Details of the Target

General Information of Target

Target ID LDTP13164
Target Name Protein sel-1 homolog 1 (SEL1L)
Gene Name SEL1L
Gene ID 6400
Synonyms
TSA305; Protein sel-1 homolog 1; Suppressor of lin-12-like protein 1; Sel-1L
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADEGKSYSEHDDERVNFPQRKKKGRGPFRWKYGEGNRRSGRGGSGIRSSRLEEDDGDVA
MSDAQDGPRVRYNPYTTRPNRRGDTWHDRDRIHVTVRRDRAPPERGGAGTSQDGTSKNWF
KITIPYGRKYDKAWLLSMIQSKCSVPFTPIEFHYENTRAQFFVEDASTASALKAVNYKIL
DRENRRISIIINSSAPPHTILNELKPEQVEQLKLIMSKRYDGSQQALDLKGLRSDPDLVA
QNIDVVLNRRSCMAATLRIIEENIPELLSLNLSNNRLYRLDDMSSIVQKAPNLKILNLSG
NELKSERELDKIKGLKLEELWLDGNSLCDTFRDQSTYISAIRERFPKLLRLDGHELPPPI
AFDVEAPTTLPPCKGSYFGTENLKSLVLHFLQQYYAIYDSGDRQGLLDAYHDGACCSLSI
PFIPQNPARSSLAEYFKDSRNVKKLKDPTLRFRLLKHTRLNVVAFLNELPKTQHDVNSFV
VDISAQTSTLLCFSVNGVFKEVDGKSRDSLRAFTRTFIAVPASNSGLCIVNDELFVRNAS
SEEIQRAFAMPAPTPSSSPVPTLSPEQQEMLQAFSTQSGMNLEWSQKCLQDNNWDYTRSA
QAFTHLKAKGEIPEVAFMK
Target Bioclass
Transporter and channel
Family
Sel-1 family
Subcellular location
Endoplasmic reticulum membrane
Function
Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling.
Uniprot ID
Q9UBV2
Ensemble ID
ENST00000336735.9
HGNC ID
HGNC:10717

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DAOY SNV: p.S96F .
HCT15 SNV: p.E83Ter .
HGC27 SNV: p.H128R .
HUH28 SNV: p.D425G .
MFE319 Deletion: p.G371VfsTer20 .
NCIH2172 SNV: p.G408C .
NCIN87 SNV: p.A114P .
SNGM SNV: p.E95Ter .
UACC257 SNV: p.E358K .
WM115 SNV: p.E252V .
WM2664 SNV: p.E252V DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		2.82  LDD0318  [1]
Jackson_1
 Probe Info  		10.63  LDD0122  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K440(8.42); K681(10.00); K688(3.45)  LDD0277  [4]
DBIA
 Probe Info  		C153(3.02); C539(4.73)  LDD3310  [5]
BTD
 Probe Info  		C539(1.00)  LDD2094  [6]
IPM
 Probe Info  		C539(8.79)  LDD1701  [6]
5E-2FA
 Probe Info  		N.A.  LDD2235  [7]
m-APA
 Probe Info  		N.A.  LDD2232  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C153(0.00); C539(0.00); C168(0.00)  LDD0037  [8]
TFBX
 Probe Info  		N.A.  LDD0027  [9]
Acrolein
 Probe Info  		H324(0.00); H385(0.00)  LDD0217  [10]
NAIA_5
 Probe Info  		C539(0.00); C311(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 69 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		6.68  LDD1725  [12]
C022
 Probe Info  		10.13  LDD1728  [12]
C040
 Probe Info  		11.55  LDD1740  [12]
C041
 Probe Info  		5.86  LDD1741  [12]
C056
 Probe Info  		18.77  LDD1753  [12]
C063
 Probe Info  		11.24  LDD1760  [12]
C082
 Probe Info  		4.92  LDD1774  [12]
C091
 Probe Info  		12.55  LDD1782  [12]
C092
 Probe Info  		23.43  LDD1783  [12]
C094
 Probe Info  		24.76  LDD1785  [12]
C106
 Probe Info  		33.59  LDD1793  [12]
C107
 Probe Info  		7.01  LDD1794  [12]
C108
 Probe Info  		11.55  LDD1795  [12]
C112
 Probe Info  		24.93  LDD1799  [12]
C131
 Probe Info  		5.43  LDD1813  [12]
C134
 Probe Info  		51.63  LDD1816  [12]
C135
 Probe Info  		19.29  LDD1817  [12]
C138
 Probe Info  		6.15  LDD1820  [12]
C139
 Probe Info  		14.93  LDD1821  [12]
C140
 Probe Info  		8.57  LDD1822  [12]
C153
 Probe Info  		19.03  LDD1834  [12]
C161
 Probe Info  		10.56  LDD1841  [12]
C169
 Probe Info  		24.59  LDD1849  [12]
C178
 Probe Info  		16.80  LDD1857  [12]
C186
 Probe Info  		9.92  LDD1864  [12]
C201
 Probe Info  		41.07  LDD1877  [12]
C206
 Probe Info  		16.91  LDD1881  [12]
C210
 Probe Info  		58.49  LDD1884  [12]
C213
 Probe Info  		16.80  LDD1887  [12]
C214
 Probe Info  		8.82  LDD1888  [12]
C218
 Probe Info  		16.91  LDD1892  [12]
C220
 Probe Info  		13.27  LDD1894  [12]
C228
 Probe Info  		22.32  LDD1901  [12]
C229
 Probe Info  		9.71  LDD1902  [12]
C231
 Probe Info  		28.64  LDD1904  [12]
C232
 Probe Info  		53.08  LDD1905  [12]
