Details of the Target

General Information of Target

Target ID LDTP01300
Target Name Cartilage-associated protein (CRTAP)
Gene Name CRTAP
Gene ID 10491
Synonyms
CASP; Cartilage-associated protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEPGRRGAAALLALLCVACALRAGRAQYERYSFRSFPRDELMPLESAYRHALDKYSGEHW
AESVGYLEISLRLHRLLRDSEAFCHRNCSAAPQPEPAAGLASYPELRLFGGLLRRAHCLK
RCKQGLPAFRQSQPSREVLADFQRREPYKFLQFAYFKANNLPKAIAAAHTFLLKHPDDEM
MKRNMAYYKSLPGAEDYIKDLETKSYESLFIRAVRAYNGENWRTSITDMELALPDFFKAF
YECLAACEGSREIKDFKDFYLSIADHYVEVLECKIQCEENLTPVIGGYPVEKFVATMYHY
LQFAYYKLNDLKNAAPCAVSYLLFDQNDKVMQQNLVYYQYHRDTWGLSDEHFQPRPEAVQ
FFNVTTLQKELYDFAKENIMDDDEGEVVEYVDDLLELEETS
Target Bioclass
Enzyme
Family
Leprecan family
Subcellular location
Secreted, extracellular space, extracellular matrix
Function Necessary for efficient 3-hydroxylation of fibrillar collagen prolyl residues.
Uniprot ID
O75718
Ensemble ID
ENST00000320954.11
HGNC ID
HGNC:2379

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 15 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K120(8.33); K123(7.69); K199(0.69)  LDD0277  [1]
BTD
 Probe Info  		C84(0.95)  LDD2089  [2]
IPM
 Probe Info  		C84(3.19)  LDD1701  [2]
DBIA
 Probe Info  		C84(1.67)  LDD0080  [3]
5E-2FA
 Probe Info  		H299(0.00); H341(0.00)  LDD2235  [4]
ATP probe
 Probe Info  		K199(0.00); K204(0.00)  LDD0199  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [4]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [6]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [7]
SF
 Probe Info  		N.A.  LDD0028  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
Crotonaldehyde
 Probe Info  		C243(0.00); H85(0.00); C247(0.00)  LDD0219  [9]
Methacrolein
 Probe Info  		C84(0.00); C247(0.00)  LDD0218  [9]
AOyne
 Probe Info  		10.50  LDD0443  [10]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 38 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		9.32  LDD1714  [12]
C017
 Probe Info  		7.62  LDD1725  [12]
C063
 Probe Info  		12.13  LDD1760  [12]
C134
 Probe Info  		31.56  LDD1816  [12]
C140
 Probe Info  		8.34  LDD1822  [12]
C153
 Probe Info  		16.68  LDD1834  [12]
C163
 Probe Info  		8.82  LDD1843  [12]
C165
 Probe Info  		13.27  LDD1845  [12]
C213
 Probe Info  		14.52  LDD1887  [12]
C218
 Probe Info  		12.64  LDD1892  [12]
C219
 Probe Info  		8.51  LDD1893  [12]
C220
 Probe Info  		13.18  LDD1894  [12]
C228
 Probe Info  		36.00  LDD1901  [12]
C231
 Probe Info  		12.55  LDD1904  [12]
C232
 Probe Info  		64.89  LDD1905  [12]
C239
 Probe Info  		6.50  LDD1912  [12]
