Details of the Target

General Information of Target

Target ID LDTP01562
Target Name Peptidyl-prolyl cis-trans isomerase FKBP9 (FKBP9)
Gene Name FKBP9
Gene ID 11328
Synonyms
FKBP60; FKBP63; Peptidyl-prolyl cis-trans isomerase FKBP9; PPIase FKBP9; EC 5.2.1.8; 63 kDa FK506-binding protein; 63 kDa FKBP; FKBP-63; FK506-binding protein 9; FKBP-9; Rotamase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAFRGWRPPPPPLLLLLLWVTGQAAPVAGLGSDAELQIERRFVPDECPRTVRSGDFVRYH
YVGTFPDGQKFDSSYDRDSTFNVFVGKGQLITGMDQALVGMCVNERRFVKIPPKLAYGNE
GVSGVIPPNSVLHFDVLLMDIWNSEDQVQIHTYFKPPSCPRTIQVSDFVRYHYNGTFLDG
TLFDSSHNRMKTYDTYVGIGWLIPGMDKGLLGMCVGEKRIITIPPFLAYGEDGDGKDIPG
QASLVFDVALLDLHNPKDSISIENKVVPENCERISQSGDFLRYHYNGTLLDGTLFDSSYS
RNRTFDTYIGQGYVIPGMDEGLLGVCIGEKRRIVVPPHLGYGEEGRGNIPGSAVLVFDIH
VIDFHNPSDSISITSHYKPPDCSVLSKKGDYLKYHYNASLLDGTLLDSTWNLGKTYNIVL
GSGQVVLGMDMGLREMCVGEKRTVIIPPHLGYGEAGVDGEVPGSAVLVFDIELLELVAGL
PEGYMFIWNGEVSPNLFEEIDKDGNGEVLLEEFSEYIHAQVASGKGKLAPGFDAELIVKN
MFTNQDRNGDGKVTAEEFKLKDQEAKHDEL
Target Bioclass
Enzyme
Subcellular location
Endoplasmic reticulum
Function PPIases accelerate the folding of proteins during protein synthesis.
Uniprot ID
O95302
Ensemble ID
ENST00000242209.9
HGNC ID
HGNC:3725

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 9 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info  		Y75(29.54)  LDD3495  [1]
DBIA
 Probe Info  		C47(2.39); C267(3.10)  LDD3310  [2]
HHS-475
 Probe Info  		Y196(0.05); Y61(0.77); Y341(1.14)  LDD0264  [3]
IA-alkyne
 Probe Info  		C47(0.00); C437(0.00); C271(0.00)  LDD0162  [4]
TFBX
 Probe Info  		N.A.  LDD0148  [5]
Acrolein
 Probe Info  		C47(0.00); C437(0.00)  LDD0217  [6]
Crotonaldehyde
 Probe Info  		C47(0.00); C271(0.00)  LDD0219  [6]
Methacrolein
 Probe Info  		C47(0.00); C214(0.00)  LDD0218  [6]
NAIA_5
 Probe Info  		C437(0.00); C214(0.00); C102(0.00); C47(0.00)  LDD2223  [7]
PAL-AfBPP Probe
Click To Hide/Show 45 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		37.79  LDD1793  [8]
C107
 Probe Info  		10.78  LDD1794  [8]
C108
 Probe Info  		11.24  LDD1795  [8]
C141
 Probe Info  		11.71  LDD1823  [8]
C147
 Probe Info  		44.63  LDD1829  [8]
C153
 Probe Info  		24.25  LDD1834  [8]
C156
 Probe Info  		5.17  LDD1836  [8]
C159
 Probe Info  		16.68  LDD1839  [8]
C160
 Probe Info  		7.52  LDD1840  [8]
C161
 Probe Info  		13.45  LDD1841  [8]
C178
 Probe Info  		50.91  LDD1857  [8]
C179
 Probe Info  		13.83  LDD1858  [8]
C217
 Probe Info  		16.00  LDD1891  [8]
C218
 Probe Info  		11.39  LDD1892  [8]
C219
 Probe Info  		9.99  LDD1893  [8]
C220
 Probe Info  		28.64  LDD1894  [8]
C228