C233
 Probe Info  		11.24  LDD1906  [12]
C234
 Probe Info  		9.19  LDD1907  [12]
C235
 Probe Info  		30.27  LDD1908  [12]
C238
 Probe Info  		12.82  LDD1911  [12]
C243
 Probe Info  		12.38  LDD1916  [12]
C244
 Probe Info  		14.52  LDD1917  [12]
C246
 Probe Info  		16.68  LDD1919  [12]
C277
 Probe Info  		9.92  LDD1947  [12]
C282
 Probe Info  		14.12  LDD1952  [12]
C289
 Probe Info  		27.86  LDD1959  [12]
C299
 Probe Info  		7.57  LDD1968  [12]
C305
 Probe Info  		10.06  LDD1974  [12]
C314
 Probe Info  		12.30  LDD1981  [12]
C338
 Probe Info  		11.55  LDD2001  [12]
C339
 Probe Info  		5.17  LDD2002  [12]
C376
 Probe Info  		6.54  LDD2036  [12]
C388
 Probe Info  		51.98  LDD2047  [12]
C390
 Probe Info  		99.73  LDD2049  [12]
C391
 Probe Info  		20.97  LDD2050  [12]
C396
 Probe Info  		5.74  LDD2055  [12]
C403
 Probe Info  		15.56  LDD2061  [12]
C407
 Probe Info  		12.47  LDD2064  [12]
FFF probe11
 Probe Info  		20.00  LDD0471  [13]
FFF probe13
 Probe Info  		20.00  LDD0475  [13]
FFF probe14
 Probe Info  		20.00  LDD0477  [13]
FFF probe15
 Probe Info  		20.00  LDD0478  [13]
FFF probe2
 Probe Info  		20.00  LDD0463  [13]
FFF probe3
 Probe Info  		20.00  LDD0464  [13]
FFF probe9
 Probe Info  		20.00  LDD0470  [13]
JN0003
 Probe Info  		20.00  LDD0469  [13]
STS-2
 Probe Info  		N.A.  LDD0138  [14]
VE-P
 Probe Info  		N.A.  LDD0396  [15]
OEA-DA
 Probe Info  		20.00  LDD0046  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C539(0.57)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C539(1.05)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C539(1.20)  LDD2152  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C539(0.24)  LDD2131  [6]
 LDCM0214  AC1 HEK-293T C539(1.26)  LDD1507  [17]
 LDCM0226  AC11 HEK-293T C539(0.99)  LDD1509  [17]
 LDCM0276  AC17 HEK-293T C539(0.88)  LDD1515  [17]
 LDCM0278  AC19 HEK-293T C539(1.04)  LDD1517  [17]
 LDCM0284  AC24 HEK-293T C539(1.09)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C539(1.17)  LDD1524  [17]
 LDCM0287  AC27 HEK-293T C539(1.06)  LDD1526  [17]
 LDCM0290  AC3 HEK-293T C539(1.11)  LDD1529  [17]
 LDCM0293  AC32 HEK-293T C539(1.04)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C539(1.22)  LDD1533  [17]
 LDCM0296  AC35 HEK-293T C539(1.04)  LDD1535  [17]
 LDCM0302  AC40 HEK-293T C539(1.15)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C539(1.07)  LDD1542  [17]
 LDCM0305  AC43 HEK-293T C539(1.10)  LDD1544  [17]
 LDCM0310  AC48 HEK-293T C539(1.14)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C539(1.20)  LDD1550  [17]
 LDCM0314  AC51 HEK-293T C539(1.06)  LDD1553  [17]
 LDCM0319  AC56 HEK-293T C539(1.15)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C539(1.23)  LDD1559  [17]
 LDCM0322  AC59 HEK-293T C539(1.02)  LDD1561  [17]
 LDCM0328  AC64 HEK-293T C539(1.16)  LDD1567  [17]
 LDCM0345  AC8 HEK-293T C539(1.04)  LDD1569  [17]
 LDCM0356  AKOS034007680 HEK-293T C539(1.09)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C539(1.23)  LDD1514  [17]
 LDCM0108  Chloroacetamide HeLa H324(0.00); H385(0.00)  LDD0222  [10]
 LDCM0367  CL1 HEK-293T C539(0.86)  LDD1571  [17]
 LDCM0369  CL100 HEK-293T C539(1.14)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C539(1.13)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C539(1.00)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C539(0.81)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C539(0.92)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C539(0.81)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C539(0.96)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C539(0.89)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C539(0.90)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C539(1.01)  LDD1582  [17]
