Details of the Target

General Information of Target

Target ID LDTP12386
Target Name Polyamine-transporting ATPase 13A2 (ATP13A2)
Gene Name ATP13A2
Gene ID 23400
Synonyms
PARK9; Polyamine-transporting ATPase 13A2; EC 7.6.2.-
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKSALFTRFFILLPWILIVIIMLDVDTRRPVPPLTPRPYFSPYAVGRGGARLPLRRGGPA
HGTQKRNQSRPQPQPEPQLPTIYAITPTYSRPVQKAELTRLANTFRQVAQLHWILVEDAA
ARSELVSRFLARAGLPSTHLHVPTPRRYKRPGLPRATEQRNAGLAWLRQRHQHQRAQPGV
LFFADDDNTYSLELFQEMRTTRKVSVWPVGLVGGRRYERPLVENGKVVGWYTGWRADRPF
AIDMAGFAVSLQVILSNPKAVFKRRGSQPGMQESDFLKQITTVEELEPKANNCTKVLVWH
TRTEKVNLANEPKYHLDTVKIEV
Target Bioclass
Enzyme
Family
Cation transport ATPase (P-type) (TC 3.A.3) family, Type V subfamily
Subcellular location
Lysosome membrane
Function
ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine. Also stimulates cellular uptake of polyamines and protects against polyamine toxicity. Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Contributes to cellular zinc homeostasis. Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress. Required for proper lysosomal and mitochondrial maintenance. Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels. Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. Promotes secretion of exosomes as well as secretion of SCNA via exosomes. Plays a role in lipid homeostasis.
Uniprot ID
Q9NQ11
Ensemble ID
ENST00000326735.13
HGNC ID
HGNC:30213

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DOTC24510 SNV: p.A554P .
HT SNV: p.K427T DBIA    Probe Info 
HT3 Deletion: p.K95RfsTer3 .
J82 SNV: p.A3V .
JURKAT Deletion: p.G505AfsTer19
SNV: p.P541L;p.N881I		 .
MCC13 SNV: p.S200F .
MOLT4 SNV: p.P474S .
NCIH446 SNV: p.V525L .
RH30 Deletion: p.Q962PfsTer150 .
SNGM SNV: p.Q322H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C194(1.51)  LDD3310  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0165  [2]
IPM
 Probe Info  		C365(0.00); C194(0.00)  LDD2156  [3]
PAL-AfBPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C064
 Probe Info  		6.41  LDD1761  [4]
C143
 Probe Info  		16.56  LDD1825  [4]
C225
 Probe Info  		6.02  LDD1898  [4]
C280
 Probe Info  		11.96  LDD1950  [4]
C282
 Probe Info  		15.67  LDD1952  [4]
C386
 Probe Info  		9.25  LDD2045  [4]
C388
 Probe Info  		35.75  LDD2047  [4]
C389
 Probe Info  		6.96  LDD2048  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HEK-293T C194(0.83)  LDD0812  [5]
 LDCM0215  AC10 HEK-293T C365(0.96); C915(1.24); C511(0.99); C80(0.93)  LDD1508  [6]
 LDCM0216  AC100 HEK-293T C194(0.95)  LDD0814  [5]
 LDCM0217  AC101 HEK-293T C194(1.11)  LDD0815  [5]
 LDCM0218  AC102 HEK-293T C194(0.71)  LDD0816  [5]
 LDCM0219  AC103 HEK-293T C194(0.86)  LDD0817  [5]
