Details of the Target

General Information of Target

Target ID LDTP03608
Target Name RAC-beta serine/threonine-protein kinase (AKT2)
Gene Name AKT2
Gene ID 208
Synonyms
RAC-beta serine/threonine-protein kinase; EC 2.7.11.1; Protein kinase Akt-2; Protein kinase B beta; PKB beta; RAC-PK-beta
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
Target Type
Literature-reported
Target Bioclass
Enzyme
Family
Protein kinase superfamily, AGC Ser/Thr protein kinase family, RAC subfamily
Subcellular location
Cytoplasm
Function
AKT2 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Involved in the inhibition of ciliogenesis associated with RAB8-dependent cilia growth.; One of the few specific substrates of AKT2 identified recently is PITX2. Phosphorylation of PITX2 impairs its association with the CCND1 mRNA-stabilizing complex thus shortening the half-life of CCND1. AKT2 seems also to be the principal isoform responsible of the regulation of glucose uptake. Phosphorylates C2CD5 on 'Ser-197' during insulin-stimulated adipocytes. AKT2 is also specifically involved in skeletal muscle differentiation, one of its substrates in this process being ANKRD2. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. Phosphorylates CLK2 on 'Thr-343'.
TTD ID
T94621
Uniprot ID
P31751
DrugMap ID
TTH24WI
Ensemble ID
ENST00000311278.10
HGNC ID
HGNC:392
ChEMBL ID
CHEMBL2431

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.Y177H DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.Y273H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.98  LDD0402  [1]
Probe 1
 Probe Info  		Y38(18.58); Y122(17.32)  LDD3495  [2]
AHL-Pu-1
 Probe Info  		C311(2.20)  LDD0168  [3]
HHS-482
 Probe Info  		Y265(0.90); Y327(0.90)  LDD0285  [4]
HHS-475
 Probe Info  		Y327(0.83); Y265(1.06)  LDD0264  [5]
HHS-465
 Probe Info  		Y327(10.00)  LDD2237  [6]
DBIA
 Probe Info  		C297(1.01); C311(0.93)  LDD0078  [7]
ATP probe
 Probe Info  		N.A.  LDD0199  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C77(0.00); C60(0.00); C297(0.00); C311(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C77(0.00); C60(0.00); C297(0.00); C311(0.00)  LDD0036  [9]
Lodoacetamide azide
 Probe Info  		C124(0.00); C77(0.00); C60(0.00); C297(0.00)  LDD0037  [9]
NAIA_5
 Probe Info  		N.A.  LDD2224  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
WYneO
 Probe Info  		N.A.  LDD0022  [11]
IPM
 Probe Info  		C77(0.00); C297(0.00)  LDD0005  [11]
SF
 Probe Info  		N.A.  LDD0028  [12]
STPyne
 Probe Info  		N.A.  LDD0009  [11]
TFBX
 Probe Info  		C297(0.00); C311(0.00)  LDD0148  [13]
VSF
 Probe Info  		N.A.  LDD0007  [11]
AOyne
 Probe Info  		15.00  LDD0443  [14]
PAL-AfBPP Probe
Click To Hide/Show 31 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		12.64  LDD1752  [15]
C064
 Probe Info  		7.78  LDD1761  [15]
C082
 Probe Info  		5.74  LDD1774  [15]
C085
 Probe Info  		5.54  LDD1777  [15]
C087
 Probe Info  		10.56  LDD1779  [15]
C138
 Probe Info  		6.11  LDD1820  [15]
C161
 Probe Info  		10.27  LDD1841  [15]
C166
 Probe Info  		8.82  LDD1846  [15]
C169
 Probe Info  		23.10  LDD1849  [15]
C173
 Probe Info  		6.45  LDD1853  [15]
C177
 Probe Info  		8.06  LDD1856  [15]
C182
 Probe Info  		5.74  LDD1860  [15]
C218
 Probe Info  		14.42  LDD1892  [15]
C260
 Probe Info  		5.94  LDD1932  [15]
C284
 Probe Info  		31.78  LDD1954  [15]
C288
 Probe Info  		6.63  LDD1958  [15]
C299
 Probe Info  		5.90  LDD1968  [15]
C310
 Probe Info  		11.16  LDD1977  [15]
C313
 Probe Info  		14.52  LDD1980  [15]
C317
 Probe Info  		14.42  LDD1983  [15]
C326
 Probe Info  		7.31  LDD1990  [15]
C348
 Probe Info  		9.92  LDD2009  [15]
C353
 Probe Info  		6.32  LDD2014  [15]
C354
 Probe Info  		8.34  LDD2015  [15]
C361
 Probe Info  		17.15  LDD2022  [15]
C363
 Probe Info  		17.75  LDD2024  [15]
C391
 Probe Info  		13.18  LDD2050  [15]
C403
 Probe Info  		25.28  LDD2061  [15]
FFF probe2
 Probe Info  		20.00  LDD0463  [16]
FFF probe3
 Probe Info  		20.00  LDD0465  [16]
FFF probe6
 Probe Info  		5.63  LDD0468  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C311(2.20)  LDD0168  [3]
 LDCM0026  4SU-RNA+native RNA HEK-293T C311(2.35)  LDD0169  [3]
 LDCM0214  AC1 HCT 116 C124(0.74); C311(1.16); C77(0.99)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C124(1.26); C311(1.12); C77(1.37)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C124(0.74); C311(1.48); C77(1.07)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C124(0.92); C311(1.68); C77(1.04)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C124(0.91); C311(1.40); C77(1.00)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C124(1.15); C311(1.82); C77(1.22)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C124(1.10); C311(1.18); C77(1.00)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C124(1.10); C311(1.66); C77(0.98)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C124(1.23); C311(1.74); C77(1.15)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C124(1.29); C311(1.49); C77(0.94)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C124(0.92); C311(1.92); C77(0.99)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C124(0.84); C311(1.11); C77(1.01)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C124(1.22); C311(1.03); C77(1.78)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C124(0.81); C311(1.70); C77(1.16)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C124(1.10); C311(1.64); C77(1.30)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C124(1.43); C311(1.47); C77(0.89)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C124(0.91); C311(0.78); C77(1.10)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C124(1.37); C311(0.97); C77(1.37)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C124(1.32); C311(0.80); C77(1.38)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C124(1.57); C311(0.90); C77(1.38)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C124(1.14); C311(0.78); C77(1.36)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C124(1.32); C311(0.79); C77(1.33)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