Details of the Target

General Information of Target

Target ID LDTP10184
Target Name HAUS augmin-like complex subunit 1 (HAUS1)
Gene Name HAUS1
Gene ID 115106
Synonyms
CCDC5; HEIC; HAUS augmin-like complex subunit 1; Coiled-coil domain-containing protein 5; Enhancer of invasion-cluster; HEI-C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSQRDTLVHLFAGGCGGTVGAILTCPLEVVKTRLQSSSVTLYISEVQLNTMAGASVNRVV
SPGPLHCLKVILEKEGPRSLFRGLGPNLVGVAPSRAIYFAAYSNCKEKLNDVFDPDSTQV
HMISAAMAGFTAITATNPIWLIKTRLQLDARNRGERRMGAFECVRKVYQTDGLKGFYRGM
SASYAGISETVIHFVIYESIKQKLLEYKTASTMENDEESVKEASDFVGMMLAAATSKTCA
TTIAYPHEVVRTRLREEGTKYRSFFQTLSLLVQEEGYGSLYRGLTTHLVRQIPNTAIMMA
TYELVVYLLNG
Target Bioclass
Other
Family
HAUS1 family
Subcellular location
Cytoplasm
Function Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex.
Uniprot ID
Q96CS2
Ensemble ID
ENST00000282058.11
HGNC ID
HGNC:25174

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A431 SNV: p.E256K .
HT115 SNV: p.F82V .
MCC13 SNV: p.L220P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0241  [1]
DBIA
 Probe Info  		C156(1.03)  LDD0531  [2]
5E-2FA
 Probe Info  		N.A.  LDD2235  [3]
m-APA
 Probe Info  		N.A.  LDD2231  [3]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [4]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [6]
AOyne
 Probe Info  		11.00  LDD0443  [7]
PAL-AfBPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C017
 Probe Info  		18.13  LDD1725  [8]
C055
 Probe Info  		15.45  LDD1752  [8]
C056
 Probe Info  		19.70  LDD1753  [8]
C070
 Probe Info  		8.88  LDD1766  [8]
C087
 Probe Info  		9.45  LDD1779  [8]
C106
 Probe Info  		17.75  LDD1793  [8]
C112
 Probe Info  		22.32  LDD1799  [8]
C201
 Probe Info  		23.92  LDD1877  [8]
C277
 Probe Info  		9.25  LDD1947  [8]
C289
 Probe Info  		25.81  LDD1959  [8]
C290
 Probe Info  		11.31  LDD1960  [8]
C293
 Probe Info  		20.53  LDD1963  [8]
C296
 Probe Info  		14.22  LDD1966  [8]
C355
 Probe Info  		31.34  LDD2016  [8]
C356
 Probe Info  		9.78  LDD2017  [8]
C361
 Probe Info  		20.53  LDD2022  [8]
C362
 Probe Info  		37.01  LDD2023  [8]
C363
 Probe Info  		18.90  LDD2024  [8]
C364
 Probe Info  		15.45  LDD2025  [8]
C386
 Probe Info  		7.41  LDD2045  [8]
C391
 Probe Info  		15.67  LDD2050  [8]
C403
 Probe Info  		20.25  LDD2061  [8]
FFF probe13
 Probe Info  		20.00  LDD0475  [9]
FFF probe14
 Probe Info  		20.00  LDD0477  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C156(1.03)  LDD0531  [2]
 LDCM0215  AC10 HEK-293T C156(1.21)  LDD0813  [2]
 LDCM0216  AC100 HEK-293T C156(0.88)  LDD0814  [2]
 LDCM0217  AC101 HEK-293T C156(0.82)  LDD0815  [2]
 LDCM0218  AC102 HEK-293T C156(1.07)  LDD0816  [2]