 Probe Info  		17.39  LDD1901  [8]
C238
 Probe Info  		14.32  LDD1911  [8]
C240
 Probe Info  		24.93  LDD1913  [8]
C265
 Probe Info  		21.86  LDD1936  [8]
C272
 Probe Info  		32.22  LDD1942  [8]
C277
 Probe Info  		8.75  LDD1947  [8]
C285
 Probe Info  		24.76  LDD1955  [8]
C293
 Probe Info  		19.56  LDD1963  [8]
C296
 Probe Info  		14.03  LDD1966  [8]
C307
 Probe Info  		9.99  LDD1975  [8]
C310
 Probe Info  		14.93  LDD1977  [8]
C313
 Probe Info  		12.38  LDD1980  [8]
C314
 Probe Info  		15.24  LDD1981  [8]
C317
 Probe Info  		6.23  LDD1983  [8]
C326
 Probe Info  		48.50  LDD1990  [8]
C355
 Probe Info  		23.10  LDD2016  [8]
C356
 Probe Info  		9.51  LDD2017  [8]
C357
 Probe Info  		8.40  LDD2018  [8]
C360
 Probe Info  		6.82  LDD2021  [8]
C361
 Probe Info  		60.55  LDD2022  [8]
C363
 Probe Info  		23.75  LDD2024  [8]
C364
 Probe Info  		14.83  LDD2025  [8]
C366
 Probe Info  		18.25  LDD2027  [8]
C367
 Probe Info  		5.82  LDD2028  [8]
C376
 Probe Info  		30.91  LDD2036  [8]
C383
 Probe Info  		15.24  LDD2042  [8]
C386
 Probe Info  		10.06  LDD2045  [8]
C388
 Probe Info  		47.18  LDD2047  [8]
STS-1
 Probe Info  		N.A.  LDD0136  [9]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0215  AC10 PaTu 8988t C47(0.52)  LDD1094  [10]
 LDCM0226  AC11 PaTu 8988t C47(0.60)  LDD1105  [10]
 LDCM0237  AC12 PaTu 8988t C47(0.64)  LDD1116  [10]
 LDCM0246  AC128 PaTu 8988t C47(0.78)  LDD1125  [10]
 LDCM0247  AC129 PaTu 8988t C47(0.70)  LDD1126  [10]
 LDCM0249  AC130 PaTu 8988t C47(1.07)  LDD1128  [10]
 LDCM0250  AC131 PaTu 8988t C47(0.93)  LDD1129  [10]
 LDCM0251  AC132 PaTu 8988t C47(1.16)  LDD1130  [10]
 LDCM0252  AC133 PaTu 8988t C47(0.44)  LDD1131  [10]
 LDCM0253  AC134 PaTu 8988t C47(0.44)  LDD1132  [10]
 LDCM0254  AC135 PaTu 8988t C47(0.43)  LDD1133  [10]
 LDCM0255  AC136 PaTu 8988t C47(0.60)  LDD1134  [10]
 LDCM0256  AC137 PaTu 8988t C47(0.39)  LDD1135  [10]
 LDCM0257  AC138 PaTu 8988t C47(0.71)  LDD1136  [10]
 LDCM0258  AC139 PaTu 8988t C47(0.71)  LDD1137  [10]
 LDCM0259  AC14 PaTu 8988t C47(0.89)  LDD1138  [10]
 LDCM0260  AC140 PaTu 8988t C47(0.93)  LDD1139  [10]
 LDCM0261  AC141 PaTu 8988t C47(1.12)  LDD1140  [10]
 LDCM0262  AC142 PaTu 8988t C47(0.60)  LDD1141  [10]
 LDCM0270  AC15 PaTu 8988t C47(0.69)  LDD1149  [10]
 LDCM0276  AC17 PaTu 8988t C47(0.56)  LDD1155  [10]
 LDCM0277  AC18 PaTu 8988t C47(0.41)  LDD1156  [10]
 LDCM0278  AC19 PaTu 8988t C47(0.79)  LDD1157  [10]
 LDCM0279  AC2 HEK-293T C271(1.03)  LDD1518  [11]
 LDCM0280  AC20 PaTu 8988t C47(0.49)  LDD1159  [10]
 LDCM0281  AC21 PaTu 8988t C47(0.35)  LDD1160  [10]
 LDCM0282  AC22 PaTu 8988t C47(0.26)  LDD1161  [10]
