Details of the Target

General Information of Target

Target ID LDTP01759
Target Name Histone-lysine N-methyltransferase NSD2 (NSD2)
Gene Name NSD2
Gene ID 7468
Synonyms
KIAA1090; MMSET; TRX5; WHSC1; Histone-lysine N-methyltransferase NSD2; EC 2.1.1.357; Multiple myeloma SET domain-containing protein; MMSET; Nuclear SET domain-containing protein 2; Protein trithorax-5; Wolf-Hirschhorn syndrome candidate 1 protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEFSIKQSPLSVQSVVKCIKMKQAPEILGSANGKTPSCEVNRECSVFLSKAQLSSSLQEG
VMQKFNGHDALPFIPADKLKDLTSRVFNGEPGAHDAKLRFESQEMKGIGTPPNTTPIKNG
SPEIKLKITKTYMNGKPLFESSICGDSAADVSQSEENGQKPENKARRNRKRSIKYDSLLE
QGLVEAALVSKISSPSDKKIPAKKESCPNTGRDKDHLLKYNVGDLVWSKVSGYPWWPCMV
SADPLLHSYTKLKGQKKSARQYHVQFFGDAPERAWIFEKSLVAFEGEGQFEKLCQESAKQ
APTKAEKIKLLKPISGKLRAQWEMGIVQAEEAASMSVEERKAKFTFLYVGDQLHLNPQVA
KEAGIAAESLGEMAESSGVSEEAAENPKSVREECIPMKRRRRAKLCSSAETLESHPDIGK
STPQKTAEADPRRGVGSPPGRKKTTVSMPRSRKGDAASQFLVFCQKHRDEVVAEHPDASG
EEIEELLRSQWSLLSEKQRARYNTKFALVAPVQAEEDSGNVNGKKRNHTKRIQDPTEDAE
AEDTPRKRLRTDKHSLRKRDTITDKTARTSSYKAMEAASSLKSQAATKNLSDACKPLKKR
NRASTAASSALGFSKSSSPSASLTENEVSDSPGDEPSESPYESADETQTEVSVSSKKSER
GVTAKKEYVCQLCEKPGSLLLCEGPCCGAFHLACLGLSRRPEGRFTCSECASGIHSCFVC
KESKTDVKRCVVTQCGKFYHEACVKKYPLTVFESRGFRCPLHSCVSCHASNPSNPRPSKG
KMMRCVRCPVAYHSGDACLAAGCSVIASNSIICTAHFTARKGKRHHAHVNVSWCFVCSKG
GSLLCCESCPAAFHPDCLNIEMPDGSWFCNDCRAGKKLHFQDIIWVKLGNYRWWPAEVCH
PKNVPPNIQKMKHEIGEFPVFFFGSKDYYWTHQARVFPYMEGDRGSRYQGVRGIGRVFKN
ALQEAEARFREIKLQREARETQESERKPPPYKHIKVNKPYGKVQIYTADISEIPKCNCKP
TDENPCGFDSECLNRMLMFECHPQVCPAGEFCQNQCFTKRQYPETKIIKTDGKGWGLVAK
RDIRKGEFVNEYVGELIDEEECMARIKHAHENDITHFYMLTIDKDRIIDAGPKGNYSRFM
NHSCQPNCETLKWTVNGDTRVGLFAVCDIPAGTELTFNYNLDCLGNEKTVCRCGASNCSG
FLGDRPKTSTTLSSEEKGKKTKKKTRRRRAKGEGKRQSEDECFRCGDGGQLVLCDRKFCT
KAYHLSCLGLGKRPFGKWECPWHHCDVCGKPSTSFCHLCPNSFCKEHQDGTAFSCTPDGR
SYCCEHDLGAASVRSTKTEKPPPEPGKPKGKRRRRRGWRRVTEGK
Target Bioclass
Enzyme
Family
Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SET2 subfamily
Subcellular location
Cytoplasm; Nucleus
Function
Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). Also monomethylates nucleosomal histone H3 at 'Lys-36' (H3K36me) in vitro. Does not trimethylate nucleosomal histone H3 at 'Lys-36' (H3K36me3). However, specifically trimethylates histone H3 at 'Lys-36' (H3K36me3) at euchromatic regions in embryonic stem (ES) cells. By methylating histone H3 at 'Lys-36', involved in the regulation of gene transcription during various biological processes. In ES cells, associates with developmental transcription factors such as SALL1 and represses inappropriate gene transcription mediated by histone deacetylation. During heart development, associates with transcription factor NKX2-5 to repress transcription of NKX2-5 target genes. Plays an essential role in adipogenesis, by regulating expression of genes involved in pre-adipocyte differentiation. During T-cell receptor (TCR) and CD28-mediated T-cell activation, promotes the transcription of transcription factor BCL6 which is required for follicular helper T (Tfh) cell differentiation. During B-cell development, required for the generation of the B1 lineage. During B2 cell activation, may contribute to the control of isotype class switch recombination (CRS), splenic germinal center formation, and the humoral immune response. Plays a role in class switch recombination of the immunoglobulin heavy chain (IgH) locus during B-cell activation. By regulating the methylation of histone H3 at 'Lys-36' and histone H4 at 'Lys-20' at the IgH locus, involved in TP53BP1 recruitment to the IgH switch region and promotes the transcription of IgA.; [Isoform 1]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2).; [Isoform 4]: Histone methyltransferase which specifically dimethylates nucleosomal histone H3 at 'Lys-36' (H3K36me2). Methylation of histone H3 at 'Lys-27' is controversial. Mono-, di- or tri-methylates histone H3 at 'Lys-27' (H3K27me, H3K27me2 and H3K27me3). Does not methylate histone H3 at 'Lys-27'. May act as a transcription regulator that binds DNA and suppresses IL5 transcription through HDAC recruitment.
Uniprot ID
O96028
Ensemble ID
ENST00000312087.10
HGNC ID
HGNC:12766
ChEMBL ID
CHEMBL3108645

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.Y502H DBIA    Probe Info 
COLO800 SNV: p.E1111K DBIA    Probe Info 
EFO27 Deletion: p.P1343QfsTer49 DBIA    Probe Info 
HCT15 Deletion: p.P1343QfsTer49 DBIA    Probe Info 
K562 SNV: p.R600Ter FFF probe13    Probe Info 
KELLY SNV: p.W867L DBIA    Probe Info 
KYSE150 SNV: p.R986H DBIA    Probe Info 
MFE319 SNV: p.Y641H DBIA    Probe Info 
MM1S SNV: p.E1099K .
RKO Deletion: .
Insertion: p.E1344RfsTer91		 DBIA    Probe Info 
SAOS2 SNV: p.R501H .
SKMEL5 SNV: p.P36S DBIA    Probe Info 
SKNSH SNV: p.S1266Y .
