Details of the Target

General Information of Target

Target ID LDTP09515
Target Name Importin-4 (IPO4)
Gene Name IPO4
Gene ID 79711
Synonyms
IMP4B; RANBP4; Importin-4; Imp4; Importin-4b; Imp4b; Ran-binding protein 4; RanBP4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MESAGLEQLLRELLLPDTERIRRATEQLQIVLRAPAALPALCDLLASAADPQIRQFAAVL
TRRRLNTRWRRLAAEQRESLKSLILTALQRETEHCVSLSLAQLSATIFRKEGLEAWPQLL
QLLQHSTHSPHSPEREMGLLLLSVVVTSRPEAFQPHHRELLRLLNETLGEVGSPGLLFYS
LRTLTTMAPYLSTEDVPLARMLVPKLIMAMQTLIPIDEAKACEALEALDELLESEVPVIT
PYLSEVLTFCLEVARNVALGNAIRIRILCCLTFLVKVKSKALLKNRLLPPLLHTLFPIVA
AEPPPGQLDPEDQDSEEEELEIELMGETPKHFAVQVVDMLALHLPPEKLCPQLMPMLEEA
LRSESPYQRKAGLLVLAVLSDGAGDHIRQRLLPPLLQIVCKGLEDPSQVVRNAALFALGQ
FSENLQPHISSYSREVMPLLLAYLKSVPLGHTHHLAKACYALENFVENLGPKVQPYLPEL
MECMLQLLRNPSSPRAKELAVSALGAIATAAQASLLPYFPAIMEHLREFLLTGREDLQPV
QIQSLETLGVLARAVGEPMRPLAEECCQLGLGLCDQVDDPDLRRCTYSLFAALSGLMGEG
LAPHLEQITTLMLLSLRSTEGIVPQYDGSSSFLLFDDESDGEEEEELMDEDVEEEDDSEI
SGYSVENAFFDEKEDTCAAVGEISVNTSVAFLPYMESVFEEVFKLLECPHLNVRKAAHEA
LGQFCCALHKACQSCPSEPNTAALQAALARVVPSYMQAVNRERERQVVMAVLEALTGVLR
SCGTLTLKPPGRLAELCGVLKAVLQRKTACQDTDEEEEEEDDDQAEYDAMLLEHAGEAIP
ALAAAAGGDSFAPFFAGFLPLLVCKTKQGCTVAEKSFAVGTLAETIQGLGAASAQFVSRL
LPVLLSTAQEADPEVRSNAIFGMGVLAEHGGHPAQEHFPKLLGLLFPLLARERHDRVRDN
ICGALARLLMASPTRKPEPQVLAALLHALPLKEDLEEWVTIGRLFSFLYQSSPDQVIDVA
PELLRICSLILADNKIPPDTKAALLLLLTFLAKQHTDSFQAALGSLPVDKAQELQAVLGL
S
Target Bioclass
Transporter and channel
Family
Importin beta family
Subcellular location
Cytoplasm
Function
Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of the histone H3-H4 dimer when in complex with ASF1 (ASF1A or ASF1B). Mediates the ligand-independent nuclear import of vitamin D receptor (VDR). In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.
Uniprot ID
Q8TEX9
Ensemble ID
ENST00000354464.11
HGNC ID
HGNC:19426

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.S492R DBIA    Probe Info 
CAL78 SNV: p.A500S DBIA    Probe Info 
COLO792 SNV: p.G848E DBIA    Probe Info 
HCT116 Deletion: p.P790LfsTer116 .
HDMYZ SNV: p.C95Y DBIA    Probe Info 
IGR1 SNV: p.A34P DBIA    Probe Info 
IGROV1 Deletion: p.E136DfsTer30 DBIA    Probe Info 
MCC13 SNV: p.H1055Y DBIA    Probe Info 
MCC26 SNV: p.S493C DBIA    Probe Info 
MDAMB468 SNV: p.H710Q DBIA    Probe Info 
MOLT4 SNV: p.E91K; p.A115V; p.E682G IA-alkyne    Probe Info 
OCIAML2 SNV: p.V31F DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.73  LDD0215  [2]
CY4
 Probe Info  		100.00  LDD0244  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K788(10.00)  LDD0277  [5]
Probe 1
 Probe Info  		Y367(6.25); Y755(14.39)  LDD3495  [6]
JZ128-DTB
 Probe Info  		C725(0.00); C42(0.00); C726(0.00); C732(0.00)  LDD0462  [7]
DA-P3
 Probe Info  		10.11  LDD0183  [8]
AHL-Pu-1
 Probe Info  		C735(3.45); C725(3.14)  LDD0168  [9]
Alkyne-RA190
 Probe Info  		2.63  LDD0300  [10]
EA-probe
 Probe Info  		C350(2.23); C42(1.10)  LDD2210  [11]
DBIA
 Probe Info  		C797(14.05); C708(17.13); C782(5.61); C459(4.74)  LDD0209  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C459(0.00); C42(0.00); C95(0.00); C797(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C962(0.00); C797(0.00)  LDD0032  [15]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [16]
Lodoacetamide azide
 Probe Info  		C459(0.00); C42(0.00); C962(0.00); C797(0.00)  LDD0037  [14]
BTD
 Probe Info  		N.A.  LDD0004  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [18]
NAIA_4
 Probe Info  		C42(0.00); C400(0.00); C459(0.00)  LDD2226  [19]
TFBX
 Probe Info  		C797(0.00); C732(0.00); C962(0.00); C708(0.00)  LDD0027  [18]
WYneN
 Probe Info  		C782(0.00); C708(0.00); C459(0.00); C400(0.00)  LDD0021  [17]
WYneO
 Probe Info  		C708(0.00); C797(0.00)  LDD0022  [17]
aHNE
 Probe Info  		N.A.  LDD0001  [17]
Compound 10
 Probe Info  		C459(0.00); C782(0.00); C797(0.00); C870(0.00)  LDD2216  [20]
ENE
 Probe Info  		C962(0.00); C708(0.00); C797(0.00)  LDD0006  [17]
IPM
 Probe Info  		C735(0.00); C400(0.00); C870(0.00); C726(0.00)  LDD0005  [17]
VSF
 Probe Info  		C400(0.00); C962(0.00); C735(0.00); C797(0.00)  LDD0007  [17]
Phosphinate-6
 Probe Info  		C870(0.00); C708(0.00); C725(0.00)  LDD0018  [21]
1c-yne
 Probe Info  		K370(0.00); K875(0.00)  LDD0228  [22]
Acrolein