C244
 Probe Info  		28.44  LDD1917  [12]
C265
 Probe Info  		13.18  LDD1936  [12]
C270
 Probe Info  		37.53  LDD1940  [12]
C273
 Probe Info  		14.12  LDD1943  [12]
C296
 Probe Info  		26.91  LDD1966  [12]
C314
 Probe Info  		11.63  LDD1981  [12]
C338
 Probe Info  		15.45  LDD2001  [12]
C343
 Probe Info  		15.56  LDD2005  [12]
C346
 Probe Info  		10.85  LDD2007  [12]
C348
 Probe Info  		10.70  LDD2009  [12]
C350
 Probe Info  		34.78  LDD2011  [12]
C353
 Probe Info  		18.38  LDD2014  [12]
C354
 Probe Info  		7.01  LDD2015  [12]
C356
 Probe Info  		7.94  LDD2017  [12]
C362
 Probe Info  		30.06  LDD2023  [12]
C363
 Probe Info  		16.34  LDD2024  [12]
C364
 Probe Info  		31.34  LDD2025  [12]
C380
 Probe Info  		9.71  LDD2039  [12]
C413
 Probe Info  		11.55  LDD2069  [12]
C432
 Probe Info  		9.51  LDD2087  [12]
STS-1
 Probe Info  		N.A.  LDD0136  [13]
STS-2
 Probe Info  		N.A.  LDD0138  [13]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C84(1.07)  LDD2117  [2]
 LDCM0214  AC1 HEK-293T C84(1.14); C317(0.98)  LDD1507  [14]
 LDCM0215  AC10 HEK-293T C84(0.93)  LDD0813  [3]
 LDCM0216  AC100 HEK-293T C84(1.36)  LDD0814  [3]
 LDCM0217  AC101 HEK-293T C84(1.30)  LDD0815  [3]
 LDCM0218  AC102 HEK-293T C84(1.21)  LDD0816  [3]
 LDCM0219  AC103 HEK-293T C84(1.20)  LDD0817  [3]
 LDCM0220  AC104 HEK-293T C84(0.99)  LDD0818  [3]
 LDCM0221  AC105 HEK-293T C84(1.10)  LDD0819  [3]
 LDCM0222  AC106 HEK-293T C84(1.20)  LDD0820  [3]
 LDCM0223  AC107 HEK-293T C84(1.04)  LDD0821  [3]
 LDCM0224  AC108 HEK-293T C84(1.12)  LDD0822  [3]
 LDCM0225  AC109 HEK-293T C84(1.10)  LDD0823  [3]
 LDCM0226  AC11 HEK-293T C84(0.77)  LDD0824  [3]
 LDCM0227  AC110 HEK-293T C84(1.22)  LDD0825  [3]
 LDCM0228  AC111 HEK-293T C84(1.31)  LDD0826  [3]
 LDCM0229  AC112 HEK-293T C84(1.15)  LDD0827  [3]
 LDCM0237  AC12 HEK-293T C84(0.84)  LDD0835  [3]
 LDCM0246  AC128 HEK-293T C84(0.82)  LDD0844  [3]
 LDCM0247  AC129 HEK-293T C84(0.69)  LDD0845  [3]
 LDCM0249  AC130 HEK-293T C84(0.84)  LDD0847  [3]
 LDCM0250  AC131 HEK-293T C84(1.08)  LDD0848  [3]
 LDCM0251  AC132 HEK-293T C84(0.77)  LDD0849  [3]
 LDCM0252  AC133 HEK-293T C84(0.78)  LDD0850  [3]
 LDCM0253  AC134 HEK-293T C84(1.01)  LDD0851  [3]
 LDCM0254  AC135 HEK-293T C84(1.00)  LDD0852  [3]
 LDCM0255  AC136 HEK-293T C84(1.01)  LDD0853  [3]
 LDCM0256  AC137 HEK-293T C84(0.76)  LDD0854  [3]
 LDCM0257  AC138 HEK-293T C84(0.81)  LDD0855  [3]
 LDCM0258  AC139 HEK-293T C84(0.80)  LDD0856  [3]
 LDCM0259  AC14 HEK-293T C84(0.75)  LDD0857  [3]
 LDCM0260  AC140 HEK-293T C84(0.93)  LDD0858  [3]
