Details of the Target

General Information of Target

Target ID LDTP05842
Target Name C-terminal-binding protein 1 (CTBP1)
Gene Name CTBP1
Gene ID 1487
Synonyms
CTBP; C-terminal-binding protein 1; CtBP1; EC 1.1.1.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSSHLLNKGLPLGVRPPIMNGPLHPRPLVALLDGRDCTVEMPILKDVATVAFCDAQSTQ
EIHEKVLNEAVGALMYHTITLTREDLEKFKALRIIVRIGSGFDNIDIKSAGDLGIAVCNV
PAASVEETADSTLCHILNLYRRATWLHQALREGTRVQSVEQIREVASGAARIRGETLGII
GLGRVGQAVALRAKAFGFNVLFYDPYLSDGVERALGLQRVSTLQDLLFHSDCVTLHCGLN
EHNHHLINDFTVKQMRQGAFLVNTARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFS
QGPLKDAPNLICTPHAAWYSEQASIEMREEAAREIRRAITGRIPDSLKNCVNKDHLTAAT
HWASMDPAVVHPELNGAAYRYPPGVVGVAPTGIPAAVEGIVPSAMSLSHGLPPVAHPPHA
PSPGQTVKPEADRDHASDQL
Target Bioclass
Enzyme
Family
D-isomer specific 2-hydroxyacid dehydrogenase family
Subcellular location
Cytoplasm
Function
Corepressor targeting diverse transcription regulators such as GLIS2 or BCL6. Has dehydrogenase activity. Involved in controlling the equilibrium between tubular and stacked structures in the Golgi complex. Functions in brown adipose tissue (BAT) differentiation.
Uniprot ID
Q13363
Ensemble ID
ENST00000290921.10
HGNC ID
HGNC:2494

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.78  LDD0402  [1]
C-Sul
 Probe Info  		2.75  LDD0066  [2]
TH211
 Probe Info  		Y319(20.00); Y206(10.59); Y203(9.31)  LDD0257  [3]
STPyne
 Probe Info  		K273(10.00)  LDD0277  [4]
IPM
 Probe Info  		N.A.  LDD0241  [5]
DBIA
 Probe Info  		C312(1.42)  LDD3314  [6]
BTD
 Probe Info  		C350(0.30); C38(0.73)  LDD2100  [7]
AHL-Pu-1
 Probe Info  		C38(20.00)  LDD0168  [8]
HHS-475
 Probe Info  		Y206(1.74)  LDD0264  [9]
AMP probe
 Probe Info  		N.A.  LDD0200  [10]
ATP probe
 Probe Info  		N.A.  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C312(0.00); C38(0.00); C54(0.00); C118(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [12]
IPIAA_L
 Probe Info  		C38(0.00); C118(0.00)  LDD0031  [13]
Lodoacetamide azide
 Probe Info  		C312(0.00); C38(0.00); C54(0.00); C350(0.00)  LDD0037  [11]
NAIA_4
 Probe Info  		C134(0.00); C312(0.00)  LDD2226  [14]
TFBX
 Probe Info  		N.A.  LDD0027  [15]
Phosphinate-6
 Probe Info  		C134(0.00); C237(0.00)  LDD0018  [16]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
Methacrolein
 Probe Info  		N.A.  LDD0218  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
NAIA_5
 Probe Info  		C54(0.00); C134(0.00); C118(0.00)  LDD2223  [14]
PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C166
 Probe Info  		6.73  LDD1846  [19]
FFF probe3