 LDCM0219  AC103 HEK-293T C156(0.80)  LDD0817  [2]
 LDCM0220  AC104 HEK-293T C156(0.94)  LDD0818  [2]
 LDCM0221  AC105 HEK-293T C156(1.00)  LDD0819  [2]
 LDCM0222  AC106 HEK-293T C156(1.26)  LDD0820  [2]
 LDCM0223  AC107 HEK-293T C156(1.19)  LDD0821  [2]
 LDCM0224  AC108 HEK-293T C156(1.15)  LDD0822  [2]
 LDCM0225  AC109 HEK-293T C156(1.16)  LDD0823  [2]
 LDCM0226  AC11 HEK-293T C156(1.05)  LDD0824  [2]
 LDCM0227  AC110 HEK-293T C156(1.11)  LDD0825  [2]
 LDCM0228  AC111 HEK-293T C156(1.13)  LDD0826  [2]
 LDCM0229  AC112 HEK-293T C156(0.99)  LDD0827  [2]
 LDCM0230  AC113 HCT 116 C156(1.01)  LDD0547  [2]
 LDCM0231  AC114 HCT 116 C156(1.07)  LDD0548  [2]
 LDCM0232  AC115 HCT 116 C156(1.00)  LDD0549  [2]
 LDCM0233  AC116 HCT 116 C156(1.17)  LDD0550  [2]
 LDCM0234  AC117 HCT 116 C156(1.45)  LDD0551  [2]
 LDCM0235  AC118 HCT 116 C156(1.25)  LDD0552  [2]
 LDCM0236  AC119 HCT 116 C156(1.26)  LDD0553  [2]
 LDCM0237  AC12 HEK-293T C156(1.38)  LDD0835  [2]
 LDCM0238  AC120 HCT 116 C156(1.34)  LDD0555  [2]
 LDCM0239  AC121 HCT 116 C156(0.98)  LDD0556  [2]
 LDCM0240  AC122 HCT 116 C156(1.21)  LDD0557  [2]
 LDCM0241  AC123 HCT 116 C156(0.99)  LDD0558  [2]
 LDCM0242  AC124 HCT 116 C156(1.18)  LDD0559  [2]
 LDCM0243  AC125 HCT 116 C156(1.48)  LDD0560  [2]
 LDCM0244  AC126 HCT 116 C156(1.08)  LDD0561  [2]
 LDCM0245  AC127 HCT 116 C156(1.30)  LDD0562  [2]
 LDCM0246  AC128 PaTu 8988t C156(1.56)  LDD1125  [2]
 LDCM0247  AC129 PaTu 8988t C156(1.34)  LDD1126  [2]
 LDCM0249  AC130 PaTu 8988t C156(1.40)  LDD1128  [2]
 LDCM0250  AC131 PaTu 8988t C156(1.10)  LDD1129  [2]
 LDCM0251  AC132 PaTu 8988t C156(1.08)  LDD1130  [2]
 LDCM0252  AC133 PaTu 8988t C156(1.26)  LDD1131  [2]
 LDCM0253  AC134 PaTu 8988t C156(1.17)  LDD1132  [2]
 LDCM0254  AC135 PaTu 8988t C156(1.33)  LDD1133  [2]
 LDCM0255  AC136 PaTu 8988t C156(1.75)  LDD1134  [2]
 LDCM0256  AC137 PaTu 8988t C156(1.61)  LDD1135  [2]
 LDCM0257  AC138 PaTu 8988t C156(1.45)  LDD1136  [2]
 LDCM0258  AC139 PaTu 8988t C156(1.54)  LDD1137  [2]
 LDCM0259  AC14 HEK-293T C156(1.37)  LDD0857  [2]
 LDCM0260  AC140 PaTu 8988t C156(1.70)  LDD1139  [2]
 LDCM0261  AC141 PaTu 8988t C156(1.21)  LDD1140  [2]
 LDCM0262  AC142 PaTu 8988t C156(1.30)  LDD1141  [2]
 LDCM0270  AC15 HEK-293T C156(1.79)  LDD0868  [2]
 LDCM0276  AC17 HCT 116 C156(1.01)  LDD0593  [2]
 LDCM0277  AC18 HCT 116 C156(0.98)  LDD0594  [2]
 LDCM0278  AC19 HCT 116 C156(1.10)  LDD0595  [2]
 LDCM0279  AC2 HCT 116 C156(1.13)  LDD0596  [2]
 LDCM0280  AC20 HCT 116 C156(0.94)  LDD0597  [2]
 LDCM0281  AC21 HCT 116 C156(0.85)  LDD0598  [2]
 LDCM0282  AC22 HCT 116 C156(1.02)  LDD0599  [2]
 LDCM0283  AC23 HCT 116 C156(0.80)  LDD0600  [2]
 LDCM0284  AC24 HCT 116 C156(1.06)  LDD0601  [2]