 Probe Info  		C962(0.00); C459(0.00); C797(0.00); C708(0.00)  LDD0217  [23]
Methacrolein
 Probe Info  		C708(0.00); C962(0.00); C797(0.00); C735(0.00)  LDD0218  [23]
W1
 Probe Info  		C400(0.00); C962(0.00); C797(0.00); C708(0.00)  LDD0236  [24]
AOyne
 Probe Info  		5.20  LDD0443  [25]
NAIA_5
 Probe Info  		C726(0.00); C725(0.00); C459(0.00); C42(0.00)  LDD2223  [19]
PAL-AfBPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C040
 Probe Info  		8.00  LDD1740  [26]
C055
 Probe Info  		14.03  LDD1752  [26]
C094
 Probe Info  		22.78  LDD1785  [26]
C100
 Probe Info  		5.28  LDD1789  [26]
C112
 Probe Info  		17.63  LDD1799  [26]
C141
 Probe Info  		11.63  LDD1823  [26]
C143
 Probe Info  		18.77  LDD1825  [26]
C158
 Probe Info  		23.59  LDD1838  [26]
C163
 Probe Info  		5.90  LDD1843  [26]
C166
 Probe Info  		6.73  LDD1846  [26]
C187
 Probe Info  		15.56  LDD1865  [26]
C201
 Probe Info  		35.02  LDD1877  [26]
C270
 Probe Info  		7.57  LDD1940  [26]
C277
 Probe Info  		11.79  LDD1947  [26]
C278
 Probe Info  		47.50  LDD1948  [26]
C296
 Probe Info  		23.43  LDD1966  [26]
C343
 Probe Info  		13.00  LDD2005  [26]
C350
 Probe Info  		22.78  LDD2011  [26]
C376
 Probe Info  		6.82  LDD2036  [26]
C403
 Probe Info  		23.92  LDD2061  [26]
C407
 Probe Info  		12.47  LDD2064  [26]
FFF probe11
 Probe Info  		5.53  LDD0471  [27]
FFF probe13
 Probe Info  		10.18  LDD0475  [27]
FFF probe14
 Probe Info  		15.87  LDD0477  [27]
FFF probe2
 Probe Info  		6.18  LDD0463  [27]
FFF probe3
 Probe Info  		5.89  LDD0464  [27]
FFF probe4
 Probe Info  		8.78  LDD0466  [27]
JN0003
 Probe Info  		5.78  LDD0469  [27]
STS-1
 Probe Info  		N.A.  LDD0136  [28]
STS-2
 Probe Info  		N.A.  LDD0138  [28]
VE-P
 Probe Info  		N.A.  LDD0396  [29]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [30]
OEA-DA
 Probe Info  		18.55  LDD0046  [31]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C962(0.96); C708(0.84); C797(0.47)  LDD2142  [32]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C782(1.01); C797(0.88)  LDD2112  [32]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C962(1.16); C782(0.82); C708(0.60)  LDD2095  [32]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C782(0.79); C708(0.92)  LDD2130  [32]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C782(0.85); C708(0.99); C797(1.37); C725(0.99)  LDD2117  [32]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C782(1.32); C708(1.01); C797(1.68); C870(1.85)  LDD2152  [32]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C708(1.17)  LDD2103  [32]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C782(0.66); C708(0.74)  LDD2132  [32]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C782(0.56); C708(0.82)  LDD2131  [32]
 LDCM0025  4SU-RNA HEK-293T C735(3.45); C725(3.14)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C735(3.51); C725(2.17); C708(2.08); C350(2.89)  LDD0169  [9]
 LDCM0561  Abegg_cp(-)-10 HeLa C350(2.32)  LDD0312  [18]
 LDCM0214  AC1 HEK-293T C870(1.05); C962(0.98); C782(1.05); C708(0.93)  LDD1507  [33]
 LDCM0215  AC10 HEK-293T C870(1.01); C962(1.00); C782(0.97); C708(0.92)  LDD1508  [33]
 LDCM0226  AC11 HEK-293T C870(0.98); C962(0.90); C782(1.01); C708(0.89)  LDD1509  [33]
 LDCM0237  AC12 HEK-293T C870(0.98); C962(0.88); C782(1.00); C708(0.91)  LDD1510  [33]
 LDCM0259  AC14 HEK-293T C870(1.00); C962(0.94); C782(1.00); C708(0.91)  LDD1512  [33]
 LDCM0270  AC15 HEK-293T C870(1.01); C962(1.00); C782(1.01); C708(0.95)  LDD1513  [33]
 LDCM0276  AC17 HEK-293T C870(1.00); C962(0.92); C782(0.99); C708(0.97)  LDD1515  [33]
 LDCM0277  AC18 HEK-293T C870(0.97); C962(1.07); C782(1.01); C708(0.99)  LDD1516  [33]
 LDCM0278  AC19 HEK-293T C870(1.46); C962(1.05); C782(1.29); C708(1.04)  LDD1517  [33]
 LDCM0279  AC2 HEK-293T C870(1.00); C962(0.98); C782(1.01); C708(0.94)  LDD1518  [33]
 LDCM0280  AC20 HEK-293T C870(1.02); C962(0.94); C782(0.99); C708(0.93)  LDD1519  [33]
 LDCM0281  AC21 HEK-293T C870(1.04); C962(0.99); C782(1.00); C708(1.05)  LDD1520  [33]
 LDCM0282  AC22 HEK-293T C870(1.00); C962(0.94); C782(0.98); C708(1.03)  LDD1521  [33]
 LDCM0283  AC23 HEK-293T C870(1.04); C962(1.05); C782(0.97); C708(0.92)  LDD1522  [33]
 LDCM0284  AC24 HEK-293T C870(1.01); C962(1.01); C782(0.99); C708(0.90)  LDD1523  [33]
