Details of the Target

General Information of Target

Target ID LDTP08606
Target Name Nurim (NRM)
Gene Name NRM
Gene ID 11270
Synonyms
NRM29; Nurim; Nuclear envelope membrane protein; Nuclear rim protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPALLLIPAALASFILAFGTGVEFVRFTSLRPLLGGIPESGGPDARQGWLAALQDRSIL
APLAWDLGLLLLFVGQHSLMAAERVKAWTSRYFGVLQRSLYVACTALALQLVMRYWEPIP
KGPVLWEARAEPWATWVPLLCFVLHVISWLLIFSILLVFDYAELMGLKQVYYHVLGLGEP
LALKSPRALRLFSHLRHPVCVELLTVLWVVPTLGTDRLLLAFLLTLYLGLAHGLDQQDLR
YLRAQLQRKLHLLSRPQDGEAE
Target Bioclass
Other
Family
Nurim family
Subcellular location
Nucleus inner membrane
Uniprot ID
Q8IXM6
Ensemble ID
ENST00000259953.8
HGNC ID
HGNC:8003

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		5.38  LDD0318  [1]
STPyne
 Probe Info  		N.A.  LDD0009  [2]
PAL-AfBPP Probe
Click To Hide/Show 62 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		7.21  LDD1714  [3]
C017
 Probe Info  		7.89  LDD1725  [3]
C055
 Probe Info  		22.47  LDD1752  [3]
C056
 Probe Info  		30.48  LDD1753  [3]
C063
 Probe Info  		26.54  LDD1760  [3]
C070
 Probe Info  		17.27  LDD1766  [3]
C072
 Probe Info  		11.88  LDD1768  [3]
C082
 Probe Info  		6.68  LDD1774  [3]
C085
 Probe Info  		5.35  LDD1777  [3]
C087
 Probe Info  		11.16  LDD1779  [3]
C091
 Probe Info  		10.27  LDD1782  [3]
C092
 Probe Info  		17.15  LDD1783  [3]
C094
 Probe Info  		25.99  LDD1785  [3]
C106
 Probe Info  		40.50  LDD1793  [3]
C107
 Probe Info  		12.21  LDD1794  [3]
C108
 Probe Info  		13.74  LDD1795  [3]
C112
 Probe Info  		75.06  LDD1799  [3]
C130
 Probe Info  		7.89  LDD1812  [3]
C134
 Probe Info  		33.13  LDD1816  [3]
C135
 Probe Info  		11.08  LDD1817  [3]
C153
 Probe Info  		21.26  LDD1834  [3]
C169
 Probe Info  		52.35  LDD1849  [3]
C170
 Probe Info  		8.40  LDD1850  [3]
C225
 Probe Info  		4.99  LDD1898  [3]
C228
 Probe Info  		42.22  LDD1901  [3]
C238
 Probe Info  		23.10  LDD1911  [3]
C240
 Probe Info  		13.45  LDD1913  [3]
C246
 Probe Info  		15.45  LDD1919  [3]
C252
 Probe Info  		11.08  LDD1925  [3]
C264
 Probe Info  		34.54  LDD1935  [3]
C265
 Probe Info  		17.88  LDD1936  [3]
C278
 Probe Info  		81.57  LDD1948  [3]
C282
 Probe Info  		22.94  LDD1952  [3]
C284
 Probe Info  		21.11  LDD1954  [3]
C285
 Probe Info  		26.91  LDD1955  [3]
C287
 Probe Info  		14.62  LDD1957  [3]
C289
 Probe Info  		42.22  LDD1959  [3]
C293
 Probe Info  		22.01  LDD1963  [3]
C296
 Probe Info  		17.75  LDD1966  [3]
C348
 Probe Info  		16.45  LDD2009  [3]
C349
 Probe Info  		20.97  LDD2010  [3]
C350
 Probe Info  		80.45  LDD2011  [3]
C362
 Probe Info  		66.26  LDD2023  [3]
C363
 Probe Info  		23.10  LDD2024  [3]
C364
 Probe Info  		24.42  LDD2025  [3]
C366
 Probe Info  		5.43  LDD2027  [3]
C376
 Probe Info  		9.06  LDD2036  [3]
C378
 Probe Info  		5.90  LDD2037  [3]
C382
 Probe Info  		12.55  LDD2041  [3]
C383
 Probe Info  		13.83  LDD2042  [3]
C386
 Probe Info  		6.54  LDD2045  [3]
C388
 Probe Info  		62.25  LDD2047  [3]
C390
 Probe Info  		30.27  LDD2049  [3]
C407
 Probe Info  		17.03  LDD2064  [3]
C419
 Probe Info  		8.46  LDD2074  [3]
C429
 Probe Info  		19.43  LDD2084  [3]
C431
 Probe Info  		32.67  LDD2086  [3]
C433
 Probe Info  		5.74  LDD2088  [3]
FFF probe11
 Probe Info  		20.00  LDD0471  [4]
FFF probe2
 Probe Info  		20.00  LDD0463  [4]
FFF probe3
 Probe Info  		20.00  LDD0464  [4]
OEA-DA
