Details of the Target

General Information of Target

Target ID LDTP11406
Target Name Transmembrane protein 59 (TMEM59)
Gene Name TMEM59
Gene ID 9528
Synonyms
C1orf8; Transmembrane protein 59; Liver membrane-bound protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDINLDWVDRRQLQRLEEMLIVVDENDKVIGADTKRNCHLNENIEKGLLHRAFSVVLFN
TKNRILIQQRSDTKVTFPGYFTDSCSSHPLYNPAELEEKDAIGVRRAAQRRLQAELGIPG
EQISPEDIVFMTIYHHKAKSDRIWGEHEICYLLLVRKNVTLNPDPSETKSILYLSQEELW
ELLEREARGEVKVTPWLRTIAERFLYRWWPHLDDVTPFVELHKIHRV
Target Bioclass
Transporter and channel
Family
TMEM59 family
Subcellular location
Late endosome membrane
Function
Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
Uniprot ID
Q9BXS4
Ensemble ID
ENST00000234831.10
HGNC ID
HGNC:1239

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
YN-1
 Probe Info  		100.00  LDD0444  [1]
Curcusone 37
 Probe Info  		3.01  LDD0188  [2]
DBIA
 Probe Info  		C80(1.00)  LDD1492  [3]
PAL-AfBPP Probe
Click To Hide/Show 45 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		7.46  LDD1740  [4]
C041
 Probe Info  		6.19  LDD1741  [4]
C055
 Probe Info  		15.24  LDD1752  [4]
C056
 Probe Info  		28.84  LDD1753  [4]
C063
 Probe Info  		19.70  LDD1760  [4]
C091
 Probe Info  		18.38  LDD1782  [4]
C092
 Probe Info  		32.22  LDD1783  [4]
C094
 Probe Info  		28.64  LDD1785  [4]
C134
 Probe Info  		20.25  LDD1816  [4]
C143
 Probe Info  		12.91  LDD1825  [4]
C156
 Probe Info  		5.28  LDD1836  [4]
C158
 Probe Info  		10.63  LDD1838  [4]
C159
 Probe Info  		32.67  LDD1839  [4]
C160
 Probe Info  		26.17  LDD1840  [4]
C161
 Probe Info  		49.52  LDD1841  [4]
C169
 Probe Info  		97.01  LDD1849  [4]
C170
 Probe Info  		99.73  LDD1850  [4]
C171
 Probe Info  		16.80  LDD1851  [4]
C173
 Probe Info  		9.38  LDD1853  [4]
C174
 Probe Info  		5.74  LDD1854  [4]
C178
 Probe Info  		18.25  LDD1857  [4]
C208
 Probe Info  		21.71  LDD1883  [4]
C210
 Probe Info  		48.17  LDD1884  [4]
C211
 Probe Info  		16.91  LDD1885  [4]
C212
 Probe Info  		6.36  LDD1886  [4]
C213
 Probe Info  		31.78  LDD1887  [4]
C218
 Probe Info  		12.30  LDD1892  [4]
C219
 Probe Info  		6.68  LDD1893  [4]
C220
 Probe Info  		21.11  LDD1894  [4]
C223
 Probe Info  		6.28  LDD1897  [4]
C225
 Probe Info  		5.10  LDD1898  [4]
C226
 Probe Info  		6.19  LDD1899  [4]
C228
 Probe Info  		18.64  LDD1901  [4]
C287
 Probe Info  		12.64  LDD1957  [4]
C288
 Probe Info  		9.78  LDD1958  [4]
C289
 Probe Info  		37.53  LDD1959  [4]
C293
 Probe Info  		16.91  LDD1963  [4]
C310
 Probe Info  		25.99  LDD1977  [4]
C343
 Probe Info  		16.00  LDD2005  [4]
C346
 Probe Info  		14.62  LDD2007  [4]
C383
 Probe Info  		14.72  LDD2042  [4]
C386
 Probe Info  		8.00  LDD2045  [4]
C388
 Probe Info  		54.57  LDD2047  [4]
FFF probe12
 Probe Info  		20.00  LDD0473  [5]
FFF probe14
 Probe Info  		20.00  LDD0477  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C52(1.10)  LDD1507  [3]
 LDCM0270  AC15 HEK-293T C80(1.02)  LDD1513  [3]
 LDCM0276  AC17 HEK-293T C52(1.21)  LDD1515  [3]
 LDCM0281  AC21 HEK-293T C52(1.38)  LDD1520  [3]
 LDCM0283  AC23 HEK-293T C80(0.86)  LDD1522  [3]
 LDCM0284  AC24 HEK-293T C80(1.04)  LDD1523  [3]
 LDCM0285  AC25 HEK-293T C52(1.14)  LDD1524  [3]
 LDCM0289  AC29 HEK-293T C52(1.25)  LDD1528  [3]
 LDCM0292  AC31 HEK-293T C80(0.93)  LDD1531  [3]
 LDCM0293  AC32 HEK-293T C80(0.95)  LDD1532  [3]