 LDCM0220  AC104 HEK-293T C194(0.54)  LDD0818  [5]
 LDCM0221  AC105 HEK-293T C194(0.59)  LDD0819  [5]
 LDCM0222  AC106 HEK-293T C194(0.74)  LDD0820  [5]
 LDCM0223  AC107 HEK-293T C194(0.83)  LDD0821  [5]
 LDCM0224  AC108 HEK-293T C194(0.61)  LDD0822  [5]
 LDCM0225  AC109 HEK-293T C194(0.62)  LDD0823  [5]
 LDCM0226  AC11 HEK-293T C365(0.98); C511(0.95); C864(0.84); C80(0.92)  LDD1509  [6]
 LDCM0227  AC110 HEK-293T C194(0.54)  LDD0825  [5]
 LDCM0228  AC111 HEK-293T C194(0.89)  LDD0826  [5]
 LDCM0229  AC112 HEK-293T C194(0.64)  LDD0827  [5]
 LDCM0237  AC12 HEK-293T C365(1.01); C915(1.18); C511(0.98); C864(0.98)  LDD1510  [6]
 LDCM0259  AC14 HEK-293T C365(1.13); C511(1.13); C194(0.96); C864(1.06)  LDD1512  [6]
 LDCM0270  AC15 HEK-293T C365(1.00); C511(0.92); C80(0.94)  LDD1513  [6]
 LDCM0276  AC17 HEK-293T C365(1.11); C511(1.09); C864(0.97)  LDD1515  [6]
 LDCM0277  AC18 HEK-293T C365(1.03); C915(0.90); C511(0.93); C80(0.95)  LDD1516  [6]
 LDCM0278  AC19 HEK-293T C365(0.95); C511(0.95); C864(1.02); C80(0.94)  LDD1517  [6]
 LDCM0279  AC2 HEK-293T C194(1.08)  LDD0877  [5]
 LDCM0280  AC20 HEK-293T C365(0.94); C915(0.96); C511(1.03); C864(1.09)  LDD1519  [6]
 LDCM0281  AC21 HEK-293T C365(1.00); C511(0.93); C194(1.07); C80(0.89)  LDD1520  [6]
 LDCM0282  AC22 HEK-293T C365(1.16); C511(0.90); C194(0.91); C864(0.91)  LDD1521  [6]
 LDCM0283  AC23 HEK-293T C365(0.87); C511(1.08); C80(1.01)  LDD1522  [6]
 LDCM0284  AC24 HEK-293T C365(0.98); C511(1.01)  LDD1523  [6]
 LDCM0285  AC25 HEK-293T C365(1.07); C511(1.02); C864(1.09)  LDD1524  [6]
 LDCM0286  AC26 HEK-293T C365(0.93); C915(1.10); C511(1.01); C80(0.95)  LDD1525  [6]
 LDCM0287  AC27 HEK-293T C365(0.90); C511(0.93); C864(0.94); C80(1.17)  LDD1526  [6]
 LDCM0288  AC28 HEK-293T C365(0.95); C915(0.99); C511(0.94); C864(1.01)  LDD1527  [6]
 LDCM0289  AC29 HEK-293T C365(1.00); C511(0.94); C194(0.91); C80(0.88)  LDD1528  [6]
 LDCM0290  AC3 HEK-293T C194(0.86)  LDD0888  [5]
 LDCM0291  AC30 HEK-293T C365(1.03); C511(1.00); C194(0.99); C864(1.05)  LDD1530  [6]
 LDCM0292  AC31 HEK-293T C365(0.85); C511(0.93); C80(1.20)  LDD1531  [6]
 LDCM0293  AC32 HEK-293T C365(1.16); C511(1.04)  LDD1532  [6]
 LDCM0294  AC33 HEK-293T C365(1.17); C511(0.94); C864(1.14)  LDD1533  [6]
 LDCM0295  AC34 HEK-293T C365(0.88); C915(1.52); C511(0.97); C80(1.07)  LDD1534  [6]
 LDCM0296  AC35 HEK-293T C365(1.00); C511(1.00); C864(0.90); C80(0.78)  LDD1535  [6]
 LDCM0297  AC36 HEK-293T C365(1.14); C915(1.17); C511(1.02); C864(0.90)  LDD1536  [6]
 LDCM0298  AC37 HEK-293T C365(1.01); C511(1.02); C194(1.41); C80(1.08)  LDD1537  [6]
 LDCM0299  AC38 HEK-293T C365(1.05); C511(1.07); C194(0.97); C864(1.04)  LDD1538  [6]