 LDCM0285  AC25 HEK-293T C156(0.67)  LDD0883  [2]
 LDCM0286  AC26 HEK-293T C156(0.78)  LDD0884  [2]
 LDCM0287  AC27 HEK-293T C156(0.94)  LDD0885  [2]
 LDCM0288  AC28 HEK-293T C156(0.81)  LDD0886  [2]
 LDCM0289  AC29 HEK-293T C156(0.72)  LDD0887  [2]
 LDCM0290  AC3 HCT 116 C156(1.03)  LDD0607  [2]
 LDCM0291  AC30 HEK-293T C156(0.77)  LDD0889  [2]
 LDCM0292  AC31 HEK-293T C156(0.78)  LDD0890  [2]
 LDCM0293  AC32 HEK-293T C156(0.88)  LDD0891  [2]
 LDCM0294  AC33 HEK-293T C156(0.77)  LDD0892  [2]
 LDCM0295  AC34 HEK-293T C156(0.84)  LDD0893  [2]
 LDCM0296  AC35 HCT 116 C156(0.99)  LDD0613  [2]
 LDCM0297  AC36 HCT 116 C156(1.00)  LDD0614  [2]
 LDCM0298  AC37 HCT 116 C156(1.36)  LDD0615  [2]
 LDCM0299  AC38 HCT 116 C156(1.16)  LDD0616  [2]
 LDCM0300  AC39 HCT 116 C156(1.12)  LDD0617  [2]
 LDCM0301  AC4 HCT 116 C156(0.97)  LDD0618  [2]
 LDCM0302  AC40 HCT 116 C156(1.25)  LDD0619  [2]
 LDCM0303  AC41 HCT 116 C156(1.27)  LDD0620  [2]
 LDCM0304  AC42 HCT 116 C156(0.93)  LDD0621  [2]
 LDCM0305  AC43 HCT 116 C156(1.19)  LDD0622  [2]
 LDCM0306  AC44 HCT 116 C156(1.13)  LDD0623  [2]
 LDCM0307  AC45 HCT 116 C156(1.22)  LDD0624  [2]
 LDCM0308  AC46 PaTu 8988t C156(1.10)  LDD1187  [2]
 LDCM0309  AC47 PaTu 8988t C156(1.42)  LDD1188  [2]
 LDCM0310  AC48 PaTu 8988t C156(1.68)  LDD1189  [2]
 LDCM0311  AC49 PaTu 8988t C156(1.50)  LDD1190  [2]
 LDCM0312  AC5 HCT 116 C156(1.00)  LDD0629  [2]
 LDCM0313  AC50 PaTu 8988t C156(1.50)  LDD1192  [2]
 LDCM0314  AC51 PaTu 8988t C156(1.25)  LDD1193  [2]
 LDCM0315  AC52 PaTu 8988t C156(1.48)  LDD1194  [2]
 LDCM0316  AC53 PaTu 8988t C156(1.93)  LDD1195  [2]
 LDCM0317  AC54 PaTu 8988t C156(2.30)  LDD1196  [2]
 LDCM0318  AC55 PaTu 8988t C156(1.65)  LDD1197  [2]
 LDCM0319  AC56 PaTu 8988t C156(1.65)  LDD1198  [2]
 LDCM0320  AC57 HCT 116 C156(0.85)  LDD0637  [2]
 LDCM0321  AC58 HCT 116 C156(0.85)  LDD0638  [2]
 LDCM0322  AC59 HCT 116 C156(1.30)  LDD0639  [2]
 LDCM0323  AC6 HEK-293T C156(1.06)  LDD0921  [2]
 LDCM0324  AC60 HCT 116 C156(1.25)  LDD0641  [2]
 LDCM0325  AC61 HCT 116 C156(1.00)  LDD0642  [2]
 LDCM0326  AC62 HCT 116 C156(1.06)  LDD0643  [2]
 LDCM0327  AC63 HCT 116 C156(1.27)  LDD0644  [2]
 LDCM0328  AC64 HCT 116 C156(1.45)  LDD0645  [2]
 LDCM0329  AC65 HCT 116 C156(1.02)  LDD0646  [2]
 LDCM0330  AC66 HCT 116 C156(0.84)  LDD0647  [2]
 LDCM0331  AC67 HCT 116 C156(1.34)  LDD0648  [2]
 LDCM0332  AC68 HCT 116 C156(0.95)  LDD0649  [2]
 LDCM0333  AC69 HCT 116 C156(0.84)  LDD0650  [2]
 LDCM0334  AC7 HEK-293T C156(1.53)  LDD0932  [2]
 LDCM0335  AC70 HCT 116 C156(0.91)  LDD0652  [2]
 LDCM0336  AC71 HCT 116 C156(0.82)  LDD0653  [2]
 LDCM0337  AC72 HCT 116 C156(0.86)  LDD0654  [2]
