Details of the Target

General Information of Target

Target ID LDTP10442
Target Name Thioredoxin domain-containing protein 15 (TXNDC15)
Gene Name TXNDC15
Gene ID 79770
Synonyms
C5orf14; Thioredoxin domain-containing protein 15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSDSGSQLGSMGSLTMKSQLQITVISAKLKENKKNWFGPSPYVEVTVDGQSKKTEKCNNT
NSPKWKQPLTVIVTPVSKLHFRVWSHQTLKSDVLLGTAALDIYETLKSNNMKLEEVVVTL
QLGGDKEPTETIGDLSICLDGLQLESEVVTNGETTCSENGVSLCLPRLECNSAISAHCNL
CLPGLSDSPISASRVAGFTGASQNDDGSRSKDETRVSTNGSDDPEDAGAGENRRVSGNNS
PSLSNGGFKPSRPPRPSRPPPPTPRRPASVNGSPSATSESDGSSTGSLPPTNTNTNTSEG
ATSGLIIPLTISGGSGPRPLNPVTQAPLPPGWEQRVDQHGRVYYVDHVEKRTTWDRPEPL
PPGWERRVDNMGRIYYVDHFTRTTTWQRPTLESVRNYEQWQLQRSQLQGAMQQFNQRFIY
GNQDLFATSQSKEFDPLGPLPPGWEKRTDSNGRVYFVNHNTRITQWEDPRSQGQLNEKPL
PEGWEMRFTVDGIPYFVDHNRRTTTYIDPRTGKSALDNGPQIAYVRDFKAKVQYFRFWCQ
QLAMPQHIKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPGEEGLDYGGVAREWFFLL
SHEVLNPMYCLFEYAGKDNYCLQINPASYINPDHLKYFRFIGRFIAMALFHGKFIDTGFS
LPFYKRILNKPVGLKDLESIDPEFYNSLIWVKENNIEECDLEMYFSVDKEILGEIKSHDL
KPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAKELEV
LLCGMQEIDLNDWQRHAIYRHYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGTCRLPVG
GFADLMGSNGPQKFCIEKVGKENWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGF
GQE
Target Bioclass
Other
Subcellular location
Cell projection, cilium membrane
Function Acts as a positive regulator of ciliary hedgehog signaling. Involved in ciliogenesis.
Uniprot ID
Q96J42
Ensemble ID
ENST00000358387.9
HGNC ID
HGNC:20652

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1395 SNV: p.S248P .
KMS11 SNV: p.P51T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
BTD
 Probe Info  		C177(0.87)  LDD2109  [1]
DBIA
 Probe Info  		C114(1.06)  LDD0532  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
IPM
 Probe Info  		N.A.  LDD2156  [4]
VSF
 Probe Info  		N.A.  LDD0007  [5]
Acrolein
 Probe Info  		C114(0.00); C177(0.00)  LDD0217  [6]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [6]
Methacrolein
 Probe Info  		C177(0.00); C114(0.00)  LDD0218  [6]
PAL-AfBPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C055
 Probe Info  		15.03  LDD1752  [7]
C056
 Probe Info  		33.82  LDD1753  [7]
C091
 Probe Info  		22.16  LDD1782  [7]
C092
 Probe Info  		35.02  LDD1783  [7]
C094
 Probe Info  		50.91  LDD1785  [7]
C106
 Probe Info  		24.93  LDD1793  [7]
C112
 Probe Info  		23.26  LDD1799  [7]
C153
 Probe Info  		16.80  LDD1834  [7]
C201
 Probe Info  		35.51  LDD1877  [7]
C231
 Probe Info  		22.78  LDD1904  [7]
C232
 Probe Info  		38.85  LDD1905  [7]
C235
 Probe Info  		30.06  LDD1908  [7]
C285
 Probe Info  		19.56  LDD1955  [7]
C287
 Probe Info  		9.19  LDD1957  [7]
C289
 Probe Info  		53.45  LDD1959  [7]
C362
 Probe Info  		62.68  LDD2023  [7]
C363
 Probe Info  		18.00  LDD2024  [7]
C364
 Probe Info  		18.90  LDD2025  [7]
C366
 Probe Info  		6.96  LDD2027  [7]
C367
 Probe Info  		5.21  LDD2028  [7]
C383
 Probe Info  		17.88  LDD2042  [7]
C386
 Probe Info  		8.22  LDD2045  [7]
C388
 Probe Info  		99.73  LDD2047  [7]
OEA-DA
 Probe Info  		20.00  LDD0046  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 HCT 116 C114(1.06)  LDD0532  [2]
 LDCM0216  AC100 HEK-293T C114(0.87)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C114(1.04)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C114(1.04)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C114(1.06)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C114(1.08)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C114(1.10)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C114(1.29)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C114(1.37)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C114(1.00)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C114(1.27)  LDD0823  [2]
 LDCM0226  AC11 HCT 116 C114(0.97)  LDD0543  [2]
 LDCM0227  AC110 HEK-293T C114(1.19)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C114(1.77)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C114(1.41)  LDD0827  [2]
 LDCM0230  AC113 HEK-293T C114(1.27)  LDD0828  [2]
 LDCM0231  AC114 HEK-293T C114(1.10)  LDD0829  [2]
 LDCM0232  AC115 HEK-293T C114(0.96)  LDD0830  [2]
 LDCM0233  AC116 HEK-293T C114(1.14)  LDD0831  [2]
 LDCM0234  AC117 HEK-293T C114(0.81)  LDD0832  [2]
 LDCM0235  AC118 HEK-293T C114(0.97)  LDD0833  [2]
