Details of the Target

General Information of Target

Target ID LDTP04626
Target Name UV excision repair protein RAD23 homolog A (RAD23A)
Gene Name RAD23A
Gene ID 5886
Synonyms
UV excision repair protein RAD23 homolog A; HR23A; hHR23A
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAVTITLKTLQQQTFKIRMEPDETVKVLKEKIEAEKGRDAFPVAGQKLIYAGKILSDDVP
IRDYRIDEKNFVVVMVTKTKAGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAARE
DKSPSEESAPTTSPESVSGSVPSSGSSGREEDAASTLVTGSEYETMLTEIMSMGYERERV
VAALRASYNNPHRAVEYLLTGIPGSPEPEHGSVQESQVSEQPATEAAGENPLEFLRDQPQ
FQNMRQVIQQNPALLPALLQQLGQENPQLLQQISRHQEQFIQMLNEPPGELADISDVEGE
VGAIGEEAPQMNYIQVTPQEKEAIERLKALGFPESLVIQAYFACEKNENLAANFLLSQNF
DDE
Target Bioclass
Other
Family
RAD23 family
Subcellular location
Nucleus
Function
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.; Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.; (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome.
Uniprot ID
P54725
Ensemble ID
ENST00000316856.7
HGNC ID
HGNC:9812

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 16 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y188(20.00)  LDD0260  [1]
STPyne
 Probe Info  		K16(7.89); K47(7.55); K53(10.00)  LDD0277  [2]
ONAyne
 Probe Info  		K36(7.69)  LDD0275  [2]
Probe 1
 Probe Info  		Y50(55.28); Y188(27.87)  LDD3495  [3]
DBIA
 Probe Info  		C344(0.84)  LDD3377  [4]
HHS-482
 Probe Info  		Y188(1.04)  LDD0285  [5]
HHS-475
 Probe Info  		Y188(0.73)  LDD0264  [6]
HHS-465
 Probe Info  		Y188(2.90)  LDD2237  [7]
Acrolein
 Probe Info  		N.A.  LDD0221  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
m-APA
 Probe Info  		N.A.  LDD2231  [9]
IA-alkyne
 Probe Info  		N.A.  LDD2241  [10]
NHS
 Probe Info  		K53(0.00); K47(0.00)  LDD0010  [11]
SF
 Probe Info  		N.A.  LDD0028  [12]
1c-yne
 Probe Info  		N.A.  LDD0228  [13]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [8]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		13.18  LDD1779  [14]
C134
 Probe Info  		22.16  LDD1816  [14]
C135
 Probe Info  		11.47  LDD1817  [14]
C138
 Probe Info  		5.10  LDD1820  [14]
C140
 Probe Info  		8.17  LDD1822  [14]
C158
 Probe Info  		9.19  LDD1838  [14]
C201
 Probe Info  		25.63  LDD1877  [14]
C213
 Probe Info  		16.34  LDD1887  [14]
C289
 Probe Info  		26.54  LDD1959  [14]
C407
 Probe Info  		17.88  LDD2064  [14]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C344(1.02)  LDD1507  [15]
 LDCM0215  AC10 HEK-293T C344(0.96)  LDD1508  [15]
 LDCM0226  AC11 HEK-293T C344(1.08)  LDD1509  [15]
 LDCM0237  AC12 HEK-293T C344(1.00)  LDD1510  [15]
