Details of the Target

General Information of Target

Target ID LDTP03829
Target Name Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST)
Gene Name DLST
Gene ID 1743
Synonyms
DLTS; Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial; EC 2.3.1.61; 2-oxoglutarate dehydrogenase complex component E2; OGDC-E2; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2K
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSRSRCVSRAFSRSLSAFQKGNCPLGRRSLPGVSLCQGPGYPNSRKVVINNSVFSVRFF
RTTAVCKDDLVTVKTPAFAESVTEGDVRWEKAVGDTVAEDEVVCEIETDKTSVQVPSPAN
GVIEALLVPDGGKVEGGTPLFTLRKTGAAPAKAKPAEAPAAAAPKAEPTAAAVPPPAAPI
PTQMPPVPSPSQPPSGKPVSAVKPTVAPPLAEPGAGKGLRSEHREKMNRMRQRIAQRLKE
AQNTCAMLTTFNEIDMSNIQEMRARHKEAFLKKHNLKLGFMSAFVKASAFALQEQPVVNA
VIDDTTKEVVYRDYIDISVAVATPRGLVVPVIRNVEAMNFADIERTITELGEKARKNELA
IEDMDGGTFTISNGGVFGSLFGTPIINPPQSAILGMHGIFDRPVAIGGKVEVRPMMYVAL
TYDHRLIDGREAVTFLRKIKAAVEDPRVLLLDL
Target Bioclass
Enzyme
Family
2-oxoacid dehydrogenase family
Subcellular location
Mitochondrion matrix
Function
Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A.
Uniprot ID
P36957
Ensemble ID
ENST00000334220.9
HGNC ID
HGNC:2911

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA Deletion: p.P176LfsTer27 DBIA    Probe Info 
CORL88 SNV: p.A166S DBIA    Probe Info 
ETK1 Insertion: . DBIA    Probe Info 
JURKAT Deletion: p.P176LfsTer27 .
KYSE150 SNV: p.Q20K DBIA    Probe Info 
REH SNV: p.A177T DBIA    Probe Info 
SSP25 Insertion: . DBIA    Probe Info 
SUPT1 Deletion: p.T146LfsTer57 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		5.14  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [4]
STPyne
 Probe Info  		K145(10.00); K152(6.09); K154(5.56); K267(7.62)  LDD0277  [5]
AZ-9
 Probe Info  		E135(10.00)  LDD2209  [6]
DBIA
 Probe Info  		C66(1.70)  LDD3310  [7]
BTD
 Probe Info  		C66(0.68)  LDD2089  [8]
IA-alkyne
 Probe Info  		C245(20.00)  LDD1707  [9]
Acrolein
 Probe Info  		N.A.  LDD0221  [10]
ATP probe
 Probe Info  		K74(0.00); K353(0.00)  LDD0199  [11]
NAIA_5
 Probe Info  		N.A.  LDD2224  [12]
IPM
 Probe Info  		N.A.  LDD0147  [13]
NHS
 Probe Info  		N.A.  LDD0010  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
1c-yne
 Probe Info  		K74(0.00); K307(0.00); K154(0.00)  LDD0228  [16]
1d-yne
 Probe Info  		N.A.  LDD0357  [16]
TER-AC
 Probe Info  		N.A.  LDD0426  [17]
TPP-AC
 Probe Info  		N.A.  LDD0427  [17]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C213
 Probe Info  		19.97  LDD1887  [18]
STS-2
 Probe Info  		N.A.  LDD0138  [19]
VE-P
 Probe Info  		N.A.  LDD0396  [20]
DA-2
 Probe Info  		N.A.  LDD0070  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C66(0.91)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C66(0.90)  LDD2152  [8]
 LDCM0214  AC1 HEK-293T C245(1.06)  LDD1507  [22]
 LDCM0215  AC10 HEK-293T C245(1.02)  LDD1508  [22]
 LDCM0226  AC11 HEK-293T C245(0.93)  LDD1509  [22]