 LDCM0380  CL110 HEK-293T C539(0.93)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C539(0.78)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C539(1.23)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C539(0.83)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C539(0.94)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C539(0.98)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C539(1.02)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C539(0.87)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C539(0.92)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C539(0.89)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C539(1.46)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C539(0.98)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C539(0.88)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C539(0.92)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C539(0.91)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C539(1.13)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C539(0.93)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C539(0.88)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C539(0.97)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C539(1.07)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C539(1.01)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C539(0.98)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C539(0.98)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C539(0.88)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C539(1.73)  LDD1608  [17]
 LDCM0406  CL19 HEK-293T C539(1.11)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C539(1.00)  LDD1611  [17]
 LDCM0412  CL24 HEK-293T C539(1.28)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C539(0.84)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C539(0.84)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C539(0.88)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C539(1.36)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C539(1.19)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C539(0.81)  LDD1622  [17]
 LDCM0420  CL31 HEK-293T C539(1.10)  LDD1624  [17]
 LDCM0425  CL36 HEK-293T C539(1.32)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C539(0.81)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C539(0.83)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C539(1.14)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C539(1.25)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C539(1.40)  LDD1635  [17]
 LDCM0433  CL43 HEK-293T C539(1.12)  LDD1637  [17]
 LDCM0438  CL48 HEK-293T C539(1.43)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C539(1.00)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C539(1.25)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C539(1.17)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C539(1.04)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C539(1.09)  LDD1647  [17]
 LDCM0446  CL55 HEK-293T C539(1.08)  LDD1649  [17]
 LDCM0452  CL60 HEK-293T C539(1.36)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C539(0.88)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C539(0.87)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C539(0.97)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C539(1.31)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C539(1.10)  LDD1660  [17]
 LDCM0459  CL67 HEK-293T C539(1.10)  LDD1662  [17]
 LDCM0462  CL7 HEK-293T C539(1.03)  LDD1665  [17]
 LDCM0465  CL72 HEK-293T C539(1.12)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C539(1.06)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C539(0.86)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C539(1.03)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C539(0.91)  LDD1673  [17]