SUDHL6 SNV: p.G325D DBIA    Probe Info 
TFK1 SNV: p.D69G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.35  LDD0402  [1]
Jackson_1
 Probe Info  		20.00  LDD0122  [2]
STPyne
 Probe Info  		K998(10.00)  LDD0277  [3]
P11
 Probe Info  		20.00  LDD0201  [4]
BTD
 Probe Info  		C594(1.27)  LDD1700  [5]
AHL-Pu-1
 Probe Info  		C594(2.58); C406(3.37)  LDD0168  [6]
DBIA
 Probe Info  		C1193(1.13); C1198(1.13); C44(1.01); C730(0.98)  LDD0078  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C406(0.00); C238(0.00); C1267(0.00); C1102(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C238(0.00); C743(0.00); C464(0.00); C294(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C394(0.00); C743(0.00); C238(0.00); C1267(0.00)  LDD0037  [8]
NAIA_4
 Probe Info  		N.A.  LDD2226  [9]
WYneN
 Probe Info  		N.A.  LDD0021  [10]
WYneO
 Probe Info  		C406(0.00); C38(0.00)  LDD0022  [10]
Compound 10
 Probe Info  		C38(0.00); C406(0.00)  LDD2216  [11]
Compound 11
 Probe Info  		N.A.  LDD2213  [11]
IPM
 Probe Info  		C406(0.00); C594(0.00); C38(0.00); C207(0.00)  LDD0005  [10]
TFBX
 Probe Info  		C594(0.00); C1193(0.00)  LDD0148  [12]
VSF
 Probe Info  		C44(0.00); C406(0.00); C38(0.00)  LDD0007  [10]
Phosphinate-6
 Probe Info  		C594(0.00); C406(0.00)  LDD0018  [13]
Acrolein
 Probe Info  		C1323(0.00); C1267(0.00)  LDD0217  [14]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [14]
Methacrolein
 Probe Info  		C406(0.00); C1323(0.00); C207(0.00); C594(0.00)  LDD0218  [14]
W1
 Probe Info  		N.A.  LDD0236  [15]
NAIA_5
 Probe Info  		C406(0.00); C238(0.00)  LDD2223  [9]
PAL-AfBPP Probe
Click To Hide/Show 20 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		18.13  LDD1793  [16]
C108
 Probe Info  		9.19  LDD1795  [16]
C161
 Probe Info  		11.55  LDD1841  [16]
C198
 Probe Info  		10.41  LDD1874  [16]
C201
 Probe Info  		28.44  LDD1877  [16]
C277
 Probe Info  		10.13  LDD1947  [16]
C284
 Probe Info  		22.47  LDD1954  [16]
C343
 Probe Info  		11.79  LDD2005  [16]
C344
 Probe Info  		6.92  LDD2006  [16]
C346
 Probe Info  		18.13  LDD2007  [16]
C363
 Probe Info  		16.45  LDD2024  [16]
C376
 Probe Info  		7.94  LDD2036  [16]
C386
 Probe Info  		8.11  LDD2045  [16]
C399
 Probe Info  		7.84  LDD2058  [16]
C419
 Probe Info  		11.96  LDD2074  [16]
C420
 Probe Info  		11.63  LDD2075  [16]
C431
 Probe Info  		15.78  LDD2086  [16]
FFF probe13
 Probe Info  		20.00  LDD0475  [17]
FFF probe2
 Probe Info  		20.00  LDD0463  [17]
Diazir
 Probe Info  		N.A.  LDD0011  [10]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C594(1.16)  LDD2112  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C594(1.32); C207(0.97)  LDD2117  [5]
 LDCM0025  4SU-RNA HEK-293T C594(2.58); C406(3.37)  LDD0168  [6]
 LDCM0026  4SU-RNA+native RNA HEK-293T C406(3.48); C144(3.52)  LDD0169  [6]
 LDCM0214  AC1 HCT 116 C1016(0.98); C1018(0.87); C1032(0.87); C1144(1.00)  LDD0531  [7]
 LDCM0215  AC10 HCT 116 C1046(0.92); C1056(0.93); C1016(0.94); C1018(0.79)  LDD0532  [7]
 LDCM0216  AC100 HCT 116 C1016(0.51); C1018(0.57); C1032(0.51); C1144(0.74)  LDD0533  [7]
 LDCM0217  AC101 HCT 116 C1016(0.65); C1018(0.65); C1032(0.65); C1144(0.79)  LDD0534  [7]
 LDCM0218  AC102 HCT 116 C1016(0.44); C1018(0.46); C1032(0.44); C1144(0.81)  LDD0535  [7]
 LDCM0219  AC103 HCT 116 C1016(0.52); C1018(0.60); C1032(0.52); C1144(0.86)  LDD0536  [7]
 LDCM0220  AC104 HCT 116 C1016(0.48); C1018(0.51); C1032(0.48); C1144(0.94)  LDD0537  [7]
 LDCM0221  AC105 HCT 116 C1016(0.55); C1018(0.53); C1032(0.55); C1144(0.87)  LDD0538  [7]
 LDCM0222  AC106 HCT 116 C1016(0.52); C1018(0.48); C1032(0.52); C1144(0.92)  LDD0539  [7]
 LDCM0223  AC107 HCT 116 C1016(0.50); C1018(0.58); C1032(0.38); C1144(0.61)  LDD0540  [7]
 LDCM0224  AC108 HCT 116 C1016(0.55); C1018(0.53); C1032(0.84); C1144(0.67)  LDD0541  [7]
 LDCM0225  AC109 HCT 116 C1016(0.70); C1018(0.58); C1032(0.81); C1144(0.71)  LDD0542  [7]
 LDCM0226  AC11 HCT 116 C1046(0.95); C1056(0.99); C1016(0.81); C1018(0.69)  LDD0543  [7]
 LDCM0227  AC110 HCT 116 C1016(0.55); C1018(0.65); C1032(0.61); C1144(0.64)  LDD0544  [7]
 LDCM0228  AC111 HCT 116 C1016(0.61); C1018(0.53); C1032(0.82); C1144(0.67)  LDD0545  [7]
 LDCM0229  AC112 HCT 116 C1016(0.52); C1018(0.52); C1032(0.54); C1144(0.69)  LDD0546  [7]
 LDCM0230  AC113 HCT 116 C1041(0.98); C1046(1.21); C1056(1.15); C1016(1.14)  LDD0547  [7]
