Details of the Target

General Information of Target

Target ID LDTP11728
Target Name Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial (QRSL1)
Gene Name QRSL1
Gene ID 55278
Synonyms
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial; Glu-AdT subunit A; EC 6.3.5.7; Glutaminyl-tRNA synthase-like protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPEIHMTGPMCLIENTNGELVANPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAG
KNKGFSLGSTVKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDVKKGDNQNDSWIFTLAV
LLSSTLVYNSMGTINQQAMDQLYYVTELTHRIRSKSSPDENENEDSADFVSFFPDFVWTL
RDFSLDLEADGQPLTPDEYLEYSLKLTQGTSQKDKNFNLPRLCIRKFFPKKKCFVFDLPI
HRRKLAQLEKLQDEELDPEFVQQVADFCSYIFSNSKTKTLSGGIKVNGPRLESLVLTYIN
AISRGDLPCMENAVLALAQIENSAAVQKAIAHYDQQMGQKVQLPAETLQELLDLHRVSER
EATEVYMKNSFKDVDHLFQKKLAAQLDKKRDDFCKQNQEASSDRCSALLQVIFSPLEEEV
KAGIYSKPGGYCLFIQKLQDLEKKYYEEPRKGIQAEEILQTYLKSKESVTDAILQTDQIL
TEKEKEIEVECVKAESAQASAKMVEEMQIKYQQMMEEKEKSYQEHVKQLTEKMERERAQL
LEEQEKTLTSKLQEQARVLKERCQGESTQLQNEIQKLQKTLKKKTKRYMSHKLKI
Target Bioclass
Enzyme
Family
Amidase family, GatA subfamily
Subcellular location
Mitochondrion
Function
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). {|HAMAP-Rule:MF_03150}.
Uniprot ID
Q9H0R6
Ensemble ID
ENST00000369046.8
HGNC ID
HGNC:21020

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 Deletion: p.Q154_P156del DBIA    Probe Info 
HCT15 SNV: p.G3S DBIA    Probe Info 
MCC13 SNV: p.P72S; p.D416N DBIA    Probe Info 
MEWO SNV: p.E495K DBIA    Probe Info 
SKNAS SNV: p.D437H DBIA    Probe Info 
SNGM SNV: p.R401H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.83  LDD0402  [1]
IPM
 Probe Info  		C483(0.00); C278(0.00)  LDD0241  [2]
AHL-Pu-1
 Probe Info  		C512(2.01)  LDD0170  [3]
DBIA
 Probe Info  		C278(132.30)  LDD0209  [4]
5E-2FA
 Probe Info  		N.A.  LDD2235  [5]
4-Iodoacetamidophenylacetylene
 Probe Info  		C483(0.00); C236(0.00); C278(0.00); C203(0.00)  LDD0038  [6]
IA-alkyne
 Probe Info  		C236(0.00); C203(0.00); C483(0.00)  LDD0036  [6]
Lodoacetamide azide
 Probe Info  		C236(0.00); C88(0.00); C278(0.00); C203(0.00)  LDD0037  [6]
Compound 10
 Probe Info  		N.A.  LDD2216  [7]
Phosphinate-6
 Probe Info  		C351(0.00); C512(0.00)  LDD0018  [8]
Acrolein
 Probe Info  		N.A.  LDD0217  [9]
AOyne
 Probe Info  		13.40  LDD0443  [10]
NAIA_5
 Probe Info  		C483(0.00); C236(0.00); C203(0.00)  LDD2223  [11]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C091
 Probe Info  		13.55  LDD1782  [12]
C166
 Probe Info  		6.87  LDD1846  [12]
C278
 Probe Info  		65.80  LDD1948  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C512(2.01)  LDD0170  [3]
 LDCM0026  4SU-RNA+native RNA DM93 C512(2.58)  LDD0171  [3]
 LDCM0214  AC1 HCT 116 C203(0.90)  LDD0531  [13]
 LDCM0215  AC10 HEK-293T C351(1.08); C278(1.08); C483(1.01); C512(1.04)  LDD1508  [14]
 LDCM0216  AC100 HCT 116 C203(0.62)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C203(0.65)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C203(0.70)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C203(0.59)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C203(0.81)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C203(0.70)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C203(0.49)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C203(0.59)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C203(0.54)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C203(0.75)  LDD0542  [13]
 LDCM0226  AC11 HEK-293T C351(1.12); C278(1.09); C483(1.18); C512(1.06)  LDD1509  [14]
 LDCM0227  AC110 HCT 116 C203(0.51)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C203(0.47)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C203(0.49)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C203(1.42)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C203(0.97)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C203(0.96)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C203(1.12)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C203(0.93)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C203(0.99)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C203(0.92)  LDD0553  [13]