 LDCM0237  AC12 HEK-293T C245(0.94)  LDD1510  [22]
 LDCM0259  AC14 HEK-293T C245(0.96)  LDD1512  [22]
 LDCM0263  AC143 HEK-293T C245(1.07)  LDD0861  [23]
 LDCM0264  AC144 HEK-293T C245(0.97)  LDD0862  [23]
 LDCM0265  AC145 HEK-293T C245(1.19)  LDD0863  [23]
 LDCM0266  AC146 HEK-293T C245(0.98)  LDD0864  [23]
 LDCM0267  AC147 HEK-293T C245(0.96)  LDD0865  [23]
 LDCM0268  AC148 HEK-293T C245(0.87)  LDD0866  [23]
 LDCM0269  AC149 HEK-293T C245(0.89)  LDD0867  [23]
 LDCM0270  AC15 HEK-293T C245(0.88)  LDD1513  [22]
 LDCM0271  AC150 HEK-293T C245(0.86)  LDD0869  [23]
 LDCM0272  AC151 HEK-293T C245(1.06)  LDD0870  [23]
 LDCM0273  AC152 HEK-293T C245(0.85)  LDD0871  [23]
 LDCM0274  AC153 HEK-293T C245(0.84)  LDD0872  [23]
 LDCM0621  AC154 HEK-293T C245(0.75)  LDD2162  [23]
 LDCM0622  AC155 HEK-293T C245(0.87)  LDD2163  [23]
 LDCM0623  AC156 HEK-293T C245(1.30)  LDD2164  [23]
 LDCM0624  AC157 HEK-293T C245(1.45)  LDD2165  [23]
 LDCM0276  AC17 HEK-293T C245(1.51)  LDD0874  [23]
 LDCM0277  AC18 HEK-293T C245(1.40)  LDD0875  [23]
 LDCM0278  AC19 HEK-293T C245(0.94)  LDD0876  [23]
 LDCM0279  AC2 HEK-293T C245(1.01)  LDD1518  [22]
 LDCM0280  AC20 HEK-293T C245(1.44)  LDD0878  [23]
 LDCM0281  AC21 HEK-293T C245(1.83)  LDD0879  [23]
 LDCM0282  AC22 HEK-293T C245(1.28)  LDD0880  [23]
 LDCM0283  AC23 HEK-293T C245(1.10)  LDD0881  [23]
 LDCM0284  AC24 HEK-293T C245(0.96)  LDD0882  [23]
 LDCM0285  AC25 HEK-293T C245(1.09)  LDD1524  [22]
 LDCM0286  AC26 HEK-293T C245(0.99)  LDD1525  [22]
 LDCM0287  AC27 HEK-293T C245(0.79)  LDD1526  [22]
 LDCM0288  AC28 HEK-293T C245(1.12)  LDD1527  [22]
 LDCM0289  AC29 HEK-293T C245(1.00)  LDD1528  [22]
 LDCM0290  AC3 HEK-293T C245(1.11)  LDD1529  [22]
 LDCM0291  AC30 HEK-293T C245(0.82)  LDD1530  [22]
 LDCM0292  AC31 HEK-293T C245(0.97)  LDD1531  [22]
 LDCM0293  AC32 HEK-293T C245(1.12)  LDD1532  [22]
 LDCM0294  AC33 HEK-293T C245(1.33)  LDD1533  [22]
 LDCM0295  AC34 HEK-293T C245(1.10)  LDD1534  [22]
 LDCM0296  AC35 HEK-293T C245(1.07)  LDD1535  [22]
 LDCM0297  AC36 HEK-293T C245(0.91)  LDD1536  [22]
 LDCM0298  AC37 HEK-293T C245(0.87)  LDD1537  [22]
 LDCM0299  AC38 HEK-293T C245(0.87)  LDD1538  [22]
 LDCM0300  AC39 HEK-293T C245(1.09)  LDD1539  [22]
 LDCM0301  AC4 HEK-293T C245(1.07)  LDD1540  [22]
 LDCM0302  AC40 HEK-293T C245(1.09)  LDD1541  [22]
 LDCM0303  AC41 HEK-293T C245(1.06)  LDD1542  [22]
 LDCM0304  AC42 HEK-293T C245(0.98)  LDD1543  [22]
 LDCM0305  AC43 HEK-293T C245(1.06)  LDD1544  [22]
 LDCM0306  AC44 HEK-293T C245(1.17)  LDD1545  [22]
 LDCM0307  AC45 HEK-293T C245(0.83)  LDD1546  [22]
 LDCM0308  AC46 HEK-293T C245(1.02)  LDD0906  [23]
 LDCM0309  AC47 HEK-293T C245(1.11)  LDD0907  [23]
 LDCM0310  AC48 HEK-293T C245(1.20)  LDD0908  [23]
 LDCM0311  AC49 HEK-293T C245(1.99)  LDD0909  [23]
 LDCM0312  AC5 HEK-293T C245(0.85)  LDD1551  [22]