C124(1.35); C311(0.75); C77(1.12)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C124(0.94); C311(0.87); C77(1.12)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C124(1.22); C311(0.85); C77(1.11)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C124(1.46); C311(0.72); C77(1.29)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C124(1.34); C311(0.72); C77(1.67)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C124(1.26); C311(0.79); C77(0.96)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C124(1.04); C311(0.96); C77(1.13)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C124(1.03); C311(0.73); C77(1.24)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C124(1.44); C311(0.92); C77(1.56)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C124(1.50); C311(0.86); C77(1.30)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C124(1.50); C311(1.35); C77(1.30)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C124(0.81); C311(0.97); C77(0.86)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C124(1.11); C311(1.16); C77(1.03)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C124(0.83); C311(0.99); C77(1.00)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C124(0.84); C311(1.02); C77(1.09)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C124(1.05); C311(1.13); C77(1.38)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C124(1.05); C311(1.27); C77(1.49)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C124(1.15); C311(1.20); C77(1.46)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C124(1.16); C311(1.19); C77(1.14)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C124(0.93); C311(1.12); C77(1.11)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C124(1.04); C311(1.36); C77(1.36)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C124(1.14); C311(1.20); C77(1.25)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C124(1.29); C311(0.98); C77(1.09)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C124(1.11); C311(1.30); C77(1.22)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C124(1.12); C311(1.33); C77(1.38)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C124(0.92); C311(1.05); C77(1.03)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C124(1.18); C311(1.11); C77(1.06)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C77(1.00); C124(1.26); C311(1.36)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C77(1.00); C311(1.05); C124(1.11)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C77(1.05); C311(1.26); C124(1.33)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C77(1.04); C311(1.37); C124(1.44)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C77(1.01); C311(1.71); C124(1.77)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C77(0.95); C124(1.46); C311(1.69)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C311(0.95); C77(1.15); C124(1.23)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C77(1.00); C124(1.05); C311(1.17)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C124(1.00); C77(1.09); C311(1.14)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C77(0.90); C311(1.28); C124(1.37)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C77(1.03); C124(1.80); C311(2.03)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C124(1.15); C311(1.39); C77(1.11)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C124(1.24); C311(1.38); C77(0.99)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C124(1.04); C311(1.13); C77(1.05)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C124(1.03); C311(1.02); C77(1.10)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C124(0.94); C77(1.07); C311(1.08)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C77(1.18); C311(1.43); C124(1.52)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C77(0.99); C311(1.14); C124(1.21)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C77(1.00); C124(1.11); C311(1.31)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C311(1.11); C77(1.17); C124(1.19)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C77(0.86); C124(1.04); C311(1.15)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C77(0.86); C124(0.96); C311(0.99)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C124(0.93); C77(1.03); C311(1.19)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C311(0.94); C124(0.99); C77(1.09)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C77(0.99); C311(1.03); C124(1.13)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C311(1.14); C77(1.17); C124(1.21)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C77(1.19); C124(1.25); C311(1.30)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C124(1.17); C311(1.23); C77(1.53)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C311(1.15); C77(1.19); C124(1.30)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C124(0.97); C77(1.32); C311(1.36)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C77(1.12); C311(1.24); C124(1.25)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C124(1.22); C311(1.29); C77(1.44)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C311(1.36); C124(1.40); C77(1.49)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C77(1.11); C311(1.20); C124(1.36)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C77(1.09); C124(1.33); C311(1.45)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C124(0.90); C77(0.96); C311(1.14)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C124(0.92); C311(1.01); C77(1.03)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C124(0.97); C311(1.08); C77(1.31)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C124(0.94); C77(1.14); C311(1.25)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C124(1.02); C311(1.34); C77(1.38)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C124(0.96); C77(1.15); C311(1.23)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C124(1.09); C311(1.11); C77(1.30)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C124(0.90); C77(1.14); C311(1.39)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