Details of the Target

General Information of Target

Target ID LDTP10093
Target Name Mitochondrial calcium uniporter regulator 1 (MCUR1)
Gene Name MCUR1
Gene ID 63933
Synonyms
C6orf79; CCDC90A; Mitochondrial calcium uniporter regulator 1; MCU regulator 1; Coiled-coil domain-containing protein 90A, mitochondrial
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEYAMKSLSLLYPKSLSRHVSVRTSVVTQQLLSEPSPKAPRARPCRVSTADRSVRKGIMA
YSLEDLLLKVRDTLMLADKPFFLVLEEDGTTVETEEYFQALAGDTVFMVLQKGQKWQPPS
EQGTRHPLSLSHKPAKKIDVARVTFDLYKLNPQDFIGCLNVKATFYDTYSLSYDLHCCGA
KRIMKEAFRWALFSMQATGHVLLGTSCYLQQLLDATEEGQPPKGKASSLIPTCLKILQ
Target Bioclass
Other
Family
CCDC90 family
Subcellular location
Mitochondrion inner membrane
Function
Key regulator of mitochondrial calcium uniporter (MCU) required for calcium entry into mitochondrion. Plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU. Probably involved in the assembly of the membrane components of the uniporter complex (uniplex).
Uniprot ID
Q96AQ8
Ensemble ID
ENST00000379170.9
HGNC ID
HGNC:21097

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
IM95 SNV: p.L253P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K283(2.95)  LDD0277  [1]
Acrolein
 Probe Info  		N.A.  LDD0227  [2]
AOyne
 Probe Info  		15.00  LDD0443  [3]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C165
 Probe Info  		13.93  LDD1845  [4]
C166
 Probe Info  		13.27  LDD1846  [4]
C187
 Probe Info  		24.76  LDD1865  [4]
C201
 Probe Info  		25.28  LDD1877  [4]
C218
 Probe Info  		19.29  LDD1892  [4]
C220
 Probe Info  		19.84  LDD1894  [4]
C278
 Probe Info  		62.25  LDD1948  [4]
C285
 Probe Info  		19.43  LDD1955  [4]
C287
 Probe Info  		8.63  LDD1957  [4]
C289
 Probe Info  		35.51  LDD1959  [4]
C388
 Probe Info  		57.68  LDD2047  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0227  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
3 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587