 LDCM0313  AC50 HEK-293T C245(1.58)  LDD0911  [23]
 LDCM0314  AC51 HEK-293T C245(1.03)  LDD0912  [23]
 LDCM0315  AC52 HEK-293T C245(1.05)  LDD0913  [23]
 LDCM0316  AC53 HEK-293T C245(1.49)  LDD0914  [23]
 LDCM0317  AC54 HEK-293T C245(1.54)  LDD0915  [23]
 LDCM0318  AC55 HEK-293T C245(1.93)  LDD0916  [23]
 LDCM0319  AC56 HEK-293T C245(1.19)  LDD0917  [23]
 LDCM0320  AC57 HEK-293T C245(1.15)  LDD1559  [22]
 LDCM0321  AC58 HEK-293T C245(0.88)  LDD1560  [22]
 LDCM0322  AC59 HEK-293T C245(0.90)  LDD1561  [22]
 LDCM0323  AC6 HEK-293T C245(0.84)  LDD1562  [22]
 LDCM0324  AC60 HEK-293T C245(1.05)  LDD1563  [22]
 LDCM0325  AC61 HEK-293T C245(0.96)  LDD1564  [22]
 LDCM0326  AC62 HEK-293T C245(0.81)  LDD1565  [22]
 LDCM0327  AC63 HEK-293T C245(1.05)  LDD1566  [22]
 LDCM0328  AC64 HEK-293T C245(1.01)  LDD1567  [22]
 LDCM0334  AC7 HEK-293T C245(0.87)  LDD1568  [22]
 LDCM0345  AC8 HEK-293T C245(1.11)  LDD1569  [22]
 LDCM0248  AKOS034007472 HEK-293T C245(0.88)  LDD1511  [22]
 LDCM0356  AKOS034007680 HEK-293T C245(1.14)  LDD1570  [22]
 LDCM0275  AKOS034007705 HEK-293T C245(1.05)  LDD1514  [22]
 LDCM0498  BS-3668 MDA-MB-231 C66(0.60)  LDD2091  [8]
 LDCM0108  Chloroacetamide HeLa C245(0.00); C104(0.00)  LDD0222  [10]
 LDCM0632  CL-Sc Hep-G2 C66(0.45)  LDD2227  [12]
 LDCM0367  CL1 HEK-293T C245(1.08)  LDD1571  [22]
 LDCM0368  CL10 HEK-293T C245(1.03)  LDD1572  [22]
 LDCM0369  CL100 HEK-293T C245(0.80)  LDD1573  [22]
 LDCM0370  CL101 HEK-293T C245(1.18)  LDD1574  [22]
 LDCM0371  CL102 HEK-293T C245(1.11)  LDD1575  [22]
 LDCM0372  CL103 HEK-293T C245(0.85)  LDD1576  [22]
 LDCM0373  CL104 HEK-293T C245(0.99)  LDD1577  [22]
 LDCM0374  CL105 HEK-293T C245(1.67)  LDD0972  [23]
 LDCM0375  CL106 HEK-293T C245(1.71)  LDD0973  [23]
 LDCM0376  CL107 HEK-293T C245(0.83)  LDD0974  [23]
 LDCM0377  CL108 HEK-293T C245(0.77)  LDD0975  [23]
 LDCM0378  CL109 HEK-293T C245(1.18)  LDD0976  [23]
 LDCM0379  CL11 HEK-293T C245(0.99)  LDD1583  [22]
 LDCM0380  CL110 HEK-293T C245(1.33)  LDD0978  [23]
 LDCM0381  CL111 HEK-293T C245(1.65)  LDD0979  [23]
 LDCM0382  CL112 HEK-293T C245(1.19)  LDD1586  [22]
 LDCM0383  CL113 HEK-293T C245(1.01)  LDD1587  [22]
 LDCM0384  CL114 HEK-293T C245(1.14)  LDD1588  [22]
 LDCM0385  CL115 HEK-293T C245(0.95)  LDD1589  [22]
 LDCM0386  CL116 HEK-293T C245(0.91)  LDD1590  [22]
 LDCM0387  CL117 HEK-293T C245(1.01)  LDD1591  [22]
 LDCM0388  CL118 HEK-293T C245(0.80)  LDD1592  [22]
 LDCM0389  CL119 HEK-293T C245(0.90)  LDD1593  [22]
 LDCM0390  CL12 HEK-293T C245(1.13)  LDD1594  [22]
 LDCM0391  CL120 HEK-293T C245(0.79)  LDD1595  [22]
 LDCM0392  CL121 HEK-293T C245(1.88)  LDD0990  [23]
 LDCM0393  CL122 HEK-293T C245(1.52)  LDD0991  [23]
 LDCM0394  CL123 HEK-293T C245(1.01)  LDD0992  [23]
 LDCM0395  CL124 HEK-293T C245(1.35)  LDD0993  [23]
 LDCM0396  CL125 HEK-293T C245(1.00)  LDD1600  [22]