 LDCM0300  AC39 HEK-293T C365(0.85); C511(1.02); C80(1.27)  LDD1539  [6]
 LDCM0301  AC4 HEK-293T C194(0.93)  LDD0899  [5]
 LDCM0302  AC40 HEK-293T C365(0.96); C511(0.87)  LDD1541  [6]
 LDCM0303  AC41 HEK-293T C365(1.24); C511(1.02); C864(0.97)  LDD1542  [6]
 LDCM0304  AC42 HEK-293T C365(0.81); C915(1.07); C511(1.00); C80(1.08)  LDD1543  [6]
 LDCM0305  AC43 HEK-293T C365(1.02); C511(1.01); C864(0.91); C80(0.82)  LDD1544  [6]
 LDCM0306  AC44 HEK-293T C365(1.00); C915(1.27); C511(0.92); C864(1.02)  LDD1545  [6]
 LDCM0307  AC45 HEK-293T C365(0.98); C511(0.99); C194(1.06); C80(1.19)  LDD1546  [6]
 LDCM0308  AC46 HEK-293T C194(0.94)  LDD0906  [5]
 LDCM0309  AC47 HEK-293T C194(0.83)  LDD0907  [5]
 LDCM0310  AC48 HEK-293T C194(0.90)  LDD0908  [5]
 LDCM0311  AC49 HEK-293T C194(1.05)  LDD0909  [5]
 LDCM0312  AC5 HEK-293T C194(0.98)  LDD0910  [5]
 LDCM0313  AC50 HEK-293T C194(0.87)  LDD0911  [5]
 LDCM0314  AC51 HEK-293T C194(1.02)  LDD0912  [5]
 LDCM0315  AC52 HEK-293T C194(0.96)  LDD0913  [5]
 LDCM0316  AC53 HEK-293T C194(1.03)  LDD0914  [5]
 LDCM0317  AC54 HEK-293T C194(1.12)  LDD0915  [5]
 LDCM0318  AC55 HEK-293T C194(0.87)  LDD0916  [5]
 LDCM0319  AC56 HEK-293T C194(0.96)  LDD0917  [5]
 LDCM0320  AC57 HEK-293T C365(1.33); C511(0.89); C864(1.06)  LDD1559  [6]
 LDCM0321  AC58 HEK-293T C365(0.99); C915(1.10); C511(0.89); C80(1.11)  LDD1560  [6]
 LDCM0322  AC59 HEK-293T C365(1.06); C511(1.06); C864(0.87); C80(0.98)  LDD1561  [6]
 LDCM0323  AC6 HEK-293T C365(1.08); C511(0.95); C194(0.91); C864(0.84)  LDD1562  [6]
 LDCM0324  AC60 HEK-293T C365(1.00); C915(1.08); C511(0.90); C864(0.93)  LDD1563  [6]
 LDCM0325  AC61 HEK-293T C365(1.00); C511(0.92); C194(0.96); C80(1.14)  LDD1564  [6]
 LDCM0326  AC62 HEK-293T C365(1.04); C511(0.98); C194(1.05); C864(0.95)  LDD1565  [6]
 LDCM0327  AC63 HEK-293T C365(0.92); C511(0.99); C80(1.19)  LDD1566  [6]
 LDCM0328  AC64 HEK-293T C365(1.11); C511(0.95)  LDD1567  [6]
 LDCM0332  AC68 HEK-293T C194(1.29)  LDD0930  [5]
 LDCM0333  AC69 HEK-293T C194(1.05)  LDD0931  [5]
 LDCM0334  AC7 HEK-293T C365(0.87); C511(0.92); C80(1.09)  LDD1568  [6]
 LDCM0335  AC70 HEK-293T C194(1.01)  LDD0933  [5]
 LDCM0336  AC71 HEK-293T C194(0.89)  LDD0934  [5]
 LDCM0337  AC72 HEK-293T C194(1.26)  LDD0935  [5]
 LDCM0338  AC73 HEK-293T C194(0.97)  LDD0936  [5]
 LDCM0339  AC74 HEK-293T C194(1.30)  LDD0937  [5]
 LDCM0340  AC75 HEK-293T C194(1.41)  LDD0938  [5]
 LDCM0341  AC76 HEK-293T C194(1.07)  LDD0939  [5]
 LDCM0342  AC77 HEK-293T C194(1.15)  LDD0940  [5]
 LDCM0343  AC78 HEK-293T C194(1.02)  LDD0941  [5]
 LDCM0344  AC79 HEK-293T C194(1.43)  LDD0942  [5]
 LDCM0345  AC8 HEK-293T C365(0.93); C511(0.87)  LDD1569  [6]
 LDCM0346  AC80 HEK-293T C194(1.57)  LDD0944  [5]