 LDCM0237  AC12 HEK-293T C351(1.23); C278(1.02); C483(0.97); C512(1.10)  LDD1510  [14]
 LDCM0238  AC120 HCT 116 C203(1.03)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C203(0.94)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C203(0.89)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C203(0.92)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C203(0.91)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C203(0.95)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C203(1.05)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C203(0.96)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C203(1.46)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C203(1.28)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C203(1.28)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C203(1.03)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C203(0.95)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C203(1.06)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C203(0.75)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C203(0.94)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C203(0.78)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C203(0.77)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C203(0.54)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C203(0.54)  LDD0575  [13]
 LDCM0259  AC14 HEK-293T C351(1.16); C278(0.98); C483(0.81); C512(1.02)  LDD1512  [14]
 LDCM0260  AC140 HCT 116 C203(0.54)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C203(0.50)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C203(0.70)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C203(0.69)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C203(0.76)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C203(0.72)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C203(0.64)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C203(0.95)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C203(0.54)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C203(0.50)  LDD0586  [13]
 LDCM0270  AC15 HEK-293T C351(1.10); C278(1.08); C512(1.05); C88(1.07)  LDD1513  [14]
 LDCM0271  AC150 HCT 116 C203(0.73)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C203(0.80)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C203(0.72)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C203(0.45)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C203(0.59)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C203(0.61)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C203(0.72)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C203(0.69)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C203(1.12)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C203(1.07)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C203(1.28)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C203(0.79)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C203(0.99)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C203(1.22)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C203(1.02)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C203(1.02)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C203(1.15)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C203(0.85)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C203(0.58)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C203(0.67)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C203(0.60)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C203(0.39)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C203(1.07)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C203(0.33)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C203(0.41)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C203(0.34)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C203(0.67)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C203(0.60)  LDD0612  [13]
 LDCM0296  AC35 HEK-293T C351(1.01); C278(1.02); C483(1.17); C512(1.08)  LDD1535  [14]
 LDCM0297  AC36 HEK-293T C351(1.33); C278(1.13); C483(1.09); C512(0.97)  LDD1536  [14]
 LDCM0298  AC37 HEK-293T C351(1.08); C278(0.95); C483(1.30); C512(0.94)  LDD1537  [14]