 LDCM0236  AC119 HEK-293T C114(1.12)  LDD0834  [2]
 LDCM0237  AC12 HCT 116 C114(0.92)  LDD0554  [2]
 LDCM0238  AC120 HEK-293T C114(0.83)  LDD0836  [2]
 LDCM0239  AC121 HEK-293T C114(0.85)  LDD0837  [2]
 LDCM0240  AC122 HEK-293T C114(1.35)  LDD0838  [2]
 LDCM0241  AC123 HEK-293T C114(1.06)  LDD0839  [2]
 LDCM0242  AC124 HEK-293T C114(1.08)  LDD0840  [2]
 LDCM0243  AC125 HEK-293T C114(1.22)  LDD0841  [2]
 LDCM0244  AC126 HEK-293T C114(1.58)  LDD0842  [2]
 LDCM0245  AC127 HEK-293T C114(1.36)  LDD0843  [2]
 LDCM0259  AC14 HCT 116 C114(0.97)  LDD0576  [2]
 LDCM0263  AC143 HEK-293T C114(1.16)  LDD0861  [2]
 LDCM0264  AC144 HEK-293T C114(1.25)  LDD0862  [2]
 LDCM0265  AC145 HEK-293T C114(1.88)  LDD0863  [2]
 LDCM0266  AC146 HEK-293T C114(1.63)  LDD0864  [2]
 LDCM0267  AC147 HEK-293T C114(1.14)  LDD0865  [2]
 LDCM0268  AC148 HEK-293T C114(1.99)  LDD0866  [2]
 LDCM0269  AC149 HEK-293T C114(0.98)  LDD0867  [2]
 LDCM0270  AC15 HCT 116 C114(0.87)  LDD0587  [2]
 LDCM0271  AC150 HEK-293T C114(1.36)  LDD0869  [2]
 LDCM0272  AC151 HEK-293T C114(1.02)  LDD0870  [2]
 LDCM0273  AC152 HEK-293T C114(1.10)  LDD0871  [2]
 LDCM0274  AC153 HEK-293T C114(1.14)  LDD0872  [2]
 LDCM0621  AC154 HEK-293T C114(0.92)  LDD2162  [2]
 LDCM0622  AC155 HEK-293T C114(1.37)  LDD2163  [2]
 LDCM0623  AC156 HEK-293T C114(2.13)  LDD2164  [2]
 LDCM0624  AC157 HEK-293T C114(2.25)  LDD2165  [2]
 LDCM0276  AC17 HCT 116 C114(1.26)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C114(1.71)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C114(1.42)  LDD0595  [2]
 LDCM0280  AC20 HCT 116 C114(1.29)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C114(1.08)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C114(1.18)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C114(1.22)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C114(1.27)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C114(0.68)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C114(0.70)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C114(0.60)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C114(0.84)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C114(0.63)  LDD0887  [2]
 LDCM0291  AC30 HEK-293T C114(0.63)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C114(0.80)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C114(0.71)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C114(0.61)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C114(0.68)  LDD0893  [2]
 LDCM0296  AC35 HCT 116 C114(1.20)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C114(1.09)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C114(0.92)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C114(0.94)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C114(0.74)  LDD0617  [2]
 LDCM0302  AC40 HCT 116 C114(1.12)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C114(0.81)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C114(0.83)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C114(1.15)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C114(1.07)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C114(1.01)  LDD0624  [2]
 LDCM0308  AC46 HCT 116 C114(1.08)  LDD0625  [2]
 LDCM0309  AC47 HCT 116 C114(0.95)  LDD0626  [2]
 LDCM0310  AC48 HCT 116 C114(0.91)  LDD0627  [2]
 LDCM0311  AC49 HCT 116 C114(1.10)  LDD0628  [2]
 LDCM0313  AC50 HCT 116 C114(0.86)  LDD0630  [2]
 LDCM0314  AC51 HCT 116 C114(1.24)  LDD0631  [2]
 LDCM0315  AC52 HCT 116 C114(1.11)  LDD0632  [2]
 LDCM0316  AC53 HCT 116 C114(1.25)  LDD0633  [2]
 LDCM0317  AC54 HCT 116 C114(0.82)  LDD0634  [2]
 LDCM0318  AC55 HCT 116 C114(1.09)  LDD0635  [2]
 LDCM0319  AC56 HCT 116 C114(1.00)  LDD0636  [2]
 LDCM0320  AC57 HCT 116 C114(1.84)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C114(1.62)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C114(1.82)  LDD0639  [2]
 LDCM0323  AC6 HCT 116 C114(0.99)  LDD0640  [2]
 LDCM0324  AC60 HCT 116 C114(1.24)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C114(1.11)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C114(1.98)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C114(1.42)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C114(1.69)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C114(1.10)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C114(1.15)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C114(1.34)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C114(0.96)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C114(0.81)  LDD0650  [2]