 LDCM0259  AC14 HEK-293T C344(1.01)  LDD1512  [15]
 LDCM0276  AC17 HEK-293T C344(1.01)  LDD1515  [15]
 LDCM0277  AC18 HEK-293T C344(1.06)  LDD1516  [15]
 LDCM0278  AC19 HEK-293T C344(1.03)  LDD1517  [15]
 LDCM0279  AC2 HEK-293T C344(0.84)  LDD1518  [15]
 LDCM0280  AC20 HEK-293T C344(0.95)  LDD1519  [15]
 LDCM0281  AC21 HEK-293T C344(1.06)  LDD1520  [15]
 LDCM0282  AC22 HEK-293T C344(1.33)  LDD1521  [15]
 LDCM0284  AC24 HEK-293T C344(1.21)  LDD1523  [15]
 LDCM0285  AC25 HEK-293T C344(0.95)  LDD1524  [15]
 LDCM0286  AC26 HEK-293T C344(0.98)  LDD1525  [15]
 LDCM0287  AC27 HEK-293T C344(0.95)  LDD1526  [15]
 LDCM0288  AC28 HEK-293T C344(0.91)  LDD1527  [15]
 LDCM0289  AC29 HEK-293T C344(1.01)  LDD1528  [15]
 LDCM0290  AC3 HEK-293T C344(0.97)  LDD1529  [15]
 LDCM0291  AC30 HEK-293T C344(1.14)  LDD1530  [15]
 LDCM0293  AC32 HEK-293T C344(1.21)  LDD1532  [15]
 LDCM0294  AC33 HEK-293T C344(1.03)  LDD1533  [15]
 LDCM0295  AC34 HEK-293T C344(0.99)  LDD1534  [15]
 LDCM0296  AC35 HEK-293T C344(1.16)  LDD1535  [15]
 LDCM0297  AC36 HEK-293T C344(0.98)  LDD1536  [15]
 LDCM0298  AC37 HEK-293T C344(0.93)  LDD1537  [15]
 LDCM0299  AC38 HEK-293T C344(1.04)  LDD1538  [15]
 LDCM0301  AC4 HEK-293T C344(1.08)  LDD1540  [15]
 LDCM0302  AC40 HEK-293T C344(0.95)  LDD1541  [15]
 LDCM0303  AC41 HEK-293T C344(0.95)  LDD1542  [15]
 LDCM0304  AC42 HEK-293T C344(0.92)  LDD1543  [15]
 LDCM0305  AC43 HEK-293T C344(1.18)  LDD1544  [15]
 LDCM0306  AC44 HEK-293T C344(1.01)  LDD1545  [15]
 LDCM0307  AC45 HEK-293T C344(0.83)  LDD1546  [15]
 LDCM0308  AC46 HEK-293T C344(1.02)  LDD1547  [15]
 LDCM0310  AC48 HEK-293T C344(1.02)  LDD1549  [15]
 LDCM0311  AC49 HEK-293T C344(0.96)  LDD1550  [15]
 LDCM0312  AC5 HEK-293T C344(0.86)  LDD1551  [15]
 LDCM0313  AC50 HEK-293T C344(0.94)  LDD1552  [15]
 LDCM0314  AC51 HEK-293T C344(1.02)  LDD1553  [15]
 LDCM0315  AC52 HEK-293T C344(1.00)  LDD1554  [15]
 LDCM0316  AC53 HEK-293T C344(0.95)  LDD1555  [15]
 LDCM0317  AC54 HEK-293T C344(0.97)  LDD1556  [15]
 LDCM0319  AC56 HEK-293T C344(1.03)  LDD1558  [15]
 LDCM0320  AC57 HEK-293T C344(0.93)  LDD1559  [15]
 LDCM0321  AC58 HEK-293T C344(0.97)  LDD1560  [15]
 LDCM0322  AC59 HEK-293T C344(1.05)  LDD1561  [15]
 LDCM0323  AC6 HEK-293T C344(1.04)  LDD1562  [15]
 LDCM0324  AC60 HEK-293T C344(1.01)  LDD1563  [15]
 LDCM0325  AC61 HEK-293T C344(1.04)  LDD1564  [15]
 LDCM0326  AC62 HEK-293T C344(1.10)  LDD1565  [15]
 LDCM0328  AC64 HEK-293T C344(0.89)  LDD1567  [15]
 LDCM0345  AC8 HEK-293T C344(1.00)  LDD1569  [15]
 LDCM0248  AKOS034007472 HEK-293T C344(0.83)  LDD1511  [15]
 LDCM0356  AKOS034007680 HEK-293T C344(1.02)  LDD1570  [15]