C124(1.10); C77(1.19); C311(1.99)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C124(1.07); C311(1.18); C77(1.25)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C77(1.01); C124(1.05); C311(1.56)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C124(1.18); C311(1.22); C77(1.80)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C77(1.13); C311(1.20); C124(1.22)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C77(0.95); C311(0.98); C124(1.12)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C77(1.06); C311(1.11); C124(1.22)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C77(1.03); C311(1.52); C124(1.62)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C124(0.81); C311(0.98); C77(1.32)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C77(1.01); C311(1.48); C124(1.55)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C77(0.95); C124(1.01); C311(1.01)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C77(1.05); C124(1.10); C311(1.14)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C77(0.98); C311(1.18); C124(1.33)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C77(0.99); C311(1.16); C124(1.33)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C77(1.06); C311(1.19); C124(1.33)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C77(0.96); C311(1.60); C124(1.82)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C77(1.23); C311(1.27)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C77(1.15); C311(1.44)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C77(1.09); C311(1.26)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C311(1.10); C124(1.11); C77(1.33)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C77(1.13); C311(1.35)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C77(1.14); C311(1.29)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C77(1.16); C311(1.34)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C77(1.05); C311(1.23)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C77(1.12); C311(1.40)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C77(1.17); C311(1.48)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C77(1.17); C311(1.58)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C77(1.22); C311(1.57)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C77(0.92); C311(1.15)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C77(0.83); C311(1.24)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C311(0.97); C77(1.05); C124(1.23)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C77(0.96); C311(1.31)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C77(1.00); C311(1.13)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C77(0.87); C311(1.30)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C77(1.10); C311(1.80)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C77(1.00); C311(1.64)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C77(0.90); C311(1.76)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C77(0.87); C311(1.41)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C77(1.01); C311(1.50)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C77(0.78); C311(1.23)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C77(0.92); C311(1.32)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C77(1.01); C311(1.12); C124(1.18)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C77(1.02); C311(1.16)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C77(0.87); C311(1.08)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C77(1.03); C311(1.59)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C77(1.17); C311(1.30); C124(1.50)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C77(1.09); C124(1.36); C311(1.37)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C77(1.18); C124(1.22); C311(1.38)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C124(1.30); C311(1.34); C77(1.39)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C124(1.09); C311(1.27); C77(1.40)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C124(1.26); C311(1.30); C77(1.38)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C77(1.19); C124(1.48); C311(1.48)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C124(1.22); C311(1.22); C77(1.23)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C311(1.19); C124(1.38); C77(1.39)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C77(1.07); C124(1.25); C311(1.32)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C124(1.10); C77(1.14); C311(1.41)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C124(1.03); C311(1.23); C77(1.37)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C77(1.21); C311(1.33); C124(1.45)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C124(1.04); C311(1.21); C77(1.24)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C77(1.44); C124(1.46); C311(1.58)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C77(1.07); C124(1.60); C311(1.70)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C124(0.90); C77(1.07); C311(1.57)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C124(1.07); C311(0.92); C77(1.29)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C311(0.96); C77(1.20); C124(1.21)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C311(1.26); C77(1.41); C124(1.90)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 11.80  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C297(1.01); C311(0.93)  LDD0078  [7]