 LDCM0338  AC73 HCT 116 C156(1.16)  LDD0655  [2]
 LDCM0339  AC74 HCT 116 C156(0.91)  LDD0656  [2]
 LDCM0340  AC75 HCT 116 C156(0.86)  LDD0657  [2]
 LDCM0341  AC76 HCT 116 C156(0.97)  LDD0658  [2]
 LDCM0342  AC77 HCT 116 C156(1.02)  LDD0659  [2]
 LDCM0343  AC78 HCT 116 C156(0.92)  LDD0660  [2]
 LDCM0344  AC79 HCT 116 C156(0.93)  LDD0661  [2]
 LDCM0345  AC8 HEK-293T C156(1.59)  LDD0943  [2]
 LDCM0346  AC80 HCT 116 C156(1.11)  LDD0663  [2]
 LDCM0347  AC81 HCT 116 C156(0.91)  LDD0664  [2]
 LDCM0348  AC82 HCT 116 C156(0.98)  LDD0665  [2]
 LDCM0349  AC83 HEK-293T C156(1.16)  LDD0947  [2]
 LDCM0350  AC84 HEK-293T C156(1.44)  LDD0948  [2]
 LDCM0351  AC85 HEK-293T C156(1.28)  LDD0949  [2]
 LDCM0352  AC86 HEK-293T C156(1.20)  LDD0950  [2]
 LDCM0353  AC87 HEK-293T C156(1.34)  LDD0951  [2]
 LDCM0354  AC88 HEK-293T C156(1.13)  LDD0952  [2]
 LDCM0355  AC89 HEK-293T C156(1.35)  LDD0953  [2]
 LDCM0357  AC90 HEK-293T C156(1.24)  LDD0955  [2]
 LDCM0358  AC91 HEK-293T C156(1.12)  LDD0956  [2]
 LDCM0359  AC92 HEK-293T C156(1.13)  LDD0957  [2]
 LDCM0360  AC93 HEK-293T C156(1.32)  LDD0958  [2]
 LDCM0361  AC94 HEK-293T C156(1.58)  LDD0959  [2]
 LDCM0362  AC95 HEK-293T C156(1.48)  LDD0960  [2]
 LDCM0363  AC96 HEK-293T C156(1.29)  LDD0961  [2]
 LDCM0364  AC97 HEK-293T C156(1.08)  LDD0962  [2]
 LDCM0365  AC98 HEK-293T C156(0.97)  LDD0963  [2]
 LDCM0366  AC99 HEK-293T C156(0.94)  LDD0964  [2]
 LDCM0248  AKOS034007472 HEK-293T C156(1.55)  LDD0846  [2]
 LDCM0356  AKOS034007680 HEK-293T C156(1.43)  LDD0954  [2]
 LDCM0275  AKOS034007705 HEK-293T C156(1.16)  LDD0873  [2]
 LDCM0367  CL1 HCT 116 C156(1.01)  LDD0684  [2]
 LDCM0368  CL10 HCT 116 C156(1.09)  LDD0685  [2]
 LDCM0369  CL100 HCT 116 C156(0.99)  LDD0686  [2]
 LDCM0370  CL101 HEK-293T C156(1.33)  LDD0968  [2]
 LDCM0371  CL102 HEK-293T C156(1.43)  LDD0969  [2]
 LDCM0372  CL103 HEK-293T C156(1.25)  LDD0970  [2]
 LDCM0373  CL104 HEK-293T C156(1.67)  LDD0971  [2]
 LDCM0374  CL105 HCT 116 C156(0.96)  LDD0691  [2]
 LDCM0375  CL106 HCT 116 C156(0.99)  LDD0692  [2]
 LDCM0376  CL107 HCT 116 C156(0.97)  LDD0693  [2]
 LDCM0377  CL108 HCT 116 C156(1.08)  LDD0694  [2]
 LDCM0378  CL109 HCT 116 C156(1.09)  LDD0695  [2]
 LDCM0379  CL11 HCT 116 C156(1.01)  LDD0696  [2]
 LDCM0380  CL110 HCT 116 C156(0.99)  LDD0697  [2]
 LDCM0381  CL111 HCT 116 C156(1.05)  LDD0698  [2]
 LDCM0382  CL112 HEK-293T C156(0.77)  LDD0980  [2]
 LDCM0383  CL113 HEK-293T C156(0.77)  LDD0981  [2]
 LDCM0384  CL114 HEK-293T C156(0.75)  LDD0982  [2]
 LDCM0385  CL115 HEK-293T C156(0.75)  LDD0983  [2]
 LDCM0386  CL116 HEK-293T C156(0.77)  LDD0984  [2]
 LDCM0387  CL117 HCT 116 C156(0.98)  LDD0704  [2]
 LDCM0388  CL118 HCT 116 C156(1.22)  LDD0705  [2]