 LDCM0299  AC38 HEK-293T C351(1.12); C278(1.04); C483(1.01); C512(0.98)  LDD1538  [14]
 LDCM0300  AC39 HEK-293T C351(0.96); C278(1.02); C512(1.11); C88(1.07)  LDD1539  [14]
 LDCM0301  AC4 HCT 116 C203(1.15)  LDD0618  [13]
 LDCM0302  AC40 HEK-293T C278(1.10); C483(0.99); C512(1.06); C88(1.04)  LDD1541  [14]
 LDCM0303  AC41 HEK-293T C351(0.99); C278(1.03); C483(0.98); C512(1.04)  LDD1542  [14]
 LDCM0304  AC42 HEK-293T C351(1.12); C278(1.10); C483(1.04); C512(1.03)  LDD1543  [14]
 LDCM0305  AC43 HEK-293T C351(1.17); C278(0.99); C483(1.26); C512(1.07)  LDD1544  [14]
 LDCM0306  AC44 HEK-293T C351(1.27); C278(1.06); C483(1.11); C512(1.06)  LDD1545  [14]
 LDCM0307  AC45 HEK-293T C351(0.97); C278(1.11); C483(1.12); C512(0.98)  LDD1546  [14]
 LDCM0308  AC46 HCT 116 C203(0.43)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C203(0.62)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C203(0.44)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C203(0.46)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C203(1.03)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C203(0.41)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C203(0.45)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C203(0.42)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C203(0.76)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C203(0.52)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C203(1.05)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C203(0.50)  LDD0636  [13]
 LDCM0320  AC57 HEK-293T C88(0.89)  LDD0918  [13]
 LDCM0321  AC58 HEK-293T C88(0.79)  LDD0919  [13]
 LDCM0322  AC59 HEK-293T C88(0.86)  LDD0920  [13]
 LDCM0323  AC6 HEK-293T C351(1.09); C278(0.97); C483(0.76); C512(1.06)  LDD1562  [14]
 LDCM0324  AC60 HEK-293T C88(0.74)  LDD0922  [13]
 LDCM0325  AC61 HEK-293T C88(0.95)  LDD0923  [13]
 LDCM0326  AC62 HEK-293T C88(0.76)  LDD0924  [13]
 LDCM0327  AC63 HEK-293T C88(1.08)  LDD0925  [13]
 LDCM0328  AC64 HEK-293T C88(0.81)  LDD0926  [13]
 LDCM0329  AC65 HEK-293T C88(1.12)  LDD0927  [13]
 LDCM0330  AC66 HEK-293T C88(0.79)  LDD0928  [13]
 LDCM0331  AC67 HEK-293T C88(0.89)  LDD0929  [13]
 LDCM0332  AC68 HCT 116 C203(0.75)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C203(0.90)  LDD0650  [13]
 LDCM0334  AC7 HEK-293T C351(1.07); C278(1.01); C512(1.01); C88(1.03)  LDD1568  [14]
 LDCM0335  AC70 HCT 116 C203(0.68)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C203(0.94)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C203(0.72)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C203(0.76)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C203(0.98)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C203(0.65)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C203(1.00)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C203(0.69)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C203(0.75)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C203(0.55)  LDD0661  [13]
 LDCM0345  AC8 HEK-293T C278(1.06); C483(1.10); C512(1.07); C88(1.09)  LDD1569  [14]
 LDCM0346  AC80 HCT 116 C203(0.90)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C203(0.68)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C203(0.87)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C203(0.37)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C203(0.37)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C203(0.60)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C203(0.79)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C203(1.22)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C203(0.76)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C203(0.44)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C203(1.29)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C203(0.43)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C203(0.35)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C203(0.46)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C203(0.88)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C203(1.25)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C203(0.74)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C203(0.36)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C203(0.53)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C203(0.62)  LDD0683  [13]