 Probe Info  		7.30  LDD0464  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C350(0.42)  LDD2142  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C54(1.67)  LDD2117  [7]
 LDCM0025  4SU-RNA HEK-293T C38(20.00)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C38(11.23)  LDD0169  [8]
 LDCM0214  AC1 HEK-293T C54(0.78); C312(1.15); C134(1.03)  LDD1507  [21]
 LDCM0215  AC10 PaTu 8988t C54(0.57); C118(0.75); C134(0.75)  LDD1094  [22]
 LDCM0226  AC11 PaTu 8988t C54(0.85); C118(0.65); C134(0.65)  LDD1105  [22]
 LDCM0237  AC12 PaTu 8988t C54(1.14); C118(0.62); C134(0.62)  LDD1116  [22]
 LDCM0259  AC14 PaTu 8988t C54(0.76); C118(1.40); C134(1.40)  LDD1138  [22]
 LDCM0270  AC15 PaTu 8988t C54(0.68); C118(0.80); C134(0.80)  LDD1149  [22]
 LDCM0276  AC17 PaTu 8988t C118(0.64); C134(0.64)  LDD1155  [22]
 LDCM0277  AC18 PaTu 8988t C118(0.57); C134(0.57)  LDD1156  [22]
 LDCM0278  AC19 PaTu 8988t C118(0.77); C134(0.77)  LDD1157  [22]
 LDCM0279  AC2 HEK-293T C54(0.99); C312(1.11); C134(1.07)  LDD1518  [21]
 LDCM0280  AC20 PaTu 8988t C118(0.45); C134(0.45)  LDD1159  [22]
 LDCM0281  AC21 PaTu 8988t C118(0.47); C134(0.47)  LDD1160  [22]
 LDCM0282  AC22 PaTu 8988t C118(0.39); C134(0.39)  LDD1161  [22]
 LDCM0283  AC23 PaTu 8988t C118(0.45); C134(0.45)  LDD1162  [22]
 LDCM0284  AC24 PaTu 8988t C118(0.34); C134(0.34)  LDD1163  [22]
 LDCM0285  AC25 PaTu 8988t C54(0.97)  LDD1164  [22]
 LDCM0286  AC26 PaTu 8988t C54(1.18)  LDD1165  [22]
 LDCM0287  AC27 PaTu 8988t C54(1.16)  LDD1166  [22]
 LDCM0288  AC28 PaTu 8988t C54(1.02)  LDD1167  [22]
 LDCM0289  AC29 PaTu 8988t C54(0.93)  LDD1168  [22]
 LDCM0290  AC3 HEK-293T C54(0.97); C312(0.80); C134(1.05)  LDD1529  [21]
 LDCM0291  AC30 PaTu 8988t C54(0.74)  LDD1170  [22]
 LDCM0292  AC31 PaTu 8988t C54(1.14)  LDD1171  [22]
 LDCM0293  AC32 PaTu 8988t C54(0.94)  LDD1172  [22]
 LDCM0294  AC33 PaTu 8988t C54(0.83)  LDD1173  [22]
 LDCM0295  AC34 PaTu 8988t C54(1.19)  LDD1174  [22]
 LDCM0296  AC35 HEK-293T C54(0.94); C312(0.79); C134(0.95)  LDD1535  [21]
 LDCM0297  AC36 HEK-293T C54(1.06); C312(1.00); C134(1.04)  LDD1536  [21]
 LDCM0298  AC37 HEK-293T C54(0.98); C312(0.97); C134(1.00)  LDD1537  [21]
 LDCM0299  AC38 HEK-293T C54(0.88); C312(1.10); C134(1.28)  LDD1538  [21]
 LDCM0300  AC39 HEK-293T C54(1.03); C312(0.75); C134(1.18)  LDD1539  [21]
 LDCM0301  AC4 HEK-293T C54(1.09); C312(1.26); C134(1.01)  LDD1540  [21]
 LDCM0302  AC40 HEK-293T C54(0.90); C312(0.87); C134(0.97)  LDD1541  [21]
 LDCM0303  AC41 HEK-293T C54(0.85); C312(1.06); C134(0.99)  LDD1542  [21]
 LDCM0304  AC42 HEK-293T C54(0.91); C312(0.89); C134(1.16)  LDD1543  [21]