 LDCM0283  AC23 PaTu 8988t C47(0.38)  LDD1162  [10]
 LDCM0284  AC24 PaTu 8988t C47(0.40)  LDD1163  [10]
 LDCM0286  AC26 HEK-293T C271(1.07)  LDD1525  [11]
 LDCM0295  AC34 HEK-293T C271(1.08)  LDD1534  [11]
 LDCM0296  AC35 PaTu 8988t C47(0.52)  LDD1175  [10]
 LDCM0297  AC36 PaTu 8988t C47(0.65)  LDD1176  [10]
 LDCM0298  AC37 PaTu 8988t C47(0.30)  LDD1177  [10]
 LDCM0299  AC38 PaTu 8988t C47(0.46)  LDD1178  [10]
 LDCM0300  AC39 PaTu 8988t C47(0.41)  LDD1179  [10]
 LDCM0302  AC40 PaTu 8988t C47(0.26)  LDD1181  [10]
 LDCM0303  AC41 PaTu 8988t C47(0.35)  LDD1182  [10]
 LDCM0304  AC42 PaTu 8988t C47(0.29)  LDD1183  [10]
 LDCM0305  AC43 PaTu 8988t C47(0.52)  LDD1184  [10]
 LDCM0306  AC44 PaTu 8988t C47(0.12)  LDD1185  [10]
 LDCM0307  AC45 PaTu 8988t C47(0.17)  LDD1186  [10]
 LDCM0308  AC46 PaTu 8988t C47(0.75)  LDD1187  [10]
 LDCM0309  AC47 PaTu 8988t C47(0.77)  LDD1188  [10]
 LDCM0310  AC48 PaTu 8988t C47(0.60)  LDD1189  [10]
 LDCM0311  AC49 PaTu 8988t C47(0.32)  LDD1190  [10]
 LDCM0313  AC50 PaTu 8988t C47(0.26)  LDD1192  [10]
 LDCM0314  AC51 PaTu 8988t C47(0.10)  LDD1193  [10]
 LDCM0315  AC52 PaTu 8988t C47(0.51)  LDD1194  [10]
 LDCM0316  AC53 PaTu 8988t C47(0.25)  LDD1195  [10]
 LDCM0317  AC54 PaTu 8988t C47(0.21)  LDD1196  [10]
 LDCM0318  AC55 PaTu 8988t C47(0.45)  LDD1197  [10]
 LDCM0319  AC56 PaTu 8988t C47(0.24)  LDD1198  [10]
 LDCM0321  AC58 HEK-293T C271(1.07)  LDD1560  [11]
 LDCM0323  AC6 PaTu 8988t C47(0.70)  LDD1202  [10]
 LDCM0334  AC7 PaTu 8988t C47(0.90)  LDD1213  [10]
 LDCM0345  AC8 PaTu 8988t C47(1.13)  LDD1224  [10]
 LDCM0248  AKOS034007472 PaTu 8988t C47(0.71)  LDD1127  [10]
 LDCM0356  AKOS034007680 PaTu 8988t C47(0.72)  LDD1235  [10]
 LDCM0275  AKOS034007705 PaTu 8988t C47(0.66)  LDD1154  [10]
 LDCM0020  ARS-1620 HCC44 C271(1.16)  LDD2171  [10]
 LDCM0108  Chloroacetamide HeLa C102(0.00); C214(0.00); C271(0.00); C47(0.00)  LDD0222  [6]
 LDCM0370  CL101 PaTu 8988t C47(0.79)  LDD1249  [10]
 LDCM0371  CL102 PaTu 8988t C47(0.72)  LDD1250  [10]
 LDCM0372  CL103 PaTu 8988t C47(0.45)  LDD1251  [10]
 LDCM0373  CL104 PaTu 8988t C47(0.87)  LDD1252  [10]
 LDCM0374  CL105 PaTu 8988t C47(0.87)  LDD1253  [10]
 LDCM0375  CL106 PaTu 8988t C47(0.74)  LDD1254  [10]
 LDCM0376  CL107 PaTu 8988t C47(0.81)  LDD1255  [10]
 LDCM0377  CL108 PaTu 8988t C47(0.62)  LDD1256  [10]
 LDCM0378  CL109 PaTu 8988t C47(0.66)  LDD1257  [10]
 LDCM0380  CL110 PaTu 8988t C47(0.57)  LDD1259  [10]
 LDCM0381  CL111 PaTu 8988t C47(0.28)  LDD1260  [10]
 LDCM0387  CL117 PaTu 8988t C47(0.36)  LDD1266  [10]
 LDCM0388  CL118 PaTu 8988t C47(0.55)  LDD1267  [10]