 LDCM0275  AKOS034007705 HEK-293T C344(0.87)  LDD1514  [15]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [8]
 LDCM0367  CL1 HEK-293T C344(1.07)  LDD1571  [15]
 LDCM0368  CL10 HEK-293T C344(0.85)  LDD1572  [15]
 LDCM0369  CL100 HEK-293T C344(0.86)  LDD1573  [15]
 LDCM0370  CL101 HEK-293T C344(1.01)  LDD1574  [15]
 LDCM0371  CL102 HEK-293T C344(1.00)  LDD1575  [15]
 LDCM0372  CL103 HEK-293T C344(1.06)  LDD1576  [15]
 LDCM0373  CL104 HEK-293T C344(0.96)  LDD1577  [15]
 LDCM0374  CL105 HEK-293T C344(1.01)  LDD1578  [15]
 LDCM0375  CL106 HEK-293T C344(1.16)  LDD1579  [15]
 LDCM0376  CL107 HEK-293T C344(1.05)  LDD1580  [15]
 LDCM0377  CL108 HEK-293T C344(0.98)  LDD1581  [15]
 LDCM0378  CL109 HEK-293T C344(0.91)  LDD1582  [15]
 LDCM0380  CL110 HEK-293T C344(1.00)  LDD1584  [15]
 LDCM0381  CL111 HEK-293T C344(1.00)  LDD1585  [15]
 LDCM0382  CL112 HEK-293T C344(0.86)  LDD1586  [15]
 LDCM0383  CL113 HEK-293T C344(1.02)  LDD1587  [15]
 LDCM0384  CL114 HEK-293T C344(0.99)  LDD1588  [15]
 LDCM0385  CL115 HEK-293T C344(1.01)  LDD1589  [15]
 LDCM0386  CL116 HEK-293T C344(1.07)  LDD1590  [15]
 LDCM0387  CL117 HEK-293T C344(1.05)  LDD1591  [15]
 LDCM0388  CL118 HEK-293T C344(1.26)  LDD1592  [15]
 LDCM0389  CL119 HEK-293T C344(0.98)  LDD1593  [15]
 LDCM0390  CL12 HEK-293T C344(0.99)  LDD1594  [15]
 LDCM0391  CL120 HEK-293T C344(1.02)  LDD1595  [15]
 LDCM0392  CL121 HEK-293T C344(1.06)  LDD1596  [15]
 LDCM0393  CL122 HEK-293T C344(1.10)  LDD1597  [15]
 LDCM0394  CL123 HEK-293T C344(0.92)  LDD1598  [15]
 LDCM0395  CL124 HEK-293T C344(0.91)  LDD1599  [15]
 LDCM0396  CL125 HEK-293T C344(1.06)  LDD1600  [15]
 LDCM0397  CL126 HEK-293T C344(1.28)  LDD1601  [15]
 LDCM0398  CL127 HEK-293T C344(1.02)  LDD1602  [15]
 LDCM0399  CL128 HEK-293T C344(0.98)  LDD1603  [15]
 LDCM0400  CL13 HEK-293T C344(1.16)  LDD1604  [15]
 LDCM0401  CL14 HEK-293T C344(1.02)  LDD1605  [15]
 LDCM0402  CL15 HEK-293T C344(0.94)  LDD1606  [15]
 LDCM0403  CL16 HEK-293T C344(0.96)  LDD1607  [15]
 LDCM0404  CL17 HEK-293T C344(0.99)  LDD1608  [15]
 LDCM0405  CL18 HEK-293T C344(0.89)  LDD1609  [15]
 LDCM0406  CL19 HEK-293T C344(1.00)  LDD1610  [15]
 LDCM0407  CL2 HEK-293T C344(1.03)  LDD1611  [15]
 LDCM0408  CL20 HEK-293T C344(0.87)  LDD1612  [15]
 LDCM0409  CL21 HEK-293T C344(0.76)  LDD1613  [15]
 LDCM0410  CL22 HEK-293T C344(0.94)  LDD1614  [15]
 LDCM0412  CL24 HEK-293T C344(1.08)  LDD1616  [15]
 LDCM0413  CL25 HEK-293T C344(1.06)  LDD1617  [15]
 LDCM0414  CL26 HEK-293T C344(1.07)  LDD1618  [15]
 LDCM0415  CL27 HEK-293T C344(0.95)  LDD1619  [15]