 LDCM0231  AC114 HCT 116 C1041(0.85); C1046(0.93); C1056(0.93); C1016(1.05)  LDD0548  [7]
 LDCM0232  AC115 HCT 116 C1041(0.79); C1046(0.85); C1056(0.83); C1016(0.88)  LDD0549  [7]
 LDCM0233  AC116 HCT 116 C1041(0.86); C1046(0.98); C1056(0.91); C1016(0.80)  LDD0550  [7]
 LDCM0234  AC117 HCT 116 C1041(0.85); C1046(1.01); C1056(0.92); C1016(0.92)  LDD0551  [7]
 LDCM0235  AC118 HCT 116 C1041(0.83); C1046(0.87); C1056(0.89); C1016(0.98)  LDD0552  [7]
 LDCM0236  AC119 HCT 116 C1041(0.80); C1046(1.01); C1056(0.91); C1016(0.93)  LDD0553  [7]
 LDCM0237  AC12 HCT 116 C1046(0.89); C1056(0.88); C1016(0.75); C1018(0.67)  LDD0554  [7]
 LDCM0238  AC120 HCT 116 C1041(0.79); C1046(0.92); C1056(0.90); C1016(0.77)  LDD0555  [7]
 LDCM0239  AC121 HCT 116 C1041(0.97); C1046(0.97); C1056(0.96); C1016(1.13)  LDD0556  [7]
 LDCM0240  AC122 HCT 116 C1041(0.95); C1046(0.87); C1056(0.94); C1016(0.88)  LDD0557  [7]
 LDCM0241  AC123 HCT 116 C1041(0.88); C1046(0.96); C1056(0.92); C1016(1.20)  LDD0558  [7]
 LDCM0242  AC124 HCT 116 C1041(0.89); C1046(1.00); C1056(0.97); C1016(1.12)  LDD0559  [7]
 LDCM0243  AC125 HCT 116 C1041(0.83); C1046(0.87); C1056(0.89); C1016(0.81)  LDD0560  [7]
 LDCM0244  AC126 HCT 116 C1041(0.87); C1046(0.96); C1056(0.93); C1016(0.92)  LDD0561  [7]
 LDCM0245  AC127 HCT 116 C1041(0.79); C1046(0.91); C1056(0.91); C1016(1.03)  LDD0562  [7]
 LDCM0246  AC128 HCT 116 C1041(1.43); C1046(1.17); C1056(0.90); C1016(1.36)  LDD0563  [7]
 LDCM0247  AC129 HCT 116 C1041(2.51); C1046(1.67); C1056(0.84); C1016(1.39)  LDD0564  [7]
 LDCM0249  AC130 HCT 116 C1041(1.03); C1046(0.89); C1056(0.76); C1016(1.61)  LDD0566  [7]
 LDCM0250  AC131 HCT 116 C1041(1.27); C1046(1.03); C1056(0.78); C1016(1.98)  LDD0567  [7]
 LDCM0251  AC132 HCT 116 C1041(1.47); C1046(1.07); C1056(0.66); C1016(1.59)  LDD0568  [7]
 LDCM0252  AC133 HCT 116 C1041(1.30); C1046(1.09); C1056(0.89); C1016(1.20)  LDD0569  [7]
 LDCM0253  AC134 HCT 116 C1041(1.21); C1046(0.93); C1056(0.65); C1016(1.34)  LDD0570  [7]
 LDCM0254  AC135 HCT 116 C1041(0.91); C1046(0.82); C1056(0.73); C1016(2.00)  LDD0571  [7]
 LDCM0255  AC136 HCT 116 C1041(1.39); C1046(1.08); C1056(0.77); C1016(1.23)  LDD0572  [7]
 LDCM0256  AC137 HCT 116 C1041(1.85); C1046(1.29); C1056(0.73); C1016(1.11)  LDD0573  [7]
 LDCM0257  AC138 HCT 116 C1041(1.02); C1046(0.79); C1056(0.56); C1016(1.41)  LDD0574  [7]
 LDCM0258  AC139 HCT 116 C1041(1.10); C1046(0.91); C1056(0.71); C1016(2.18)  LDD0575  [7]
 LDCM0259  AC14 HCT 116 C1046(0.83); C1056(0.86); C1016(1.04); C1018(0.93)  LDD0576  [7]
 LDCM0260  AC140 HCT 116 C1041(1.78); C1046(1.22); C1056(0.66); C1016(1.34)  LDD0577  [7]
 LDCM0261  AC141 HCT 116 C1041(1.04); C1046(0.81); C1056(0.58); C1016(1.34)  LDD0578  [7]
 LDCM0262  AC142 HCT 116 C1041(1.85); C1046(1.31); C1056(0.78); C1016(1.44)  LDD0579  [7]
 LDCM0263  AC143 HCT 116 C1041(1.07); C1046(0.84); C1056(1.03); C207(0.66)  LDD0580  [7]
 LDCM0264  AC144 HCT 116 C1280(0.53); C1018(0.63); C1026(0.70); C207(0.78)  LDD0581  [7]
 LDCM0265  AC145 HCT 116 C1026(0.60); C1148(0.78); C294(0.81); C1018(0.84)  LDD0582  [7]
 LDCM0266  AC146 HCT 116 C1148(0.73); C1280(0.84); C207(0.84); C294(0.91)  LDD0583  [7]
 LDCM0267  AC147 HCT 116 C1280(0.54); C1018(0.67); C1148(0.78); C1032(0.83)  LDD0584  [7]
 LDCM0268  AC148 HCT 116 C1280(0.53); C207(0.65); C294(0.72); C1148(0.89)  LDD0585  [7]
 LDCM0269  AC149 HCT 116 C1280(0.60); C1148(0.78); C1323(0.84); C1324(0.84)  LDD0586  [7]
 LDCM0270  AC15 HCT 116 C1016(0.78); C44(0.78); C1026(0.81); C730(0.84)  LDD0587  [7]
 LDCM0271  AC150 HCT 116 C1148(0.71); C1144(0.82); C38(0.86); C1245(0.86)  LDD0588  [7]
 LDCM0272  AC151 HCT 116 C1026(0.67); C1148(0.80); C1016(0.82); C1144(0.83)  LDD0589  [7]
 LDCM0273  AC152 HCT 116 C1280(0.55); C1018(0.64); C1026(0.71); C1032(0.75)  LDD0590  [7]
 LDCM0274  AC153 HCT 116 C1280(0.58); C207(0.59); C294(0.91); C1242(0.94)  LDD0591  [7]
 LDCM0621  AC154 HCT 116 C1041(1.06); C1046(1.33); C1056(1.06); C1016(0.91)  LDD2158  [7]
 LDCM0622  AC155 HCT 116 C1041(0.92); C1046(1.12); C1056(0.90); C1016(0.97)  LDD2159  [7]
 LDCM0623  AC156 HCT 116 C1041(1.30); C1046(1.14); C1056(1.23); C1016(0.86)  LDD2160  [7]
 LDCM0624  AC157 HCT 116 C1041(1.10); C1046(1.55); C1056(1.14); C1016(0.94)  LDD2161  [7]
 LDCM0276  AC17 HCT 116 C44(0.70); C1016(0.75); C1041(0.75); C899(0.79)  LDD0593  [7]