 LDCM0261  AC141 HEK-293T C84(0.95)  LDD0859  [3]
 LDCM0262  AC142 HEK-293T C84(0.87)  LDD0860  [3]
 LDCM0270  AC15 HEK-293T C84(0.81)  LDD0868  [3]
 LDCM0276  AC17 HEK-293T C84(0.85)  LDD0874  [3]
 LDCM0277  AC18 HEK-293T C84(1.04)  LDD0875  [3]
 LDCM0278  AC19 HEK-293T C84(1.10)  LDD0876  [3]
 LDCM0279  AC2 HEK-293T C84(1.19); C317(1.06)  LDD1518  [14]
 LDCM0280  AC20 HEK-293T C84(1.10)  LDD0878  [3]
 LDCM0281  AC21 HEK-293T C84(1.10)  LDD0879  [3]
 LDCM0282  AC22 HEK-293T C84(1.13)  LDD0880  [3]
 LDCM0283  AC23 HEK-293T C84(0.98)  LDD0881  [3]
 LDCM0284  AC24 HEK-293T C84(1.16)  LDD0882  [3]
 LDCM0285  AC25 HEK-293T C84(0.99); C317(0.86)  LDD1524  [14]
 LDCM0286  AC26 HEK-293T C84(1.10); C317(1.11)  LDD1525  [14]
 LDCM0287  AC27 HEK-293T C84(0.91); C317(0.94)  LDD1526  [14]
 LDCM0288  AC28 HEK-293T C84(1.04); C317(1.12)  LDD1527  [14]
 LDCM0289  AC29 HEK-293T C317(1.13)  LDD1528  [14]
 LDCM0290  AC3 HEK-293T C84(1.05); C317(0.98)  LDD1529  [14]
 LDCM0291  AC30 HEK-293T C84(1.01); C317(1.08); C88(0.97)  LDD1530  [14]
 LDCM0292  AC31 HEK-293T C84(0.95); C317(1.14)  LDD1531  [14]
 LDCM0293  AC32 HEK-293T C84(1.02)  LDD1532  [14]
 LDCM0294  AC33 HEK-293T C84(1.06); C317(0.93)  LDD1533  [14]
 LDCM0295  AC34 HEK-293T C84(1.03); C317(1.14)  LDD1534  [14]
 LDCM0296  AC35 HCT 116 C84(0.98)  LDD0613  [3]
 LDCM0297  AC36 HCT 116 C84(1.00)  LDD0614  [3]
 LDCM0298  AC37 HCT 116 C84(1.31)  LDD0615  [3]
 LDCM0299  AC38 HCT 116 C84(1.09)  LDD0616  [3]
 LDCM0300  AC39 HCT 116 C84(1.02)  LDD0617  [3]
 LDCM0301  AC4 HEK-293T C84(1.05); C317(1.07)  LDD1540  [14]
 LDCM0302  AC40 HCT 116 C84(1.04)  LDD0619  [3]
 LDCM0303  AC41 HCT 116 C84(1.13)  LDD0620  [3]
 LDCM0304  AC42 HCT 116 C84(1.23)  LDD0621  [3]
 LDCM0305  AC43 HCT 116 C84(1.00)  LDD0622  [3]
 LDCM0306  AC44 HCT 116 C84(1.25)  LDD0623  [3]
 LDCM0307  AC45 HCT 116 C84(1.27)  LDD0624  [3]
 LDCM0308  AC46 HCT 116 C84(0.82)  LDD0625  [3]
 LDCM0309  AC47 HCT 116 C84(0.81)  LDD0626  [3]
 LDCM0310  AC48 HCT 116 C84(0.83)  LDD0627  [3]
 LDCM0311  AC49 HCT 116 C84(0.86)  LDD0628  [3]
 LDCM0312  AC5 HEK-293T C317(1.09)  LDD1551  [14]
 LDCM0313  AC50 HCT 116 C84(0.82)  LDD0630  [3]
 LDCM0314  AC51 HCT 116 C84(0.87)  LDD0631  [3]
 LDCM0315  AC52 HCT 116 C84(0.82)  LDD0632  [3]
 LDCM0316  AC53 HCT 116 C84(1.03)  LDD0633  [3]
 LDCM0317  AC54 HCT 116 C84(0.82)  LDD0634  [3]
 LDCM0318  AC55 HCT 116 C84(1.15)  LDD0635  [3]
 LDCM0319  AC56 HCT 116 C84(0.82)  LDD0636  [3]
 LDCM0320  AC57 HCT 116 C84(1.35)  LDD0637  [3]