 LDCM0416  CL28 HEK-293T C344(0.94)  LDD1620  [15]
 LDCM0417  CL29 HEK-293T C344(0.97)  LDD1621  [15]
 LDCM0418  CL3 HEK-293T C344(1.06)  LDD1622  [15]
 LDCM0419  CL30 HEK-293T C344(1.04)  LDD1623  [15]
 LDCM0420  CL31 HEK-293T C344(1.06)  LDD1624  [15]
 LDCM0421  CL32 HEK-293T C344(0.98)  LDD1625  [15]
 LDCM0422  CL33 HEK-293T C344(0.88)  LDD1626  [15]
 LDCM0423  CL34 HEK-293T C344(0.93)  LDD1627  [15]
 LDCM0425  CL36 HEK-293T C344(1.24)  LDD1629  [15]
 LDCM0426  CL37 HEK-293T C344(1.13)  LDD1630  [15]
 LDCM0428  CL39 HEK-293T C344(1.01)  LDD1632  [15]
 LDCM0429  CL4 HEK-293T C344(0.93)  LDD1633  [15]
 LDCM0430  CL40 HEK-293T C344(0.96)  LDD1634  [15]
 LDCM0431  CL41 HEK-293T C344(0.87)  LDD1635  [15]
 LDCM0432  CL42 HEK-293T C344(0.97)  LDD1636  [15]
 LDCM0433  CL43 HEK-293T C344(0.98)  LDD1637  [15]
 LDCM0434  CL44 HEK-293T C344(0.84)  LDD1638  [15]
 LDCM0435  CL45 HEK-293T C344(0.80)  LDD1639  [15]
 LDCM0436  CL46 HEK-293T C344(1.00)  LDD1640  [15]
 LDCM0438  CL48 HEK-293T C344(0.92)  LDD1642  [15]
 LDCM0439  CL49 HEK-293T C344(1.09)  LDD1643  [15]
 LDCM0440  CL5 HEK-293T C344(0.95)  LDD1644  [15]
 LDCM0441  CL50 HEK-293T C344(1.23)  LDD1645  [15]
 LDCM0443  CL52 HEK-293T C344(0.95)  LDD1646  [15]
 LDCM0444  CL53 HEK-293T C344(0.95)  LDD1647  [15]
 LDCM0445  CL54 HEK-293T C344(0.92)  LDD1648  [15]
 LDCM0446  CL55 HEK-293T C344(1.15)  LDD1649  [15]
 LDCM0447  CL56 HEK-293T C344(0.95)  LDD1650  [15]
 LDCM0448  CL57 HEK-293T C344(0.84)  LDD1651  [15]
 LDCM0449  CL58 HEK-293T C344(0.94)  LDD1652  [15]
 LDCM0451  CL6 HEK-293T C344(0.85)  LDD1654  [15]
 LDCM0452  CL60 HEK-293T C344(1.06)  LDD1655  [15]
 LDCM0453  CL61 HEK-293T C344(1.02)  LDD1656  [15]
 LDCM0454  CL62 HEK-293T C344(1.22)  LDD1657  [15]
 LDCM0455  CL63 HEK-293T C344(1.09)  LDD1658  [15]
 LDCM0456  CL64 HEK-293T C344(0.93)  LDD1659  [15]
 LDCM0457  CL65 HEK-293T C344(0.98)  LDD1660  [15]
 LDCM0458  CL66 HEK-293T C344(1.06)  LDD1661  [15]
 LDCM0459  CL67 HEK-293T C344(1.01)  LDD1662  [15]
 LDCM0460  CL68 HEK-293T C344(0.98)  LDD1663  [15]
 LDCM0461  CL69 HEK-293T C344(0.92)  LDD1664  [15]
 LDCM0462  CL7 HEK-293T C344(0.96)  LDD1665  [15]
 LDCM0463  CL70 HEK-293T C344(0.97)  LDD1666  [15]
 LDCM0465  CL72 HEK-293T C344(1.03)  LDD1668  [15]
 LDCM0466  CL73 HEK-293T C344(1.14)  LDD1669  [15]
 LDCM0467  CL74 HEK-293T C344(0.98)  LDD1670  [15]
 LDCM0469  CL76 HEK-293T C344(0.87)  LDD1672  [15]
 LDCM0470  CL77 HEK-293T C344(0.96)  LDD1673  [15]
 LDCM0471  CL78 HEK-293T C344(0.88)  LDD1674  [15]
 LDCM0472  CL79 HEK-293T C344(1.14)  LDD1675  [15]