 LDCM0294  AC33 HEK-293T C52(1.35)  LDD1533  [3]
 LDCM0298  AC37 HEK-293T C52(1.23)  LDD1537  [3]
 LDCM0300  AC39 HEK-293T C80(1.11)  LDD1539  [3]
 LDCM0302  AC40 HEK-293T C80(1.10)  LDD1541  [3]
 LDCM0303  AC41 HEK-293T C52(1.36)  LDD1542  [3]
 LDCM0307  AC45 HEK-293T C52(0.97)  LDD1546  [3]
 LDCM0309  AC47 HEK-293T C80(0.98)  LDD1548  [3]
 LDCM0310  AC48 HEK-293T C80(1.12)  LDD1549  [3]
 LDCM0311  AC49 HEK-293T C52(1.13)  LDD1550  [3]
 LDCM0312  AC5 HEK-293T C52(1.12)  LDD1551  [3]
 LDCM0316  AC53 HEK-293T C52(1.11)  LDD1555  [3]
 LDCM0318  AC55 HEK-293T C80(1.01)  LDD1557  [3]
 LDCM0319  AC56 HEK-293T C80(1.21)  LDD1558  [3]
 LDCM0320  AC57 HEK-293T C52(1.08)  LDD1559  [3]
 LDCM0325  AC61 HEK-293T C52(1.13)  LDD1564  [3]
 LDCM0327  AC63 HEK-293T C80(1.03)  LDD1566  [3]
 LDCM0328  AC64 HEK-293T C80(1.04)  LDD1567  [3]
 LDCM0334  AC7 HEK-293T C80(0.88)  LDD1568  [3]
 LDCM0345  AC8 HEK-293T C80(0.72)  LDD1569  [3]
 LDCM0248  AKOS034007472 HEK-293T C52(1.37)  LDD1511  [3]
 LDCM0356  AKOS034007680 HEK-293T C52(1.08)  LDD1570  [3]
 LDCM0275  AKOS034007705 HEK-293T C80(1.05)  LDD1514  [3]
 LDCM0379  CL11 HEK-293T C80(1.15)  LDD1583  [3]
 LDCM0390  CL12 HEK-293T C80(1.25)  LDD1594  [3]
 LDCM0404  CL17 HEK-293T C52(1.18)  LDD1608  [3]
 LDCM0409  CL21 HEK-293T C52(0.89)  LDD1613  [3]
 LDCM0411  CL23 HEK-293T C80(1.27)  LDD1615  [3]
 LDCM0412  CL24 HEK-293T C80(1.38)  LDD1616  [3]
 LDCM0417  CL29 HEK-293T C52(1.16)  LDD1621  [3]
 LDCM0422  CL33 HEK-293T C52(0.97)  LDD1626  [3]
 LDCM0424  CL35 HEK-293T C80(1.07)  LDD1628  [3]
 LDCM0425  CL36 HEK-293T C80(1.57)  LDD1629  [3]
 LDCM0431  CL41 HEK-293T C52(1.35)  LDD1635  [3]
 LDCM0435  CL45 HEK-293T C52(1.18)  LDD1639  [3]
 LDCM0437  CL47 HEK-293T C80(1.29)  LDD1641  [3]
 LDCM0438  CL48 HEK-293T C80(1.58)  LDD1642  [3]
 LDCM0440  CL5 HEK-293T C52(1.15)  LDD1644  [3]
 LDCM0444  CL53 HEK-293T C52(1.25)  LDD1647  [3]
 LDCM0448  CL57 HEK-293T C52(1.13)  LDD1651  [3]
 LDCM0450  CL59 HEK-293T C80(1.24)  LDD1653  [3]
 LDCM0452  CL60 HEK-293T C80(1.46)  LDD1655  [3]
 LDCM0457  CL65 HEK-293T C52(1.23)  LDD1660  [3]
 LDCM0461  CL69 HEK-293T C52(1.14)  LDD1664  [3]
 LDCM0464  CL71 HEK-293T C80(1.29)  LDD1667  [3]
 LDCM0465  CL72 HEK-293T C80(1.50)  LDD1668  [3]
 LDCM0470  CL77 HEK-293T C52(1.37)  LDD1673  [3]
 LDCM0475  CL81 HEK-293T C52(1.05)  LDD1678  [3]
 LDCM0477  CL83 HEK-293T C80(1.08)  LDD1680  [3]
 LDCM0478  CL84 HEK-293T C80(0.77)  LDD1681  [3]
 LDCM0483  CL89 HEK-293T C52(1.29)  LDD1686  [3]
 LDCM0484  CL9 HEK-293T C52(1.24)  LDD1687  [3]
 LDCM0488  CL93 HEK-293T C52(1.17)  LDD1691  [3]
 LDCM0490  CL95 HEK-293T C80(1.08)  LDD1693  [3]
 LDCM0491  CL96 HEK-293T C80(1.32)  LDD1694  [3]
 LDCM0033  Curcusone1d MCF-7 3.01  LDD0188  [2]
 LDCM0022  KB02 HEK-293T C80(1.00)  LDD1492  [3]
 LDCM0023  KB03 HEK-293T C80(1.07)  LDD1497  [3]
 LDCM0024  KB05 HEK-293T C80(1.14)  LDD1502  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Autophagy-related protein 16-1 (ATG16L1) WD repeat ATG16 family Q676U5

References

1 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
2 Total Synthesis and Target Identification of the Curcusone Diterpenes. J Am Chem Soc. 2021 Mar 24;143(11):4379-4386. doi: 10.1021/jacs.1c00557. Epub 2021 Mar 11.
3 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.