 LDCM0321  AC58 HCT 116 C84(1.23)  LDD0638  [3]
 LDCM0322  AC59 HCT 116 C84(1.09)  LDD0639  [3]
 LDCM0323  AC6 HEK-293T C84(0.89)  LDD0921  [3]
 LDCM0324  AC60 HCT 116 C84(0.91)  LDD0641  [3]
 LDCM0325  AC61 HCT 116 C84(1.10)  LDD0642  [3]
 LDCM0326  AC62 HCT 116 C84(1.19)  LDD0643  [3]
 LDCM0327  AC63 HCT 116 C84(1.04)  LDD0644  [3]
 LDCM0328  AC64 HCT 116 C84(1.09)  LDD0645  [3]
 LDCM0329  AC65 HCT 116 C84(1.20)  LDD0646  [3]
 LDCM0330  AC66 HCT 116 C84(1.16)  LDD0647  [3]
 LDCM0331  AC67 HCT 116 C84(1.02)  LDD0648  [3]
 LDCM0334  AC7 HEK-293T C84(1.02)  LDD0932  [3]
 LDCM0345  AC8 HEK-293T C84(0.75)  LDD0943  [3]
 LDCM0349  AC83 HEK-293T C84(1.10)  LDD0947  [3]
 LDCM0350  AC84 HEK-293T C84(0.97)  LDD0948  [3]
 LDCM0351  AC85 HEK-293T C84(0.89)  LDD0949  [3]
 LDCM0352  AC86 HEK-293T C84(0.81)  LDD0950  [3]
 LDCM0353  AC87 HEK-293T C84(0.97)  LDD0951  [3]
 LDCM0354  AC88 HEK-293T C84(0.92)  LDD0952  [3]
 LDCM0355  AC89 HEK-293T C84(0.85)  LDD0953  [3]
 LDCM0357  AC90 HEK-293T C84(0.88)  LDD0955  [3]
 LDCM0358  AC91 HEK-293T C84(1.07)  LDD0956  [3]
 LDCM0359  AC92 HEK-293T C84(1.06)  LDD0957  [3]
 LDCM0360  AC93 HEK-293T C84(1.12)  LDD0958  [3]
 LDCM0361  AC94 HEK-293T C84(0.86)  LDD0959  [3]
 LDCM0362  AC95 HEK-293T C84(1.06)  LDD0960  [3]
 LDCM0363  AC96 HEK-293T C84(0.97)  LDD0961  [3]
 LDCM0364  AC97 HEK-293T C84(1.21)  LDD0962  [3]
 LDCM0365  AC98 HEK-293T C84(1.07)  LDD0963  [3]
 LDCM0366  AC99 HEK-293T C84(1.16)  LDD0964  [3]
 LDCM0545  Acetamide MDA-MB-231 C84(0.50)  LDD2138  [2]
 LDCM0248  AKOS034007472 HEK-293T C84(0.92)  LDD0846  [3]
 LDCM0356  AKOS034007680 HEK-293T C84(0.74)  LDD0954  [3]
 LDCM0275  AKOS034007705 HEK-293T C84(0.76)  LDD0873  [3]
 LDCM0108  Chloroacetamide HeLa C277(0.00); C84(0.00); C243(0.00); H85(0.00)  LDD0222  [9]
 LDCM0367  CL1 HCT 116 C84(0.91)  LDD0684  [3]
 LDCM0368  CL10 HCT 116 C84(0.90)  LDD0685  [3]
 LDCM0369  CL100 HEK-293T C84(1.00); C317(0.97)  LDD1573  [14]
 LDCM0370  CL101 HEK-293T C84(0.88)  LDD0968  [3]
 LDCM0371  CL102 HEK-293T C84(0.91)  LDD0969  [3]
 LDCM0372  CL103 HEK-293T C84(1.26)  LDD0970  [3]
 LDCM0373  CL104 HEK-293T C84(1.12)  LDD0971  [3]
 LDCM0374  CL105 HEK-293T C84(0.94)  LDD0972  [3]
 LDCM0375  CL106 HEK-293T C84(0.82)  LDD0973  [3]
 LDCM0376  CL107 HEK-293T C84(0.87)  LDD0974  [3]
 LDCM0377  CL108 HEK-293T C84(1.32)  LDD0975  [3]
 LDCM0378  CL109 HEK-293T C84(1.05)  LDD0976  [3]
 LDCM0379  CL11 HCT 116 C84(0.74)  LDD0696  [3]
 LDCM0380  CL110 HEK-293T C84(0.88)  LDD0978  [3]
 LDCM0381  CL111 HEK-293T C84(0.81)  LDD0979  [3]