 LDCM0397  CL126 HEK-293T C245(1.14)  LDD1601  [22]
 LDCM0398  CL127 HEK-293T C245(0.92)  LDD1602  [22]
 LDCM0399  CL128 HEK-293T C245(1.29)  LDD1603  [22]
 LDCM0400  CL13 HEK-293T C245(1.10)  LDD1604  [22]
 LDCM0401  CL14 HEK-293T C245(0.96)  LDD1605  [22]
 LDCM0402  CL15 HEK-293T C245(0.91)  LDD1606  [22]
 LDCM0403  CL16 HEK-293T C245(1.04)  LDD1607  [22]
 LDCM0404  CL17 HEK-293T C245(1.30)  LDD1608  [22]
 LDCM0405  CL18 HEK-293T C245(0.91)  LDD1609  [22]
 LDCM0406  CL19 HEK-293T C245(1.30)  LDD1610  [22]
 LDCM0407  CL2 HEK-293T C245(0.99)  LDD1611  [22]
 LDCM0408  CL20 HEK-293T C245(1.11)  LDD1612  [22]
 LDCM0409  CL21 HEK-293T C245(1.23)  LDD1613  [22]
 LDCM0410  CL22 HEK-293T C245(1.06)  LDD1614  [22]
 LDCM0411  CL23 HEK-293T C245(0.99)  LDD1615  [22]
 LDCM0412  CL24 HEK-293T C245(1.07)  LDD1616  [22]
 LDCM0413  CL25 HEK-293T C245(1.04)  LDD1617  [22]
 LDCM0414  CL26 HEK-293T C245(0.76)  LDD1618  [22]
 LDCM0415  CL27 HEK-293T C245(1.15)  LDD1619  [22]
 LDCM0416  CL28 HEK-293T C245(0.99)  LDD1620  [22]
 LDCM0417  CL29 HEK-293T C245(1.29)  LDD1621  [22]
 LDCM0418  CL3 HEK-293T C245(1.05)  LDD1622  [22]
 LDCM0419  CL30 HEK-293T C245(0.92)  LDD1623  [22]
 LDCM0420  CL31 HEK-293T C245(1.49)  LDD1018  [23]
 LDCM0421  CL32 HEK-293T C245(1.37)  LDD1019  [23]
 LDCM0422  CL33 HEK-293T C245(1.22)  LDD1020  [23]
 LDCM0423  CL34 HEK-293T C245(1.50)  LDD1021  [23]
 LDCM0424  CL35 HEK-293T C245(1.31)  LDD1022  [23]
 LDCM0425  CL36 HEK-293T C245(1.38)  LDD1023  [23]
 LDCM0426  CL37 HEK-293T C245(1.51)  LDD1024  [23]
 LDCM0428  CL39 HEK-293T C245(1.60)  LDD1026  [23]
 LDCM0429  CL4 HEK-293T C245(1.31)  LDD1633  [22]
 LDCM0430  CL40 HEK-293T C245(1.16)  LDD1028  [23]
 LDCM0431  CL41 HEK-293T C245(1.35)  LDD1029  [23]
 LDCM0432  CL42 HEK-293T C245(1.91)  LDD1030  [23]
 LDCM0433  CL43 HEK-293T C245(1.53)  LDD1031  [23]
 LDCM0434  CL44 HEK-293T C245(1.32)  LDD1032  [23]
 LDCM0435  CL45 HEK-293T C245(1.71)  LDD1033  [23]
 LDCM0436  CL46 HEK-293T C245(1.18)  LDD1640  [22]
 LDCM0437  CL47 HEK-293T C245(0.89)  LDD1641  [22]
 LDCM0438  CL48 HEK-293T C245(1.08)  LDD1642  [22]
 LDCM0439  CL49 HEK-293T C245(1.26)  LDD1643  [22]
 LDCM0440  CL5 HEK-293T C245(1.22)  LDD1644  [22]
 LDCM0441  CL50 HEK-293T C245(0.79)  LDD1645  [22]
 LDCM0443  CL52 HEK-293T C245(0.94)  LDD1646  [22]
 LDCM0444  CL53 HEK-293T C245(1.12)  LDD1647  [22]
 LDCM0445  CL54 HEK-293T C245(1.14)  LDD1648  [22]
 LDCM0446  CL55 HEK-293T C245(1.00)  LDD1649  [22]
 LDCM0447  CL56 HEK-293T C245(1.26)  LDD1650  [22]
 LDCM0448  CL57 HEK-293T C245(0.99)  LDD1651  [22]
 LDCM0449  CL58 HEK-293T C245(1.00)  LDD1652  [22]
 LDCM0450  CL59 HEK-293T C245(0.93)  LDD1653  [22]
 LDCM0451  CL6 HEK-293T C245(1.04)  LDD1654  [22]
 LDCM0452  CL60 HEK-293T C245(1.10)  LDD1655  [22]
 LDCM0453  CL61 HEK-293T C245(1.11)  LDD1656  [22]
 LDCM0454  CL62 HEK-293T C245(0.93)  LDD1657  [22]