 LDCM0277  AC18 HCT 116 C1016(0.62); C1032(0.64); C1041(0.68); C1018(0.76)  LDD0594  [7]
 LDCM0278  AC19 HCT 116 C1041(0.62); C1016(0.67); C1032(0.71); C1148(0.74)  LDD0595  [7]
 LDCM0279  AC2 HCT 116 C1148(0.68); C1018(0.80); C1032(0.80); C730(0.81)  LDD0596  [7]
 LDCM0280  AC20 HCT 116 C1315(0.71); C899(0.78); C44(0.78); C1016(0.81)  LDD0597  [7]
 LDCM0281  AC21 HCT 116 C899(0.72); C1148(0.78); C44(0.78); C1016(0.80)  LDD0598  [7]
 LDCM0282  AC22 HCT 116 C1315(0.66); C44(0.67); C899(0.72); C207(0.78)  LDD0599  [7]
 LDCM0283  AC23 HCT 116 C44(0.66); C899(0.72); C1041(0.75); C1315(0.75)  LDD0600  [7]
 LDCM0284  AC24 HCT 116 C44(0.65); C1041(0.69); C1046(0.73); C1056(0.73)  LDD0601  [7]
 LDCM0285  AC25 HCT 116 C1324(0.65); C1052(0.69); C1032(0.71); C670(0.75)  LDD0602  [7]
 LDCM0286  AC26 HCT 116 C1026(0.68); C1016(0.71); C1052(0.72); C1018(0.73)  LDD0603  [7]
 LDCM0287  AC27 HCT 116 C1032(0.75); C1018(0.75); C1016(0.79); C1052(0.82)  LDD0604  [7]
 LDCM0288  AC28 HCT 116 C1032(0.62); C1018(0.66); C1052(0.66); C1016(0.67)  LDD0605  [7]
 LDCM0289  AC29 HCT 116 C1052(0.65); C1148(0.69); C1046(0.74); C1056(0.74)  LDD0606  [7]
 LDCM0290  AC3 HCT 116 C1148(0.73); C730(0.77); C735(0.77); C1016(0.81)  LDD0607  [7]
 LDCM0291  AC30 HCT 116 C1148(0.49); C1032(0.66); C1018(0.67); C1016(0.68)  LDD0608  [7]
 LDCM0292  AC31 HCT 116 C1018(0.83); C1032(0.84); C670(0.85); C673(0.85)  LDD0609  [7]
 LDCM0293  AC32 HCT 116 C1052(0.63); C670(0.74); C673(0.74); C1032(0.75)  LDD0610  [7]
 LDCM0294  AC33 HCT 116 C1052(0.62); C1032(0.69); C1016(0.74); C1046(0.75)  LDD0611  [7]
 LDCM0295  AC34 HCT 116 C1148(0.65); C1018(0.66); C1032(0.71); C1016(0.73)  LDD0612  [7]
 LDCM0296  AC35 HCT 116 C1245(0.54); C1254(0.54); C1324(0.82); C207(0.88)  LDD0613  [7]
 LDCM0297  AC36 HCT 116 C207(0.88); C1052(0.89); C1315(0.91); C1144(0.93)  LDD0614  [7]
 LDCM0298  AC37 HCT 116 C1052(0.76); C1046(0.81); C1056(0.86); C1041(0.88)  LDD0615  [7]
 LDCM0299  AC38 HCT 116 C1315(0.86); C1324(0.87); C1144(0.95); C1148(0.98)  LDD0616  [7]
 LDCM0300  AC39 HCT 116 C1245(0.88); C1254(0.88); C1148(0.98); C1041(0.98)  LDD0617  [7]
 LDCM0301  AC4 HCT 116 C1148(0.66); C1144(0.75); C730(0.82); C735(0.82)  LDD0618  [7]
 LDCM0302  AC40 HCT 116 C1052(0.85); C1046(0.87); C1056(0.90); C1245(0.93)  LDD0619  [7]
 LDCM0303  AC41 HCT 116 C1052(0.75); C1324(0.87); C1148(0.89); C1046(0.89)  LDD0620  [7]
 LDCM0304  AC42 HCT 116 C1052(0.72); C1046(0.79); C1056(0.86); C1148(0.89)  LDD0621  [7]
 LDCM0305  AC43 HCT 116 C1324(0.88); C38(0.88); C1323(0.90); C1315(0.91)  LDD0622  [7]
 LDCM0306  AC44 HCT 116 C1324(0.77); C1148(0.87); C1041(0.88); C1056(0.88)  LDD0623  [7]
 LDCM0307  AC45 HCT 116 C1046(0.84); C1148(0.87); C1041(0.89); C1056(0.91)  LDD0624  [7]
 LDCM0308  AC46 HCT 116 C1288(0.86); C1323(0.89); C1026(0.91); C1242(0.92)  LDD0625  [7]
 LDCM0309  AC47 HCT 116 C1041(0.70); C1144(0.94); C1026(0.97); C1056(0.98)  LDD0626  [7]
 LDCM0310  AC48 HCT 116 C1323(0.81); C1324(0.83); C44(0.88); C1144(0.89)  LDD0627  [7]
 LDCM0311  AC49 HCT 116 C1026(0.78); C1245(0.81); C1254(0.81); C1041(0.81)  LDD0628  [7]
 LDCM0312  AC5 HCT 116 C1148(0.70); C38(0.82); C730(0.84); C735(0.84)  LDD0629  [7]
 LDCM0313  AC50 HCT 116 C1242(0.90); C1026(0.92); C44(0.93); C1280(0.96)  LDD0630  [7]
 LDCM0314  AC51 HCT 116 C1323(0.74); C1324(0.82); C1315(0.86); C1144(0.87)  LDD0631  [7]
 LDCM0315  AC52 HCT 116 C1041(0.71); C1288(0.82); C1026(0.82); C1280(0.86)  LDD0632  [7]
 LDCM0316  AC53 HCT 116 C1280(0.88); C1026(0.88); C1242(0.89); C1018(0.94)  LDD0633  [7]
 LDCM0317  AC54 HCT 116 C1026(0.81); C1016(0.89); C1041(0.89); C1242(0.90)  LDD0634  [7]
 LDCM0318  AC55 HCT 116 C1148(0.93); C1041(0.95); C1280(0.97); C1144(1.01)  LDD0635  [7]
 LDCM0319  AC56 HCT 116 C1148(0.74); C1041(0.92); C1285(0.94); C1280(0.96)  LDD0636  [7]
 LDCM0320  AC57 HCT 116 C1026(0.78); C1148(0.88); C1198(0.90); C1280(0.92)  LDD0637  [7]
 LDCM0321  AC58 HCT 116 C1148(0.74); C670(0.84); C673(0.84); C1032(0.87)  LDD0638  [7]
 LDCM0322  AC59 HCT 116 C1026(0.70); C294(0.73); C1018(0.80); C1032(0.80)  LDD0639  [7]
 LDCM0323  AC6 HCT 116 C1148(0.86); C38(0.86); C1018(0.89); C730(0.90)  LDD0640  [7]
 LDCM0324  AC60 HCT 116 C207(0.93); C1148(0.93); C1280(0.96); C1026(0.99)  LDD0641  [7]
 LDCM0325  AC61 HCT 116 C294(1.00); C1280(1.03); C44(1.07); C1198(1.09)  LDD0642  [7]
 LDCM0326  AC62 HCT 116 C1026(0.80); C1148(0.85); C1280(0.88); C1198(0.95)  LDD0643  [7]