 LDCM0305  AC43 HEK-293T C54(0.98); C312(0.83); C134(0.98)  LDD1544  [21]
 LDCM0306  AC44 HEK-293T C54(1.03); C312(1.00); C134(0.88)  LDD1545  [21]
 LDCM0307  AC45 HEK-293T C54(0.91); C312(0.94); C134(0.98)  LDD1546  [21]
 LDCM0308  AC46 PaTu 8988t C118(0.76); C134(0.76)  LDD1187  [22]
 LDCM0309  AC47 PaTu 8988t C118(0.65); C134(0.65)  LDD1188  [22]
 LDCM0310  AC48 PaTu 8988t C118(0.40); C134(0.40)  LDD1189  [22]
 LDCM0311  AC49 PaTu 8988t C118(0.52); C134(0.52)  LDD1190  [22]
 LDCM0312  AC5 HEK-293T C54(0.95); C312(1.09); C134(1.06)  LDD1551  [21]
 LDCM0313  AC50 PaTu 8988t C118(0.59); C134(0.59)  LDD1192  [22]
 LDCM0314  AC51 PaTu 8988t C118(0.69); C134(0.69)  LDD1193  [22]
 LDCM0315  AC52 PaTu 8988t C118(0.56); C134(0.56)  LDD1194  [22]
 LDCM0316  AC53 PaTu 8988t C118(0.41); C134(0.41)  LDD1195  [22]
 LDCM0317  AC54 PaTu 8988t C118(0.36); C134(0.36)  LDD1196  [22]
 LDCM0318  AC55 PaTu 8988t C118(0.54); C134(0.54)  LDD1197  [22]
 LDCM0319  AC56 PaTu 8988t C118(0.55); C134(0.55)  LDD1198  [22]
 LDCM0320  AC57 HEK-293T C54(0.85); C312(0.95); C134(1.01)  LDD1559  [21]
 LDCM0321  AC58 HEK-293T C54(1.01); C312(1.01); C134(0.92)  LDD1560  [21]
 LDCM0322  AC59 HEK-293T C54(0.99); C312(0.87); C134(1.14)  LDD1561  [21]
 LDCM0323  AC6 PaTu 8988t C54(1.04); C118(0.70); C134(0.70)  LDD1202  [22]
 LDCM0324  AC60 HEK-293T C54(1.03); C312(0.91); C134(1.04)  LDD1563  [21]
 LDCM0325  AC61 HEK-293T C54(0.93); C312(1.06); C134(0.97)  LDD1564  [21]
 LDCM0326  AC62 HEK-293T C54(1.01); C312(1.29); C134(1.01)  LDD1565  [21]
 LDCM0327  AC63 HEK-293T C54(1.01); C312(0.91); C134(1.05)  LDD1566  [21]
 LDCM0328  AC64 HEK-293T C54(0.96); C312(1.08); C134(1.04)  LDD1567  [21]
 LDCM0334  AC7 PaTu 8988t C54(1.84); C118(1.00); C134(1.00)  LDD1213  [22]
 LDCM0345  AC8 PaTu 8988t C54(1.09); C118(1.58); C134(1.58)  LDD1224  [22]
 LDCM0248  AKOS034007472 PaTu 8988t C54(0.85); C118(0.83); C134(0.83)  LDD1127  [22]
 LDCM0356  AKOS034007680 PaTu 8988t C54(0.78); C118(0.47); C134(0.47)  LDD1235  [22]
 LDCM0275  AKOS034007705 PaTu 8988t C54(0.80); C118(0.64); C134(0.64)  LDD1154  [22]
 LDCM0156  Aniline NCI-H1299 9.34  LDD0403  [1]
 LDCM0108  Chloroacetamide HeLa C54(0.00); C38(0.00)  LDD0222  [17]
 LDCM0367  CL1 PaTu 8988t C54(0.73)  LDD1246  [22]
 LDCM0368  CL10 PaTu 8988t C54(0.46)  LDD1247  [22]
 LDCM0369  CL100 HEK-293T C54(0.98); C312(1.16); C134(1.19)  LDD1573  [21]
 LDCM0370  CL101 PaTu 8988t C54(1.21); C118(0.85); C134(0.85)  LDD1249  [22]
 LDCM0371  CL102 PaTu 8988t C54(1.69); C118(0.91); C134(0.91)  LDD1250  [22]
