Details of the Target

General Information of Target

Target ID LDTP10381
Target Name Peroxisomal membrane protein 11C (PEX11G)
Gene Name PEX11G
Gene ID 92960
Synonyms
PEX11C; Peroxisomal membrane protein 11C; Peroxin-11C; Peroxisomal biogenesis factor 11C; Protein PEX11 homolog gamma; PEX11-gamma
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEGNGPAAVHYQPASPPRDACVYSSCYCEENIWKLCEYIKNHDQYPLEECYAVFISNERK
MIPIWKQQARPGDGPVIWDYHVVLLHVSSGGQNFIYDLDTVLPFPCLFDTYVEDAFKSDD
DIHPQFRRKFRVIRADSYLKNFASDRSHMKDSSGNWREPPPPYPCIETGDSKMNLNDFIS
MDPKVGWGAVYTLSEFTHRFGSKNC
Target Bioclass
Other
Family
Peroxin-11 family
Subcellular location
Peroxisome membrane
Function Promotes membrane protrusion and elongation on the peroxisomal surface.
Uniprot ID
Q96HA9
Ensemble ID
ENST00000221480.6
HGNC ID
HGNC:20208

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO800 SNV: p.T163S .
HS936T SNV: p.L49M .
SNGM SNV: p.S164N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C106(0.86)  LDD1508  [1]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C166
 Probe Info  		7.41  LDD1846  [2]
C226
 Probe Info  		5.58  LDD1899  [2]
C274
 Probe Info  		5.86  LDD1944  [2]
C275
 Probe Info  		6.45  LDD1945  [2]
C277
 Probe Info  		14.72  LDD1947  [2]
C285
 Probe Info  		28.44  LDD1955  [2]
C286
 Probe Info  		19.84  LDD1956  [2]
C287
 Probe Info  		10.20  LDD1957  [2]
C288
 Probe Info  		13.45  LDD1958  [2]
C289
 Probe Info  		37.27  LDD1959  [2]
C290
 Probe Info  		16.56  LDD1960  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HEK-293T C106(0.86)  LDD1508  [1]
 LDCM0277  AC18 HEK-293T C106(0.98)  LDD1516  [1]
 LDCM0279  AC2 HEK-293T C106(0.99)  LDD1518  [1]
 LDCM0286  AC26 HEK-293T C106(0.94)  LDD1525  [1]
 LDCM0295  AC34 HEK-293T C106(0.94)  LDD1534  [1]
 LDCM0304  AC42 HEK-293T C106(0.99)  LDD1543  [1]
 LDCM0313  AC50 HEK-293T C106(0.81)  LDD1552  [1]
 LDCM0321  AC58 HEK-293T C106(0.97)  LDD1560  [1]
 LDCM0405  CL18 HEK-293T C106(0.77)  LDD1609  [1]
 LDCM0419  CL30 HEK-293T C106(0.77)  LDD1623  [1]
 LDCM0432  CL42 HEK-293T C106(0.85)  LDD1636  [1]
 LDCM0445  CL54 HEK-293T C106(0.93)  LDD1648  [1]
 LDCM0451  CL6 HEK-293T C106(0.95)  LDD1654  [1]
 LDCM0458  CL66 HEK-293T C106(0.83)  LDD1661  [1]
 LDCM0471  CL78 HEK-293T C106(0.81)  LDD1674  [1]
 LDCM0485  CL90 HEK-293T C106(0.97)  LDD1688  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Lysoplasmalogenase TMEM86B (TMEM86B) TMEM86 family Q8N661
Transporter and channel
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
G protein-activated inward rectifier potassium channel 2 (KCNJ6) Inward rectifier-type potassium channel family P48051
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
2 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587