 LDCM0248  AKOS034007472 HEK-293T C351(1.14); C278(0.98); C483(0.89); C512(1.03)  LDD1511  [14]
 LDCM0356  AKOS034007680 HEK-293T C351(1.06); C278(1.03); C483(1.09); C512(1.10)  LDD1570  [14]
 LDCM0275  AKOS034007705 HEK-293T C278(1.03); C483(1.04); C512(1.12); C88(1.02)  LDD1514  [14]
 LDCM0156  Aniline NCI-H1299 12.36  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C203(0.97)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C203(0.71)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C203(0.72)  LDD0686  [13]
 LDCM0370  CL101 HEK-293T C351(1.14); C278(0.99); C483(0.97); C512(1.03)  LDD1574  [14]
 LDCM0371  CL102 HEK-293T C351(1.12); C278(1.15); C483(0.99); C512(0.91)  LDD1575  [14]
 LDCM0372  CL103 HEK-293T C351(1.03); C278(1.02); C483(0.99); C512(1.02)  LDD1576  [14]
 LDCM0373  CL104 HEK-293T C351(1.00); C278(0.91); C483(0.85); C512(1.03)  LDD1577  [14]
 LDCM0374  CL105 HCT 116 C203(1.03)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C203(1.09)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C203(0.97)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C203(1.09)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C203(0.93)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C203(0.66)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C203(1.15)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C203(0.80)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C203(0.66)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C203(0.37)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C203(0.36)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C203(0.48)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C203(0.59)  LDD0703  [13]
 LDCM0387  CL117 HEK-293T C351(1.11); C278(1.00); C483(1.42); C512(0.97)  LDD1591  [14]
 LDCM0388  CL118 HEK-293T C351(1.12); C278(1.04); C483(1.02); C512(0.96)  LDD1592  [14]
 LDCM0389  CL119 HEK-293T C351(1.18); C278(1.14); C483(1.13); C512(1.08)  LDD1593  [14]
 LDCM0390  CL12 HCT 116 C203(0.71)  LDD0707  [13]
 LDCM0391  CL120 HEK-293T C351(1.01); C278(0.99); C483(0.92); C512(1.05)  LDD1595  [14]
 LDCM0392  CL121 HCT 116 C203(0.63)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C203(0.64)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C203(0.70)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C203(0.50)  LDD0712  [13]
 LDCM0396  CL125 HEK-293T C88(0.93)  LDD0994  [13]
 LDCM0397  CL126 HEK-293T C88(0.71)  LDD0995  [13]
 LDCM0398  CL127 HEK-293T C88(0.69)  LDD0996  [13]
 LDCM0399  CL128 HEK-293T C88(0.68)  LDD0997  [13]
 LDCM0400  CL13 HCT 116 C203(0.74)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C203(0.79)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C203(0.89)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C203(0.94)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C203(1.01)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C203(1.03)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C203(1.17)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C203(0.79)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C203(1.23)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C203(1.24)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C203(1.05)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C203(1.15)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C203(1.09)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C203(0.92)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C203(0.96)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C203(1.26)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C203(1.12)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C203(1.30)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C203(0.75)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C203(1.23)  LDD0736  [13]
 LDCM0420  CL31 HEK-293T C351(1.11); C278(1.07); C483(1.03); C512(0.94)  LDD1624  [14]
 LDCM0421  CL32 HEK-293T C351(1.37); C278(0.98); C483(1.05); C512(1.01)  LDD1625  [14]