 LDCM0372  CL103 PaTu 8988t C54(0.77); C118(0.68); C134(0.68)  LDD1251  [22]
 LDCM0373  CL104 PaTu 8988t C54(0.94); C118(0.97); C134(0.97)  LDD1252  [22]
 LDCM0374  CL105 PaTu 8988t C118(0.92); C134(0.92)  LDD1253  [22]
 LDCM0375  CL106 PaTu 8988t C118(0.83); C134(0.83)  LDD1254  [22]
 LDCM0376  CL107 PaTu 8988t C118(0.72); C134(0.72)  LDD1255  [22]
 LDCM0377  CL108 PaTu 8988t C118(0.71); C134(0.71)  LDD1256  [22]
 LDCM0378  CL109 PaTu 8988t C118(0.53); C134(0.53)  LDD1257  [22]
 LDCM0379  CL11 PaTu 8988t C54(0.57)  LDD1258  [22]
 LDCM0380  CL110 PaTu 8988t C118(0.57); C134(0.57)  LDD1259  [22]
 LDCM0381  CL111 PaTu 8988t C118(0.54); C134(0.54)  LDD1260  [22]
 LDCM0382  CL112 PaTu 8988t C54(1.14)  LDD1261  [22]
 LDCM0383  CL113 PaTu 8988t C54(1.10)  LDD1262  [22]
 LDCM0384  CL114 PaTu 8988t C54(1.47)  LDD1263  [22]
 LDCM0385  CL115 PaTu 8988t C54(0.90)  LDD1264  [22]
 LDCM0386  CL116 PaTu 8988t C54(0.93)  LDD1265  [22]
 LDCM0387  CL117 HEK-293T C54(0.98); C312(1.23); C134(1.01)  LDD1591  [21]
 LDCM0388  CL118 HEK-293T C54(0.94); C312(1.09); C134(0.96)  LDD1592  [21]
 LDCM0389  CL119 HEK-293T C54(1.11); C312(0.93); C134(0.94)  LDD1593  [21]
 LDCM0390  CL12 PaTu 8988t C54(0.58)  LDD1269  [22]
 LDCM0391  CL120 HEK-293T C54(1.00); C312(1.09); C134(0.88)  LDD1595  [21]
 LDCM0392  CL121 PaTu 8988t C118(0.50); C134(0.50)  LDD1271  [22]
 LDCM0393  CL122 PaTu 8988t C118(0.59); C134(0.59)  LDD1272  [22]
 LDCM0394  CL123 PaTu 8988t C118(0.40); C134(0.40)  LDD1273  [22]
 LDCM0395  CL124 PaTu 8988t C118(0.52); C134(0.52)  LDD1274  [22]
 LDCM0396  CL125 HEK-293T C54(0.96); C312(1.14); C134(0.78)  LDD1600  [21]
 LDCM0397  CL126 HEK-293T C54(0.92); C312(1.08); C134(0.89)  LDD1601  [21]
 LDCM0398  CL127 HEK-293T C54(1.19); C312(1.08); C134(1.00)  LDD1602  [21]
 LDCM0399  CL128 HEK-293T C54(1.10); C312(1.18); C134(0.89)  LDD1603  [21]
 LDCM0400  CL13 PaTu 8988t C54(0.44)  LDD1279  [22]
 LDCM0401  CL14 PaTu 8988t C54(0.54)  LDD1280  [22]
 LDCM0402  CL15 PaTu 8988t C54(0.53)  LDD1281  [22]
 LDCM0403  CL16 PaTu 8988t C54(0.99)  LDD1282  [22]
 LDCM0404  CL17 PaTu 8988t C54(0.70)  LDD1283  [22]
 LDCM0405  CL18 PaTu 8988t C54(0.60)  LDD1284  [22]
 LDCM0406  CL19 PaTu 8988t C54(0.59)  LDD1285  [22]
 LDCM0407  CL2 PaTu 8988t C54(0.64)  LDD1286  [22]
 LDCM0408  CL20 PaTu 8988t C54(0.54)  LDD1287  [22]
 LDCM0409  CL21 PaTu 8988t C54(0.38)  LDD1288  [22]
 LDCM0410  CL22 PaTu 8988t C54(0.46)  LDD1289  [22]
 LDCM0411  CL23 PaTu 8988t C54(0.32)  LDD1290  [22]
 LDCM0412  CL24 PaTu 8988t C54(0.37)  LDD1291  [22]
 LDCM0413  CL25 PaTu 8988t C54(0.43)  LDD1292  [22]