 LDCM0285  AC25 HEK-293T C870(1.02); C962(0.99); C782(0.97); C708(0.94)  LDD1524  [33]
 LDCM0286  AC26 HEK-293T C870(1.01); C962(1.06); C782(1.02); C708(0.95)  LDD1525  [33]
 LDCM0287  AC27 HEK-293T C870(1.02); C962(0.89); C782(1.00); C708(0.91)  LDD1526  [33]
 LDCM0288  AC28 HEK-293T C870(1.05); C962(0.91); C782(0.98); C708(0.87)  LDD1527  [33]
 LDCM0289  AC29 HEK-293T C870(1.00); C962(1.13); C782(0.99); C708(0.95)  LDD1528  [33]
 LDCM0290  AC3 HEK-293T C870(0.99); C962(0.90); C782(1.02); C708(0.90)  LDD1529  [33]
 LDCM0291  AC30 HEK-293T C870(1.05); C962(0.90); C782(1.00); C708(0.99)  LDD1530  [33]
 LDCM0292  AC31 HEK-293T C870(1.01); C962(0.93); C782(0.98); C708(0.92)  LDD1531  [33]
 LDCM0293  AC32 HEK-293T C870(0.97); C962(0.99); C782(0.97); C708(0.95)  LDD1532  [33]
 LDCM0294  AC33 HEK-293T C870(0.98); C962(0.94); C782(0.95); C708(0.92)  LDD1533  [33]
 LDCM0295  AC34 HEK-293T C870(0.99); C962(1.01); C782(1.01); C708(0.92)  LDD1534  [33]
 LDCM0296  AC35 HEK-293T C870(0.93); C962(0.91); C782(1.01); C708(0.92)  LDD1535  [33]
 LDCM0297  AC36 HEK-293T C870(0.94); C962(0.86); C782(0.99); C708(0.90)  LDD1536  [33]
 LDCM0298  AC37 HEK-293T C870(0.97); C962(1.00); C782(0.91); C708(0.94)  LDD1537  [33]
 LDCM0299  AC38 HEK-293T C870(0.95); C962(0.95); C782(0.97); C708(0.89)  LDD1538  [33]
 LDCM0300  AC39 HEK-293T C870(0.97); C962(0.94); C782(0.99); C708(0.92)  LDD1539  [33]
 LDCM0301  AC4 HEK-293T C870(0.98); C962(0.90); C782(0.98); C708(0.93)  LDD1540  [33]
 LDCM0302  AC40 HEK-293T C870(0.96); C962(1.00); C782(0.97); C708(1.02)  LDD1541  [33]
 LDCM0303  AC41 HEK-293T C870(0.99); C962(0.96); C782(0.94); C708(0.93)  LDD1542  [33]
 LDCM0304  AC42 HEK-293T C870(1.09); C962(1.06); C782(1.00); C708(0.95)  LDD1543  [33]
 LDCM0305  AC43 HEK-293T C870(0.92); C962(0.98); C782(0.95); C708(0.89)  LDD1544  [33]
 LDCM0306  AC44 HEK-293T C870(0.93); C962(0.88); C782(0.99); C708(0.91)  LDD1545  [33]
 LDCM0307  AC45 HEK-293T C870(1.01); C962(0.94); C782(0.94); C708(0.91)  LDD1546  [33]
 LDCM0308  AC46 HEK-293T C870(0.95); C962(0.93); C782(1.03); C708(0.89)  LDD1547  [33]
 LDCM0309  AC47 HEK-293T C870(0.93); C962(0.96); C782(0.99); C708(0.94)  LDD1548  [33]
 LDCM0310  AC48 HEK-293T C870(0.94); C962(0.86); C782(0.93); C708(0.95)  LDD1549  [33]
 LDCM0311  AC49 HEK-293T C870(1.00); C962(0.93); C782(1.02); C708(0.96)  LDD1550  [33]
 LDCM0312  AC5 HEK-293T C870(1.02); C962(0.90); C782(0.98); C708(0.94)  LDD1551  [33]
 LDCM0313  AC50 HEK-293T C870(0.99); C962(0.99); C782(1.01); C708(0.91)  LDD1552  [33]
 LDCM0314  AC51 HEK-293T C870(0.93); C962(1.04); C782(1.01); C708(0.96)  LDD1553  [33]
 LDCM0315  AC52 HEK-293T C870(0.94); C962(0.91); C782(1.00); C708(0.97)  LDD1554  [33]
 LDCM0316  AC53 HEK-293T C870(0.97); C962(1.00); C782(0.95); C708(0.94)  LDD1555  [33]
 LDCM0317  AC54 HEK-293T C870(0.97); C962(0.93); C782(1.02); C708(0.98)  LDD1556  [33]
 LDCM0318  AC55 HEK-293T C870(0.97); C962(0.98); C782(0.99); C708(0.97)  LDD1557  [33]
 LDCM0319  AC56 HEK-293T C870(0.95); C962(0.96); C782(1.00); C708(0.98)  LDD1558  [33]
 LDCM0320  AC57 HEK-293T C870(1.04); C962(0.96); C782(1.00); C708(0.92)  LDD1559  [33]
 LDCM0321  AC58 HEK-293T C870(1.05); C962(0.96); C782(1.01); C708(0.95)  LDD1560  [33]
 LDCM0322  AC59 HEK-293T C870(0.98); C962(0.99); C782(0.98); C708(0.93)  LDD1561  [33]
 LDCM0323  AC6 HEK-293T C870(1.05); C962(0.90); C782(0.99); C708(0.99)  LDD1562  [33]
 LDCM0324  AC60 HEK-293T C870(1.00); C962(0.87); C782(0.99); C708(1.00)  LDD1563  [33]
 LDCM0325  AC61 HEK-293T C870(1.07); C962(0.96); C782(1.01); C708(0.94)  LDD1564  [33]
 LDCM0326  AC62 HEK-293T C870(1.04); C962(0.95); C782(0.98); C708(0.96)  LDD1565  [33]
 LDCM0327  AC63 HEK-293T C870(1.08); C962(1.02); C782(0.99); C708(0.98)  LDD1566  [33]
 LDCM0328  AC64 HEK-293T C870(0.95); C962(0.96); C782(0.97); C708(0.97)  LDD1567  [33]
 LDCM0334  AC7 HEK-293T C870(0.98); C962(0.94); C782(0.99); C708(0.88)  LDD1568  [33]
 LDCM0345  AC8 HEK-293T C870(0.99); C962(0.95); C782(1.02); C708(0.98)  LDD1569  [33]
 LDCM0545  Acetamide MDA-MB-231 C782(0.85); C708(0.53)  LDD2138  [32]
 LDCM0520  AKOS000195272 MDA-MB-231 C962(1.19); C782(1.00); C870(0.84); C1027(1.09)  LDD2113  [32]
 LDCM0248  AKOS034007472 HEK-293T C870(1.02); C962(1.04); C782(1.03); C708(0.91)  LDD1511  [33]