 LDCM0389  CL119 HCT 116 C156(1.05)  LDD0706  [2]
 LDCM0390  CL12 HCT 116 C156(1.19)  LDD0707  [2]
 LDCM0391  CL120 HCT 116 C156(1.12)  LDD0708  [2]
 LDCM0392  CL121 PaTu 8988t C156(1.48)  LDD1271  [2]
 LDCM0393  CL122 PaTu 8988t C156(1.58)  LDD1272  [2]
 LDCM0394  CL123 PaTu 8988t C156(1.95)  LDD1273  [2]
 LDCM0395  CL124 PaTu 8988t C156(1.38)  LDD1274  [2]
 LDCM0396  CL125 HCT 116 C156(1.14)  LDD0713  [2]
 LDCM0397  CL126 HCT 116 C156(0.76)  LDD0714  [2]
 LDCM0398  CL127 HCT 116 C156(0.91)  LDD0715  [2]
 LDCM0399  CL128 HCT 116 C156(0.82)  LDD0716  [2]
 LDCM0400  CL13 HCT 116 C156(1.12)  LDD0717  [2]
 LDCM0401  CL14 HCT 116 C156(1.22)  LDD0718  [2]
 LDCM0402  CL15 HCT 116 C156(1.06)  LDD0719  [2]
 LDCM0403  CL16 HCT 116 C156(1.00)  LDD0720  [2]
 LDCM0404  CL17 HEK-293T C156(0.93)  LDD1002  [2]
 LDCM0405  CL18 HEK-293T C156(0.98)  LDD1003  [2]
 LDCM0406  CL19 HEK-293T C156(1.11)  LDD1004  [2]
 LDCM0407  CL2 HCT 116 C156(1.02)  LDD0724  [2]
 LDCM0408  CL20 HEK-293T C156(1.06)  LDD1006  [2]
 LDCM0409  CL21 HEK-293T C156(1.30)  LDD1007  [2]
 LDCM0410  CL22 HEK-293T C156(0.94)  LDD1008  [2]
 LDCM0411  CL23 HEK-293T C156(0.83)  LDD1009  [2]
 LDCM0412  CL24 HEK-293T C156(0.81)  LDD1010  [2]
 LDCM0413  CL25 HEK-293T C156(0.91)  LDD1011  [2]
 LDCM0414  CL26 HEK-293T C156(1.00)  LDD1012  [2]
 LDCM0415  CL27 HEK-293T C156(0.91)  LDD1013  [2]
 LDCM0416  CL28 HEK-293T C156(0.78)  LDD1014  [2]
 LDCM0417  CL29 HEK-293T C156(0.96)  LDD1015  [2]
 LDCM0418  CL3 HCT 116 C156(1.00)  LDD0735  [2]
 LDCM0419  CL30 HEK-293T C156(1.13)  LDD1017  [2]
 LDCM0420  CL31 HCT 116 C156(0.71)  LDD0737  [2]
 LDCM0421  CL32 HCT 116 C156(0.96)  LDD0738  [2]
 LDCM0422  CL33 HCT 116 C156(0.88)  LDD0739  [2]
 LDCM0423  CL34 HCT 116 C156(0.98)  LDD0740  [2]
 LDCM0424  CL35 HCT 116 C156(1.11)  LDD0741  [2]
 LDCM0425  CL36 HCT 116 C156(0.97)  LDD0742  [2]
 LDCM0426  CL37 HCT 116 C156(1.17)  LDD0743  [2]
 LDCM0428  CL39 HCT 116 C156(1.13)  LDD0745  [2]
 LDCM0429  CL4 HCT 116 C156(1.14)  LDD0746  [2]
 LDCM0430  CL40 HCT 116 C156(1.10)  LDD0747  [2]
 LDCM0431  CL41 HCT 116 C156(1.04)  LDD0748  [2]
 LDCM0432  CL42 HCT 116 C156(1.04)  LDD0749  [2]
 LDCM0433  CL43 HCT 116 C156(1.14)  LDD0750  [2]
 LDCM0434  CL44 HCT 116 C156(1.08)  LDD0751  [2]
 LDCM0435  CL45 HCT 116 C156(1.09)  LDD0752  [2]
 LDCM0436  CL46 HCT 116 C156(0.69)  LDD0753  [2]
 LDCM0437  CL47 HCT 116 C156(1.21)  LDD0754  [2]
 LDCM0438  CL48 HCT 116 C156(1.04)  LDD0755  [2]
 LDCM0439  CL49 HCT 116 C156(1.46)  LDD0756  [2]
 LDCM0440  CL5 HCT 116 C156(0.93)  LDD0757  [2]
 LDCM0441  CL50 HCT 116 C156(1.31)  LDD0758  [2]
 LDCM0442  CL51 HCT 116 C156(1.33)  LDD0759  [2]