 LDCM0473  CL8 HEK-293T C344(0.60)  LDD1676  [15]
 LDCM0474  CL80 HEK-293T C344(1.00)  LDD1677  [15]
 LDCM0475  CL81 HEK-293T C344(1.11)  LDD1678  [15]
 LDCM0476  CL82 HEK-293T C344(0.94)  LDD1679  [15]
 LDCM0478  CL84 HEK-293T C344(0.98)  LDD1681  [15]
 LDCM0479  CL85 HEK-293T C344(1.19)  LDD1682  [15]
 LDCM0480  CL86 HEK-293T C344(1.05)  LDD1683  [15]
 LDCM0481  CL87 HEK-293T C344(1.04)  LDD1684  [15]
 LDCM0482  CL88 HEK-293T C344(1.10)  LDD1685  [15]
 LDCM0483  CL89 HEK-293T C344(1.00)  LDD1686  [15]
 LDCM0484  CL9 HEK-293T C344(0.93)  LDD1687  [15]
 LDCM0485  CL90 HEK-293T C344(0.77)  LDD1688  [15]
 LDCM0486  CL91 HEK-293T C344(1.14)  LDD1689  [15]
 LDCM0487  CL92 HEK-293T C344(0.83)  LDD1690  [15]
 LDCM0488  CL93 HEK-293T C344(0.91)  LDD1691  [15]
 LDCM0489  CL94 HEK-293T C344(0.91)  LDD1692  [15]
 LDCM0491  CL96 HEK-293T C344(0.86)  LDD1694  [15]
 LDCM0492  CL97 HEK-293T C344(0.95)  LDD1695  [15]
 LDCM0493  CL98 HEK-293T C344(1.03)  LDD1696  [15]
 LDCM0494  CL99 HEK-293T C344(0.96)  LDD1697  [15]
 LDCM0495  E2913 HEK-293T C344(1.05)  LDD1698  [15]
 LDCM0468  Fragment33 HEK-293T C344(1.01)  LDD1671  [15]
 LDCM0427  Fragment51 HEK-293T C344(1.05)  LDD1631  [15]
 LDCM0116  HHS-0101 DM93 Y188(0.73)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y188(0.84)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y188(0.71)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y188(1.03)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y188(1.02)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0123  JWB131 DM93 Y188(1.04)  LDD0285  [5]
 LDCM0124  JWB142 DM93 Y188(1.03)  LDD0286  [5]
 LDCM0125  JWB146 DM93 Y188(1.26)  LDD0287  [5]
 LDCM0126  JWB150 DM93 Y188(2.68)  LDD0288  [5]
 LDCM0127  JWB152 DM93 Y188(1.58)  LDD0289  [5]
 LDCM0128  JWB198 DM93 Y188(1.33)  LDD0290  [5]
 LDCM0129  JWB202 DM93 Y188(0.98)  LDD0291  [5]
 LDCM0130  JWB211 DM93 Y188(0.96)  LDD0292  [5]
 LDCM0022  KB02 OPM-2 C344(0.97)  LDD2543  [4]
 LDCM0023  KB03 OPM-2 C344(0.85)  LDD2960  [4]
 LDCM0024  KB05 OPM-2 C344(0.84)  LDD3377  [4]
 LDCM0109  NEM HeLa N.A.  LDD0223  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 18 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) Histone-lysine methyltransferase family O43463
Ubiquitin carboxyl-terminal hydrolase MINDY-3 (MINDY3) MINDY deubiquitinase family Q9H8M7
Phospholipid phosphatase-related protein type 1 (PLPPR1) PA-phosphatase related phosphoesterase family Q8TBJ4
Ubiquitin carboxyl-terminal hydrolase 25 (USP25) Peptidase C19 family Q9UHP3
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) Peptidase C64 family P21580