 LDCM0455  CL63 HEK-293T C245(0.94)  LDD1658  [22]
 LDCM0456  CL64 HEK-293T C245(0.92)  LDD1659  [22]
 LDCM0457  CL65 HEK-293T C245(1.29)  LDD1660  [22]
 LDCM0458  CL66 HEK-293T C245(0.85)  LDD1661  [22]
 LDCM0459  CL67 HEK-293T C245(0.97)  LDD1662  [22]
 LDCM0460  CL68 HEK-293T C245(1.28)  LDD1663  [22]
 LDCM0461  CL69 HEK-293T C245(1.03)  LDD1664  [22]
 LDCM0462  CL7 HEK-293T C245(1.32)  LDD1665  [22]
 LDCM0463  CL70 HEK-293T C245(1.07)  LDD1666  [22]
 LDCM0464  CL71 HEK-293T C245(1.09)  LDD1667  [22]
 LDCM0465  CL72 HEK-293T C245(1.12)  LDD1668  [22]
 LDCM0466  CL73 HEK-293T C245(0.99)  LDD1669  [22]
 LDCM0467  CL74 HEK-293T C245(0.77)  LDD1670  [22]
 LDCM0469  CL76 HEK-293T C245(0.98)  LDD1672  [22]
 LDCM0470  CL77 HEK-293T C245(1.55)  LDD1673  [22]
 LDCM0471  CL78 HEK-293T C245(1.03)  LDD1674  [22]
 LDCM0472  CL79 HEK-293T C245(0.91)  LDD1675  [22]
 LDCM0473  CL8 HEK-293T C245(1.21)  LDD1676  [22]
 LDCM0474  CL80 HEK-293T C245(1.04)  LDD1677  [22]
 LDCM0475  CL81 HEK-293T C245(1.08)  LDD1678  [22]
 LDCM0476  CL82 HEK-293T C245(1.10)  LDD1679  [22]
 LDCM0477  CL83 HEK-293T C245(1.06)  LDD1680  [22]
 LDCM0478  CL84 HEK-293T C245(1.12)  LDD1681  [22]
 LDCM0479  CL85 HEK-293T C245(1.19)  LDD1682  [22]
 LDCM0480  CL86 HEK-293T C245(0.89)  LDD1683  [22]
 LDCM0481  CL87 HEK-293T C245(0.99)  LDD1684  [22]
 LDCM0482  CL88 HEK-293T C245(1.00)  LDD1685  [22]
 LDCM0483  CL89 HEK-293T C245(1.06)  LDD1686  [22]
 LDCM0484  CL9 HEK-293T C245(1.10)  LDD1687  [22]
 LDCM0485  CL90 HEK-293T C245(1.16)  LDD1688  [22]
 LDCM0486  CL91 HEK-293T C245(1.07)  LDD1689  [22]
 LDCM0487  CL92 HEK-293T C245(1.16)  LDD1690  [22]
 LDCM0488  CL93 HEK-293T C245(0.91)  LDD1691  [22]
 LDCM0489  CL94 HEK-293T C245(0.91)  LDD1692  [22]
 LDCM0490  CL95 HEK-293T C245(1.07)  LDD1693  [22]
 LDCM0491  CL96 HEK-293T C245(1.06)  LDD1694  [22]
 LDCM0492  CL97 HEK-293T C245(1.17)  LDD1695  [22]
 LDCM0493  CL98 HEK-293T C245(1.08)  LDD1696  [22]
 LDCM0494  CL99 HEK-293T C245(0.86)  LDD1697  [22]
 LDCM0495  E2913 HEK-293T C245(0.87)  LDD1698  [22]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C66(1.15)  LDD1702  [8]
 LDCM0468  Fragment33 HEK-293T C245(0.96)  LDD1671  [22]
 LDCM0427  Fragment51 HEK-293T C245(1.45)  LDD1025  [23]
 LDCM0107  IAA HeLa N.A.  LDD0221  [10]
 LDCM0022  KB02 T cell C245(20.00)  LDD1707  [9]
 LDCM0023  KB03 MDA-MB-231 C66(1.27)  LDD1701  [8]
 LDCM0024  KB05 COLO792 C66(1.70)  LDD3310  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C66(0.41)  LDD2121  [8]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C66(0.68)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C66(1.53)  LDD2090  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C66(0.47)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C66(0.78)  LDD2099  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C66(0.88)  