 LDCM0414  CL26 PaTu 8988t C54(0.38)  LDD1293  [22]
 LDCM0415  CL27 PaTu 8988t C54(0.60)  LDD1294  [22]
 LDCM0416  CL28 PaTu 8988t C54(0.30)  LDD1295  [22]
 LDCM0417  CL29 PaTu 8988t C54(0.27)  LDD1296  [22]
 LDCM0418  CL3 PaTu 8988t C54(0.42)  LDD1297  [22]
 LDCM0419  CL30 PaTu 8988t C54(0.38)  LDD1298  [22]
 LDCM0420  CL31 HEK-293T C54(1.02); C312(0.41); C134(0.93)  LDD1624  [21]
 LDCM0421  CL32 HEK-293T C54(1.05); C312(0.51); C134(0.93)  LDD1625  [21]
 LDCM0422  CL33 HEK-293T C54(0.88); C312(0.53); C134(0.84)  LDD1626  [21]
 LDCM0423  CL34 HEK-293T C54(1.07); C312(0.39); C134(0.86)  LDD1627  [21]
 LDCM0424  CL35 HEK-293T C54(1.14); C312(0.34); C134(0.90)  LDD1628  [21]
 LDCM0425  CL36 HEK-293T C54(1.00); C312(0.50); C134(0.95)  LDD1629  [21]
 LDCM0426  CL37 HEK-293T C54(1.00); C312(1.07); C134(0.84)  LDD1630  [21]
 LDCM0428  CL39 HEK-293T C54(1.08); C312(0.91); C134(1.01)  LDD1632  [21]
 LDCM0429  CL4 PaTu 8988t C54(0.41)  LDD1308  [22]
 LDCM0430  CL40 HEK-293T C54(1.01); C312(1.00); C134(1.00)  LDD1634  [21]
 LDCM0431  CL41 HEK-293T C54(0.88); C312(0.80); C134(0.95)  LDD1635  [21]
 LDCM0432  CL42 HEK-293T C54(0.91); C312(0.62); C134(0.92)  LDD1636  [21]
 LDCM0433  CL43 HEK-293T C54(1.02); C312(0.51); C134(0.93)  LDD1637  [21]
 LDCM0434  CL44 HEK-293T C54(1.02); C312(0.52); C134(0.98)  LDD1638  [21]
 LDCM0435  CL45 HEK-293T C54(0.88); C312(0.56); C134(0.92)  LDD1639  [21]
 LDCM0436  CL46 PaTu 8988t C118(1.20); C134(1.20)  LDD1315  [22]
 LDCM0437  CL47 PaTu 8988t C118(0.78); C134(0.78)  LDD1316  [22]
 LDCM0438  CL48 PaTu 8988t C118(1.36); C134(1.36)  LDD1317  [22]
 LDCM0439  CL49 PaTu 8988t C118(1.60); C134(1.60)  LDD1318  [22]
 LDCM0440  CL5 PaTu 8988t C54(0.40)  LDD1319  [22]
 LDCM0441  CL50 PaTu 8988t C118(0.86); C134(0.86)  LDD1320  [22]
 LDCM0442  CL51 PaTu 8988t C118(0.95); C134(0.95)  LDD1321  [22]
 LDCM0443  CL52 PaTu 8988t C118(0.76); C134(0.76)  LDD1322  [22]
 LDCM0444  CL53 PaTu 8988t C118(0.58); C134(0.58)  LDD1323  [22]
 LDCM0445  CL54 PaTu 8988t C118(0.74); C134(0.74)  LDD1324  [22]
 LDCM0446  CL55 PaTu 8988t C118(0.99); C134(0.99)  LDD1325  [22]
 LDCM0447  CL56 PaTu 8988t C118(0.36); C134(0.36)  LDD1326  [22]
 LDCM0448  CL57 PaTu 8988t C118(0.72); C134(0.72)  LDD1327  [22]
 LDCM0449  CL58 PaTu 8988t C118(0.70); C134(0.70)  LDD1328  [22]
 LDCM0450  CL59 PaTu 8988t C118(0.86); C134(0.86)  LDD1329  [22]
 LDCM0451  CL6 PaTu 8988t C54(0.62)  LDD1330  [22]
 LDCM0452  CL60 PaTu 8988t C118(0.71); C134(0.71)  LDD1331  [22]
 LDCM0453  CL61 PaTu 8988t C118(0.55); C134(0.55)  LDD1332  [22]