 LDCM0327  AC63 HCT 116 C1280(0.77); C1026(0.84); C1148(0.88); C1198(1.03)  LDD0644  [7]
 LDCM0328  AC64 HCT 116 C1280(0.82); C294(0.83); C1026(0.91); C1148(0.98)  LDD0645  [7]
 LDCM0329  AC65 HCT 116 C1026(0.71); C1148(0.83); C1323(0.86); C1324(0.86)  LDD0646  [7]
 LDCM0330  AC66 HCT 116 C1026(0.69); C294(0.70); C1198(0.78); C1148(0.80)  LDD0647  [7]
 LDCM0331  AC67 HCT 116 C1026(0.78); C1323(0.78); C1324(0.78); C1148(0.86)  LDD0648  [7]
 LDCM0332  AC68 HCT 116 C38(0.61); C207(0.76); C1242(0.80); C730(0.84)  LDD0649  [7]
 LDCM0333  AC69 HCT 116 C38(0.43); C730(0.72); C735(0.72); C1242(0.79)  LDD0650  [7]
 LDCM0334  AC7 HCT 116 C1018(0.83); C1032(0.86); C730(0.92); C735(0.92)  LDD0651  [7]
 LDCM0335  AC70 HCT 116 C38(0.41); C1285(0.76); C1280(0.79); C730(0.79)  LDD0652  [7]
 LDCM0336  AC71 HCT 116 C38(0.53); C1242(0.76); C730(0.80); C735(0.80)  LDD0653  [7]
 LDCM0337  AC72 HCT 116 C38(0.34); C730(0.79); C735(0.79); C1046(0.87)  LDD0654  [7]
 LDCM0338  AC73 HCT 116 C1046(1.11); C1041(1.38); C1056(1.41); C38(0.48)  LDD0655  [7]
 LDCM0339  AC74 HCT 116 C38(0.44); C1242(0.87); C1280(0.95); C1245(0.97)  LDD0656  [7]
 LDCM0340  AC75 HCT 116 C38(0.46); C1242(0.84); C1280(0.90); C1285(0.90)  LDD0657  [7]
 LDCM0341  AC76 HCT 116 C38(0.55); C1280(0.84); C730(0.89); C735(0.89)  LDD0658  [7]
 LDCM0342  AC77 HCT 116 C38(0.39); C730(0.84); C735(0.84); C1280(0.95)  LDD0659  [7]
 LDCM0343  AC78 HCT 116 C38(0.35); C1280(0.88); C1285(0.90); C730(0.95)  LDD0660  [7]
 LDCM0344  AC79 HCT 116 C38(0.45); C730(0.82); C735(0.82); C1285(0.91)  LDD0661  [7]
 LDCM0345  AC8 HCT 116 C1018(0.71); C1016(0.73); C1032(0.74); C1026(0.79)  LDD0662  [7]
 LDCM0346  AC80 HCT 116 C38(0.37); C730(0.78); C735(0.78); C1242(0.79)  LDD0663  [7]
 LDCM0347  AC81 HCT 116 C38(0.45); C1245(0.76); C1254(0.76); C1242(0.97)  LDD0664  [7]
 LDCM0348  AC82 HCT 116 C38(0.47); C1280(0.84); C1285(0.84); C730(0.85)  LDD0665  [7]
 LDCM0349  AC83 HCT 116 C1315(0.64); C1016(0.83); C1018(0.85); C1148(0.85)  LDD0666  [7]
 LDCM0350  AC84 HCT 116 C1315(0.66); C1018(0.72); C1016(0.75); C1032(0.75)  LDD0667  [7]
 LDCM0351  AC85 HCT 116 C1315(0.68); C1148(0.75); C1018(0.75); C1245(0.77)  LDD0668  [7]
 LDCM0352  AC86 HCT 116 C1315(0.75); C1032(0.77); C1148(0.79); C1018(0.79)  LDD0669  [7]
 LDCM0353  AC87 HCT 116 C1026(0.73); C1245(0.77); C1254(0.77); C1018(0.77)  LDD0670  [7]
 LDCM0354  AC88 HCT 116 C1026(0.62); C1018(0.64); C1032(0.65); C1016(0.68)  LDD0671  [7]
 LDCM0355  AC89 HCT 116 C1026(0.64); C1315(0.65); C1018(0.74); C1148(0.76)  LDD0672  [7]
 LDCM0357  AC90 HCT 116 C294(0.65); C1315(0.72); C1018(0.79); C1032(0.80)  LDD0674  [7]
 LDCM0358  AC91 HCT 116 C1315(0.58); C1148(0.72); C294(0.77); C1018(0.82)  LDD0675  [7]
 LDCM0359  AC92 HCT 116 C1148(0.69); C1315(0.71); C1018(0.74); C1026(0.74)  LDD0676  [7]
 LDCM0360  AC93 HCT 116 C1018(0.66); C1032(0.67); C1026(0.68); C1315(0.68)  LDD0677  [7]
 LDCM0361  AC94 HCT 116 C1315(0.56); C294(0.60); C1016(0.66); C1018(0.72)  LDD0678  [7]
 LDCM0362  AC95 HCT 116 C1315(0.71); C294(0.86); C899(0.95); C1198(1.01)  LDD0679  [7]
 LDCM0363  AC96 HCT 116 C1315(0.54); C1148(0.70); C1144(0.78); C1016(0.79)  LDD0680  [7]
 LDCM0364  AC97 HCT 116 C1026(0.63); C1148(0.68); C1018(0.69); C1032(0.70)  LDD0681  [7]
 LDCM0365  AC98 HCT 116 C1148(0.52); C1016(0.66); C1032(0.66); C1245(0.68)  LDD0682  [7]
 LDCM0366  AC99 HCT 116 C1148(0.59); C1016(0.59); C1032(0.59); C1018(0.62)  LDD0683  [7]
 LDCM0248  AKOS034007472 HCT 116 C1046(1.06); C1056(1.07); C1016(1.03); C1018(0.84)  LDD0565  [7]
 LDCM0356  AKOS034007680 HCT 116 C1018(0.84); C1032(0.88); C1323(0.90); C1324(0.90)  LDD0673  [7]
 LDCM0275  AKOS034007705 HCT 116 C1016(0.82); C1026(0.85); C1148(0.87); C1018(0.88)  LDD0592  [7]
 LDCM0156  Aniline NCI-H1299 11.60  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C1193(1.13); C1198(1.13); C44(1.01); C730(0.98)  LDD0078  [7]
 LDCM0088  C45 HEK-293T 20.00  LDD0201  [4]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C406(0.45)  LDD2227  [9]
 LDCM0367  CL1 HCT 116 C1242(0.70); C1245(0.77); C1254(0.77); C1324(0.90)  LDD0684  [7]
 LDCM0368  CL10 HCT 116 C44(0.96); C294(0.99); C1242(1.12); C1315(1.17)  LDD0685  [7]
 LDCM0369  CL100 HCT 116 C1148(0.68); C1016(0.68); C1018(0.77); C1032(0.77)  LDD0686  [7]
 LDCM0370  CL101 HCT 116 C1018(0.78); C1032(0.80); C1016(0.83); C1026(0.87)  LDD0687  [7]
