C278(1.08); C280(1.08)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C278(0.97); C280(0.97)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C278(1.09); C280(1.09)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C278(1.07); C280(1.07)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C278(0.94); C280(0.94)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C278(1.14); C280(1.14)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C278(1.19); C280(1.19)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C278(1.40); C280(1.40)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C278(1.07); C280(1.07)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C278(1.12); C280(1.12)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C278(0.95); C280(0.95)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C278(1.18); C280(1.18)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C278(0.71); C280(0.71)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C278(0.71); C280(0.71)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C278(0.91); C280(0.91)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C278(0.85); C280(0.85)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C278(0.79); C280(0.79)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C278(0.76); C280(0.76)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C278(0.81); C280(0.81)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C278(1.06); C280(1.06)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C278(0.80); C280(0.80)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C278(0.75); C280(0.75)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C278(1.27); C280(1.27)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C278(0.77); C280(0.77)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C278(1.04); C280(1.04)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C278(0.76); C280(0.76)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C278(0.87); C280(0.87)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C278(1.04); C280(1.04)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C278(0.83); C280(0.83)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C278(1.03); C280(1.03)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C278(0.96); C280(0.96)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C278(0.81); C280(0.81)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C278(0.93); C280(0.93)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C278(0.80); C280(0.80)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C278(1.01); C280(1.01)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C278(0.90); C280(0.90)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C278(0.98); C280(0.98)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C278(0.80); C280(0.80)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C278(0.99); C280(0.99)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C278(1.24); C280(1.24)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C278(1.08); C280(1.08)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C278(0.88); C280(0.88)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C278(1.02); C280(1.02)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C278(0.78); C280(0.78)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C278(0.98); C280(0.98)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C278(1.09); C280(1.09)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C278(1.01); C280(1.01)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C278(0.99); C280(0.99)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C278(0.91); C280(0.91)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C278(0.96); C280(0.96)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C278(0.93); C280(0.93)  LDD0811  [7]
 LDCM0468  Fragment33 HCT 116 C278(1.05); C280(1.05)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C278(1.05); C280(1.05)  LDD0744  [7]
 LDCM0109  NEM HeLa N.A.  LDD0229  [6]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
9 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
15 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570