 LDCM0382  CL112 HEK-293T C84(1.06); C317(1.03)  LDD1586  [14]
 LDCM0383  CL113 HEK-293T C84(1.04); C317(1.09)  LDD1587  [14]
 LDCM0384  CL114 HEK-293T C317(1.06)  LDD1588  [14]
 LDCM0385  CL115 HEK-293T C84(1.10); C317(1.03)  LDD1589  [14]
 LDCM0386  CL116 HEK-293T C84(0.85); C317(0.97)  LDD1590  [14]
 LDCM0387  CL117 HCT 116 C84(1.03)  LDD0704  [3]
 LDCM0388  CL118 HCT 116 C84(0.98)  LDD0705  [3]
 LDCM0389  CL119 HCT 116 C84(1.02)  LDD0706  [3]
 LDCM0390  CL12 HCT 116 C84(1.00)  LDD0707  [3]
 LDCM0391  CL120 HCT 116 C84(1.11)  LDD0708  [3]
 LDCM0392  CL121 HCT 116 C84(0.91)  LDD0709  [3]
 LDCM0393  CL122 HCT 116 C84(1.08)  LDD0710  [3]
 LDCM0394  CL123 HCT 116 C84(0.83)  LDD0711  [3]
 LDCM0395  CL124 HCT 116 C84(0.85)  LDD0712  [3]
 LDCM0396  CL125 HCT 116 C84(1.11)  LDD0713  [3]
 LDCM0397  CL126 HCT 116 C84(0.92)  LDD0714  [3]
 LDCM0398  CL127 HCT 116 C84(1.04)  LDD0715  [3]
 LDCM0399  CL128 HCT 116 C84(1.14)  LDD0716  [3]
 LDCM0400  CL13 HCT 116 C84(1.00)  LDD0717  [3]
 LDCM0401  CL14 HCT 116 C84(0.83)  LDD0718  [3]
 LDCM0402  CL15 HCT 116 C84(0.88)  LDD0719  [3]
 LDCM0403  CL16 HEK-293T C84(1.01)  LDD1001  [3]
 LDCM0404  CL17 HCT 116 C84(0.90)  LDD0721  [3]
 LDCM0405  CL18 HCT 116 C84(0.95)  LDD0722  [3]
 LDCM0406  CL19 HCT 116 C84(1.09)  LDD0723  [3]
 LDCM0407  CL2 HCT 116 C84(0.85)  LDD0724  [3]
 LDCM0408  CL20 HCT 116 C84(0.84)  LDD0725  [3]
 LDCM0409  CL21 HCT 116 C84(0.97)  LDD0726  [3]
 LDCM0410  CL22 HCT 116 C84(0.92)  LDD0727  [3]
 LDCM0411  CL23 HCT 116 C84(1.11)  LDD0728  [3]
 LDCM0412  CL24 HCT 116 C84(0.89)  LDD0729  [3]
 LDCM0413  CL25 HCT 116 C84(1.01)  LDD0730  [3]
 LDCM0414  CL26 HCT 116 C84(1.02)  LDD0731  [3]
 LDCM0415  CL27 HCT 116 C84(0.98)  LDD0732  [3]
 LDCM0416  CL28 HCT 116 C84(0.95)  LDD0733  [3]
 LDCM0417  CL29 HCT 116 C84(0.95)  LDD0734  [3]
 LDCM0418  CL3 HCT 116 C84(0.81)  LDD0735  [3]
 LDCM0419  CL30 HCT 116 C84(1.25)  LDD0736  [3]
 LDCM0420  CL31 HCT 116 C84(1.02)  LDD0737  [3]
 LDCM0421  CL32 HCT 116 C84(0.81)  LDD0738  [3]
 LDCM0422  CL33 HCT 116 C84(0.73)  LDD0739  [3]
 LDCM0423  CL34 HCT 116 C84(0.79)  LDD0740  [3]
 LDCM0424  CL35 HCT 116 C84(0.86)  LDD0741  [3]
 LDCM0425  CL36 HCT 116 C84(0.82)  LDD0742  [3]
 LDCM0426  CL37 HCT 116 C84(0.95)  LDD0743  [3]
 LDCM0428  CL39 HCT 116 C84(0.78)  LDD0745  [3]
 LDCM0429  CL4 HCT 116 C84(0.88)  LDD0746  [3]
 LDCM0430  CL40 HCT 116 C84(0.62)  LDD0747  [3]
 LDCM0431  CL41 HCT 116 C84(0.70)  LDD0748  [3]
 LDCM0432  CL42 HCT 116 C84(0.70)  LDD0749  [3]
 LDCM0433  CL43 HCT 116 C84(0.68)  LDD0750  [3]