 LDCM0347  AC81 HEK-293T C194(1.12)  LDD0945  [5]
 LDCM0348  AC82 HEK-293T C194(1.63)  LDD0946  [5]
 LDCM0365  AC98 HEK-293T C194(0.89)  LDD0963  [5]
 LDCM0366  AC99 HEK-293T C194(1.31)  LDD0964  [5]
 LDCM0248  AKOS034007472 HEK-293T C365(1.02); C511(0.97); C194(0.99); C80(1.29)  LDD1511  [6]
 LDCM0356  AKOS034007680 HEK-293T C365(1.19); C511(0.96); C864(0.95)  LDD1570  [6]
 LDCM0275  AKOS034007705 HEK-293T C365(0.97); C511(1.05)  LDD1514  [6]
 LDCM0367  CL1 HEK-293T C365(1.17); C915(1.19); C511(0.94)  LDD1571  [6]
 LDCM0368  CL10 HEK-293T C365(1.65); C511(1.56); C194(1.14); C864(1.05)  LDD1572  [6]
 LDCM0369  CL100 HEK-293T C194(0.77)  LDD0967  [5]
 LDCM0370  CL101 HEK-293T C365(1.16); C915(0.91); C511(0.95)  LDD1574  [6]
 LDCM0371  CL102 HEK-293T C365(1.32); C511(0.96); C194(1.00); C864(0.94)  LDD1575  [6]
 LDCM0372  CL103 HEK-293T C365(0.97); C194(1.04); C864(0.75)  LDD1576  [6]
 LDCM0373  CL104 HEK-293T C365(1.12); C194(1.02); C864(0.91)  LDD1577  [6]
 LDCM0374  CL105 HEK-293T C365(1.03); C915(0.97); C511(0.86)  LDD1578  [6]
 LDCM0375  CL106 HEK-293T C365(1.17); C511(0.88); C194(0.99); C864(1.05)  LDD1579  [6]
 LDCM0376  CL107 HEK-293T C365(0.93); C194(1.05); C864(0.85)  LDD1580  [6]
 LDCM0377  CL108 HEK-293T C365(1.33); C194(0.99); C864(1.02)  LDD1581  [6]
 LDCM0378  CL109 HEK-293T C365(1.16); C915(1.30); C511(0.85)  LDD1582  [6]
 LDCM0379  CL11 HEK-293T C365(1.30); C511(1.44); C80(1.23)  LDD1583  [6]
 LDCM0380  CL110 HEK-293T C365(0.95); C511(0.93); C194(1.21); C864(1.01)  LDD1584  [6]
 LDCM0381  CL111 HEK-293T C365(1.41); C194(0.98); C864(0.85)  LDD1585  [6]
 LDCM0382  CL112 HEK-293T C365(1.03); C194(0.96); C864(0.95)  LDD1586  [6]
 LDCM0383  CL113 HEK-293T C365(0.93); C915(0.91); C511(0.91)  LDD1587  [6]
 LDCM0384  CL114 HEK-293T C365(1.51); C511(0.97); C194(1.00); C864(0.93)  LDD1588  [6]
 LDCM0385  CL115 HEK-293T C365(1.12); C194(1.09); C864(0.72)  LDD1589  [6]
 LDCM0386  CL116 HEK-293T C365(0.94); C194(0.95); C864(0.99)  LDD1590  [6]
 LDCM0387  CL117 HEK-293T C365(0.98); C915(0.89); C511(0.87)  LDD1591  [6]
 LDCM0388  CL118 HEK-293T C365(1.09); C511(0.91); C194(1.12); C864(1.05)  LDD1592  [6]
 LDCM0389  CL119 HEK-293T C365(0.95); C194(1.10); C864(0.80)  LDD1593  [6]
 LDCM0390  CL12 HEK-293T C365(1.58); C511(1.46)  LDD1594  [6]
 LDCM0391  CL120 HEK-293T C365(1.15); C194(1.03); C864(0.86)  LDD1595  [6]
 LDCM0392  CL121 HEK-293T C194(0.92)  LDD0990  [5]
 LDCM0393  CL122 HEK-293T C194(0.97)  LDD0991  [5]
 LDCM0394  CL123 HEK-293T C194(0.83)  LDD0992  [5]
 LDCM0395  CL124 HEK-293T C194(0.90)  LDD0993  [5]
 LDCM0396  CL125 HEK-293T C365(1.05); C915(1.26); C511(0.95)  LDD1600  [6]
 LDCM0397  CL126 HEK-293T C365(1.24); C511(0.97); C194(1.07); C864(0.89)  LDD1601  [6]