 LDCM0443  CL52 HCT 116 C156(0.99)  LDD0760  [2]
 LDCM0444  CL53 HCT 116 C156(0.76)  LDD0761  [2]
 LDCM0445  CL54 HCT 116 C156(1.13)  LDD0762  [2]
 LDCM0446  CL55 HCT 116 C156(0.80)  LDD0763  [2]
 LDCM0447  CL56 HCT 116 C156(1.21)  LDD0764  [2]
 LDCM0448  CL57 HCT 116 C156(0.93)  LDD0765  [2]
 LDCM0449  CL58 HCT 116 C156(0.98)  LDD0766  [2]
 LDCM0450  CL59 HCT 116 C156(1.02)  LDD0767  [2]
 LDCM0451  CL6 HCT 116 C156(1.09)  LDD0768  [2]
 LDCM0452  CL60 HCT 116 C156(1.26)  LDD0769  [2]
 LDCM0453  CL61 HEK-293T C156(0.84)  LDD1051  [2]
 LDCM0454  CL62 HEK-293T C156(0.96)  LDD1052  [2]
 LDCM0455  CL63 HEK-293T C156(0.84)  LDD1053  [2]
 LDCM0456  CL64 HEK-293T C156(0.91)  LDD1054  [2]
 LDCM0457  CL65 HEK-293T C156(0.90)  LDD1055  [2]
 LDCM0458  CL66 HEK-293T C156(0.96)  LDD1056  [2]
 LDCM0459  CL67 HEK-293T C156(1.30)  LDD1057  [2]
 LDCM0460  CL68 HEK-293T C156(1.14)  LDD1058  [2]
 LDCM0461  CL69 HEK-293T C156(0.87)  LDD1059  [2]
 LDCM0462  CL7 HCT 116 C156(1.08)  LDD0779  [2]
 LDCM0463  CL70 HEK-293T C156(0.92)  LDD1061  [2]
 LDCM0464  CL71 HEK-293T C156(0.90)  LDD1062  [2]
 LDCM0465  CL72 HEK-293T C156(1.00)  LDD1063  [2]
 LDCM0466  CL73 HEK-293T C156(0.98)  LDD1064  [2]
 LDCM0467  CL74 HEK-293T C156(0.85)  LDD1065  [2]
 LDCM0469  CL76 HEK-293T C156(1.01)  LDD1067  [2]
 LDCM0470  CL77 HEK-293T C156(0.90)  LDD1068  [2]
 LDCM0471  CL78 HEK-293T C156(0.99)  LDD1069  [2]
 LDCM0472  CL79 HEK-293T C156(1.00)  LDD1070  [2]
 LDCM0473  CL8 HCT 116 C156(1.07)  LDD0790  [2]
 LDCM0474  CL80 HEK-293T C156(0.89)  LDD1072  [2]
 LDCM0475  CL81 HEK-293T C156(1.05)  LDD1073  [2]
 LDCM0476  CL82 HEK-293T C156(1.02)  LDD1074  [2]
 LDCM0477  CL83 HEK-293T C156(0.96)  LDD1075  [2]
 LDCM0478  CL84 HEK-293T C156(0.99)  LDD1076  [2]
 LDCM0479  CL85 HEK-293T C156(0.98)  LDD1077  [2]
 LDCM0480  CL86 HEK-293T C156(0.94)  LDD1078  [2]
 LDCM0481  CL87 HEK-293T C156(1.04)  LDD1079  [2]
 LDCM0482  CL88 HEK-293T C156(1.01)  LDD1080  [2]
 LDCM0483  CL89 HEK-293T C156(1.05)  LDD1081  [2]
 LDCM0484  CL9 HCT 116 C156(1.26)  LDD0801  [2]
 LDCM0485  CL90 HEK-293T C156(0.94)  LDD1083  [2]
 LDCM0486  CL91 HCT 116 C156(1.09)  LDD0803  [2]
 LDCM0487  CL92 HCT 116 C156(0.95)  LDD0804  [2]
 LDCM0488  CL93 HCT 116 C156(0.95)  LDD0805  [2]
 LDCM0489  CL94 HCT 116 C156(0.95)  LDD0806  [2]
 LDCM0490  CL95 HCT 116 C156(1.09)  LDD0807  [2]
 LDCM0491  CL96 HCT 116 C156(0.96)  LDD0808  [2]
 LDCM0492  CL97 HCT 116 C156(1.10)  LDD0809  [2]
 LDCM0493  CL98 HCT 116 C156(1.12)  LDD0810  [2]
 LDCM0494  CL99 HCT 116 C156(1.06)  LDD0811  [2]
 LDCM0495  E2913 HEK-293T C156(1.36)  LDD1698  [10]
 LDCM0468  Fragment33 HEK-293T C156(1.06)  LDD1066  [2]