 LDCM0434  CL44 HCT 116 C84(0.73)  LDD0751  [3]
 LDCM0435  CL45 HCT 116 C84(0.65)  LDD0752  [3]
 LDCM0436  CL46 HCT 116 C84(1.19)  LDD0753  [3]
 LDCM0437  CL47 HCT 116 C84(0.92)  LDD0754  [3]
 LDCM0438  CL48 HCT 116 C84(1.04)  LDD0755  [3]
 LDCM0439  CL49 HCT 116 C84(1.20)  LDD0756  [3]
 LDCM0440  CL5 HCT 116 C84(0.83)  LDD0757  [3]
 LDCM0441  CL50 HCT 116 C84(1.18)  LDD0758  [3]
 LDCM0442  CL51 HCT 116 C84(1.09)  LDD0759  [3]
 LDCM0443  CL52 HCT 116 C84(1.17)  LDD0760  [3]
 LDCM0444  CL53 HCT 116 C84(0.53)  LDD0761  [3]
 LDCM0445  CL54 HCT 116 C84(1.14)  LDD0762  [3]
 LDCM0446  CL55 HCT 116 C84(1.09)  LDD0763  [3]
 LDCM0447  CL56 HCT 116 C84(0.87)  LDD0764  [3]
 LDCM0448  CL57 HCT 116 C84(0.89)  LDD0765  [3]
 LDCM0449  CL58 HCT 116 C84(1.30)  LDD0766  [3]
 LDCM0450  CL59 HCT 116 C84(1.03)  LDD0767  [3]
 LDCM0451  CL6 HCT 116 C84(0.86)  LDD0768  [3]
 LDCM0452  CL60 HCT 116 C84(1.19)  LDD0769  [3]
 LDCM0453  CL61 HCT 116 C84(1.29)  LDD0770  [3]
 LDCM0454  CL62 HCT 116 C84(1.35)  LDD0771  [3]
 LDCM0455  CL63 HCT 116 C84(1.35)  LDD0772  [3]
 LDCM0456  CL64 HCT 116 C84(1.05)  LDD0773  [3]
 LDCM0457  CL65 HCT 116 C84(1.21)  LDD0774  [3]
 LDCM0458  CL66 HCT 116 C84(1.24)  LDD0775  [3]
 LDCM0459  CL67 HCT 116 C84(1.35)  LDD0776  [3]
 LDCM0460  CL68 HCT 116 C84(1.20)  LDD0777  [3]
 LDCM0461  CL69 HCT 116 C84(1.25)  LDD0778  [3]
 LDCM0462  CL7 HCT 116 C84(0.94)  LDD0779  [3]
 LDCM0463  CL70 HCT 116 C84(1.18)  LDD0780  [3]
 LDCM0464  CL71 HCT 116 C84(1.65)  LDD0781  [3]
 LDCM0465  CL72 HCT 116 C84(1.45)  LDD0782  [3]
 LDCM0466  CL73 HCT 116 C84(1.13)  LDD0783  [3]
 LDCM0467  CL74 HCT 116 C84(1.33)  LDD0784  [3]
 LDCM0469  CL76 HCT 116 C84(0.95)  LDD0786  [3]
 LDCM0470  CL77 HCT 116 C84(1.01)  LDD0787  [3]
 LDCM0471  CL78 HCT 116 C84(0.99)  LDD0788  [3]
 LDCM0472  CL79 HCT 116 C84(1.01)  LDD0789  [3]
 LDCM0473  CL8 HCT 116 C84(0.64)  LDD0790  [3]
 LDCM0474  CL80 HCT 116 C84(1.22)  LDD0791  [3]
 LDCM0475  CL81 HCT 116 C84(1.15)  LDD0792  [3]
 LDCM0476  CL82 HCT 116 C84(1.06)  LDD0793  [3]
 LDCM0477  CL83 HCT 116 C84(1.05)  LDD0794  [3]
 LDCM0478  CL84 HCT 116 C84(1.03)  LDD0795  [3]
 LDCM0479  CL85 HCT 116 C84(0.86)  LDD0796  [3]
 LDCM0480  CL86 HCT 116 C84(0.93)  LDD0797  [3]
 LDCM0481  CL87 HCT 116 C84(0.94)  LDD0798  [3]
 LDCM0482  CL88 HCT 116 C84(0.94)  LDD0799  [3]
 LDCM0483  CL89 HCT 116 C84(1.28)  LDD0800  [3]
 LDCM0484  CL9 HCT 116 C84(0.95)  LDD0801  [3]
 LDCM0485  CL90 HCT 116 C84(0.79)  LDD0802  [3]
 LDCM0486  CL91 HEK-293T C84(0.82); C317(1.08)  LDD1689  [14]