 LDCM0356  AKOS034007680 HEK-293T C870(1.02); C962(0.92); C782(0.98); C708(0.93)  LDD1570  [33]
 LDCM0275  AKOS034007705 HEK-293T C870(1.04); C962(1.00); C782(1.04); C708(0.98)  LDD1514  [33]
 LDCM0156  Aniline NCI-H1299 C708(0.00); C95(0.00)  LDD0404  [1]
 LDCM0498  BS-3668 MDA-MB-231 C782(0.96); C726(1.56)  LDD2091  [32]
 LDCM0108  Chloroacetamide HeLa C962(0.00); C797(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C782(5.02); C95(2.19); C459(1.54); C708(1.47)  LDD2227  [19]
 LDCM0367  CL1 HEK-293T C870(0.98); C962(1.02); C782(1.11); C708(1.13)  LDD1571  [33]
 LDCM0368  CL10 HEK-293T C870(1.65); C962(1.11); C782(1.17); C708(3.33)  LDD1572  [33]
 LDCM0369  CL100 HEK-293T C870(1.07); C962(0.95); C782(1.05); C350(1.08)  LDD1573  [33]
 LDCM0370  CL101 HEK-293T C870(0.97); C962(1.03); C782(1.01); C708(1.00)  LDD1574  [33]
 LDCM0371  CL102 HEK-293T C870(1.14); C962(1.04); C782(0.96); C708(1.66)  LDD1575  [33]
 LDCM0372  CL103 HEK-293T C870(1.04); C962(0.89); C782(0.99); C708(0.97)  LDD1576  [33]
 LDCM0373  CL104 HEK-293T C870(0.99); C962(0.99); C782(1.01); C350(1.03)  LDD1577  [33]
 LDCM0374  CL105 HEK-293T C870(0.98); C962(1.14); C782(1.01); C708(1.13)  LDD1578  [33]
 LDCM0375  CL106 HEK-293T C870(1.01); C962(1.03); C782(1.01); C708(1.26)  LDD1579  [33]
 LDCM0376  CL107 HEK-293T C870(0.97); C962(0.89); C782(1.00); C708(0.94)  LDD1580  [33]
 LDCM0377  CL108 HEK-293T C870(0.95); C962(0.97); C782(0.97); C350(0.99)  LDD1581  [33]
 LDCM0378  CL109 HEK-293T C870(1.06); C962(1.05); C782(1.07); C708(1.13)  LDD1582  [33]
 LDCM0379  CL11 HEK-293T C870(1.06); C962(1.12); C782(1.15); C708(1.43)  LDD1583  [33]
 LDCM0380  CL110 HEK-293T C870(1.22); C962(1.12); C782(0.99); C708(1.71)  LDD1584  [33]
 LDCM0381  CL111 HEK-293T C870(1.10); C962(0.91); C782(0.94); C708(1.35)  LDD1585  [33]
 LDCM0382  CL112 HEK-293T C870(1.03); C962(1.07); C782(0.95); C350(0.97)  LDD1586  [33]
 LDCM0383  CL113 HEK-293T C870(0.91); C962(0.96); C782(0.96); C708(0.93)  LDD1587  [33]
 LDCM0384  CL114 HEK-293T C870(1.10); C962(1.07); C782(1.01); C708(1.87)  LDD1588  [33]
 LDCM0385  CL115 HEK-293T C870(0.94); C962(0.95); C782(0.94); C708(0.96)  LDD1589  [33]
 LDCM0386  CL116 HEK-293T C870(0.92); C962(0.93); C782(0.96); C350(1.12)  LDD1590  [33]
 LDCM0387  CL117 HEK-293T C870(0.94); C962(0.97); C782(0.95); C708(0.97)  LDD1591  [33]
 LDCM0388  CL118 HEK-293T C870(0.96); C962(0.99); C782(0.94); C708(0.88)  LDD1592  [33]
 LDCM0389  CL119 HEK-293T C870(0.95); C962(0.94); C782(0.97); C708(0.94)  LDD1593  [33]
 LDCM0390  CL12 HEK-293T C870(1.12); C962(1.07); C782(1.16); C708(1.33)  LDD1594  [33]
 LDCM0391  CL120 HEK-293T C870(0.99); C962(0.96); C782(1.00); C350(1.05)  LDD1595  [33]
 LDCM0392  CL121 HEK-293T C870(0.89); C962(1.01); C782(1.01); C708(1.03)  LDD1596  [33]
 LDCM0393  CL122 HEK-293T C870(1.00); C962(1.10); C782(0.95); C708(1.09)  LDD1597  [33]
 LDCM0394  CL123 HEK-293T C870(1.22); C962(1.41); C782(1.07); C708(1.65)  LDD1598  [33]
 LDCM0395  CL124 HEK-293T C870(0.95); C962(1.20); C782(1.02); C350(1.24)  LDD1599  [33]
 LDCM0396  CL125 HEK-293T C870(1.05); C962(0.91); C782(1.00); C708(0.92)  LDD1600  [33]
 LDCM0397  CL126 HEK-293T C870(1.07); C962(1.07); C782(0.91); C708(1.14)  LDD1601  [33]
 LDCM0398  CL127 HEK-293T C870(1.03); C962(0.98); C782(0.94); C708(0.93)  LDD1602  [33]
 LDCM0399  CL128 HEK-293T C870(0.94); C962(0.95); C782(1.02); C350(1.02)  LDD1603  [33]
 LDCM0400  CL13 HEK-293T C870(0.96); C962(0.92); C782(1.13); C708(1.11)  LDD1604  [33]
 LDCM0401  CL14 HEK-293T C870(1.00); C962(0.98); C782(0.91); C708(1.03)  LDD1605  [33]
 LDCM0402  CL15 HEK-293T C870(1.39); C962(1.25); C782(1.20); C708(2.27)  LDD1606  [33]
 LDCM0403  CL16 HEK-293T C870(0.98); C962(0.96); C782(1.05); C350(1.09)  LDD1607  [33]
 LDCM0404  CL17 HEK-293T C870(1.35); C962(1.12); C782(1.02); C708(2.09)  LDD1608  [33]
 LDCM0405  CL18 HEK-293T C870(1.05); C962(1.01); C782(1.02); C708(0.95)  LDD1609  [33]
 LDCM0406  CL19 HEK-293T C870(1.02); C962(0.99); C782(1.11); C708(0.98)  LDD1610  [33]
 LDCM0407  CL2 HEK-293T C870(1.08); C962(0.98); C782(0.97); C708(1.01)  LDD1611  [33]
 LDCM0408  CL20 HEK-293T C870(0.99); C962(0.98); C782(1.07); C708(0.92)  LDD1612  [33]