 LDCM0371  CL102 HCT 116 C1018(0.75); C730(0.75); C735(0.75); C1032(0.78)  LDD0688  [7]
 LDCM0372  CL103 HCT 116 C38(0.85); C899(0.86); C1056(0.91); C1016(0.91)  LDD0689  [7]
 LDCM0373  CL104 HCT 116 C1323(0.78); C1324(0.78); C1026(0.83); C38(0.84)  LDD0690  [7]
 LDCM0374  CL105 HCT 116 C44(0.72); C1041(0.73); C1016(0.73); C1032(0.74)  LDD0691  [7]
 LDCM0375  CL106 HCT 116 C44(0.70); C1041(0.74); C1315(0.77); C1016(0.79)  LDD0692  [7]
 LDCM0376  CL107 HCT 116 C1041(0.60); C44(0.67); C1052(0.70); C1016(0.72)  LDD0693  [7]
 LDCM0377  CL108 HCT 116 C1041(0.61); C1016(0.66); C1052(0.67); C44(0.68)  LDD0694  [7]
 LDCM0378  CL109 HCT 116 C1041(0.58); C1032(0.67); C1016(0.68); C1046(0.69)  LDD0695  [7]
 LDCM0379  CL11 HCT 116 C1315(1.01); C294(1.01); C44(1.08); C1242(1.28)  LDD0696  [7]
 LDCM0380  CL110 HCT 116 C44(0.66); C1016(0.67); C1026(0.67); C1032(0.70)  LDD0697  [7]
 LDCM0381  CL111 HCT 116 C1016(0.62); C1041(0.64); C1032(0.65); C1018(0.72)  LDD0698  [7]
 LDCM0382  CL112 HCT 116 C670(0.71); C673(0.71); C1032(0.76); C1148(0.76)  LDD0699  [7]
 LDCM0383  CL113 HCT 116 C1052(0.58); C1018(0.63); C1032(0.64); C1016(0.68)  LDD0700  [7]
 LDCM0384  CL114 HCT 116 C670(0.61); C673(0.61); C1052(0.66); C1148(0.81)  LDD0701  [7]
 LDCM0385  CL115 HCT 116 C1052(0.59); C1032(0.67); C670(0.67); C673(0.67)  LDD0702  [7]
 LDCM0386  CL116 HCT 116 C1052(0.67); C670(0.75); C673(0.75); C1026(0.78)  LDD0703  [7]
 LDCM0387  CL117 HCT 116 C1052(0.95); C1245(1.02); C1254(1.02); C1026(1.04)  LDD0704  [7]
 LDCM0388  CL118 HCT 116 C1046(0.81); C1056(0.84); C1052(0.84); C1041(0.85)  LDD0705  [7]
 LDCM0389  CL119 HCT 116 C1052(0.71); C1046(0.72); C1056(0.73); C1245(0.78)  LDD0706  [7]
 LDCM0390  CL12 HCT 116 C294(0.96); C1148(0.96); C44(1.01); C1242(1.11)  LDD0707  [7]
 LDCM0391  CL120 HCT 116 C1324(0.74); C1046(0.82); C1056(0.84); C1052(0.84)  LDD0708  [7]
 LDCM0392  CL121 HCT 116 C1041(0.54); C1056(0.59); C1242(0.67); C1016(0.69)  LDD0709  [7]
 LDCM0393  CL122 HCT 116 C1242(0.89); C1288(0.90); C1324(0.91); C1041(0.94)  LDD0710  [7]
 LDCM0394  CL123 HCT 116 C1148(0.40); C1288(0.72); C1280(0.78); C1016(0.79)  LDD0711  [7]
 LDCM0395  CL124 HCT 116 C1288(0.71); C1041(0.74); C1280(0.89); C1242(0.94)  LDD0712  [7]
 LDCM0396  CL125 HCT 116 C294(0.78); C1198(0.79); C1193(0.85); C1018(0.85)  LDD0713  [7]
 LDCM0397  CL126 HCT 116 C294(0.67); C1016(0.82); C670(0.83); C673(0.83)  LDD0714  [7]
 LDCM0398  CL127 HCT 116 C1026(0.77); C1018(0.86); C1032(0.88); C294(0.92)  LDD0715  [7]
 LDCM0399  CL128 HCT 116 C1148(0.74); C1018(0.83); C1026(0.85); C1032(0.85)  LDD0716  [7]
 LDCM0400  CL13 HCT 116 C44(0.97); C1315(1.02); C294(1.06); C207(1.10)  LDD0717  [7]
 LDCM0401  CL14 HCT 116 C1242(0.78); C1148(0.92); C1144(0.94); C1315(0.98)  LDD0718  [7]
 LDCM0402  CL15 HCT 116 C294(0.88); C1315(0.92); C44(1.02); C730(1.02)  LDD0719  [7]
 LDCM0403  CL16 HCT 116 C1016(0.67); C1026(0.67); C38(0.83); C1018(0.86)  LDD0720  [7]
 LDCM0404  CL17 HCT 116 C1032(0.80); C1016(0.81); C1026(0.82); C1052(0.87)  LDD0721  [7]
 LDCM0405  CL18 HCT 116 C899(0.92); C38(1.13); C1032(1.19); C1144(1.21)  LDD0722  [7]
 LDCM0406  CL19 HCT 116 C1026(0.74); C1052(0.79); C1056(0.84); C1046(0.89)  LDD0723  [7]
 LDCM0407  CL2 HCT 116 C294(0.62); C1315(0.89); C207(0.94); C1026(0.94)  LDD0724  [7]
 LDCM0408  CL20 HCT 116 C1046(0.72); C1026(0.74); C1056(0.79); C1052(0.85)  LDD0725  [7]
 LDCM0409  CL21 HCT 116 C1026(0.77); C1046(0.78); C899(0.85); C1016(0.89)  LDD0726  [7]
 LDCM0410  CL22 HCT 116 C1032(0.82); C1016(0.83); C1026(0.84); C38(0.87)  LDD0727  [7]
 LDCM0411  CL23 HCT 116 C1026(0.59); C1046(0.71); C1056(0.75); C1052(0.78)  LDD0728  [7]
 LDCM0412  CL24 HCT 116 C1056(0.85); C1046(0.86); C1016(1.02); C1018(1.10)  LDD0729  [7]
 LDCM0413  CL25 HCT 116 C1046(0.70); C1056(0.78); C1016(0.73); C1018(0.83)  LDD0730  [7]
 LDCM0414  CL26 HCT 116 C1046(0.72); C1056(0.78); C1016(0.78); C1018(0.85)  LDD0731  [7]
 LDCM0415  CL27 HCT 116 C1046(0.74); C1056(0.76); C1016(0.78); C1018(0.86)  LDD0732  [7]
 LDCM0416  CL28 HCT 116 C1046(0.74); C1056(0.78); C1016(0.84); C1018(0.92)  LDD0733  [7]
 LDCM0417  CL29 HCT 116 C1046(0.82); C1056(0.84); C1016(0.99); C1018(1.05)  LDD0734  [7]
 LDCM0418  CL3 HCT 116 C1046(1.03); C1056(1.03); C1016(1.00); C1018(0.96)  LDD0735  [7]
 LDCM0419  CL30 HCT 116 C1046(0.96); C1056(1.07); C1016(0.78); C1018(0.87)  LDD0736  [7]