 LDCM0454  CL62 PaTu 8988t C118(1.77); C134(1.77)  LDD1333  [22]
 LDCM0455  CL63 PaTu 8988t C118(1.78); C134(1.78)  LDD1334  [22]
 LDCM0456  CL64 PaTu 8988t C118(1.16); C134(1.16)  LDD1335  [22]
 LDCM0457  CL65 PaTu 8988t C118(1.00); C134(1.00)  LDD1336  [22]
 LDCM0458  CL66 PaTu 8988t C118(1.34); C134(1.34)  LDD1337  [22]
 LDCM0459  CL67 PaTu 8988t C118(0.77); C134(0.77)  LDD1338  [22]
 LDCM0460  CL68 PaTu 8988t C118(0.51); C134(0.51)  LDD1339  [22]
 LDCM0461  CL69 PaTu 8988t C118(0.53); C134(0.53)  LDD1340  [22]
 LDCM0462  CL7 PaTu 8988t C54(0.52)  LDD1341  [22]
 LDCM0463  CL70 PaTu 8988t C118(0.54); C134(0.54)  LDD1342  [22]
 LDCM0464  CL71 PaTu 8988t C118(1.32); C134(1.32)  LDD1343  [22]
 LDCM0465  CL72 PaTu 8988t C118(1.65); C134(1.65)  LDD1344  [22]
 LDCM0466  CL73 PaTu 8988t C118(0.66); C134(0.66)  LDD1345  [22]
 LDCM0467  CL74 PaTu 8988t C118(0.58); C134(0.58)  LDD1346  [22]
 LDCM0469  CL76 HEK-293T C54(1.01); C312(1.01); C134(0.90)  LDD1672  [21]
 LDCM0470  CL77 HEK-293T C54(0.80); C312(0.78); C134(0.99)  LDD1673  [21]
 LDCM0471  CL78 HEK-293T C54(1.07); C312(0.66); C134(0.92)  LDD1674  [21]
 LDCM0472  CL79 HEK-293T C54(1.10); C312(0.64); C134(0.82)  LDD1675  [21]
 LDCM0473  CL8 PaTu 8988t C54(0.33)  LDD1352  [22]
 LDCM0474  CL80 HEK-293T C54(1.10); C312(0.59); C134(0.83)  LDD1677  [21]
 LDCM0475  CL81 HEK-293T C54(0.99); C312(0.56); C134(0.85)  LDD1678  [21]
 LDCM0476  CL82 HEK-293T C54(1.01); C312(0.45); C134(0.82)  LDD1679  [21]
 LDCM0477  CL83 HEK-293T C54(1.08); C312(0.40); C134(0.86)  LDD1680  [21]
 LDCM0478  CL84 HEK-293T C54(0.96); C312(0.64); C134(0.93)  LDD1681  [21]
 LDCM0479  CL85 HEK-293T C54(1.06); C312(1.34); C134(0.74)  LDD1682  [21]
 LDCM0480  CL86 HEK-293T C54(0.95); C312(1.37); C134(1.09)  LDD1683  [21]
 LDCM0481  CL87 HEK-293T C54(1.15); C312(0.95); C134(0.78)  LDD1684  [21]
 LDCM0482  CL88 HEK-293T C54(1.08); C312(1.27); C134(1.08)  LDD1685  [21]
 LDCM0483  CL89 HEK-293T C54(0.83); C312(1.03); C134(0.88)  LDD1686  [21]
 LDCM0484  CL9 PaTu 8988t C54(0.50)  LDD1363  [22]
 LDCM0485  CL90 HEK-293T C54(0.68); C312(0.66); C134(0.87)  LDD1688  [21]
 LDCM0486  CL91 HEK-293T C54(1.06); C312(0.66); C134(0.92)  LDD1689  [21]
 LDCM0487  CL92 HEK-293T C54(1.01); C312(0.75); C134(0.88)  LDD1690  [21]
 LDCM0488  CL93 HEK-293T C54(1.01); C312(0.66); C134(0.94)  LDD1691  [21]
 LDCM0489  CL94 HEK-293T C54(0.98); C312(0.50); C134(0.91)  LDD1692  [21]
 LDCM0490  CL95 HEK-293T C54(0.87); C312(0.41); C134(0.91)  LDD1693  [21]
 LDCM0491  CL96 HEK-293T C54(1.04); C312(0.73); C134(0.92)  LDD1694  [21]