 LDCM0472  CL79 HEK-293T C539(1.20)  LDD1675  [17]
 LDCM0478  CL84 HEK-293T C539(1.49)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C539(0.76)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C539(0.77)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C539(0.96)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C539(0.84)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C539(1.20)  LDD1686  [17]
 LDCM0486  CL91 HEK-293T C539(1.12)  LDD1689  [17]
 LDCM0491  CL96 HEK-293T C539(0.95)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C539(0.87)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C539(1.16)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C539(0.96)  LDD1697  [17]
 LDCM0495  E2913 HEK-293T C539(1.10)  LDD1698  [17]
 LDCM0625  F8 Ramos C710(1.02)  LDD2187  [18]
 LDCM0572  Fragment10 Ramos C710(1.42)  LDD2189  [18]
 LDCM0573  Fragment11 Ramos C710(0.85)  LDD2190  [18]
 LDCM0574  Fragment12 Ramos C710(1.54)  LDD2191  [18]
 LDCM0575  Fragment13 Ramos C710(1.65)  LDD2192  [18]
 LDCM0576  Fragment14 Ramos C710(1.11)  LDD2193  [18]
 LDCM0579  Fragment20 Ramos C710(0.86)  LDD2194  [18]
 LDCM0580  Fragment21 Ramos C710(2.08)  LDD2195  [18]
 LDCM0582  Fragment23 Ramos C710(0.78)  LDD2196  [18]
 LDCM0578  Fragment27 Ramos C710(1.54)  LDD2197  [18]
 LDCM0588  Fragment30 Ramos C710(1.47)  LDD2199  [18]
 LDCM0589  Fragment31 Ramos C710(1.32)  LDD2200  [18]
 LDCM0590  Fragment32 Ramos C710(2.30)  LDD2201  [18]
 LDCM0468  Fragment33 HEK-293T C539(0.90)  LDD1671  [17]
 LDCM0596  Fragment38 Ramos C710(2.07)  LDD2203  [18]
 LDCM0566  Fragment4 Ramos C710(0.68)  LDD2184  [18]
 LDCM0427  Fragment51 HEK-293T C539(0.89)  LDD1631  [17]
 LDCM0614  Fragment56 Ramos C710(1.45)  LDD2205  [18]
 LDCM0571  Fragment9 Ramos C710(1.35)  LDD2188  [18]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 HEK-293T C710(1.02); C539(0.88)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C710(1.07); C539(0.88)  LDD1497  [17]
 LDCM0024  KB05 COLO792 C153(3.02); C539(4.73)  LDD3310  [5]
 LDCM0109  NEM HeLa H324(0.00); H385(0.00)  LDD0223  [10]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C539(1.00)  LDD2094  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C539(0.86)  LDD2104  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C539(1.04)  LDD2109  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C539(0.97)  LDD2111  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C539(0.78)  LDD2115  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C539(1.04)  LDD2123  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C539(1.89)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C539(1.08)  LDD2129  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C539(1.22)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C539(1.75)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C539(1.07)  LDD2137  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C539(1.42)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C539(0.98)  LDD2146  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
FAD-dependent oxidoreductase domain-containing protein 2 (FOXRED2) FOXRED2 family Q8IWF2
E3 ubiquitin-protein ligase synoviolin (SYVN1) HRD1 family Q86TM6
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
NT-3 growth factor receptor (NTRK3) Tyr protein kinase family Q16288
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein OS-9 (OS9) OS-9 family Q13438

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
14 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
15 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
16 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578