 LDCM0420  CL31 HCT 116 C1016(0.88); C1018(0.85); C1026(0.84); C1032(0.85)  LDD0737  [7]
 LDCM0421  CL32 HCT 116 C1016(1.48); C1018(1.43); C1026(1.53); C1032(1.43)  LDD0738  [7]
 LDCM0422  CL33 HCT 116 C1016(1.54); C1018(1.34); C1026(1.74); C1032(1.34)  LDD0739  [7]
 LDCM0423  CL34 HCT 116 C1016(1.09); C1018(0.94); C1026(1.25); C1032(0.94)  LDD0740  [7]
 LDCM0424  CL35 HCT 116 C1016(0.86); C1018(0.80); C1026(0.91); C1032(0.80)  LDD0741  [7]
 LDCM0425  CL36 HCT 116 C1016(0.96); C1018(0.87); C1026(1.05); C1032(0.87)  LDD0742  [7]
 LDCM0426  CL37 HCT 116 C1016(0.83); C1018(0.88); C1026(0.78); C1032(0.88)  LDD0743  [7]
 LDCM0428  CL39 HCT 116 C1016(0.93); C1018(0.97); C1026(0.90); C1032(0.97)  LDD0745  [7]
 LDCM0429  CL4 HCT 116 C1046(0.92); C1056(0.92); C1016(0.97); C1018(1.07)  LDD0746  [7]
 LDCM0430  CL40 HCT 116 C1016(0.80); C1018(0.73); C1026(0.86); C1032(0.73)  LDD0747  [7]
 LDCM0431  CL41 HCT 116 C1016(1.14); C1018(0.96); C1026(1.33); C1032(0.96)  LDD0748  [7]
 LDCM0432  CL42 HCT 116 C1016(1.25); C1018(1.01); C1026(1.49); C1032(1.01)  LDD0749  [7]
 LDCM0433  CL43 HCT 116 C1016(1.05); C1018(0.92); C1026(1.19); C1032(0.92)  LDD0750  [7]
 LDCM0434  CL44 HCT 116 C1016(1.09); C1018(1.03); C1026(1.16); C1032(1.03)  LDD0751  [7]
 LDCM0435  CL45 HCT 116 C1016(0.97); C1018(0.98); C1026(0.96); C1032(0.98)  LDD0752  [7]
 LDCM0436  CL46 HCT 116 C1041(0.90); C1046(0.95); C1056(0.94); C1016(0.92)  LDD0753  [7]
 LDCM0437  CL47 HCT 116 C1041(0.91); C1046(1.28); C1056(0.94); C1016(0.97)  LDD0754  [7]
 LDCM0438  CL48 HCT 116 C1041(0.95); C1046(1.15); C1056(0.97); C1016(1.01)  LDD0755  [7]
 LDCM0439  CL49 HCT 116 C1041(0.76); C1046(0.60); C1056(0.78); C1016(0.97)  LDD0756  [7]
 LDCM0440  CL5 HCT 116 C1046(1.03); C1056(1.03); C1016(1.06); C1018(1.17)  LDD0757  [7]
 LDCM0441  CL50 HCT 116 C1041(0.73); C1046(1.11); C1056(0.81); C1016(0.90)  LDD0758  [7]
 LDCM0442  CL51 HCT 116 C1041(0.91); C1046(0.97); C1056(0.89); C1016(0.97)  LDD0759  [7]
 LDCM0443  CL52 HCT 116 C1041(0.89); C1046(0.94); C1056(0.88); C1016(1.20)  LDD0760  [7]
 LDCM0444  CL53 HCT 116 C1041(0.76); C1046(0.84); C1056(0.81); C1016(1.22)  LDD0761  [7]
 LDCM0445  CL54 HCT 116 C1041(0.65); C1046(0.73); C1056(0.65); C1016(0.99)  LDD0762  [7]
 LDCM0446  CL55 HCT 116 C1041(0.73); C1046(0.89); C1056(0.84); C1016(0.93)  LDD0763  [7]
 LDCM0447  CL56 HCT 116 C1041(0.86); C1046(1.02); C1056(0.91); C1016(0.95)  LDD0764  [7]
 LDCM0448  CL57 HCT 116 C1041(0.81); C1046(0.94); C1056(0.88); C1016(1.22)  LDD0765  [7]
 LDCM0449  CL58 HCT 116 C1041(0.95); C1046(1.30); C1056(0.94); C1016(0.94)  LDD0766  [7]
 LDCM0450  CL59 HCT 116 C1041(0.93); C1046(0.96); C1056(0.96); C1016(1.33)  LDD0767  [7]
 LDCM0451  CL6 HCT 116 C1046(1.49); C1056(1.49); C1016(1.52); C1018(1.62)  LDD0768  [7]
 LDCM0452  CL60 HCT 116 C1041(0.99); C1046(1.09); C1056(1.00); C1016(0.92)  LDD0769  [7]
 LDCM0453  CL61 HCT 116 C1016(1.11); C1018(1.12); C1026(1.13); C1032(1.14)  LDD0770  [7]
 LDCM0454  CL62 HCT 116 C1016(0.91); C1018(0.94); C1026(1.02); C1032(0.90)  LDD0771  [7]
 LDCM0455  CL63 HCT 116 C1016(1.00); C1018(1.00); C1026(1.08); C1032(1.00)  LDD0772  [7]
 LDCM0456  CL64 HCT 116 C1016(1.01); C1018(1.01); C1026(1.05); C1032(1.03)  LDD0773  [7]
 LDCM0457  CL65 HCT 116 C1016(0.98); C1018(1.04); C1026(1.05); C1032(1.01)  LDD0774  [7]
 LDCM0458  CL66 HCT 116 C1016(0.94); C1018(0.99); C1026(1.00); C1032(0.97)  LDD0775  [7]
 LDCM0459  CL67 HCT 116 C1016(0.88); C1018(0.88); C1026(0.91); C1032(0.89)  LDD0776  [7]
 LDCM0460  CL68 HCT 116 C1016(1.15); C1018(1.16); C1026(1.21); C1032(1.15)  LDD0777  [7]
 LDCM0461  CL69 HCT 116 C1016(1.69); C1018(1.83); C1026(1.35); C1032(1.51)  LDD0778  [7]
 LDCM0462  CL7 HCT 116 C1046(1.37); C1056(1.37); C1016(1.33); C1018(1.35)  LDD0779  [7]
 LDCM0463  CL70 HCT 116 C1016(1.23); C1018(1.26); C1026(1.33); C1032(1.23)  LDD0780  [7]
 LDCM0464  CL71 HCT 116 C1016(0.87); C1018(0.87); C1026(0.88); C1032(0.90)  LDD0781  [7]
 LDCM0465  CL72 HCT 116 C1016(0.99); C1018(1.00); C1026(0.97); C1032(1.01)  LDD0782  [7]
 LDCM0466  CL73 HCT 116 C1016(0.87); C1018(0.87); C1026(0.94); C1032(0.87)  LDD0783  [7]
 LDCM0467  CL74 HCT 116 C1016(0.98); C1018(1.02); C1026(1.07); C1032(1.00)  LDD0784  [7]
 LDCM0469  CL76 HCT 116 C1041(20.00); C1046(20.00); C1056(20.00); C1016(1.47)  LDD0786  [7]