 LDCM0492  CL97 HEK-293T C54(0.95); C312(1.07); C134(0.97)  LDD1695  [21]
 LDCM0493  CL98 HEK-293T C54(0.95); C312(1.10); C134(1.02)  LDD1696  [21]
 LDCM0494  CL99 HEK-293T C54(1.09); C312(1.09); C134(0.92)  LDD1697  [21]
 LDCM0495  E2913 HEK-293T C54(1.22); C312(1.03); C134(0.93)  LDD1698  [21]
 LDCM0625  F8 Ramos C38(0.86); C54(0.80)  LDD2187  [23]
 LDCM0572  Fragment10 Ramos C38(0.98); C54(0.57)  LDD2189  [23]
 LDCM0573  Fragment11 Ramos C38(0.38); C54(0.88)  LDD2190  [23]
 LDCM0574  Fragment12 Ramos C38(1.30); C54(0.64)  LDD2191  [23]
 LDCM0576  Fragment14 Ramos C38(1.32); C54(0.35)  LDD2193  [23]
 LDCM0579  Fragment20 Ramos C38(0.86); C54(0.72)  LDD2194  [23]
 LDCM0580  Fragment21 Ramos C54(1.02)  LDD2195  [23]
 LDCM0582  Fragment23 Ramos C38(1.15); C54(1.64)  LDD2196  [23]
 LDCM0578  Fragment27 Ramos C54(0.92)  LDD2197  [23]
 LDCM0586  Fragment28 Ramos C54(1.04)  LDD2198  [23]
 LDCM0588  Fragment30 Ramos C38(1.58); C54(0.66)  LDD2199  [23]
 LDCM0590  Fragment32 Ramos C38(1.01); C54(0.56)  LDD2201  [23]
 LDCM0468  Fragment33 PaTu 8988t C118(0.89); C134(0.89)  LDD1347  [22]
 LDCM0596  Fragment38 Ramos C38(1.25); C54(0.56)  LDD2203  [23]
 LDCM0566  Fragment4 Ramos C38(0.65); C54(2.01)  LDD2184  [23]
 LDCM0427  Fragment51 HEK-293T C54(0.99); C312(0.94); C134(1.27)  LDD1631  [21]
 LDCM0610  Fragment52 Ramos C54(0.68)  LDD2204  [23]
 LDCM0614  Fragment56 Ramos C54(0.55)  LDD2205  [23]
 LDCM0569  Fragment7 Ramos C38(0.67); C54(1.83)  LDD2186  [23]
 LDCM0571  Fragment9 Ramos C38(1.00); C54(0.54)  LDD2188  [23]
 LDCM0116  HHS-0101 DM93 Y206(1.74)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y206(0.66)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y206(1.04)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y206(2.30)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y206(1.24)  LDD0268  [9]
 LDCM0107  IAA HeLa C54(0.00); H63(0.00)  LDD0221  [17]
 LDCM0022  KB02 HEK-293T C54(1.06); C134(1.05); C118(1.01); C134(1.01)  LDD1492  [21]
 LDCM0023  KB03 HEK-293T C54(1.10); C134(1.06); C118(0.98); C134(0.98)  LDD1497  [21]
 LDCM0024  KB05 IGR37 C312(1.42)  LDD3314  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [17]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C350(0.30); C38(0.73)  LDD2100  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C350(0.33)  LDD2104  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C38(0.43)  LDD2106  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C38(0.55)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C350(0.39)  LDD2110  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C54(1.16)  LDD2122  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C350(0.95)  LDD2127  [7]