 LDCM0422  CL33 HEK-293T C351(0.85); C278(0.93); C483(1.10); C512(0.96)  LDD1626  [14]
 LDCM0423  CL34 HEK-293T C351(1.32); C278(0.96); C483(0.83); C512(1.00)  LDD1627  [14]
 LDCM0424  CL35 HEK-293T C351(1.20); C278(0.97); C512(1.12); C88(1.04)  LDD1628  [14]
 LDCM0425  CL36 HEK-293T C278(1.01); C483(0.94); C512(1.09); C88(0.96)  LDD1629  [14]
 LDCM0426  CL37 HEK-293T C351(0.82); C278(0.95); C483(1.35); C512(1.05)  LDD1630  [14]
 LDCM0428  CL39 HEK-293T C351(1.01); C278(1.19); C483(1.05); C512(1.03)  LDD1632  [14]
 LDCM0429  CL4 HCT 116 C203(0.75)  LDD0746  [13]
 LDCM0430  CL40 HEK-293T C351(0.97); C278(1.01); C483(0.97); C512(1.06)  LDD1634  [14]
 LDCM0431  CL41 HEK-293T C351(1.05); C278(1.12); C483(0.88); C512(1.26)  LDD1635  [14]
 LDCM0432  CL42 HEK-293T C351(1.03); C278(1.18); C483(1.12); C512(1.08)  LDD1636  [14]
 LDCM0433  CL43 HEK-293T C351(0.98); C278(1.02); C483(1.28); C512(1.01)  LDD1637  [14]
 LDCM0434  CL44 HEK-293T C351(1.18); C278(1.06); C483(1.14); C512(0.97)  LDD1638  [14]
 LDCM0435  CL45 HEK-293T C351(0.84); C278(1.08); C483(1.03); C512(1.11)  LDD1639  [14]
 LDCM0436  CL46 HEK-293T C351(1.09); C278(1.01); C483(1.08); C512(0.99)  LDD1640  [14]
 LDCM0437  CL47 HEK-293T C351(1.00); C278(1.07); C512(0.95); C88(1.15)  LDD1641  [14]
 LDCM0438  CL48 HEK-293T C278(1.01); C483(1.10); C512(1.06); C88(0.97)  LDD1642  [14]
 LDCM0439  CL49 HEK-293T C351(0.98); C278(1.01); C483(1.38); C512(1.01)  LDD1643  [14]
 LDCM0440  CL5 HCT 116 C203(0.85)  LDD0757  [13]
 LDCM0441  CL50 HEK-293T C351(1.15); C278(1.12); C483(1.05); C512(1.16)  LDD1645  [14]
 LDCM0443  CL52 HEK-293T C351(1.00); C278(1.02); C483(0.83); C512(1.08)  LDD1646  [14]
 LDCM0444  CL53 HEK-293T C351(1.10); C278(1.05); C483(0.91); C512(1.03)  LDD1647  [14]
 LDCM0445  CL54 HEK-293T C351(1.21); C278(1.15); C483(0.95); C512(1.03)  LDD1648  [14]
 LDCM0446  CL55 HEK-293T C351(1.15); C278(1.08); C483(1.21); C512(1.21)  LDD1649  [14]
 LDCM0447  CL56 HEK-293T C351(1.21); C278(1.05); C483(0.99); C512(0.98)  LDD1650  [14]
 LDCM0448  CL57 HEK-293T C351(0.81); C278(0.97); C483(1.05); C512(1.07)  LDD1651  [14]
 LDCM0449  CL58 HEK-293T C351(1.20); C278(0.98); C483(0.92); C512(0.97)  LDD1652  [14]
 LDCM0450  CL59 HEK-293T C351(1.18); C278(1.08); C512(1.00); C88(1.01)  LDD1653  [14]
 LDCM0451  CL6 HCT 116 C203(0.84)  LDD0768  [13]
 LDCM0452  CL60 HEK-293T C278(1.04); C483(1.13); C512(0.98); C88(1.10)  LDD1655  [14]
 LDCM0453  CL61 HEK-293T C351(1.06); C278(1.07); C483(1.09); C512(1.04)  LDD1656  [14]
 LDCM0454  CL62 HEK-293T C351(1.16); C278(1.04); C483(1.08); C512(0.98)  LDD1657  [14]
 LDCM0455  CL63 HEK-293T C351(1.15); C278(1.16); C483(1.09); C512(1.10)  LDD1658  [14]
 LDCM0456  CL64 HEK-293T C351(1.17); C278(1.01); C483(0.89); C512(1.08)  LDD1659  [14]
 LDCM0457  CL65 HEK-293T C351(1.08); C278(1.04); C483(0.96); C512(1.05)  LDD1660  [14]
 LDCM0458  CL66 HEK-293T C351(1.10); C278(1.09); C483(1.01); C512(1.24)  LDD1661  [14]
 LDCM0459  CL67 HEK-293T C351(1.11); C278(0.98); C483(1.14); C512(1.09)  LDD1662  [14]
 LDCM0460  CL68 HEK-293T C351(1.33); C278(1.09); C483(1.14); C512(0.92)  LDD1663  [14]
 LDCM0461  CL69 HEK-293T C351(0.93); C278(1.05); C483(1.28); C512(0.94)  LDD1664  [14]
 LDCM0462  CL7 HCT 116 C203(0.56)  LDD0779  [13]
 LDCM0463  CL70 HEK-293T C351(1.16); C278(0.99); C483(0.93); C512(0.93)  LDD1666  [14]
 LDCM0464  CL71 HEK-293T C351(1.18); C278(1.05); C512(1.08); C88(1.04)  LDD1667  [14]
 LDCM0465  CL72 HEK-293T C278(0.91); C483(1.22); C512(1.14); C88(0.90)  LDD1668  [14]
 LDCM0466  CL73 HEK-293T C351(1.04); C278(0.93); C483(0.91); C512(1.00)  LDD1669  [14]
 LDCM0467  CL74 HEK-293T C351(1.01); C278(1.20); C483(1.14); C512(1.03)  LDD1670  [14]
 LDCM0469  CL76 HEK-293T C351(0.94); C278(0.97); C483(1.12); C512(1.06)  LDD1672  [14]
 LDCM0470  CL77 HEK-293T C351(1.02); C278(1.14); C483(1.03); C512(1.08)  LDD1673  [14]
 LDCM0471  CL78 HEK-293T C351(1.10); C278(1.22); C483(1.08); C512(1.14)  LDD1674  [14]
 LDCM0472  CL79 HEK-293T C351(1.01); C278(1.01); C483(1.28); C512(1.15)  LDD1675  [14]
 LDCM0473  CL8 HCT 116 C203(0.82)  LDD0790  [13]
 LDCM0474  CL80 HEK-293T C351(1.24); C278(1.12); C483(1.14); C512(0.97)  LDD1677  [14]