 LDCM0398  CL127 HEK-293T C365(1.30); C194(1.09); C864(0.82)  LDD1602  [6]
 LDCM0399  CL128 HEK-293T C365(1.08); C194(0.97); C864(0.97)  LDD1603  [6]
 LDCM0400  CL13 HEK-293T C365(1.13); C915(0.93); C511(0.84)  LDD1604  [6]
 LDCM0401  CL14 HEK-293T C365(1.18); C511(0.98); C194(0.99); C864(0.92)  LDD1605  [6]
 LDCM0402  CL15 HEK-293T C365(1.09); C194(1.09); C864(0.87)  LDD1606  [6]
 LDCM0403  CL16 HEK-293T C365(1.12); C194(1.07); C864(0.96)  LDD1607  [6]
 LDCM0404  CL17 HEK-293T C365(1.65); C511(1.45); C864(0.97)  LDD1608  [6]
 LDCM0405  CL18 HEK-293T C365(1.03); C915(1.13); C511(1.00); C80(0.87)  LDD1609  [6]
 LDCM0406  CL19 HEK-293T C365(1.10); C511(1.14); C864(0.94); C80(0.83)  LDD1610  [6]
 LDCM0407  CL2 HEK-293T C365(1.48); C511(1.11); C194(1.01); C864(0.92)  LDD1611  [6]
 LDCM0408  CL20 HEK-293T C365(1.22); C915(1.11); C511(1.22); C864(1.12)  LDD1612  [6]
 LDCM0409  CL21 HEK-293T C365(1.33); C511(1.32); C194(1.12); C80(1.62)  LDD1613  [6]
 LDCM0410  CL22 HEK-293T C365(1.41); C511(1.47); C194(1.22); C864(0.97)  LDD1614  [6]
 LDCM0411  CL23 HEK-293T C365(1.17); C511(1.33); C80(1.22)  LDD1615  [6]
 LDCM0412  CL24 HEK-293T C365(1.34); C511(1.31)  LDD1616  [6]
 LDCM0413  CL25 HEK-293T C365(1.21); C915(1.05); C511(1.09)  LDD1617  [6]
 LDCM0414  CL26 HEK-293T C365(1.12); C511(0.97); C194(1.07); C864(0.96)  LDD1618  [6]
 LDCM0415  CL27 HEK-293T C365(0.89); C194(1.04); C864(0.70)  LDD1619  [6]
 LDCM0416  CL28 HEK-293T C365(1.16); C194(1.07); C864(0.87)  LDD1620  [6]
 LDCM0417  CL29 HEK-293T C365(0.92); C511(1.24); C864(1.02)  LDD1621  [6]
 LDCM0418  CL3 HEK-293T C365(1.12); C194(1.06); C864(0.98)  LDD1622  [6]
 LDCM0419  CL30 HEK-293T C365(0.93); C915(1.10); C511(1.09); C80(0.82)  LDD1623  [6]
 LDCM0420  CL31 HEK-293T C365(1.21); C511(1.19); C864(0.87); C80(1.17)  LDD1624  [6]
 LDCM0421  CL32 HEK-293T C365(1.14); C915(1.43); C511(1.16); C864(1.15)  LDD1625  [6]
 LDCM0422  CL33 HEK-293T C365(1.81); C511(1.49); C194(1.05); C80(1.97)  LDD1626  [6]
 LDCM0423  CL34 HEK-293T C365(1.25); C511(1.50); C194(1.11); C864(1.19)  LDD1627  [6]
 LDCM0424  CL35 HEK-293T C365(1.29); C511(1.26); C80(1.36)  LDD1628  [6]
 LDCM0425  CL36 HEK-293T C365(1.29); C511(1.30)  LDD1629  [6]
 LDCM0426  CL37 HEK-293T C365(1.06); C915(0.88); C511(0.82)  LDD1630  [6]
 LDCM0428  CL39 HEK-293T C365(1.17); C194(0.98); C864(0.85)  LDD1632  [6]
 LDCM0429  CL4 HEK-293T C365(1.43); C194(0.96); C864(0.95)  LDD1633  [6]
 LDCM0430  CL40 HEK-293T C365(1.09); C194(0.94); C864(1.00)  LDD1634  [6]
 LDCM0431  CL41 HEK-293T C365(1.27); C511(1.07); C864(1.00)  LDD1635  [6]
 LDCM0432  CL42 HEK-293T C365(0.95); C915(1.24); C511(1.12); C80(0.85)  LDD1636  [6]