LDD2104  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C66(0.82)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C66(0.78)  LDD2109  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C66(0.88)  LDD2111  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C66(0.73)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C66(2.11)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C66(0.82)  LDD2123  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C66(0.69)  LDD2125  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C66(0.92)  LDD2127  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C66(1.01)  LDD2129  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C66(1.04)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C66(0.89)  LDD2137  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C66(0.84)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C66(0.17)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C66(1.33)  LDD2143  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C66(1.08)  LDD2146  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C66(0.61)  LDD2150  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 19 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) 3-beta-HSD family P14060
26S proteasome regulatory subunit 6B (PSMC4) AAA ATPase family P43686
Phosphoserine aminotransferase (PSAT1) Class-V pyridoxal-phosphate-dependent aminotransferase family Q9Y617
Corrinoid adenosyltransferase MMAB (MMAB) Cob(I)alamin adenosyltransferase family Q96EY8
Deoxyribonuclease-1-like 1 (DNASE1L1) DNase I family P49184
Fumarylacetoacetate hydrolase domain-containing protein 2A (FAHD2A) FAH family Q96GK7
Galactoside alpha-(1,2)-fucosyltransferase 2 (FUT2) Glycosyltransferase 11 family Q10981
Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) Isocitrate and isopropylmalate dehydrogenases family O75874
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) NLRP family Q96P20
Ubiquitin carboxyl-terminal hydrolase 12 (USP12) Peptidase C19 family O75317
E3 SUMO-protein ligase PIAS4 (PIAS4) PIAS family Q8N2W9
Serine/threonine-protein phosphatase with EF-hands 1 (PPEF1) PPP phosphatase family O14829
26S proteasome non-ATPase regulatory subunit 2 (PSMD2) Proteasome subunit S2 family Q13200
Cyclin-dependent kinase 1 (CDK1) CMGC Ser/Thr protein kinase family P06493
Ras-related protein Rab-31 (RAB31) Rab family Q13636
Ras-related protein Rab-3C (RAB3C) Rab family Q96E17
Ras-related protein Rap-1b (RAP1B) Ras family P61224
Tryptophan 2,3-dioxygenase (TDO2) Tryptophan 2,3-dioxygenase family P48775
Protein MFI (MFI) . Q8NCR3
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein epsilon (YWHAE) 14-3-3 family P62258
Gap junction alpha-5 protein (GJA5) Connexin family P36382
Huntingtin (HTT) Huntingtin family P42858