 LDCM0475  CL81 HEK-293T C351(0.93); C278(0.97); C483(1.37); C512(0.97)  LDD1678  [14]
 LDCM0476  CL82 HEK-293T C351(1.16); C278(1.13); C483(0.92); C512(1.06)  LDD1679  [14]
 LDCM0477  CL83 HEK-293T C351(0.87); C278(0.98); C512(0.94); C88(1.03)  LDD1680  [14]
 LDCM0478  CL84 HEK-293T C278(1.04); C483(0.93); C512(1.01); C88(1.04)  LDD1681  [14]
 LDCM0479  CL85 HEK-293T C351(0.99); C278(1.10); C483(1.10); C512(1.16)  LDD1682  [14]
 LDCM0480  CL86 HEK-293T C351(1.09); C278(1.09); C483(1.09); C512(1.01)  LDD1683  [14]
 LDCM0481  CL87 HEK-293T C351(1.03); C278(1.04); C483(0.98); C512(1.05)  LDD1684  [14]
 LDCM0482  CL88 HEK-293T C351(1.01); C278(0.99); C483(1.12); C512(1.11)  LDD1685  [14]
 LDCM0483  CL89 HEK-293T C351(1.13); C278(1.10); C483(1.09); C512(1.02)  LDD1686  [14]
 LDCM0484  CL9 HCT 116 C203(0.63)  LDD0801  [13]
 LDCM0485  CL90 HEK-293T C351(1.11); C278(1.15); C483(0.93); C512(1.42)  LDD1688  [14]
 LDCM0486  CL91 HCT 116 C203(1.06)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C203(0.99)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C203(1.14)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C203(1.14)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C203(1.04)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C203(1.11)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C203(1.11)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C203(0.82)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C203(0.76)  LDD0811  [13]
 LDCM0495  E2913 HEK-293T C351(0.99); C278(1.13); C483(1.03); C512(0.98)  LDD1698  [14]
 LDCM0625  F8 Ramos C278(0.87); C483(0.74); C88(1.09)  LDD2187  [15]
 LDCM0572  Fragment10 Ramos C278(0.54); C483(0.70); C88(1.13)  LDD2189  [15]
 LDCM0573  Fragment11 Ramos C278(3.88); C483(3.67); C88(0.50)  LDD2190  [15]
 LDCM0574  Fragment12 Ramos C278(0.75); C483(0.85); C88(1.72)  LDD2191  [15]
 LDCM0575  Fragment13 Ramos C278(1.03); C483(0.88); C88(1.20)  LDD2192  [15]
 LDCM0576  Fragment14 Ramos C278(0.62); C483(0.57); C88(1.43)  LDD2193  [15]
 LDCM0579  Fragment20 Ramos C278(0.64); C483(0.80); C88(0.95)  LDD2194  [15]
 LDCM0580  Fragment21 Ramos C278(0.77); C483(0.93); C88(1.42)  LDD2195  [15]
 LDCM0582  Fragment23 Ramos C278(0.75); C483(0.95); C88(1.02)  LDD2196  [15]
 LDCM0578  Fragment27 Ramos C278(1.04); C483(0.91); C88(1.14)  LDD2197  [15]
 LDCM0586  Fragment28 Ramos C278(0.59); C483(1.18); C88(0.41)  LDD2198  [15]
 LDCM0588  Fragment30 Ramos C278(1.14); C483(0.83); C88(1.45)  LDD2199  [15]
 LDCM0589  Fragment31 Ramos C278(0.72); C483(0.89); C88(1.45)  LDD2200  [15]
 LDCM0590  Fragment32 Ramos C278(0.47); C483(0.67); C88(1.23)  LDD2201  [15]
 LDCM0468  Fragment33 HEK-293T C351(1.19); C278(1.04); C483(1.08); C512(1.02)  LDD1671  [14]
 LDCM0596  Fragment38 Ramos C278(0.86); C483(0.47); C88(1.16)  LDD2203  [15]
 LDCM0566  Fragment4 Ramos C278(0.80); C483(0.82); C88(0.37)  LDD2184  [15]
 LDCM0427  Fragment51 HEK-293T C351(0.98); C278(1.02); C483(1.13); C512(1.00)  LDD1631  [14]
 LDCM0610  Fragment52 Ramos C278(1.64); C483(0.69); C88(1.01)  LDD2204  [15]
 LDCM0614  Fragment56 Ramos C278(1.39); C483(0.77); C88(1.44)  LDD2205  [15]
 LDCM0569  Fragment7 Ramos C278(0.70); C483(0.60); C88(0.51)  LDD2186  [15]
 LDCM0571  Fragment9 Ramos C278(0.57); C483(0.76); C88(1.20)  LDD2188  [15]
 LDCM0022  KB02 HEK-293T C203(1.04); C88(0.98); C483(0.87); C512(0.98)  LDD1492  [14]
 LDCM0023  KB03 Jurkat C278(132.30)  LDD0209  [4]
 LDCM0024  KB05 G361 C483(2.29)  LDD3311  [16]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial (GATB) GatB/GatE family O75879
Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (GATC) GatC family O43716

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
5 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
6 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
7 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
8 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
9 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
10 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
15 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
16 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840