 LDCM0367  CL1 HCT 116 C124(0.74); C311(1.01); C77(1.05)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C77(1.16); C124(1.30); C311(1.34)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C311(1.04); C124(1.17); C77(1.26)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C311(1.05); C77(1.31); C124(1.56)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C311(0.85); C124(1.04); C77(1.57)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C311(0.88); C77(1.02); C124(1.10)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C311(0.89); C124(1.08); C77(1.15)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C311(1.25); C77(1.28); C124(1.34)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C77(1.22); C311(1.53); C124(1.53)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C124(1.20); C77(1.34); C311(1.46)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C77(1.38); C311(1.41); C124(1.72)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C77(1.17); C311(1.22); C124(1.33)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C77(1.05); C124(1.27); C311(1.36)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C77(1.26); C311(1.41); C124(1.53)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C77(1.08); C124(1.13); C311(1.33)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C311(1.01); C124(1.11); C77(1.37)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C77(0.99); C124(1.34); C311(1.34)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C124(1.16); C77(1.36); C311(1.41)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C77(1.10); C311(1.19); C124(1.29)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C124(1.19); C311(1.27); C77(1.35)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C77(1.14); C124(1.41); C311(2.44)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C124(0.99); C77(1.20); C311(1.90)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C77(1.09); C311(1.14); C124(1.15)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C77(1.00); C311(1.30); C124(1.48)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C311(1.01); C124(1.04); C77(1.20)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C311(0.95); C124(1.12); C77(1.12)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C77(0.94); C124(1.20); C311(1.29)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C77(1.03); C124(1.39); C311(1.54)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C77(1.00); C311(1.36); C124(1.48)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C311(1.08); C77(1.19)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C77(1.12); C311(1.69)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C77(1.04); C311(1.14)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C311(1.17); C77(1.18)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C77(0.99); C311(1.13); C124(1.18)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C77(1.05); C124(1.13); C311(1.15)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C77(1.03); C124(1.06); C311(1.24)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C311(0.98); C77(1.13)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C77(1.15); C311(1.19)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C311(1.07); C77(1.23)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C77(1.10); C311(1.19)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C124(0.85); C77(0.85); C311(1.02)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C311(1.19); C77(1.31)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C77(1.38); C311(1.39)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C77(1.61); C311(1.76)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C311(1.09); C77(1.38)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C311(1.29); C77(1.50)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C311(1.63); C77(1.38)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C311(1.12); C77(1.18)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C311(1.13); C77(1.24)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C311(1.21); C77(1.37)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C311(1.12); C77(1.37)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C124(0.87); C311(1.06); C77(0.87)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C311(0.98); C77(1.26)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C311(1.09); C77(1.42)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C311(1.15); C77(1.03)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C311(1.50); C77(1.20)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C311(1.43); C77(1.34)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C311(1.36); C77(1.69)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C311(1.27); C77(1.52)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C311(1.57); C77(1.30)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C311(1.85); C77(1.31)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C124(1.04); C311(0.99); C77(0.98)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C311(1.47); C77(1.46)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C311(1.24); C77(1.11)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C311(1.95); C77(1.34)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C311(1.52); C77(1.44)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C311(1.31); C77(1.38)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C311(1.63); C77(1.52)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C311(1.07); C77(1.29)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C311(1.04); C77(1.22)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C311(0.93); C77(1.31)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C311(0.92); C77(1.19)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C124(1.03); C311(0.92); C77(0.93)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C311(1.18); C77(1.11)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C311(1.16); C77(1.23)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C311(1.11); C77(1.16)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C311(0.99); C77(0.85)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C311(1.11); C77(1.12)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C311(0.98); C77(1.18)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C311(1.10); C77(1.13)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C311(1.02); C77(1.10)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C311(0.99); C77(1.18)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C311(1.14); C77(1.22)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C124(0.95); C311(1.11); C77(0.96)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