26S proteasome non-ATPase regulatory subunit 2 (PSMD2) Proteasome subunit S2 family Q13200
26S proteasome non-ATPase regulatory subunit 4 (PSMD4) Proteasome subunit S5A family P55036
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
TNF receptor-associated factor 3 (TRAF3) TNF receptor-associated factor family Q13114
TNF receptor-associated factor 6 (TRAF6) TNF receptor-associated factor family Q9Y4K3
Elongation factor 1-alpha 1 (EEF1A1) Classic translation factor GTPase family P68104
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase (NGLY1) PNGase family Q96IV0
E3 ubiquitin-protein ligase TRIM50 (TRIM50) TRIM/RBCC family Q86XT4
E3 ubiquitin-protein ligase TRIM8 (TRIM8) TRIM/RBCC family Q9BZR9
Ataxin-3 (ATXN3) . P54252
E3 ubiquitin-protein ligase makorin-1 (MKRN1) . Q9UHC7
E3 ubiquitin-protein ligase NRDP1 (RNF41) . Q9H4P4
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Choline transporter-like protein 5 (SLC44A5) CTL (choline transporter-like) family Q8NCS7
Huntingtin (HTT) Huntingtin family P42858
Integrin alpha-V (ITGAV) Integrin alpha chain family P06756
Peroxisome proliferator-activated receptor alpha (PPARA) Nuclear hormone receptor family Q07869
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transcriptional repressor protein YY1 (YY1) YY transcription factor family P25490
Zinc finger and BTB domain-containing protein 26 (ZBTB26) . Q9HCK0
Zinc finger and BTB domain-containing protein 44 (ZBTB44) . Q8NCP5
Zinc finger and BTB domain-containing protein 8A (ZBTB8A) . Q96BR9
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Alpha-sarcoglycan (SGCA) Sarcoglycan alpha/epsilon family Q16586
TNF receptor-associated factor 5 (TRAF5) TNF receptor-associated factor family O00463
NEDD8 (NEDD8) Ubiquitin family Q15843
Ubiquitin-ribosomal protein eL40 fusion protein (UBA52) Ubiquitin family; Eukaryotic ribosomal protein eL40 family P62987
Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A) Ubiquitin family; Eukaryotic ribosomal protein eS31 family P62979
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
ADP-ribosylation factor GTPase-activating protein 3 (ARFGAP3) . Q9NP61
AN1-type zinc finger protein 6 (ZFAND6) . Q6FIF0
Ankyrin repeat domain-containing protein 40 (ANKRD40) . Q6AI12
Centrobin (CNTROB) . Q8N137
DAZ-associated protein 2 (DAZAP2) . Q15038
Sequestosome-1 (SQSTM1) . Q13501
TRAF3-interacting JNK-activating modulator (TRAF3IP3) . Q9Y228
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
15 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402