 LDCM0334  AC7 HCT 116 C114(0.91)  LDD0651  [2]
 LDCM0335  AC70 HCT 116 C114(0.89)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C114(0.85)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C114(0.85)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C114(1.09)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C114(1.10)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C114(1.28)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C114(1.02)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C114(1.00)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C114(0.92)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C114(1.00)  LDD0661  [2]
 LDCM0345  AC8 HCT 116 C114(0.92)  LDD0662  [2]
 LDCM0346  AC80 HCT 116 C114(0.91)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C114(0.90)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C114(0.96)  LDD0665  [2]
 LDCM0349  AC83 HCT 116 C114(0.90)  LDD0666  [2]
 LDCM0350  AC84 HCT 116 C114(0.87)  LDD0667  [2]
 LDCM0351  AC85 HCT 116 C114(0.84)  LDD0668  [2]
 LDCM0352  AC86 HCT 116 C114(0.71)  LDD0669  [2]
 LDCM0353  AC87 HCT 116 C114(0.64)  LDD0670  [2]
 LDCM0354  AC88 HCT 116 C114(0.88)  LDD0671  [2]
 LDCM0355  AC89 HCT 116 C114(0.86)  LDD0672  [2]
 LDCM0357  AC90 HCT 116 C114(0.75)  LDD0674  [2]
 LDCM0358  AC91 HCT 116 C114(0.68)  LDD0675  [2]
 LDCM0359  AC92 HCT 116 C114(0.63)  LDD0676  [2]
 LDCM0360  AC93 HCT 116 C114(0.73)  LDD0677  [2]
 LDCM0361  AC94 HCT 116 C114(0.83)  LDD0678  [2]
 LDCM0362  AC95 HCT 116 C114(0.59)  LDD0679  [2]
 LDCM0363  AC96 HCT 116 C114(0.71)  LDD0680  [2]
 LDCM0364  AC97 HCT 116 C114(0.81)  LDD0681  [2]
 LDCM0365  AC98 HEK-293T C114(0.86)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C114(1.61)  LDD0964  [2]
 LDCM0248  AKOS034007472 HCT 116 C114(1.04)  LDD0565  [2]
 LDCM0356  AKOS034007680 HCT 116 C114(0.99)  LDD0673  [2]
 LDCM0275  AKOS034007705 HCT 116 C114(1.08)  LDD0592  [2]
 LDCM0367  CL1 HCT 116 C114(0.94)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C114(1.14)  LDD0685  [2]
 LDCM0370  CL101 HCT 116 C114(1.10)  LDD0687  [2]
 LDCM0371  CL102 HCT 116 C114(0.76)  LDD0688  [2]
 LDCM0372  CL103 HCT 116 C114(1.02)  LDD0689  [2]
 LDCM0373  CL104 HCT 116 C114(0.87)  LDD0690  [2]
 LDCM0374  CL105 HCT 116 C114(1.33)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C114(1.48)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C114(1.39)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C114(1.46)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C114(1.31)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C114(1.38)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C114(1.65)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C114(1.24)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C114(0.65)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C114(0.72)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C114(0.56)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C114(0.57)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C114(0.46)  LDD0984  [2]
 LDCM0387  CL117 HCT 116 C114(0.77)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C114(0.81)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C114(0.99)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C114(1.55)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C114(0.95)  LDD0708  [2]
 LDCM0392  CL121 HCT 116 C114(0.93)  LDD0709  [2]
 LDCM0393  CL122 HCT 116 C114(1.15)  LDD0710  [2]
 LDCM0394  CL123 HCT 116 C114(1.05)  LDD0711  [2]
 LDCM0395  CL124 HCT 116 C114(1.17)  LDD0712  [2]
 LDCM0396  CL125 HCT 116 C114(1.06)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C114(1.33)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C114(0.98)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C114(1.88)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C114(0.96)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C114(1.09)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C114(1.08)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C114(1.18)  LDD0720  [2]
 LDCM0404  CL17 HCT 116 C114(0.97)  LDD0721  [2]
 LDCM0405  CL18 HCT 116 C114(1.23)  LDD0722  [2]
 LDCM0406  CL19 HCT 116 C114(1.08)  LDD0723  [2]