 LDCM0409  CL21 HEK-293T C870(1.36); C962(1.57); C782(1.12); C708(2.13)  LDD1613  [33]
 LDCM0410  CL22 HEK-293T C870(0.96); C962(0.99); C782(1.09); C708(1.03)  LDD1614  [33]
 LDCM0411  CL23 HEK-293T C870(1.05); C962(1.19); C782(1.16); C708(1.02)  LDD1615  [33]
 LDCM0412  CL24 HEK-293T C870(1.02); C962(1.08); C782(1.08); C708(1.11)  LDD1616  [33]
 LDCM0413  CL25 HEK-293T C870(1.08); C962(1.30); C782(1.13); C708(1.35)  LDD1617  [33]
 LDCM0414  CL26 HEK-293T C870(0.98); C962(1.05); C782(0.96); C708(0.93)  LDD1618  [33]
 LDCM0415  CL27 HEK-293T C870(0.97); C962(0.99); C782(1.02); C708(0.94)  LDD1619  [33]
 LDCM0416  CL28 HEK-293T C870(1.03); C962(1.09); C782(1.08); C350(1.03)  LDD1620  [33]
 LDCM0417  CL29 HEK-293T C870(0.99); C962(0.96); C782(1.01); C708(0.93)  LDD1621  [33]
 LDCM0418  CL3 HEK-293T C870(1.01); C962(0.96); C782(1.03); C708(1.01)  LDD1622  [33]
 LDCM0419  CL30 HEK-293T C870(1.02); C962(1.06); C782(1.06); C708(0.93)  LDD1623  [33]
 LDCM0420  CL31 HEK-293T C870(1.03); C962(1.00); C782(0.99); C708(1.00)  LDD1624  [33]
 LDCM0421  CL32 HEK-293T C870(0.98); C962(0.90); C782(1.05); C708(0.92)  LDD1625  [33]
 LDCM0422  CL33 HEK-293T C870(1.62); C962(1.33); C782(1.11); C708(2.45)  LDD1626  [33]
 LDCM0423  CL34 HEK-293T C870(1.01); C962(1.00); C782(1.12); C708(1.29)  LDD1627  [33]
 LDCM0424  CL35 HEK-293T C870(0.96); C962(1.14); C782(1.08); C708(1.14)  LDD1628  [33]
 LDCM0425  CL36 HEK-293T C870(0.99); C962(1.02); C782(1.10); C708(1.26)  LDD1629  [33]
 LDCM0426  CL37 HEK-293T C870(1.08); C962(1.11); C782(1.05); C708(1.03)  LDD1630  [33]
 LDCM0428  CL39 HEK-293T C870(1.00); C962(0.90); C782(0.94); C708(1.14)  LDD1632  [33]
 LDCM0429  CL4 HEK-293T C870(1.01); C962(0.99); C782(1.09); C350(1.14)  LDD1633  [33]
 LDCM0430  CL40 HEK-293T C870(0.99); C962(1.04); C782(1.06); C350(0.98)  LDD1634  [33]
 LDCM0431  CL41 HEK-293T C870(1.14); C962(1.02); C782(1.01); C708(1.30)  LDD1635  [33]
 LDCM0432  CL42 HEK-293T C870(1.02); C962(1.06); C782(1.01); C708(1.01)  LDD1636  [33]
 LDCM0433  CL43 HEK-293T C870(0.98); C962(0.94); C782(1.02); C708(1.05)  LDD1637  [33]
 LDCM0434  CL44 HEK-293T C870(1.08); C962(1.04); C782(1.02); C708(0.95)  LDD1638  [33]
 LDCM0435  CL45 HEK-293T C870(1.13); C962(1.10); C782(0.97); C708(1.64)  LDD1639  [33]
 LDCM0436  CL46 HEK-293T C870(1.03); C962(1.00); C782(1.07); C708(1.20)  LDD1640  [33]
 LDCM0437  CL47 HEK-293T C870(0.99); C962(1.05); C782(1.08); C708(1.17)  LDD1641  [33]
 LDCM0438  CL48 HEK-293T C870(0.98); C962(1.05); C782(1.12); C708(1.27)  LDD1642  [33]
 LDCM0439  CL49 HEK-293T C870(0.96); C962(0.95); C782(1.02); C708(0.98)  LDD1643  [33]
 LDCM0440  CL5 HEK-293T C870(1.03); C962(1.02); C782(0.98); C708(0.99)  LDD1644  [33]
 LDCM0441  CL50 HEK-293T C870(1.00); C962(1.13); C782(0.97); C708(1.29)  LDD1645  [33]
 LDCM0443  CL52 HEK-293T C870(0.95); C962(0.95); C782(1.03); C350(1.06)  LDD1646  [33]
 LDCM0444  CL53 HEK-293T C870(1.13); C962(1.04); C782(0.99); C708(1.60)  LDD1647  [33]
 LDCM0445  CL54 HEK-293T C870(1.21); C962(1.65); C782(1.21); C708(1.56)  LDD1648  [33]
 LDCM0446  CL55 HEK-293T C870(0.93); C962(0.91); C782(0.97); C708(0.95)  LDD1649  [33]
 LDCM0447  CL56 HEK-293T C870(0.92); C962(0.91); C782(0.98); C708(1.11)  LDD1650  [33]
 LDCM0448  CL57 HEK-293T C870(1.16); C962(1.22); C782(1.05); C708(1.61)  LDD1651  [33]
 LDCM0449  CL58 HEK-293T C870(0.98); C962(1.06); C782(1.04); C708(1.20)  LDD1652  [33]
 LDCM0450  CL59 HEK-293T C870(0.92); C962(0.96); C782(1.08); C708(1.13)  LDD1653  [33]
 LDCM0451  CL6 HEK-293T C870(1.25); C962(1.72); C782(1.07); C708(1.50)  LDD1654  [33]
 LDCM0452  CL60 HEK-293T C870(0.97); C962(1.06); C782(1.05); C708(1.31)  LDD1655  [33]
 LDCM0453  CL61 HEK-293T C870(0.91); C962(0.93); C782(0.98); C708(0.89)  LDD1656  [33]
 LDCM0454  CL62 HEK-293T C870(0.99); C962(1.03); C782(0.90); C708(0.88)  LDD1657  [33]
 LDCM0455  CL63 HEK-293T C870(0.94); C962(0.97); C782(0.94); C708(0.87)  LDD1658  [33]
 LDCM0456  CL64 HEK-293T C870(1.13); C962(1.17); C782(1.07); C350(1.23)  LDD1659  [33]
 LDCM0457  CL65 HEK-293T C870(1.00); C962(0.93); C782(1.03); C708(0.95)  LDD1660  [33]
 LDCM0458  CL66 HEK-293T C870(0.98); C962(0.97); C782(0.98); C708(1.11)  LDD1661  [33]
 LDCM0459  CL67 HEK-293T C870(0.97); C962(0.93); C782(0.99); C708(0.86)  LDD1662  [33]