 LDCM0389  CL119 PaTu 8988t C47(0.41)  LDD1268  [10]
 LDCM0391  CL120 PaTu 8988t C47(0.73)  LDD1270  [10]
 LDCM0392  CL121 PaTu 8988t C47(0.63)  LDD1271  [10]
 LDCM0393  CL122 PaTu 8988t C47(0.54)  LDD1272  [10]
 LDCM0394  CL123 PaTu 8988t C47(0.40)  LDD1273  [10]
 LDCM0395  CL124 PaTu 8988t C47(0.30)  LDD1274  [10]
 LDCM0405  CL18 HEK-293T C271(1.13)  LDD1609  [11]
 LDCM0419  CL30 HEK-293T C271(1.01)  LDD1623  [11]
 LDCM0420  CL31 PaTu 8988t C47(0.36)  LDD1299  [10]
 LDCM0421  CL32 PaTu 8988t C47(0.23)  LDD1300  [10]
 LDCM0422  CL33 PaTu 8988t C47(0.14)  LDD1301  [10]
 LDCM0423  CL34 PaTu 8988t C47(0.14)  LDD1302  [10]
 LDCM0424  CL35 PaTu 8988t C47(0.11)  LDD1303  [10]
 LDCM0425  CL36 PaTu 8988t C47(0.11)  LDD1304  [10]
 LDCM0426  CL37 PaTu 8988t C47(0.07)  LDD1305  [10]
 LDCM0428  CL39 PaTu 8988t C47(0.17)  LDD1307  [10]
 LDCM0430  CL40 PaTu 8988t C47(0.28)  LDD1309  [10]
 LDCM0431  CL41 PaTu 8988t C47(0.13)  LDD1310  [10]
 LDCM0432  CL42 PaTu 8988t C47(0.08)  LDD1311  [10]
 LDCM0433  CL43 PaTu 8988t C47(0.06)  LDD1312  [10]
 LDCM0434  CL44 PaTu 8988t C47(0.12)  LDD1313  [10]
 LDCM0435  CL45 PaTu 8988t C47(0.20)  LDD1314  [10]
 LDCM0445  CL54 HEK-293T C271(1.03)  LDD1648  [11]
 LDCM0451  CL6 HEK-293T C271(0.96)  LDD1654  [11]
 LDCM0458  CL66 HEK-293T C271(1.01)  LDD1661  [11]
 LDCM0471  CL78 HEK-293T C271(1.08)  LDD1674  [11]
 LDCM0485  CL90 HEK-293T C271(0.96)  LDD1688  [11]
 LDCM0427  Fragment51 PaTu 8988t C47(0.05)  LDD1306  [10]
 LDCM0116  HHS-0101 DM93 Y196(0.05); Y61(0.77); Y341(1.14)  LDD0264  [3]
 LDCM0117  HHS-0201 DM93 Y196(0.52); Y61(0.85); Y341(1.25)  LDD0265  [3]
 LDCM0118  HHS-0301 DM93 Y196(0.05); Y61(0.78); Y341(1.33)  LDD0266  [3]
 LDCM0119  HHS-0401 DM93 Y196(0.05); Y61(1.21); Y341(2.01)  LDD0267  [3]
 LDCM0120  HHS-0701 DM93 Y196(0.05); Y61(0.58); Y341(0.98)  LDD0268  [3]
 LDCM0022  KB02 42-MG-BA C39(2.78)  LDD2244  [2]
 LDCM0023  KB03 769-P C39(2.68)  LDD2663  [2]
 LDCM0024  KB05 COLO792 C47(2.39); C267(3.10)  LDD3310  [2]
 LDCM0109  NEM HeLa N.A.  LDD0223  [6]
 LDCM0021  THZ1 HCT 116 C271(1.16)  LDD2173  [10]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
4 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
5 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
6 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
7 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
8 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
9 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
10 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
11 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402