 LDCM0427  Fragment51 HCT 116 C156(0.98)  LDD0744  [2]
 LDCM0022  KB02 HEK-293T C156(0.98)  LDD1492  [10]
 LDCM0023  KB03 HEK-293T C156(1.05)  LDD1497  [10]
 LDCM0024  KB05 MOLM-13 C80(2.06)  LDD3333  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Adenylate kinase 8 (AK8) Adenylate kinase family Q96MA6
DNA-directed RNA polymerase III subunit RPC3 (POLR3C) Eukaryotic RPC3/POLR3C RNA polymerase subunit family Q9BUI4
Lysine-specific histone demethylase 1A (KDM1A) Flavin monoamine oxidase family O60341
Serine/threonine-protein kinase N1 (PKN1) AGC Ser/Thr protein kinase family Q16512
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
E3 ubiquitin-protein ligase TRIM23 (TRIM23) Arf family P36406
GTPase HRas (HRAS) Ras family P01112
Thioredoxin, mitochondrial (TXN2) Thioredoxin family Q99757
Kinesin-like protein KIFC3 (KIFC3) Kinesin family Q9BVG8
E3 ubiquitin-protein ligase TRIM69 (TRIM69) TRIM/RBCC family Q86WT6
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Tumor susceptibility gene 101 protein (TSG101) Ubiquitin-conjugating enzyme family Q99816
V-type proton ATPase subunit D (ATP6V1D) V-ATPase D subunit family Q9Y5K8
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D (SSC5D) . A1L4H1
Tripartite motif-containing protein 54 (TRIM54) . Q9BYV2
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Glutamate receptor ionotropic, NMDA 2C (GRIN2C) Glutamate-gated ion channel family Q14957
Nuclear pore glycoprotein p62 (NUP62) Nucleoporin NSP1/NUP62 family P37198
Nucleoporin p54 (NUP54) NUP54 family Q7Z3B4
Nucleoporin p58/p45 (NUP58) NUP58 family Q9BVL2
Dystrophin (DMD) . P11532
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 11 (KLF11) Sp1 C2H2-type zinc-finger protein family O14901
Transcriptional enhancer factor TEF-3 (TEAD4) . Q15561
Other
Click To Hide/Show 56 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Biogenesis of lysosome-related organelles complex 1 subunit 6 (BLOC1S6) BLOC1S6 family Q9UL45
BLOC-1-related complex subunit 6 (BORCS6) BORCS6 family Q96GS4
Cerebellar degeneration-related protein 2 (CDR2) CDR2 family Q01850
Centromere protein P (CENPP) CENP-P/CTF19 family Q6IPU0
Cep170-like protein (CEP170P1) CEP170 family Q96L14
Centrosomal protein of 63 kDa (CEP63) CEP63 family Q96MT8
Protein chibby homolog 2 (CBY2) Chibby family Q8NA61
Dynactin subunit 2 (DCTN2) Dynactin subunit 2 family Q13561
Dysbindin (DTNBP1) Dysbindin family Q96EV8
Protein FAM161B (FAM161B) FAM161 family Q96MY7
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
HAUS augmin-like complex subunit 4 (HAUS4) HAUS4 family Q9H6D7
HAUS augmin-like complex subunit 6 (HAUS6) HAUS6 family Q7Z4H7
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) IFIT family O14879
