Details of the Target

General Information of Target

Target ID LDTP08796
Target Name Protein SYS1 homolog (SYS1)
Gene Name SYS1
Gene ID 90196
Synonyms
C20orf169; Protein SYS1 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGQFRSYVWDPLLILSQIVLMQTVYYGSLGLWLALVDGLVRSSPSLDQMFDAEILGFST
PPGRLSMMSFILNALTCALGLLYFIRRGKQCLDFTVTVHFFHLLGCWFYSSRFPSALTWW
LVQAVCIALMAVIGEYLCMRTELKEIPLNSAPKSNV
Target Bioclass
Other
Family
SYS1 family
Subcellular location
Golgi apparatus membrane
Function Involved in protein trafficking. May serve as a receptor for ARFRP1.
Uniprot ID
Q8N2H4
Ensemble ID
ENST00000243918.10
HGNC ID
HGNC:16162

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 Substitution: p.L30P .
HCC1806 Substitution: p.L30P .
SKNAS SNV: p.R140Q .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 32 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		18.51  LDD1728  [1]
C055
 Probe Info  		23.26  LDD1752  [1]
C056
 Probe Info  		45.89  LDD1753  [1]
C091
 Probe Info  		19.16  LDD1782  [1]
C092
 Probe Info  		28.44  LDD1783  [1]
C094
 Probe Info  		27.86  LDD1785  [1]
C106
 Probe Info  		27.10  LDD1793  [1]
C108
 Probe Info  		11.24  LDD1795  [1]
C178
 Probe Info  		48.50  LDD1857  [1]
C194
 Probe Info  		44.94  LDD1870  [1]
C196
 Probe Info  		30.27  LDD1872  [1]
C197
 Probe Info  		10.34  LDD1873  [1]
C198
 Probe Info  		34.54  LDD1874  [1]
C201
 Probe Info  		42.81  LDD1877  [1]
C206
 Probe Info  		20.53  LDD1881  [1]
C210
 Probe Info  		55.33  LDD1884  [1]
C211
 Probe Info  		10.13  LDD1885  [1]
C213
 Probe Info  		31.34  LDD1887  [1]
C218
 Probe Info  		23.10  LDD1892  [1]
C219
 Probe Info  		6.82  LDD1893  [1]
C220
 Probe Info  		35.26  LDD1894  [1]
C225
 Probe Info  		17.27  LDD1898  [1]
C226
 Probe Info  		13.83  LDD1899  [1]
C228
 Probe Info  		85.63  LDD1901  [1]
C243
 Probe Info  		19.29  LDD1916  [1]
C244
 Probe Info  		19.97  LDD1917  [1]
C246
 Probe Info  		44.63  LDD1919  [1]
C249
 Probe Info  		27.86  LDD1922  [1]
C419
 Probe Info  		11.79  LDD2074  [1]
C420
 Probe Info  		14.62  LDD2075  [1]
C431
 Probe Info  		22.32  LDD2086  [1]
OEA-DA
 Probe Info  		19.43  LDD0046  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
Very long chain fatty acid elongase 5 (ELOVL5) ELO family Q9NYP7
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Estradiol 17-beta-dehydrogenase 11 (HSD17B11) Short-chain dehydrogenases/reductases (SDR) family Q8NBQ5
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proton-coupled zinc antiporter SLC30A8 (SLC30A8) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q8IWU4
Transmembrane 4 L6 family member 19 (TM4SF19) L6 tetraspanin family Q96DZ7
Multiple coagulation factor deficiency protein 2 (MCFD2) . Q8NI22
Syntenin-1 (SDCBP) . O00560
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 3DL3 (KIR3DL3) Immunoglobulin superfamily Q8N743
Poliovirus receptor (PVR) Nectin family P15151
Cytokine and receptor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tumor necrosis factor ligand superfamily member 14 (TNFSF14) Tumor necrosis factor family O43557
Interleukin-3 receptor subunit alpha (IL3RA) Type I cytokine receptor family P26951
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Small ribosomal subunit protein mS40 (MRPS18B) Bacterial ribosomal protein bS18 family Q9Y676
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Transmembrane protein 248 (TMEM248) TMEM248 family Q9NWD8

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
2 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570