 LDCM0460  CL68 HEK-293T C870(1.01); C962(0.94); C782(0.99); C708(1.03)  LDD1663  [33]
 LDCM0461  CL69 HEK-293T C870(1.01); C962(1.14); C782(0.98); C708(1.14)  LDD1664  [33]
 LDCM0462  CL7 HEK-293T C870(1.02); C962(0.97); C782(1.05); C708(0.97)  LDD1665  [33]
 LDCM0463  CL70 HEK-293T C870(0.99); C962(0.97); C782(1.09); C708(0.97)  LDD1666  [33]
 LDCM0464  CL71 HEK-293T C870(0.98); C962(1.09); C782(1.04); C708(1.14)  LDD1667  [33]
 LDCM0465  CL72 HEK-293T C870(1.01); C962(1.09); C782(1.10); C708(1.00)  LDD1668  [33]
 LDCM0466  CL73 HEK-293T C870(0.97); C962(1.04); C782(1.03); C708(1.36)  LDD1669  [33]
 LDCM0467  CL74 HEK-293T C870(0.99); C962(0.99); C782(0.95); C708(0.91)  LDD1670  [33]
 LDCM0469  CL76 HEK-293T C870(0.91); C962(0.94); C782(1.03); C350(1.06)  LDD1672  [33]
 LDCM0470  CL77 HEK-293T C870(1.16); C962(0.99); C782(0.98); C708(1.65)  LDD1673  [33]
 LDCM0471  CL78 HEK-293T C870(0.97); C962(1.00); C782(1.04); C708(0.92)  LDD1674  [33]
 LDCM0472  CL79 HEK-293T C870(0.96); C962(0.98); C782(1.04); C708(0.97)  LDD1675  [33]
 LDCM0473  CL8 HEK-293T C870(2.49); C962(2.26); C782(1.72); C708(3.38)  LDD1676  [33]
 LDCM0474  CL80 HEK-293T C870(0.98); C962(0.98); C782(1.03); C708(0.89)  LDD1677  [33]
 LDCM0475  CL81 HEK-293T C870(1.02); C962(0.99); C782(0.99); C708(0.85)  LDD1678  [33]
 LDCM0476  CL82 HEK-293T C870(0.98); C962(0.95); C782(1.13); C708(0.99)  LDD1679  [33]
 LDCM0477  CL83 HEK-293T C870(1.00); C962(1.09); C782(1.07); C708(1.19)  LDD1680  [33]
 LDCM0478  CL84 HEK-293T C870(1.08); C962(1.12); C782(1.15); C708(1.65)  LDD1681  [33]
 LDCM0479  CL85 HEK-293T C870(1.05); C962(1.00); C782(0.99); C708(0.88)  LDD1682  [33]
 LDCM0480  CL86 HEK-293T C870(1.02); C962(1.18); C782(0.89); C708(0.99)  LDD1683  [33]
 LDCM0481  CL87 HEK-293T C870(1.01); C962(0.97); C782(0.94); C708(0.99)  LDD1684  [33]
 LDCM0482  CL88 HEK-293T C870(1.01); C962(0.93); C782(1.05); C350(1.10)  LDD1685  [33]
 LDCM0483  CL89 HEK-293T C870(1.01); C962(0.98); C782(0.93); C708(0.89)  LDD1686  [33]
 LDCM0484  CL9 HEK-293T C870(1.12); C962(1.08); C782(0.96); C708(1.16)  LDD1687  [33]
 LDCM0485  CL90 HEK-293T C870(1.89); C962(1.56); C782(1.12); C708(2.15)  LDD1688  [33]
 LDCM0486  CL91 HEK-293T C870(0.98); C962(0.73); C782(0.96); C708(0.97)  LDD1689  [33]
 LDCM0487  CL92 HEK-293T C870(1.05); C962(0.92); C782(1.00); C708(1.25)  LDD1690  [33]
 LDCM0488  CL93 HEK-293T C870(1.14); C962(1.11); C782(1.00); C708(1.39)  LDD1691  [33]
 LDCM0489  CL94 HEK-293T C870(0.96); C962(0.92); C782(1.02); C708(1.13)  LDD1692  [33]
 LDCM0490  CL95 HEK-293T C870(1.66); C962(1.68); C782(1.32); C708(4.14)  LDD1693  [33]
 LDCM0491  CL96 HEK-293T C870(1.08); C962(1.17); C782(1.11); C708(1.53)  LDD1694  [33]
 LDCM0492  CL97 HEK-293T C870(1.03); C962(1.32); C782(1.10); C708(1.27)  LDD1695  [33]
 LDCM0493  CL98 HEK-293T C870(0.98); C962(0.97); C782(0.95); C708(1.15)  LDD1696  [33]
 LDCM0494  CL99 HEK-293T C870(0.96); C962(0.91); C782(0.95); C708(1.22)  LDD1697  [33]
 LDCM0191  Compound 21 HEK-293T 3.37  LDD0508  [27]
 LDCM0634  CY-0357 Hep-G2 C708(0.59)  LDD2228  [19]
 LDCM0495  E2913 HEK-293T C870(0.92); C962(0.88); C782(0.86); C708(1.29)  LDD1698  [33]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C782(4.52); C400(3.76)  LDD1702  [32]
 LDCM0031  Epigallocatechin gallate HEK-293T 10.11  LDD0183  [8]
 LDCM0175  Ethacrynic acid HeLa C350(2.23); C42(1.10)  LDD2210  [11]
 LDCM0625  F8 Ramos C708(0.87); C400(0.74); C962(1.32); C42(1.04)  LDD2187  [34]
 LDCM0572  Fragment10 Ramos C400(0.49); C962(0.63); C42(0.63)  LDD2189  [34]
 LDCM0573  Fragment11 Ramos C400(1.87); C962(0.16); C42(0.16)  LDD2190  [34]
 LDCM0574  Fragment12 Ramos C400(0.66); C962(0.63); C42(0.86)  LDD2191  [34]
 LDCM0575  Fragment13 Ramos C708(1.36); C400(0.97); C962(0.85); C42(0.97)  LDD2192  [34]
 LDCM0576  Fragment14 Ramos C708(0.55); C400(1.21); C962(0.61); C42(1.34)  LDD2193  [34]
 LDCM0579  Fragment20 Ramos C400(0.50); C962(0.58); C42(0.71)  LDD2194  [34]
 LDCM0580  Fragment21 Ramos C708(1.48); C400(1.40); C962(1.15); C42(1.12)  LDD2195  [34]
 LDCM0582  Fragment23 Ramos C708(0.59); C400(0.95); C962(0.86); C42(1.21)  LDD2196  [34]
 LDCM0578  Fragment27 Ramos C708(1.17); C400(0.94); C962(0.81); C42(1.23)  LDD2197  [34]