 LDCM0470  CL77 HCT 116 C1041(0.71); C1046(0.71); C1056(0.71); C1016(0.93)  LDD0787  [7]
 LDCM0471  CL78 HCT 116 C1041(0.57); C1046(0.57); C1056(0.57); C1016(0.93)  LDD0788  [7]
 LDCM0472  CL79 HCT 116 C1041(0.71); C1046(0.71); C1056(0.71); C1016(1.12)  LDD0789  [7]
 LDCM0473  CL8 HCT 116 C1046(1.45); C1056(1.45); C1016(1.70); C1018(2.03)  LDD0790  [7]
 LDCM0474  CL80 HCT 116 C1041(3.56); C1046(3.56); C1056(3.56); C1016(1.55)  LDD0791  [7]
 LDCM0475  CL81 HCT 116 C1041(0.48); C1046(0.48); C1056(0.48); C1016(1.10)  LDD0792  [7]
 LDCM0476  CL82 HCT 116 C1041(0.60); C1046(0.60); C1056(0.60); C1016(1.24)  LDD0793  [7]
 LDCM0477  CL83 HCT 116 C1041(0.62); C1046(0.62); C1056(0.62); C1016(1.08)  LDD0794  [7]
 LDCM0478  CL84 HCT 116 C1041(0.69); C1046(0.69); C1056(0.69); C1016(1.46)  LDD0795  [7]
 LDCM0479  CL85 HCT 116 C1041(0.46); C1046(0.46); C1056(0.46); C1016(0.98)  LDD0796  [7]
 LDCM0480  CL86 HCT 116 C1041(0.76); C1046(0.76); C1056(0.76); C1016(1.02)  LDD0797  [7]
 LDCM0481  CL87 HCT 116 C1041(0.46); C1046(0.46); C1056(0.46); C1016(1.04)  LDD0798  [7]
 LDCM0482  CL88 HCT 116 C1041(0.55); C1046(0.55); C1056(0.55); C1016(1.03)  LDD0799  [7]
 LDCM0483  CL89 HCT 116 C1041(0.58); C1046(0.58); C1056(0.58); C1016(1.28)  LDD0800  [7]
 LDCM0484  CL9 HCT 116 C1046(1.26); C1056(1.26); C1016(1.22); C1018(1.17)  LDD0801  [7]
 LDCM0485  CL90 HCT 116 C1041(0.66); C1046(0.66); C1056(0.66); C1016(1.14)  LDD0802  [7]
 LDCM0486  CL91 HCT 116 C1016(1.00); C1018(0.95); C1032(0.95); C1144(0.91)  LDD0803  [7]
 LDCM0487  CL92 HCT 116 C1016(0.90); C1018(0.82); C1032(0.82); C1144(1.07)  LDD0804  [7]
 LDCM0488  CL93 HCT 116 C1016(1.58); C1018(1.48); C1032(1.48); C1144(0.97)  LDD0805  [7]
 LDCM0489  CL94 HCT 116 C1016(0.93); C1018(1.08); C1032(1.08); C1144(0.90)  LDD0806  [7]
 LDCM0490  CL95 HCT 116 C1016(0.81); C1018(0.91); C1032(0.91); C1144(0.95)  LDD0807  [7]
 LDCM0491  CL96 HCT 116 C1016(0.90); C1018(1.24); C1032(1.24); C1144(1.08)  LDD0808  [7]
 LDCM0492  CL97 HCT 116 C1016(0.69); C1018(0.65); C1032(0.65); C1144(0.91)  LDD0809  [7]
 LDCM0493  CL98 HCT 116 C1016(0.75); C1018(0.71); C1032(0.71); C1144(0.84)  LDD0810  [7]
 LDCM0494  CL99 HCT 116 C1016(0.71); C1018(0.81); C1032(0.81); C1144(0.97)  LDD0811  [7]
 LDCM0495  E2913 HEK-293T C207(1.20); C594(1.12); C294(1.08); C394(0.94)  LDD1698  [18]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C743(1.70); C1267(1.53); C1323(1.19); C1315(1.11)  LDD1702  [5]
 LDCM0468  Fragment33 HCT 116 C1016(0.93); C1018(0.96); C1026(0.97); C1032(0.99)  LDD0785  [7]
 LDCM0427  Fragment51 HCT 116 C1016(1.27); C1018(0.97); C1026(1.57); C1032(0.97)  LDD0744  [7]
 LDCM0022  KB02 HCT 116 C1245(1.96); C1254(1.96); C730(1.81); C735(1.81)  LDD0080  [7]
 LDCM0023  KB03 HCT 116 C1245(2.59); C1254(2.59); C730(2.47); C735(2.47)  LDD0081  [7]
 LDCM0024  KB05 HCT 116 C1245(1.95); C1254(1.95); C730(1.93); C735(1.93)  LDD0082  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C207(1.45)  LDD2100  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C594(1.08)  LDD2104  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C594(1.24)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C594(0.84); C38(0.62); C294(0.95)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C38(10.30)  LDD2111  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C594(0.58)  LDD2116  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C594(0.97)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C594(0.95); C294(0.92)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C594(0.99)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C594(0.70)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C594(1.22)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C594(1.25); C294(1.41)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C594(1.02)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C594(1.27)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C594(0.94)  LDD2140  [5]
 LDCM0021  THZ1 HCT 116 C707(1.17); C710(1.17); C720(1.17); C1242(1.46)  LDD2173  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Androgen receptor (AR) Nuclear hormone receptor family P10275
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
HORMA domain-containing protein 2 (HORMAD2) . Q8N7B1
Mediator of DNA damage checkpoint protein 1 (MDC1) . Q14676
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402