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) Mitochondrial carrier (TC 2.A.29) family Q02978
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myoneurin (MYNN) Krueppel C2H2-type zinc-finger protein family Q9NPC7
Transcription factor Sp6 (SP6) Sp1 C2H2-type zinc-finger protein family Q3SY56
THAP domain-containing protein 7 (THAP7) . Q9BT49
Zinc fingers and homeoboxes protein 1, isoform 2 (ZHX1-C8orf76) . Q96EF9
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myosin-binding protein H-like (MYBPHL) MyBP family A2RUH7
HLA class II histocompatibility antigen, DR beta 3 chain (HLA-DRB3) MHC class II family P79483
Other
Click To Hide/Show 27 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCR4-NOT transcription complex subunit 3 (CNOT3) CNOT2/3/5 family O75175
Dynein regulatory complex subunit 7 (DRC7) DRC7 family Q8IY82
Epithelial cell adhesion molecule (EPCAM) EPCAM family P16422
Protein eva-1 homolog B (EVA1B) EVA1 family Q9NVM1
Guanine nucleotide-binding protein G(o) subunit alpha (GNAO1) G-alpha family P09471
Pre-mRNA-splicing factor ISY1 homolog (ISY1) ISY1 family Q9ULR0
Protein LEG1 homolog (LEG1) LEG1 family Q6P5S2
Nucleosome assembly protein 1-like 1 (NAP1L1) Nucleosome assembly protein (NAP) family P55209
NXPE family member 1 (NXPE1) NXPE family Q8N323
RNA-binding protein 5 (RBM5) RBM5/RBM10 family P52756
tRNA selenocysteine 1-associated protein 1 (TRNAU1AP) RRM TRSPAP family Q9NX07
Thrombospondin-3 (THBS3) Thrombospondin family P49746
Targeting protein for Xklp2 (TPX2) TPX2 family Q9ULW0
Tubulin beta chain (TUBB) Tubulin family P07437
UPF0500 protein C1orf216 (C1orf216) UPF0500 family Q8TAB5
POC1 centriolar protein homolog A (POC1A) WD repeat POC1 family Q8NBT0
Epidermal growth factor-like protein 8 (EGFL8) . Q99944
Galectin-1 (LGALS1) . P09382
Melanoma-associated antigen 2 (MAGEA2; MAGEA2B) . P43356
Mitochondrial antiviral-signaling protein (MAVS) . Q7Z434
NKG2-A/NKG2-B type II integral membrane protein (KLRC1) . P26715
PML-RARA-regulated adapter molecule 1 (PRAM1) . Q96QH2
Pygopus homolog 1 (PYGO1) . Q9Y3Y4
Ras association domain-containing protein 2 (RASSF2) . P50749
Spermatogenesis-associated protein 17 (SPATA17) . Q96L03
Splicing factor 45 (RBM17) . Q96I25
Sprouty-related, EVH1 domain-containing protein 2 (SPRED2) . Q7Z698

References

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2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
7 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
10 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
18 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
19 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
20 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
21 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
22 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
23 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.