 LDCM0433  CL43 HEK-293T C365(1.17); C511(1.20); C864(0.93); C80(1.11)  LDD1637  [6]
 LDCM0434  CL44 HEK-293T C365(1.12); C915(1.28); C511(1.30); C864(0.95)  LDD1638  [6]
 LDCM0435  CL45 HEK-293T C365(1.54); C511(1.22); C194(1.00); C80(1.18)  LDD1639  [6]
 LDCM0436  CL46 HEK-293T C194(1.64)  LDD1034  [5]
 LDCM0437  CL47 HEK-293T C194(1.29)  LDD1035  [5]
 LDCM0438  CL48 HEK-293T C194(1.25)  LDD1036  [5]
 LDCM0439  CL49 HEK-293T C194(1.46)  LDD1037  [5]
 LDCM0440  CL5 HEK-293T C365(1.38); C511(1.11); C864(0.97)  LDD1644  [6]
 LDCM0441  CL50 HEK-293T C194(1.23)  LDD1039  [5]
 LDCM0442  CL51 HEK-293T C194(1.26)  LDD1040  [5]
 LDCM0443  CL52 HEK-293T C194(1.10)  LDD1041  [5]
 LDCM0444  CL53 HEK-293T C194(1.06)  LDD1042  [5]
 LDCM0445  CL54 HEK-293T C194(1.43)  LDD1043  [5]
 LDCM0446  CL55 HEK-293T C194(1.26)  LDD1044  [5]
 LDCM0447  CL56 HEK-293T C194(1.02)  LDD1045  [5]
 LDCM0448  CL57 HEK-293T C194(1.20)  LDD1046  [5]
 LDCM0449  CL58 HEK-293T C194(0.93)  LDD1047  [5]
 LDCM0450  CL59 HEK-293T C194(1.25)  LDD1048  [5]
 LDCM0451  CL6 HEK-293T C365(1.45); C915(1.00); C511(1.21); C80(1.29)  LDD1654  [6]
 LDCM0452  CL60 HEK-293T C194(1.44)  LDD1050  [5]
 LDCM0453  CL61 HEK-293T C365(0.98); C915(1.08); C511(0.87)  LDD1656  [6]
 LDCM0454  CL62 HEK-293T C365(1.19); C511(0.96); C194(0.95); C864(1.00)  LDD1657  [6]
 LDCM0455  CL63 HEK-293T C365(1.03); C194(1.15); C864(0.93)  LDD1658  [6]
 LDCM0456  CL64 HEK-293T C365(1.28); C194(1.07); C864(0.93)  LDD1659  [6]
 LDCM0457  CL65 HEK-293T C365(1.19); C511(1.07); C864(0.82)  LDD1660  [6]
 LDCM0458  CL66 HEK-293T C365(1.30); C915(1.26); C511(1.07); C80(0.96)  LDD1661  [6]
 LDCM0459  CL67 HEK-293T C365(1.03); C511(1.10); C864(0.91); C80(1.23)  LDD1662  [6]
 LDCM0460  CL68 HEK-293T C365(1.33); C915(1.06); C511(1.19); C864(1.18)  LDD1663  [6]
 LDCM0461  CL69 HEK-293T C365(1.08); C511(1.27); C194(1.05); C80(1.36)  LDD1664  [6]
 LDCM0462  CL7 HEK-293T C365(1.02); C511(1.12); C864(0.95); C80(0.68)  LDD1665  [6]
 LDCM0463  CL70 HEK-293T C365(1.05); C511(1.50); C194(1.12); C864(1.03)  LDD1666  [6]
 LDCM0464  CL71 HEK-293T C365(1.25); C511(1.16); C80(1.52)  LDD1667  [6]
 LDCM0465  CL72 HEK-293T C365(1.35); C511(1.30)  LDD1668  [6]
 LDCM0466  CL73 HEK-293T C365(1.29); C915(0.98); C511(0.93)  LDD1669  [6]
 LDCM0467  CL74 HEK-293T C365(1.16); C511(0.83); C194(1.05); C864(1.10)  LDD1670  [6]
 LDCM0469  CL76 HEK-293T C365(1.23); C194(1.09); C864(0.84)  LDD1672  [6]
 LDCM0470  CL77 HEK-293T C365(1.78); C511(1.26); C864(1.21)  LDD1673  [6]
 LDCM0471  CL78 HEK-293T C365(1.07); C915(1.05); C511(0.97); C80(0.94)  LDD1674  [6]
 LDCM0472  CL79 HEK-293T C365(1.02); C511(1.10); C864(0.93); C80(0.93)  LDD1675  [6]