C311(1.50); C77(1.24)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C311(1.61); C77(0.97)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C311(1.15); C77(0.99)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C311(1.27); C77(1.06)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C311(1.57); C77(0.93)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C311(1.46); C77(0.98)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C311(1.97); C77(1.22)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C311(1.47); C77(0.92)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C311(1.61); C77(1.01)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C311(1.42); C77(1.25)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C124(1.20); C311(1.07); C77(1.27)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C311(1.33); C77(0.98)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C311(1.93); C77(0.99)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C311(1.20); C77(1.04)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C311(1.43); C77(0.92)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C311(1.35); C77(1.02)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C311(1.10); C77(0.98)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C311(1.02); C77(0.92)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C311(1.12); C77(1.09)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C311(1.34); C77(1.06)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C124(1.52); C311(1.54); C77(0.92)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C311(1.06); C77(0.95)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C311(1.15); C77(1.04)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C311(1.56); C77(1.21)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C311(1.36); C77(1.17)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C311(1.81); C77(1.51)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C311(1.13); C77(1.23)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C311(1.06); C77(0.89)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C311(1.16); C77(1.20)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C311(1.41); C77(1.11)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C311(1.93); C77(1.33)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C124(1.24); C311(1.06); C77(0.74)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C311(0.98); C77(0.88)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C124(1.12); C311(1.40); C77(1.14)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C124(1.21); C311(1.03); C77(1.19)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C124(1.00); C311(0.97); C77(1.08)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C124(0.94); C311(1.66); C77(1.29)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C124(1.33); C311(1.36); C77(1.04)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C124(1.04); C311(1.16); C77(1.29)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C124(1.44); C311(1.65); C77(1.21)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C124(1.01); C311(1.36); C77(1.62)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C124(0.92); C311(1.25); C77(1.34)  LDD0811  [7]
 LDCM0634  CY-0357 Hep-G2 C124(0.92)  LDD2228  [10]
 LDCM0495  E2913 HEK-293T C124(0.95); C311(0.79); C77(1.02)  LDD1698  [17]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C77(1.23)  LDD1702  [18]
 LDCM0468  Fragment33 HCT 116 C311(1.45); C77(0.97)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C311(1.64); C77(1.67)  LDD0744  [7]
 LDCM0116  HHS-0101 DM93 Y327(0.83); Y265(1.06)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y327(0.84); Y265(1.30)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y327(0.60); Y265(1.09)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y327(0.85); Y265(0.98)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y327(0.99); Y265(1.36)  LDD0268  [5]
 LDCM0123  JWB131 DM93 Y265(0.90); Y327(0.90)  LDD0285  [4]
 LDCM0124  JWB142 DM93 Y265(0.70); Y327(0.51)  LDD0286  [4]
 LDCM0125  JWB146 DM93 Y265(3.61); Y327(0.85)  LDD0287  [4]
 LDCM0126  JWB150 DM93 Y265(1.24); Y327(4.76)  LDD0288  [4]
 LDCM0127  JWB152 DM93 Y265(2.88); Y327(1.31)  LDD0289  [4]
 LDCM0128  JWB198 DM93 Y265(0.83); Y327(0.70)  LDD0290  [4]
 LDCM0129  JWB202 DM93 Y265(1.03); Y327(0.32)  LDD0291  [4]
 LDCM0130  JWB211 DM93 Y265(0.81); Y327(0.75)  LDD0292  [4]
 LDCM0022  KB02 HCT 116 C311(2.05); C77(1.05)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C311(1.75); C77(1.26)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C311(3.55); C77(0.89)  LDD0082  [7]
 LDCM0628  OTUB2-COV-1 HEK-293T C297(1.82)  LDD2207  [19]
 LDCM0021  THZ1 HCT 116 C297(0.94); C77(1.09)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycogen synthase kinase-3 beta (GSK3B) CMGC Ser/Thr protein kinase family P49841
E3 ubiquitin-protein ligase TTC3 (TTC3) . P53804
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vimentin (VIM) Intermediate filament family P08670
PRKCA-binding protein (PICK1) . Q9NRD5
Vinexin (SORBS3) . O60504

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 7 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
(2s)-1-(1h-indol-3-yl)-3-{[5-(3-methyl-1h-indazol-5-yl)Pyridin-3-yl]Oxy}Propan-2-amine Small molecular drug DB08073
Akt Inhibitor Viii Small molecular drug D05APZ
Pht-427 Small molecular drug D0M9QJ
Pmid20005102c1 Small molecular drug D0L2WP
4-(4-chlorophenyl)-4-[4-(1h-pyrazol-4-yl)Phenyl]Piperidine . DB07859
Isoquinoline-5-sulfonic Acid (2-(2-(4-chlorobenzyloxy)Ethylamino)Ethyl)Amide . DB07947
N-[(1s)-2-amino-1-phenylethyl]-5-(1h-pyrrolo[23-b]Pyridin-4-yl)Thiophene-2-carboxamide . DB07812

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
3 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
13 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
14 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
18 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
19 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.