 LDCM0586  Fragment28 Ramos C708(0.96); C400(0.68); C962(0.73); C42(0.54)  LDD2198  [34]
 LDCM0588  Fragment30 Ramos C708(6.63); C400(0.89); C962(1.17); C42(1.02)  LDD2199  [34]
 LDCM0589  Fragment31 Ramos C708(1.30); C400(0.62); C962(1.10); C42(1.63)  LDD2200  [34]
 LDCM0590  Fragment32 Ramos C400(0.47); C962(0.68); C42(1.29)  LDD2201  [34]
 LDCM0468  Fragment33 HEK-293T C870(0.97); C962(0.95); C782(0.95); C708(0.98)  LDD1671  [33]
 LDCM0596  Fragment38 Ramos C708(1.31); C400(0.45); C962(0.89); C42(0.89)  LDD2203  [34]
 LDCM0566  Fragment4 Ramos C400(0.91); C962(1.05); C42(0.70)  LDD2184  [34]
 LDCM0427  Fragment51 HEK-293T C870(1.03); C962(1.03); C782(0.98); C708(0.94)  LDD1631  [33]
 LDCM0610  Fragment52 Ramos C708(1.04); C400(1.36); C962(0.83); C42(1.33)  LDD2204  [34]
 LDCM0614  Fragment56 Ramos C400(1.11); C962(0.88); C42(1.58)  LDD2205  [34]
 LDCM0569  Fragment7 Ramos C708(4.56); C400(0.64); C42(0.47)  LDD2186  [34]
 LDCM0571  Fragment9 Ramos C400(0.52); C962(0.51); C42(1.29)  LDD2188  [34]
 LDCM0107  IAA HeLa C797(0.00); C962(0.00)  LDD0221  [23]
 LDCM0179  JZ128 PC-3 C725(0.00); C42(0.00); C726(0.00); C732(0.00)  LDD0462  [7]
 LDCM0022  KB02 HEK-293T C870(0.81); C962(1.00); C782(0.97); C708(0.74)  LDD1492  [33]
 LDCM0023  KB03 Jurkat C797(14.05); C708(17.13); C782(5.61); C459(4.74)  LDD0209  [12]
 LDCM0024  KB05 G361 C459(4.33); C350(3.69); C400(5.19); C870(5.69)  LDD3311  [35]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C708(1.26); C797(1.14)  LDD2102  [32]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C782(1.03); C708(0.88)  LDD2121  [32]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C782(1.11); C708(0.82)  LDD2089  [32]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C962(1.14); C708(1.27); C797(1.45)  LDD2090  [32]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C782(1.05); C708(0.93)  LDD2092  [32]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C782(1.03); C708(1.22); C797(1.24)  LDD2093  [32]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C782(1.20); C708(1.07); C725(1.12)  LDD2094  [32]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C782(0.54); C708(0.13); C870(0.39)  LDD2096  [32]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C962(0.92); C782(1.00); C797(1.05); C725(1.54)  LDD2097  [32]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C782(1.07); C708(1.36); C797(0.90)  LDD2098  [32]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C962(1.09); C782(1.64); C708(0.86); C797(1.12)  LDD2099  [32]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C708(1.14)  LDD2100  [32]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C962(1.61); C782(0.90); C708(0.53); C797(0.78)  LDD2101  [32]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C962(0.92); C782(0.55); C708(0.94)  LDD2104  [32]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C782(1.07); C708(1.13); C797(1.30)  LDD2105  [32]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C962(0.81); C708(0.98); C797(0.55)  LDD2106  [32]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C962(1.02); C782(1.03); C708(1.06); C797(1.24)  LDD2107  [32]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C962(0.80); C708(1.05)  LDD2108  [32]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C782(0.63); C708(0.89); C870(0.76); C725(0.66)  LDD2109  [32]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C708(2.66); C797(1.09)  LDD2110  [32]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C782(1.07); C708(1.03); C797(1.36); C870(0.88)  LDD2111  [32]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C782(0.62); C708(0.68)  LDD2114  [32]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C962(0.89); C708(0.56); C797(0.43); C870(0.50)  LDD2115  [32]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C782(0.84); C708(0.25); C725(0.32)  LDD2116  [32]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C962(0.17); C782(0.73); C708(0.23); C725(0.25)  LDD2118  [32]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C962(2.15); C782(1.67); C708(2.21); C797(1.80)  LDD2119  [32]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C782(0.99); C708(0.85); C797(0.65); C726(0.85)  LDD2120  [32]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C962(0.12); C782(0.69); C708(0.25); C870(0.17)  