 LDCM0487  CL92 HEK-293T C84(1.08); C317(1.10)  LDD1690  [14]
 LDCM0488  CL93 HEK-293T C317(1.14)  LDD1691  [14]
 LDCM0489  CL94 HEK-293T C84(1.09); C317(1.21); C88(1.08)  LDD1692  [14]
 LDCM0490  CL95 HEK-293T C84(1.27); C317(1.11)  LDD1693  [14]
 LDCM0491  CL96 HEK-293T C84(0.89)  LDD1694  [14]
 LDCM0492  CL97 HEK-293T C84(0.99); C317(1.13)  LDD1695  [14]
 LDCM0493  CL98 HEK-293T C317(1.03)  LDD1696  [14]
 LDCM0494  CL99 HEK-293T C84(0.99); C317(1.02)  LDD1697  [14]
 LDCM0495  E2913 HEK-293T C84(1.21); C317(1.04)  LDD1698  [14]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C317(3.91); C84(2.31)  LDD1702  [2]
 LDCM0468  Fragment33 HCT 116 C84(1.18)  LDD0785  [3]
 LDCM0427  Fragment51 HCT 116 C84(0.91)  LDD0744  [3]
 LDCM0107  IAA HeLa C277(0.00); C247(0.00); H85(0.00); C243(0.00)  LDD0221  [9]
 LDCM0022  KB02 HCT 116 C84(1.67)  LDD0080  [3]
 LDCM0023  KB03 HCT 116 C84(2.55)  LDD0081  [3]
 LDCM0024  KB05 HCT 116 C84(1.79)  LDD0082  [3]
 LDCM0109  NEM HeLa H169(0.00); H85(0.00)  LDD0223  [9]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C84(0.95)  LDD2089  [2]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C84(1.08)  LDD2093  [2]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C84(1.04)  LDD2099  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C84(0.53)  LDD2104  [2]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C84(0.62)  LDD2106  [2]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C84(1.07)  LDD2107  [2]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C84(1.23)  LDD2109  [2]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C84(1.74)  LDD2119  [2]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C84(1.02)  LDD2123  [2]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C84(1.03)  LDD2125  [2]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C84(1.27)  LDD2127  [2]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C84(0.48)  LDD2134  [2]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C84(1.85)  LDD2136  [2]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C84(1.07)  LDD2137  [2]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C84(1.18)  LDD2140  [2]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C84(2.28)  LDD2144  [2]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C84(1.03)  LDD2146  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
4 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
5 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
8 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402