 LDCM0473  CL8 HEK-293T C365(1.66); C915(1.08); C511(1.50); C864(1.31)  LDD1676  [6]
 LDCM0474  CL80 HEK-293T C365(1.08); C915(1.01); C511(1.19); C864(1.14)  LDD1677  [6]
 LDCM0475  CL81 HEK-293T C365(1.16); C511(1.23); C194(1.14); C80(1.25)  LDD1678  [6]
 LDCM0476  CL82 HEK-293T C365(1.06); C511(1.46); C194(1.10); C864(1.04)  LDD1679  [6]
 LDCM0477  CL83 HEK-293T C365(1.27); C511(1.22); C80(0.84)  LDD1680  [6]
 LDCM0478  CL84 HEK-293T C365(1.23); C511(1.43)  LDD1681  [6]
 LDCM0479  CL85 HEK-293T C365(0.92); C915(0.95); C511(0.87)  LDD1682  [6]
 LDCM0480  CL86 HEK-293T C365(1.08); C511(0.80); C194(1.16); C864(0.96)  LDD1683  [6]
 LDCM0481  CL87 HEK-293T C365(1.14); C194(1.14); C864(0.71)  LDD1684  [6]
 LDCM0482  CL88 HEK-293T C365(0.98); C194(0.99); C864(0.81)  LDD1685  [6]
 LDCM0483  CL89 HEK-293T C365(1.04); C511(0.85); C864(0.95)  LDD1686  [6]
 LDCM0484  CL9 HEK-293T C365(1.32); C511(1.40); C194(1.27); C80(1.31)  LDD1687  [6]
 LDCM0485  CL90 HEK-293T C365(1.64); C915(0.88); C511(0.87); C80(1.60)  LDD1688  [6]
 LDCM0486  CL91 HEK-293T C194(1.01)  LDD1084  [5]
 LDCM0487  CL92 HEK-293T C194(0.90)  LDD1085  [5]
 LDCM0488  CL93 HEK-293T C194(0.91)  LDD1086  [5]
 LDCM0489  CL94 HEK-293T C194(0.84)  LDD1087  [5]
 LDCM0490  CL95 HEK-293T C194(0.96)  LDD1088  [5]
 LDCM0491  CL96 HEK-293T C194(0.95)  LDD1089  [5]
 LDCM0492  CL97 HEK-293T C194(0.93)  LDD1090  [5]
 LDCM0493  CL98 HEK-293T C194(0.77)  LDD1091  [5]
 LDCM0494  CL99 HEK-293T C194(0.80)  LDD1092  [5]
 LDCM0495  E2913 HEK-293T C365(1.44); C194(1.12); C864(0.87)  LDD1698  [6]
 LDCM0201  EV-3 T cell C365(8.48)  LDD0515  [7]
 LDCM0468  Fragment33 HEK-293T C365(1.06); C194(1.10); C864(0.91)  LDD1671  [6]
 LDCM0427  Fragment51 HEK-293T C365(1.08); C511(0.88); C194(0.92); C864(0.97)  LDD1631  [6]
 LDCM0022  KB02 HEK-293T C365(1.04); C495(1.05); C864(0.89); C511(1.02)  LDD1492  [6]
 LDCM0023  KB03 HEK-293T C365(1.04); C495(1.00); C864(0.94); C511(1.08)  LDD1497  [6]
 LDCM0024  KB05 COLO792 C194(1.51)  LDD3310  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock cognate 71 kDa protein (HSPA8) Heat shock protein 70 family P11142
Histone deacetylase 6 (HDAC6) Histone deacetylase family Q9UBN7
AP2-associated protein kinase 1 (AAK1) Ser/Thr protein kinase family Q2M2I8
Cyclin-G-associated kinase (GAK) Ser/Thr protein kinase family O14976
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) NIP3 family O60238
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Synaptotagmin-11 (SYT11) Synaptotagmin family Q9BT88
Protein YIF1A (YIF1A) YIF1 family O95070

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019
4 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
7 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.