LDD2122  [32]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C782(0.99); C708(1.00); C797(0.96); C726(0.69)  LDD2123  [32]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C962(0.11); C782(0.56); C708(0.40)  LDD2124  [32]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C782(0.96); C708(0.93); C870(0.78); C725(0.99)  LDD2125  [32]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C962(0.12); C782(0.56); C708(0.28); C870(0.45)  LDD2126  [32]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C962(1.44); C782(1.19); C708(0.97); C797(1.03)  LDD2127  [32]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C782(1.23); C797(0.74)  LDD2128  [32]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C962(1.03); C782(1.34); C708(4.09); C797(1.45)  LDD2129  [32]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C782(0.93); C708(0.56); C797(0.61); C725(0.85)  LDD2133  [32]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C782(0.54); C708(0.46); C797(0.43); C1027(0.62)  LDD2134  [32]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C962(1.66); C782(1.92); C708(0.85); C797(2.03)  LDD2135  [32]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C962(1.16); C782(1.54); C708(1.10); C797(0.66)  LDD2136  [32]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C962(1.10); C782(1.07); C708(0.96); C797(0.96)  LDD2137  [32]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C708(3.89); C782(3.35); C797(2.87); C870(2.00)  LDD1700  [32]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C782(1.00); C708(0.95); C726(1.08); C870(0.78)  LDD2140  [32]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C782(0.74); C797(0.59); C870(0.81)  LDD2141  [32]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C782(0.89); C708(1.07); C726(0.69); C725(0.90)  LDD2143  [32]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C962(2.45); C708(2.52); C797(1.41); C726(1.04)  LDD2144  [32]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C708(4.08)  LDD2145  [32]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C782(1.11); C708(1.08); C797(0.90); C726(1.11)  LDD2146  [32]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C708(1.30)  LDD2147  [32]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C962(0.80); C782(0.46); C797(0.47); C725(0.52)  LDD2148  [32]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C782(0.68); C708(0.22)  LDD2149  [32]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C962(0.52); C782(0.77); C708(0.58); C797(0.76)  LDD2150  [32]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C962(0.17); C782(0.70); C708(0.39)  LDD2151  [32]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C962(1.25); C708(2.32); C797(2.16)  LDD2153  [32]
 LDCM0627  NUDT7-COV-1 HEK-293T C42(5.08); C95(0.90); C708(0.75)  LDD2206  [36]
 LDCM0628  OTUB2-COV-1 HEK-293T C95(0.99); C708(0.27)  LDD2207  [36]
 LDCM0131  RA190 MM1.R 2.63  LDD0300  [10]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [30]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
CCAAT/enhancer-binding protein delta (CEBPD) BZIP family P49716
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
T-complex protein 11-like protein 1 (TCP11L1) TCP11 family Q9NUJ3
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964

References

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2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
8 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
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14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
18 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
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24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
27 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
28 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
29 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
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Mass spectrometry data entry: PXD007570
32 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
33 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
35 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
36 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.