 LDCM0407  CL2 HCT 116 C114(1.07)  LDD0724  [2]
 LDCM0408  CL20 HCT 116 C114(1.02)  LDD0725  [2]
 LDCM0409  CL21 HCT 116 C114(1.35)  LDD0726  [2]
 LDCM0410  CL22 HCT 116 C114(1.82)  LDD0727  [2]
 LDCM0411  CL23 HCT 116 C114(1.04)  LDD0728  [2]
 LDCM0412  CL24 HCT 116 C114(1.37)  LDD0729  [2]
 LDCM0413  CL25 HCT 116 C114(1.25)  LDD0730  [2]
 LDCM0414  CL26 HCT 116 C114(1.19)  LDD0731  [2]
 LDCM0415  CL27 HCT 116 C114(1.24)  LDD0732  [2]
 LDCM0416  CL28 HCT 116 C114(1.18)  LDD0733  [2]
 LDCM0417  CL29 HCT 116 C114(1.11)  LDD0734  [2]
 LDCM0418  CL3 HCT 116 C114(1.08)  LDD0735  [2]
 LDCM0419  CL30 HCT 116 C114(1.03)  LDD0736  [2]
 LDCM0420  CL31 HCT 116 C114(1.02)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C114(1.05)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C114(1.15)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C114(1.11)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C114(1.11)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C114(1.06)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C114(1.06)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C114(1.01)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C114(1.21)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C114(0.85)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C114(0.82)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C114(0.72)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C114(0.95)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C114(1.10)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C114(1.14)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C114(0.96)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C114(0.78)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C114(0.97)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C114(0.91)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C114(1.15)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C114(0.99)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C114(1.02)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C114(1.05)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C114(0.96)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C114(0.96)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C114(0.85)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C114(0.97)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C114(0.92)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C114(0.87)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C114(0.93)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C114(1.14)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C114(0.92)  LDD0769  [2]
 LDCM0453  CL61 HCT 116 C114(1.00)  LDD0770  [2]
 LDCM0454  CL62 HCT 116 C114(1.17)  LDD0771  [2]
 LDCM0455  CL63 HCT 116 C114(1.16)  LDD0772  [2]
 LDCM0456  CL64 HCT 116 C114(1.43)  LDD0773  [2]
 LDCM0457  CL65 HCT 116 C114(1.12)  LDD0774  [2]
 LDCM0458  CL66 HCT 116 C114(1.36)  LDD0775  [2]
 LDCM0459  CL67 HCT 116 C114(1.30)  LDD0776  [2]
 LDCM0460  CL68 HCT 116 C114(1.19)  LDD0777  [2]
 LDCM0461  CL69 HCT 116 C114(1.13)  LDD0778  [2]
 LDCM0462  CL7 HCT 116 C114(1.13)  LDD0779  [2]
 LDCM0463  CL70 HCT 116 C114(1.08)  LDD0780  [2]
 LDCM0464  CL71 HCT 116 C114(1.54)  LDD0781  [2]
 LDCM0465  CL72 HCT 116 C114(1.15)  LDD0782  [2]
 LDCM0466  CL73 HCT 116 C114(1.34)  LDD0783  [2]
 LDCM0467  CL74 HCT 116 C114(1.43)  LDD0784  [2]
 LDCM0473  CL8 HCT 116 C114(1.11)  LDD0790  [2]
 LDCM0484  CL9 HCT 116 C114(1.15)  LDD0801  [2]
 LDCM0468  Fragment33 HCT 116 C114(1.13)  LDD0785  [2]
 LDCM0427  Fragment51 HCT 116 C114(0.61)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C114(1.10)  LDD1492  [9]
 LDCM0023  KB03 HEK-293T C114(0.94)  LDD1497  [9]
 LDCM0024  KB05 HMCB C97(1.19)  LDD3312  [10]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C177(0.87)  LDD2109  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C177(0.81)  LDD2136  [1]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C177(1.03)  LDD2141  [1]

References

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Mass spectrometry data entry: PXD039908 , PXD029761
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
5 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
9 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
10 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840