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin, type I cuticular Ha1 (KRT31) Intermediate filament family Q15323
Keratin, type I cuticular Ha8 (KRT38) Intermediate filament family O76015
Keratin, type I cytoskeletal 15 (KRT15) Intermediate filament family P19012
Keratin, type I cytoskeletal 18 (KRT18) Intermediate filament family P05783
Keratin, type I cytoskeletal 19 (KRT19) Intermediate filament family P08727
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Keratin, type II cytoskeletal 1 (KRT1) Intermediate filament family P04264
Keratin, type II cytoskeletal 3 (KRT3) Intermediate filament family P12035
Phakinin (BFSP2) Intermediate filament family Q13515
KxDL motif-containing protein 1 (KXD1) KXD1 family Q9BQD3
Protein LDOC1 (LDOC1) LDOC1 family O95751
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) MAD1 family Q9Y6D9
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
Outer dynein arm-docking complex subunit 1 (ODAD1) ODA1/DCC2 family Q96M63
FGFR1 oncogene partner 2 (FGFR1OP2) SIKE family Q9NVK5
Synaptonemal complex central element protein 1 (SYCE1) SYCE family Q8N0S2
Syntaxin-11 (STX11) Syntaxin family O75558
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Gelsolin (GSN) Villin/gelsolin family P06396
Vacuolar protein sorting-associated protein 37C (VPS37C) VPS37 family A5D8V6
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Arfaptin-2 (ARFIP2) . P53365
Cancer-associated gene 1 protein (CAGE1) . Q8TC20
Centrosomal protein of 44 kDa (CEP44) . Q9C0F1
Centrosomal protein of 55 kDa (CEP55) . Q53EZ4
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
Coiled-coil domain-containing protein 57 (CCDC57) . Q2TAC2
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Intraflagellar transport protein 20 homolog (IFT20) . Q8IY31
Leucine rich adaptor protein 1 (LURAP1) . Q96LR2
Melanoma-associated antigen 6 (MAGEA6) . P43360
Mirror-image polydactyly gene 1 protein (MIPOL1) . Q8TD10
Myomegalin (PDE4DIP) . Q5VU43
Ninein-like protein (NINL) . Q9Y2I6
Sperm-associated antigen 5 (SPAG5) . Q96R06
Synaptonemal complex central element protein 3 (SYCE3) . A1L190
TNF receptor-associated factor 1 (TRAF1) . Q13077
Uncharacterized protein C3orf62 (C3orf62) . Q6ZUJ4

References

1 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
2 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
3 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
4 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
7 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
10 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
11 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840