 LDCM0131  RA190 MM1.R C54(1.13)  LDD0304  [24]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-terminal-binding protein 1 (CTBP1) D-isomer specific 2-hydroxyacid dehydrogenase family Q13363
C-terminal-binding protein 2 (CTBP2) D-isomer specific 2-hydroxyacid dehydrogenase family P56545
Cryptochrome-2 (CRY2) DNA photolyase class-1 family Q49AN0
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1) CAMK Ser/Thr protein kinase family Q13131
Mitogen-activated protein kinase 9 (MAPK9) CMGC Ser/Thr protein kinase family P45984
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) . Q9NQ66
E3 SUMO-protein ligase CBX4 (CBX4) . O00257
Transcription factor
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein Hox-B5 (HOXB5) Antp homeobox family P09067
DNA-binding protein Ikaros (IKZF1) Ikaros C2H2-type zinc-finger protein family Q13422
Krueppel-like factor 3 (KLF3) Krueppel C2H2-type zinc-finger protein family P57682
Krueppel-like factor 4 (KLF4) Krueppel C2H2-type zinc-finger protein family O43474
Zinc finger protein 516 (ZNF516) Krueppel C2H2-type zinc-finger protein family Q92618
Hypermethylated in cancer 1 protein (HIC1) Krueppel C2H2-type zinc-finger protein family Q14526
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Krueppel-like factor 12 (KLF12) Sp1 C2H2-type zinc-finger protein family Q9Y4X4
Homeobox protein TGIF1 (TGIF1) TALE/TGIF homeobox family Q15583
Teashirt homolog 3 (TSHZ3) Teashirt C2H2-type zinc-finger protein family Q63HK5
THAP domain-containing protein 11 (THAP11) THAP11 family Q96EK4
Forkhead box protein P2 (FOXP2) . O15409
Ligand-dependent corepressor (LCOR) . Q96JN0
Ligand-dependent nuclear receptor corepressor-like protein (LCORL) . Q8N3X6
Zinc finger protein 366 (ZNF366) . Q8N895
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BCAS3 microtubule associated cell migration factor (BCAS3) BCAS3 family Q9H6U6
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) CDKN2 cyclin-dependent kinase inhibitor family P55273
Centrosomal protein of 68 kDa (CEP68) . Q76N32
Hemogen (HEMGN) . Q9BXL5
Nuclear receptor-interacting protein 1 (NRIP1) . P48552
Nucleolar protein 4-like (NOL4L) . Q96MY1
Retinoic acid-induced protein 2 (RAI2) . Q9Y5P3

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Formic Acid Small molecular drug DB01942

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
23 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
24 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.