 Probe Info  		13.51  LDD0046  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 3 (AGR3) AGR family Q8TD06
rRNA methyltransferase 1, mitochondrial (MRM1) RNA methyltransferase TrmH family Q6IN84
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP) EBP family Q15125
NADH-cytochrome b5 reductase 3 (CYB5R3) Flavoprotein pyridine nucleotide cytochrome reductase family P00387
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Vesicle transport protein GOT1A (GOLT1A) GOT1 family Q6ZVE7
Histone deacetylase 11 (HDAC11) Histone deacetylase family Q96DB2
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Ribonuclease H1 (RNASEH1) RNase H family O60930
17-beta-hydroxysteroid dehydrogenase 13 (HSD17B13) Short-chain dehydrogenases/reductases (SDR) family Q7Z5P4
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
GTP-binding protein SAR1a (SAR1A) SAR1 family Q9NR31
Tripartite motif-containing protein 59 (TRIM59) TRIM/RBCC family Q8IWR1
V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B) V-ATPase proteolipid subunit family Q99437
Transporter and channel
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ileal sodium/bile acid cotransporter (SLC10A2) Bile acid:sodium symporter (BASS) family Q12908
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Proton-coupled zinc antiporter SLC30A2 (SLC30A2) Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family Q9BRI3
Clarin-1 (CLRN1) Clarin family P58418
Aquaporin-2 (AQP2) MIP/aquaporin (TC 1.A.8) family P41181
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Peroxisome assembly protein 12 (PEX12) Pex2/pex10/pex12 family O00623
Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15) Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family Q9H2J7
Syntaxin-1A (STX1A) Syntaxin family Q16623
Zinc transporter ZIP2 (SLC39A2) ZIP transporter (TC 2.A.5) family Q9NP94
SUN domain-containing protein 2 (SUN2) . Q9UH99
Thioredoxin-related transmembrane protein 2 (TMX2) . Q9Y320
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cannabinoid receptor 2 (CNR2) G-protein coupled receptor 1 family P34972
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
G-protein coupled receptor 151 (GPR151) G-protein coupled receptor 1 family Q8TDV0
G-protein coupled receptor 42 (GPR42) G-protein coupled receptor 1 family O15529
Long-wave-sensitive opsin 1 (OPN1LW) G-protein coupled receptor 1 family P04000
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Killer cell immunoglobulin-like receptor 2DL3 (KIR2DL3) Immunoglobulin superfamily P43628
HERV-H LTR-associating protein 2 (HHLA2) . Q9UM44
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Regulator of microtubule dynamics protein 3 (RMDN3) RMDN family Q96TC7
Receptor-transporting protein 4 (RTP4) TMEM7 family Q96DX8
Bcl-2-interacting killer (BIK) . Q13323
Endoplasmic reticulum resident protein 29 (ERP29) . P30040
FERM domain-containing protein 3 (FRMD3) . A2A2Y4
Protocadherin gamma-A4 (PCDHGA4) . Q9Y5G9
Serine-rich single-pass membrane protein 1 (SSMEM1) . Q8WWF3
Sperm-associated antigen 4 protein (SPAG4) . Q9NPE6
Transmembrane protein 52B (TMEM52B) . Q4KMG9

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
3 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
4 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
5 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570